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Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Zheng, Ming Shan,Hwang, Nam-Kyung,Kim, Do-Hoon,Moon, Tae-Chul,Son, Jong-Keun,Chag, Hyeun-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, ${\alpha}-spinaterol$ (1), ursolic acid (2), ergosterol peroxide (3), ${\alpha}-spinaterol$ glucoside (4), 2-methoxy-9-${\beta}$-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with $IC_{50}$ values of 21.04 ${\mu}M$, 42.30 ${\mu}M$, 32.82 ${\mu}M$, and 17.18 ${\mu}M$, respectively.
Zheng, Ming-Shan,Lee, Yeun-Kyung,Li, Ying,HwangBo, Kyoung,Lee, Chong-Soon,Kim, Jae-Ryong,Lee, Sunny Kyung-Seon,Chang, Hyun-Wook,Son, Jong-Keun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9
Twenty five compounds including ten triterpenes (1-3, 5-11), six flavonoids (12-15, 24, 25), five lignans (17, 18, 21-23), two butenyl clohexnone glycosides (19-20), one fructofuranoside (16) and one fatty acid (4) were isolated from the roots of Ulmus davidiana var. japonica. The structures of those compounds were identified by comparing their physicochemical and spectral data with those of published in literatures. All the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 4 and 19 showed more potent inhibitory acitivities ($IC_{50}$: 39 and 19 ${\mu}M$, respectively) than camptothecin, as the positive control ($IC_{50}$: 46 ${\mu}M$) against topoisomerase I. Compounds, 4, 10, 12, 19, 24 and 25 showed strong inhibitory activities toward DNA topoisomerase II ($IC_{50}$: 0.1, 0.52, 0.47, 0.42, 0.17 ${\mu}M$ and 17 nM, respectively), which were more potent than that of etoposide as positive control ($IC_{50}$: 20 ${\mu}M$). In A549 cell line, 5 and 6 showed cytotoxicities ($IC_{50}$: 4 ${\mu}M$ and 3 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin as positive control: 10.3 ${\mu}M$). In the HepG2 cell line, 3, 5 and 7 showed cytotoxicity ($IC_{50}$: 4, 3 and 4 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 0.3 ${\mu}M$). Compounds 6, 12 and 23 showed cytotoxicities in the HT-29 cell line ($IC_{50}$: 19, 19 and 15 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 2 ${\mu}M$).
Zheng, Shan,Song, Qing-Kun,Zhao, Lin,Huang, Rong,Sun, Li,Li, Jing,Fan, Jin-Hu,Zhang, Bao-Ning,Yang, Hong-Jian,Xu, Feng,Zhang, Bin,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
The aim of this study was to detail characteristics of mammary Paget's disease (PD) representing the whole population in China. A total of 4211 female breast cancer inpatients at seven tertiary hospitals from seven representative geographical regions of China were collected randomly during 1999 to 2008. Data for demography, risk factors, diagnostic imaging test, physical examination and pathologic characters were surveyed and biomarker status was tested by immunohistochemistry. The differences of demography and risk factors between PD with breast cancer and other lesions were compared using Chi-square test or t-test, with attention to physical examination and pathological characters. The percentage of PD was 1.6% (68/4211) in all breast cancers. The mean age at diagnosis was 48.1, and 63.2% (43/68) patients were premenopausal. There is no difference in demography and risk factors between PD with breast cancer and other breast cancer (P > 0.05). The main pattern of PD in physical exam and pathologic pattern were patients presenting with a palpable mass in breast (65/68, 95.6%) and PD with underlying invasive cancer (82.4%, 56/68) respectively. The rate of multifocal disease was 7.4% (5/68). PD with invasive breast cancer showed larger tumor size, more multifocal disease, lower ER and PR expression and higher HER2 overexpression than those in other invasive breast cancer (P < 0.05). These results suggested that PD in China is a concomitant disease of breast cancer, and that PD with underlying invasive cancer has more multiple foci and more aggressive behavior compared with other breast invasive cancer. We address the urgent needs for establishing diagnostic and therapeutic guidelines for mammary PD in China.
Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica
Ming Shan Zheng,Jong Keun Son,Gao Li,Ying Li,서창섭,Yeun-Kyung Lee,Jun-Sub Jung,송동근,Hong-Beom Bae,Sang-Hyun Kwak,Hyun-Wook Chang,김재룡 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Ming Shan Zheng,Do Hoon Kim,Nam Kyung Hwang,Tae Chul Moon,Jong Keun Son,장현욱 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, α-spinaterol (1), ursolic acid (2), ergosterol peroxide (3), α- spinaterol glucoside (4), 2-methoxy-9-β-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5- LOX activity with IC50 values of 21.04 µM, 42.30 µM, 32.82 µM, and 17.18 µM, respectively.
Stochastic Resonance Control by Coupling Two Fractional Bistable Systems
Yongjun Zheng,Fei Wang,Shan-an Zhu 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.11
In order to enhance or produce stochastic resonance (SR), to obtain the required output response with specific properties, two bistable systems based on fractional over-damped Langevin equation are coupled into one multi-steady-state system via nonlinear method, one fractional bistable system where inherent parameters can be controlled is fed into the other system, the kinetic characteristics of the new coupled system is found much richer than each single fractional system. Theoretical analysis and numerical simulation results show that the SR can be enhanced or produced by adjusting parameters as coupling coefficient, fractional system inherent parameters as well as the external periodical signal amplitude while another fractional system’s parameters fixed. The coupled system has high practical value, which provides a reliable theoretical basis for the control and its applications of artificially generated stochastic resonance.