CYP2E1^*5B, CYP2E1^*6, CYP2E1^*7B, CYP2E1^*2, and CYP2E1^*3 Allele Frequencies in Iranian Populations

Shahriary, Ghazaleh Mohammadzadeh,Galehdari, Hamid,Jalali, Amir,Zanganeh, Fatemeh,Alavi, Seyed Mohammad Reza,Aghanoori, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran Materials and Methods: Two hundred healthy individuals of an Iranian population from the southwest were included in this study. PCR-restriction fragment length polymorphism and Tetra-ARMS PCR methods were applied for CYP2E1 genotyping. Results: The allele frequencies for $^*5B$, $^*6$, $^*7B$, $^*2$, and $^*3$ were calculated to be 1.5%, 16%, 28.5%, 0%, and 2.75% respectively. Results of this study showed that no significant differences in genotype and allele frequencies of five single nucleotide polymorphisms with respect to the gender and tribes. The chi-square test showed that the genotype frequencies of $CYP2E1^*5B$ were similar to Caucasians, but the distribution of $CYP2E1^*6$ genotypes was similar to Asians. The frequencies of $CYP2E1^*2$ (0%) and $CYP2E1^*3$ (2.75%) alleles were within the range for Caucasians and Orientals. In the case of $CYP2E1^*7B$, the data werelimited. Accordingly, the results were only compared with Europeans and the comparison showed significant differences. Conclusions: In conclusion, ethnic and geographic differences may explain discrepancies in the prevalence of CYP2E1 polymorphisms.

Prevalence of Oxaliplatin-induced Chronic Neuropathy and Influencing Factors in Patients with Colorectal Cancer in Iran

Shahriari-Ahmadi, Ali,Fahimi, Ali,Payandeh, Mehrdad,Sadeghi, Masoud Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: The chemotherapeutic agent oxaliplatin can cause acute and chronic forms of peripheral neuropathy. The aim of this study was to evaluate the incidence of chronic neuropathy and its risk factors in colorectal cancer (CRC) patients treated with FOLFOX or XELOX regimens in the Oncology Ward of Hazrate-Rasoul Hospital in Tehran. Materials and Methods: A total of 130 patients with CRC were entered into our study, aged over 18 years, without history of receiving other neurotoxic agents or other predisposing factors such as diabetes or neurologic diseases and kidney and liver dysfunction. For the FOLFOX regimen, patients received oxaliplatin, 85mg/m2, every 2 weeks for 12 courses and with the XELOX regimen, oxaliplatin was $130mg/m^2$, every 3 weeks for 8 courses. Based on Common Toxicity Criteria (CTC or NCI-CTC v.3), the patients were divided into 5 groups (grades) based on the severity of their symptoms. Results: Fifty-seven patients (43.8%) were male and 73(56.2%) female. Some 19 patients (14.7%) had BMI<20, 97(74.6%) were between 20-25 and 14 (10.8%) ${\geq}25$. In 105 patients (80.7%) neuropathy was found. There was significant correlation between BMI, hypomagnesaemia and especially, severity of anemia in patients with neuropathy compared to those without. Conclusions: Oxaliplatin regimens can induce chronic neuropathy in CRC patients, with anemia, high BMI and hypomagnesaemia as risk factors that can predispose to this kind of neurotoxicity.

