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      • SCIESCOPUSKCI등재

        Inhibitory Effects of Curcuma xanthorrhiza Supercritical Extract and Xanthorrhizol on LPS-Induced Inflammation in HGF-1 Cells and RANKL-Induced Osteoclastogenesis in RAW264.7 Cells

        ( Siyeon Kim ),( Kyo Eun Kook ),( Changhee Kim ),( Jae-kwan Hwang ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.8

        Periodontal disease is triggered by the host immune response to pathogens in the microbial biofilm. Worsening of periodontal disease destroys the tooth-supporting tissues and alveolar bone. As oral inflammation can induce systemic diseases in humans, it is important to prevent periodontal disease. In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells. LPS-upregulated inflammatory factors, such as nuclear factor kappa B p65 and interleukin-1β, were prominently reduced by CXS and XAN. In addition, RANKL-induced osteoclastic factors, such as nuclear factor of activated T-cells c1, tartrate-resistant acid phosphatase, and cathepsin K, were decreased in the presence of CXS and XAN. CXS and XAN inhibited the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway. Collectively, these results provide evidence that CXS and XAN suppress LPS-induced inflammation and RANKL-induced osteoclastogenesis by suppressing the MAPK/AP-1 pathway.

      • KCI등재

        Physiological and psychological neck load imposed by ballistic helmets during simulated military activities

        Siyeon Kim,정원영 한국의류학회 2020 Fashion and Textiles Vol.7 No.1

        The wearing of ballistic helmets commonly coordinated with a night vision device (NVD) often imposes a load to the neck of a soldier. A lighter ballistic helmet promises comfort and enhanced combat performance, but technological developments have not provided a complete solution satisfying all the requirements, including cost. Moreover, the change in munition has led to increasing demand for the attachment of more accessories to the helmet, providing advanced functions but additional weight. Therefore, the current study quantifed the neck muscle strain caused by the varying weight of a ballistic helmet, particularly during simulated infantry activities with moderate neck fexion and neck extension against a head-weight in the prone position. Eight healthy males participated on four separate days. On each day, diferent loads were placed on the head: 0 kg (no helmet, NH) to 2.07 kg (1.5 kg helmet with a 0.5 kg night vision device, HH&NVD). The results showed that prone shooting imposed substantial muscular strain on the splenius capitis (neck extensor), resulting in a 7–9% maximal voluntary contraction depending on the overall helmet loads. In addition, a gradual increase in the subjective neck load and pain in proportion to the overall weight of the helmet assembly was noted, and the heaviest loads caused severe complaints for muscular discomfort. This paper recommends strategies for designing and developing ballistic helmets as well as further methodological issues on evaluating neck muscle strain caused by the helmet weight.

      • Re-Visioning of the “Universal” in Adrienne Rich’s Poetry

        Siyeon Kim Ewha Institute of English and American Studies 2023 Journal of English and American studies Vol.21 No.2

        Literary critics have long acknowledged that Adrienne Rich’s poetic style changes from being self-effacing to woman-identified. This paper traces the development of Rich’s poetry through “Snapshots of a Daughter-in-Law” and “Diving into the Wreck,” which are both poems about the reality of women’s lives. The shift in Rich’s style of writing shows how she embarks on a feminist journey to find a new “universal” language that conveys the experiences of men and women alike. “Snapshots of a Daughter-in-Law” could be seen as an early yet incomplete attempt at using this “universal” language; the division between Rich and her female characters, as well as her reliance on allusion, reveal that Rich was still under the influence of male poets. However, over the years, Rich overcomes these shortcomings and succeeds in moving towards a feminist poetics. In addition to feminism, Rich’s thematic concerns come to include queer theory, which can be observed in “Diving into the Wreck.” By comparing two works from different points in Rich’s poetic career, this paper illuminates how Rich struggled to include women and queer groups in the male-dominated world of literature.

