http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
In situ synthesis of luminescent carbon nanoparticles toward target bioimaging.
Sharker, Shazid Md,Kim, Sung Min,Lee, Jung Eun,Jeong, Ji Hoon,In, Insik,Lee, Kang Dea,Lee, Haeshin,Park, Sung Young RSC Pub 2015 Nanoscale Vol.7 No.12
<P>This paper describes the in situ synthesis of single fluorescence carbon nanoparticles (FCNs) for target bioimaging applications derived from biocompatible hyaluronic acid (HA) without using common conjugation processes. FCNs formed via the dehydration of hyaluronic acid, which were obtained by carbonizing HA, and partially carbonized HA fluorescence carbon nanoparticles (HA-FCNs), formed by a lower degree of carbonization, show good aqueous solubility, small particle size (<20 nm) and different fluorescence intensities with a red shift. After confirming the cytotoxicity of HA-FCNs and FCNs, we carried out in vitro and in vivo bioimaging studies where HA-FCNs themselves functioned as single particle triggers in target imaging. The converted nanocrystal carbon particles from HA provide outstanding features for in vitro and in vivo new targeted delivery and diagnostic tools.</P>
Sharker, S.Md.,Kim, S.M.,Lee, J.E.,Choi, K.H.,Shin, G.,Lee, S.,Lee, K.D.,Jeong, J.H.,Lee, H.,Park, S.Y. Elsevier Science Publishers 2015 Journal of controlled release Vol.217 No.-
We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO<SUB>3</SUB>) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO<SUB>3</SUB>-HA) to a tumor site. Near-infrared (NIR) irradiated WO<SUB>3</SUB>-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10nm HA thickness on WO<SUB>3</SUB> (WO<SUB>3</SUB>-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO<SUB>3</SUB>-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
Sharker, Shazid Md,Jeong, Chan Jin,Kim, Sung Min,Lee, Jung-Eun,Jeong, Ji Hoon,In, Insik,Lee, Haeshin,Park, Sung Young Wiley-VCH 2014 Chemistry - An Asian Journal Vol.9 No.10
<P>We report a stimuli-responsive fluorescent nanomaterial, based on graphene oxide coupled with a polymer conjugated with photochromic spiropyran (SP) dye and hydrophobic boron dipyrromethane (BODIPY) dye, for application in triggered target multicolor bioimaging. Graphene oxide (GO) was reduced by catechol-conjugated polymers under mildly alkaline conditions, which enabled to formation of functionalized multicolor graphene nanoparticles that can be induced by irradiation with UV light and by changing the pH from acidic to neutral. Investigation of these nanoparticles by using AFM, fluorescence emission, and in vitro cell and in vivo imaging revealed that they show different tunable colors in bioimaging applications and, more specifically, in cancer-cell detection. The stability, biocompatibility, and quenching efficacy of this nanocomposite open a different perspective for cell imaging in different independent colors, sequentially and simultaneously.</P>
Sharker, Shazid Md.,Kim, Sung Min,Kim, Sung Han,In, Insik,Lee, Haeshin,Park, Sung Young The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.28
<P>The development of cooperative drug delivery systems that can detect and target the disease site, with rapid trigger controlled drug release (internally and externally), is widely expected to change the landscape of future drug carriers. In this study a drug delivery system was developed for the cancer-targeted release of chemotherapeutic agents inside living cells. This system is an environment sensitive (pH), and external photothermally remote controlled, cooperative image-guided drug delivery matrix. Partially carbonized fluorescence hyaluronic acid (HA-FCN) was conjugated with boronic acid (BA) to promote the formation of boronate ester with diol groups of β-cyclodextrin (CD) [HA-FCN-CD]. The pH influence mediated release of paclitaxel (PTX) from the CD cavity of HA-FCN-CD was utilized for targeted cancer bioimaging. This active-target delivery system (HA-FCN-CD-PTX) was found to show optical absorption properties similar to those of the near infrared (NIR) light sensitive carbonized material. This system exploits acidity for triggered drug release and rapid generation of mild photothermal heat to trigger burst release of PTX. Cooperative guided bioimaging that employs both internal pH responsive and external NIR controlled drug carriers is a promising method for chemotherapeutic release that can be adjusted according to physiological needs.</P>
( Shazid Md. Sharker ),김성민,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
We report a pH-dependent, NIR-sensitive, reduced graphene oxide (rGO) hybrid nano-composite synthesize via electrostatic interaction with indocyanine green (ICG) which is designed not only to destroy localized cancer cells but also be minimally invasive to surrounding normal cells. From pH 5.0 to 7.4, the near-infrared (NIR) irradiated hybrid nano-composites showed pH dependent photo-thermal heat generation capability, due to the pH response relief and quenching effects of poly(2-dimethyl amino ethyl methacrylate) [poly(PDMAEMA)] with ICG on a single rGO sheets. The in vitro cellular uptake and local NIR irradiated in vivo tumor ablation after 18 days treatment are very promising to fight against cancer.