Oncology Nurses Knowledge and Attitudes Regarding Cancer Pain Management

Shahriary, Shahdad,Shiryazdi, Seyed Mostafa,Shiryazdi, Seyed Ali,Arjomandi, Amir,Haghighi, Fatemeh,Vakili, Fariba Mir,Mostafaie, Naiemeh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: Oncology nurses play a crucial role in cancer pain management and must be highly informed to ensure their effective practice in the cancer setting. The aim of this study was to determine the baseline level of knowledge and attitudes of oncology nurses regarding cancer pain management. Materials and Methods: A cross-sectional survey research design was employed. The sample comprised 58 cancer nurses working in Shahid Sadoughi hospital, Yazd, Iran. The "Nurses Knowledge and Attitudes Survey Regarding Pain" (NKAS) tool and a demographic form were utilized to ascertain the knowledge and attitudes of oncology nurses working in oncology settings. Results: The average correct response rate for oncology nurses was 66.6%, ranging from 12.1% to 94.8%. The nurses mean score on the knowledge and attitudes survey regarding pain management was 28.5%. Results revealed that the mean percentage score overall was 65.7%. Only 8.6% of nurse participants obtained a passing score of 75% or greater. Widespread knowledge deficits and poor attitudes were noted in this study, particularly regard pharmacological management of pain. Conclusions: The present study provides important information about knowledge deficits in pain management among oncology nurses and limited training regarding pain management. Our results support the universal concern of inadequate knowledge and attitudes of nurses regarding cancer pain. It is suggested educational and quality improvement initiatives in pain management could enhance nurses knowledge in the area of pain and possibly improve practice.

Simulation of Microstructure Evolution during Hot Rolling

D. Shahriari,Y. H. Do,S.J. Baek,S.K. Kim,K.T. Kim 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11

Steel alloys undergo complicated microstructure evolution during hot rolling which determines the quality and the mechanical properties of products. Mechanisms based on thermo-elasto-viscoplastic are developed that completely integrates mechanics and heat transfer in the workpiece and the evolution of grain size, static and dynamic and metadynamic recryctaliztion and their effects on flow of materials. Using finite element method basic equations for material flow with different hot rolling process parameters such as friction factor, rolling speed, heat transfer coefficient initial workpiece temperature have been solved. The effects of hot rolling variables on rolling force and recrystallization kinetics also have been analyzed. Simulated results show good agreements with the measured values.

Evaluation of Die Chilling Effects during Forging of Nimonic-80A Superalloy

D. Shahriari,M.H. Sadeghi,A. Amiri,M. Cheraghzadeh 한국소성가공학회 2010 기타자료 Vol.2010 No.6

Nimonic-80A is a kind of nickel-based superalloys which is used in high temperature components of land gas turbines. In this paper, the influence of four design factors: die temperature, strain rate, friction coefficient and geometry size of ring sample over the variation of internal diameters (VID) and forging load (FL) was studied. It was done by means of design methodology based on DOE-designated full factorial and FE simulations. FEM and experimental results showed that the variation of internal diameters and forging load had inverse proportion to the die temperature. Regression models were developed by using the response surface methodology (RSM) for VID and FL. Rate of the dynamic recrystallization varied depending on different amounts of die temperature. The results can be used in the semi-isothermal forging of complex part of the Nimonic-80A.

Sinterability and flexural strength of monolithic ZrB2: role of nano‑carbon black and SiC

Mostafa Shahriari Asl,Zohre Balak 한국탄소학회 2023 Carbon Letters Vol.33 No.6

In this research, synergetic and separate influence of nano-carbon black (C.Bn) and SiC on the microstructure and flexural strength of ZrB2 were investigated. So, ZrB2 and ZrB2- 30vol%-based composites containing 10 and 15 vol% C.Bn as well as ZrB2- 15 vol% SiC were fabricated via spark plasma sintering at 1850 °C for soaking time of 8 min under the applied pressure of 35 MPa. Relative density was measured by Archimedes method. Microstructural evaluation was carried out by applying the field emission electron microscopy (FESEM), and flexural strength was measured by three-point bending test. It was found the relative density improves in the presence of C.Bn and SiC especially in synergetic state so that the full densification was gained in Z30Si10C.Bn and Z30Si15C.Bn composites through their reactions with impurities at 1850 °C. In the monolithic ZrB2 system, the C.Bn addition improves the flexural strength slightly to 300 MPa and 315 MPa from 290 MPa. However, co-doped 10 vol% C.Bn with 30 vol% SiC resulted to achieve maximum flexural strength of 486 MPa in comparison with individually applying each of them (395 MPa for Z30Si and 300 MPa for Z10 C.Bn).