      • KCI등재

        마우스 T 세포 림프종 EL4 세포에 대한 metformin 단독 및 2-deoxy-D-glucose와 병용의 항암효과

        Si-Yeon Kim,주홍구 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.3

        Metformin is a treatment used widely for non-insulin-dependent diabetes mellitus with few side effects and acts by inhibiting hepatic gluconeogenesis and glucose absorption from the gastrointestinal tract. Lymphoma is one of the most common hematological malignancies in dogs. Chemotherapy is used mainly on lymphoma, but further research on developing anticancer drugs for lymphoma is needed because of its severe side effects. This study examined the anticancer effects of metformin alone and in combination with 2-deoxy-D-glucose (2-DG), a glucose analog, on EL4 cells (mouse T cell lymphoma). Metformin reduced the metabolic activity of EL4 cells and showed an additive effect when combined with 2-DG. In addition, cell death was confirmed using a trypan blue exclusion test, Hochest 33342/propidium iodide (PI) staining, and Annexin V/PI staining. An analysis of the cell cycle and mitochondria membrane potential (MMP) to investigate the mechanism of action showed that metformin stopped the G2/M phase of EL4 cells, and metformin + 2-DG decreased MMP. Metformin exhibited anticancer effects as a G2/M phase arrest mechanism in EL4 cells and showed additive effects when combined with 2-DG via MMP reduction. Unlike cytotoxic chemotherapeutic anticancer drugs, metformin and 2-DG are related to cellular glucose metabolism and have little toxicity. Therefore, metformin and 2-DG can be an alternative to reduce the toxicity caused by chemotherapeutic anticancer drugs. Nevertheless, research is needed to verify the in vivo efficacy of metformin and 2-DG before they can be used in lymphoma treatments.

      • KCI등재

        주택매매가격지수와 소비자심리지수 간의 인과관계 분석: 한국과 중국을 중심으로

        ( Si Yeon Kim ),( Xiao Zhen Fang ),( Seon Jong Yoo ) 현대중국학회 2013 現代中國硏究 Vol.15 No.1

        중국경제는 1978년 개혁과 개방 정책을 추진한 이래 매우 빠른 속도로 발전해 미국 다음으로 세계 2위의 경제규모를 갖게 되었다. 중국 내 국민 경제의 상당부분을 부동산 투자가 차지하게 되었고 이에 따라 중국 부동 산가 격은 계속 상승하고 있으며, 1990년대부터 중국 부동산개발 규모가 매년 평균 20%이상 고속 성장하고 있다. 한국과 중국 간에 경제교류가 양·질적인 면에서 지속적으로 이루어지고 양국 간에 경제교류는 더욱 확 대 될 것으로 기대되고 있다. 중국 경제가 세계 전반에서 차지하는 비중을 볼 때 중국 경제 성장에 따른 파급효과를 예의주시할 필요가 있다. 중 국 통계청은 우리나라보다 한발 앞서 소비자심리지수를 발표하였고 경기 흐름을 살펴볼 수 있는 주요한 지표로 자리매김하였다. 최근 들어 주택시장 참여자들의 심리가 주택시장에 영향을 줄 수 있다는 여러 가지 연구들 이 발표되고 있으며 이러한 연구들은 소비자심리가 경제상황에 미치는 영 향에 대한 연구가 국·내외에서 활발히 진행되고 있다. 본 연구는 2008년 7월부터 2013년 2월까지로 한국 및 중국 소비자심 리지 수 자료와 주택매매가격지수(한국: 서울·부산·인천, 중국: 북경·상 해·청도)의 주택 시계 열 자료를 이용하여 양국의 소비자심리지수가 각 도 시의 주택매매가격지수에 얼마만큼의 영향을 받는 지와 더불어 시장의 주 기가 어떻게 형성되는지 혹은 주기에 영향을 미치는 요인은 무엇인지를 규명하는 데에 초점을 두었다. 본 연구는 종합적으로 한·중 양국의 소비자심리지수가 각국 주택매매 가격지수에 어느 정도 영향을 미치는지에 대해 파악하여 사전에 시장 흐름을 파악할 수 있는 수단으로써 정확도 분석을 위하여 계량통계를 이용 하여 분석하였다. 특히 본 연구에서 얻어진 결과와 같이 한국의 결과에 비하여 중국 3개의 도시(북경·상해·청도)의 주택매매가격지수가 중국의 소비자심리지수와 매우 높은 설명력을 지니고 있음을 확인하였다. 이는 중국 경제 흐름을 파악하는 데에 있어서 소비자심리지수는 중국 내 주택가 격과 동행하기 때문에 중요한 경지지표가 된다. 세계경제에서 중국이 끼 치는 영향력을 생각한다면 중국의 소비자심리지수에 주목할 필요가 있을 것으로 보인다. 이런 의미에서 본 연구는 한국과 중국의 주택시장의 경제 지표 중 하 나인 소비자심리지수를 이용하여 분석을 실시했다는 점에서 그 의의가 있으며 향후 자료의 누적으로 인해 긴 시계 열 자료를 이용할 수 있다면 다 양한 변수를 이용하여 검증하는 방법의 개발이 필요할 것으로 보인다. Since an economical revolution in 1978 and an employment of an open door policy, China`s economy has grown at an exponential rate, scoring the second biggest economy of the world next to the U.S.. As real estate investment started to play a major role in its domestic economy, the price rate for real estate in China has significantly increased, and its size of development has expanded more than 20 percent a year on average since 1990s. It is expected that the economic exchange between South Korea and China has been active both in its quality and size, and will increase every year. Considering the size that the economy of China takes up the global economy, it has quickly become very important to focus on studying the effect of China`s economy to the world with its fast paced growth. Be one step ahead Korean government, National Bureau of Statistics of China released its Customer Sentiment Index [CSI] and made it an important indicator of its economic flow. In real estate market, although there are multiple macro economic indexes, predicting the economic change is very difficult. Recently, several researches report that the sentiment of real estate investment participants can affect its market, and these researches that study the relationship between consumer sentiment and economic change have been active both domestically and internationally. This using Housing Price Index and Time Series Analysis of selected city in each countr research was conducted between July 2008 to Feb 2013 and its focus of study involves the extent of Housing Price Index of each city affecting the both country`s CSI, the shaping factors of market interval and its reasoning, y: Seoul, Pusan, and Incheon for South Korea, and Beijing, Shanghai, and Qingdao for China. In this research, chapter I discusses the objectives and background of this study, chapter II for advanced research on the relationship between housing market and consumer sentiment, and chapter III consists of a brief definition of CSI, an overview of the economies in both nations based on several economic indicators, and thus the foundation of the basis for an empirical study. Chapter IV measures the relevant factors, in an attempt to explain the relationship between housing market and consumer sentiment. Finally, chapter V summarizes the result of analysis and proposes the future research objectives.

