고랭지 농업 용수확보를 위한 소규모 빗물 이용시설 적용방안

전계원(Kye Won Jun)(全桂元),장창덕(Chang Deok Jang)(張昌德),정승권(Seung Kwon Jung)(鄭承權),전병희(Byong Hee Jun)(田炳熙) 위기관리 이론과 실천 2013 Crisisonomy Vol.9 No.8

최근 기후변화로 지난 2009년과 2012년에 강원도 태백시에서는 가뭄으로 인하여 엄청난 피해를 경험한 적이 있다. 또한 가뭄과 장마의 예측은 점점 더 어려워져 가는 실정이다. 특히 태백시의 87일간의 가뭄과 제한급수에 따른 피해액은 일상생활 134억원, 산업부문 338억원, 공공부문 47억원, 정신적ㆍ사회적 피해 1, 430억원 등 총 1, 949억원에 달하는 것으로 분석되었다. 태백시에 또 다른 큰 문제점은 가뭄으로 인한 고랭지 농업 피해로 인한 손실이다. 고랭지 배추를 생산하는 태백시는 우리나라 유일의 고산지역의 도시로서, 고랭지 농업이 특히 발달한 지역이다. 특히 태백 고랭지 배추는 태백시 농산품의 95.9%, 총 경지면적의 86.6%를 차지하고 있으므로, 배추의 생산성이 태백시 농산품 생산성을 대변한다고 할 수 있다. 본 연구에서는 태백시의 공공기관과 고랭지 농업 지역을 직접 방문하여 소규모 빗물 이용 시설에 대한 현황조사 및 시설의 상태를 점검하고 가뭄발생시 고랭지 농업지역의 피해를 최소화 할 수 있도록 소규모 빗물 이용 시설의 적용 방안 및 효과를 분석하였다. Recently, drought and rainy season are getting more serious. It is getting hard to forecast about drought because drought frequency is getting shorter than before. In 2009(winter) and 2012(summer), Taebaek-si was suffered from enormous damage due to the drought. Particularly, in 2009, cost of damage due to drought and restriction on water supply for 87days were estimated daily life sector 134 billion won, industry sector 338 billion won, the public sector 47 billion won, mental and social damage 1, 430 billion won. The other big issue of Taebaek is decrease in products of Highland Agricultural caused by the drought. Highland chinese cabbage which is the most important agricultural product in Taebaek-si account for 95.9% of all agricultural production of Taebaek-si and account for 86.6% of all gross area. For this reason, chinese cabbage of Taebaek-si is tropical agricultural product and is in charge of supply cabbage definitely. It is considered that if small scale rainwater harvesting system would be installed in highland agriculture area, it could reduce damage of drought at low cost and damage of cabbage would be decrease by system. For this study, We have researched regarding current status of Small Scale Rainwater Harvesting System of Highland Agriculture area in Taebaek-si and have compared with the amount of damage and installation cost in case of drought for the beneficial effects of Small Scale Rainwater Harvesting System, flexible supply of water and damage minimization of agricultural products.

Acute Contralateral Radiculopathy after Unilateral Transforaminal Lumbar Interbody Fusion

Jang, Kyoung-Min,Park, Seung-Won,Kim, Young-Baeg,Park, Yong-Sook,Nam, Taek-Kyun,Lee, Young-Seok The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.58 No.4

Objective : Cases of contralateral radiculopathy after a transforaminal lumbar interbody fusion with a single cage (unilateral TLIF) had been reported, but the phenomenon has not been explained satisfactorily. The purpose of this study was to determine its incidence, causes, and risk factors. Methods : We did retrospective study with 546 patients who underwent a unilateral TLIF, and used CT and MRI to study the causes of contralateral radicular symptoms that appeared within a week postoperatively. Clinical and radiological results were compared by dividing the patients into the symptomatic group and asymptomatic group. Results : Contralateral symptoms occurred in 32 (5.9%) of the patients underwent unilateral TLIF. The most common cause of contralateral symptoms was a contralateral foraminal stenosis in 22 (68.8%), screw malposition in 4 (12.5%), newly developed herniated nucleus pulposus in 3 (9.3%), hematoma in 1 (3.1%), and unknown origin in 2 patients (6.3%). 16 (50.0%) of the 32 patients received revision surgery. There was no difference in visual analogue scale and Oswestry disability index between the two groups at discharge. Both preoperative and postoperative contralateral foraminal areas were significantly smaller, and postoperative segmental angle was significantly greater in the symptomatic group comparing to those of the asymptomatic group (p<0.05). Conclusion : The incidence rate is not likely to be small (5.9%). If unilateral TLIF is performed for cases when preoperative contralateral foraminal stenosis already exists or when a large restoration of segmental lordosis is required, the probability of developing contralateral radiculopathy is increased and caution from the surgeon is needed.