An accurate and simple model for flexible satellites for three-dimensional studies

Shahram Shahriari,Shahram Azadi,Majid M. Moghaddam 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.6

In this paper, an accurate and simple model of a satellite with two flexible solar panels for three-dimensional dynamic studies is proposed and compared with other models. In the proposed model, each solar panel is assumed to be rigid and attached to the satellite body via a simple hinge, a torsional spring, and a torsional damper. Kane's method is utilized to derive the equations of motion. The model of flexible satellite with the assumption of Euler-Bernoulli beam for the solar panels, generally used in the literature, has been introduced for comparison. A comprehensive model of flexible satellite, considering solar panels as flexible and finite element panels, has been provided in ADAMS environment as a reference when comparing the two mentioned models. The Euler-Bernoulli model does not appropriately simulate the three-dimensional motion of satellite. Conversely, the hinged, rigid-panel model proposed in this paper provides suitable results in both two- and three-dimensional maneuvers.

Modeling Deformation Flow Curves and Dynamic Recrystallization of BA-160 Steel During Hot Compression

Babak Shahriari,Reza Vafaei,Ehsan Mohammad Sharifi,Khosro Farmanesh 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5

The hot deformation behavior of a high strength low carbon steel was investigated using hot compression test at the temperaturerange of 850–1100 °C and under strain rates varying from 0.001 to 1 s −1 . It was found that the fl ow curves of the steelwere typical of dynamic recrystallization at the temperature of 950 °C and above; at tested strain rates lower than 1 s −1 . Avery good correlation between the fl ow stress and Zener–Hollomon parameter was obtained using a hyperbolic sine function. The activation energy of deformation was found to be around 390 kJ mol −1 . The kinetics of dynamic recrystallization of thesteel was studied by comparing it with a hypothetical dynamic recovery curve, and the dynamically fraction recrystallizedwas modeled by the Kolmogorov–Johnson–Mehl–Avrami relation. The Avrami exponent was approximately constant around1.8, which suggested that the type of nucleation was one of site saturation on grain boundaries and edges.

Study of Back Bending in 157,158Er Isotopes by Using Electromagnetic Reduced Transition Probabilities

Mehran Shahriarie,Saeed Mohammadi,Zohreh Firouzi 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.1

Electromagnetic reduced transition probabilities B(E2) and B(M1) calculated by using the PSM (Projected Shell Model) code are used to study the back-bending phenomenon in $^{157,158}$Er isotopes. As a result, two great drops in the B(E2)/B(M1) ratio were observed in spins 12 $\hbar$ and (37/2) $\hbar$ for the $^{158}$Er and the $^{157}$Er isotopes, respectively, which coincident exactly with the inertia change versus rotational frequency in the usual back-bending plots for these isotopes.

Removal of Chromium (III) from Wastewater by Electrocoagulation Method

Toktam Shahriari,Gholamreza Nabi Bidhendi,Naser Mehrdadi,Ali Torabian 대한토목학회 2014 KSCE Journal of Civil Engineering Vol.18 No.4

The industrial wastewaters mostly contain toxic compounds such as chromium which would be harmful. Among the novel technologies for removing these pollutants, electrocoagulation can be considered as an effective method. This method enjoys some advantages like less amount of produced sludge and high efficiency in removal of pollutants. In this study, electrocoagulation method was used for the removal of chromium from synthetic wastewater polluted by chromium sulfate. For this purpose, the removal of chromium (III) with different concentrations from artificial wastewater was investigated. The best concentration was obtained at removal efficiency of 99.96%. A cubic tank made of Plexiglas with an effective volume of 2.5 L was used as electrocoagulation reactor. A total number of 10 metal plates made of iron in 11 × 7 cm and 2 mm thick were placed inside the tank. Electrodes of bipolar and monopolar array were also used in the reactor. The optimal values of pH, magnetic stirrer rotation, test time and settling times, temperature and voltage parameters were specified according to the primary concentration (500 mg/L). The optimal pH was 6. The mechanism of chromium removal was also investigated, and the results showed that the reactions in the electrocoagulation process are exothermic.