Fluorescent carbon nanoparticle derived from hyaluronic acid for cancer targeted imaging
( Shazid Md. Sharker ),김성한,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Cancer targeted biocompatible bio-imaging carrier has the potential to revolutionized diagnosis and therapy. To address these potentialities, we report in situ synthesis of hyaluronic acid fluorescent carbon nanoparticle (HA-FCN) and fluorescent carbon nanoparticle (FCN) obtain from the controlled carbonization method using the biocompatible hyaluronic acid (HA). The FCN with remaining HA (HA-FCN) and without identification of remaining HA (FCN) both showed aqueous solubility and small particle size (<20 nm) with different in fluorescence intensity. Without typical conjugation, HA-FCN itself appeared for the trigger targeted bioimaging for the probe. These findings speculate outstanding features in new drug delivery, sensors, diagnostic tools and different biomedical application.
( Shazid Md. Sharker ),이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Biodegradable polydioxanone (PDO) stents were coated with hyaluronic acid-dopamine (HA-DA) and barium sulfate (BaSO4) to enhance biocompatibility, tissue adhesiveness and radio-opacity for the treatment of esophageal diseases. The HA-DA conjugate was synt
Surface functionalization via catechol conjugated polymer coated substrate
( Shazid Md. Sharker ),정찬진,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
We report an effective surface polymerization and functionalization method by using catechol (CCDP) grafted poly[(2-hydroxyethyl methacrylate)-co-(2-(dimethylamino)ethyl methacrylate)] [poly(HEMA-co-DMAEAM)-g-CCDP, CGPH] composite. The functionalization have carried out via radical polymerization of N-isopropylacrylamide (NIPAAm) and ring opening polymerization (ROP) of carprolactone in a hydroxyl functional group of HEMA on a adhered substrate. Inspired by the adhesive properties of catechol, the silver nanoparticle (AgNPs) deposited on the substrate have performed significant antimicrobial effect. Interactions with both surface and inorganic AgNPs prompted catechol as a convenient surface modification tools.
Cancer targeted fluorescent carbon nanoparticle derived from hyaluronic acid
( Shazid Md. Sharker ),이해신,박성영 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
Targeted biocompatible bio-imaging carrier has the potential to revolutionized cancer diagnosis and therapy. To address these potentialities, we report one-step synthesis of hyaluronic acid fluorescent carbon nanoparticle (HA-FCN) and fluorescent carbon nanoparticle (FCN) obtain from the controlled carbonization method using the biocompatible hyaluronic acid (HA). The FCN with remaining HA (HA-FCN) and without identification of remaining HA (FCN) both showed aqueous solubility and small particle size (<20 nm) with different in fluorescence intensity. As a single particle, HA-FCN itself appeared for the first time to trigger targeted imaging for the probe. These findings speculate outstanding features for generating new target delivery and diagnostic tools.
Kang, E.B.,Sharker, S.Md.,In, I.,Park, S.Y. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.43 No.-
<P>Fluorescent carbon nanoparticles based target drug delivery with bio-imaging systems offer tremendous scope for future. We described Pluronic mimicking fluorescent nanoparticles (Plu-FNPs) surface decorated doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folk acid (FA) [Plu-FNPs-FA-DOX]. The acid labile of hydrazine linkage to DOX can easily break off by controlled pH inducing release of conjugated DOX at site of over-expressed folate receptors (FR). This nanoparticle system can deliver DOX to the target FR and trace the delivery pathway of cancer cells. The approaching platform demonstrates the selectivity and sensitivity of molecular targets, thereby able to maximize the therapeutic efficiency. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>