      • KCI등재

        Research Trends in Electromagnetic Shielding using MXene-based Composite Materials

        Siyeon Kim,Jongmin Byun 한국분말재료학회(구 한국분말야금학회) 2024 한국분말재료학회지 (KPMI) Vol.31 No.1

        Recent advancements in electronic devices and wireless communication technologies, particularly the rise of 5G, have raised concerns about the escalating electromagnetic pollution and its potential adverse impacts on human health and electronics. As a result, the demand for effective electromagnetic interference (EMI) shielding materials has grown significantly. Traditional materials face limitations in providing optimal solutions owing to inadequacy and low performance due to small thickness. MXene-based composite materials have emerged as promising candidates in this context owing to their exceptional electrical properties, high conductivity, and superior EMI shielding efficiency across a broad frequency range. This review examines the recent developments and advantages of MXene-based composite materials in EMI shielding applications, emphasizing their potential to address the challenges posed by electromagnetic pollution and to foster advancements in modern electronics systems and vital technologies.

      • KCI등재

        Cooling performance measurements of different types of cooling vests using thermal manikin

        Siyeon Kim,Seojin Lee,Sora Shin,Daeyoung Lim 한국의류학회 2024 Fashion and Textiles Vol.11 No.1

        This study compared the effectiveness of five commercially available cooling vests using three distinct thermal manikin test protocols. In addition, the constraints associated with each test protocol were elucidated, facilitating the identification of suitable evaluation methods for the different cooling vests. The cooling performances of the vests were evaluated using three thermal manikin test scenarios, incorporating the adaptations from Ciuha et al. (Ergonomics 64:625–639, 2021) and ASTM F2371-16, along with a modified protocol simulating the hot and humid weather in a South Korean summer. The results revealed substantial variations in the cooling performance across different test protocols, highlighting the importance of carefully selecting thermal manikin test methods. Moreover, the specific cooling vests exhibited immeasurable performance in certain test methods, which presents the limitations inherent in each testing scenario. For example, when evaluated with a non-sweating thermal manikin, the air-cooling vests exhibited the worst cooling performance, showing an average cooling rate of 1.0 W and cooling durations of five minutes. In contrast, the same vests demonstrated superior performance when assessed using the ASTM F2371-16 method, revealing an effective cooling rate of 114.8 W and sustained cooling durations exceeding eight hours. These results emphasize the lack of a one-size-fits-all evaluation method for cooling vests and the need for accessible guidelines to inform decision-makers aiming to enhance workplace safety and comfort.

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