Case Reports : A Case of Pulmonary Cryptococcosis by Capsule-deficient Cryptococcus neoformans

Won Seok Cheon,Kwang Seok Eom,Byoung Kwan Yoo,Seung Hun Jang,Joon Woo Bahn,Dong Gyu Kim,Ki Suck Jung 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.1

Delayed Diagnosis of Small Cell Lung Cancer in a Patient with Allergic Bronchopulmonary Aspergillosis

Won Sik Jung,Jin Won Jang,Seung Yong Park,Yeong Hun Choe,Yong Chul Lee,So Ri Kim 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.2

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder induced by Aspergillus fumigatus that occurs generally in patients with underlying chronic airway disorders. However, the development of ABPA associated with lung malignancy remains unknown. An 80-year-old woman was admitted for evaluation of chronic cough. Her radiologic finding was a mass like opacity with mucoid impaction, showing finger-in-glove sign, one of the typical radiologic findings for ABPA. In addition, laboratory tests revealed that her data satisfied the diagnostic criteria for ABPA. Interestingly, final pathologic examination showed that the mass lesion was small cell lung cancer. Here, we describe a case of delayed diagnosis of small cell lung cancer with ABPA, suggesting that a possibility of accompanying lung malignancy such as small cell lung cancer should be considered in patients with ABPA. This case let us realize the importance of clinical suspicion that different entities of diseases can be occurred simultaneously for the correct diagnosis without delay.

Identification of a Rare 3 bp <i>BRAF</i> Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction

Jang, Mi-Ae,Lee, Seung-Tae,Oh, Young Lyun,Kim, Sun Wook,Chung, Jae Hoon,Ki, Chang-Seok,Kim, Jong-Won The Korean Society for Laboratory Medicine 2012 Annals of Laboratory Medicine Vol.32 No.3

<P>Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the <I>BRAF</I> gene. The substitution of a valine for a glutamic acid (V600E) comprises up to 95-100% of <I>BRAF</I> mutations; therefore, most diagnostic methods, including allele-specific PCR and real-time PCR, are designed to detect this mutation. Nevertheless, other mutations can also comprise the genetic background of PTC. Recently, a novel and sensitive technique called mutant enrichment with 3'-modified oligonucleotides (MEMO) PCR has been introduced. When we applied allelespecific PCR and MEMO-PCR for the detection of the <I>BRAF</I> V600E mutation, we found an unusual 3' bp deletion mutation (c.1799_1801delTGA) only when using MEMO-PCR. This deletion results in the introduction of a glutamic acid into the B-Raf activation segment (p.V600_K601delinsE), leading to an elevated basal kinase activity of <I>BRAF</I>. This is the first report of a rare 3 bp <I>BRAF</I> deletion in a PTC patient that could not be detected by allele-specific PCR.</P>

Fabrication and Cold Test of a 9-MeV C-Band Accelerating Column

Seung Hun Kim,Sang Koo Kang,Dong Eun Lee,Sang Jin Lee,Hee Chang Kim,Jungyu Yi,Kyoung Won Jang,Dong Hyeok Jeong,Heuijin Lim,Man Woo Lee 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.7

A 9-MeV electron linear accelerator based on C-band microwaves for medical applications is being assembled at the Dongnam Institute of Radiological and Medical Sciences (DIRAMS). The accelerating column has an on-axis coupled structure and will be operated with a π/2-mode standing wave. Parameters of the cavities are selected based on simulations with CST MICROWAVE STUDIOⓇ (CST MWS), and the cold test and micro-machining are performed to obtain the desired RF characteristics of the cavity. Then, the bead-pull test is conducted to measure the RF properties of the full accelerating column structure. The fabrication of the C-band accelerating column and the results of the low-power RF tests are discussed.

Identification of C4orf32 as a Novel Type I Endoplasmic Reticulum Resident Membrane Protein

Seung-Hwan Lee(이승환),Sang-Won Park(박상원),Jin-A Lee(이진아),Deok-Jin Jang(장덕진) 한국생명과학회 2019 생명과학회지 Vol.29 No.9

세포막 단백질의 topology는 막단백질의 중요한 특징이다. 우리는 이전에 C4orf32단백질을 클로닝 하였으나, 이 단백질의 세포내 위치나 topology는 알지 못했다. 이번 연구를 통해 C4orf32는 세포내에서 소포체에 위치되는 막단백질임을 알게 되었다. C4orf32의 topology를 알기 위해 protease protection assay, fluorescence protease protection (FPP) assay, FRB/rapamycin/FKBP system을 활용하였다. Protease protection assay와 FPP assay를 적용한 결과 C-말단에 GFP를 붙인 C4orf32-GFP의 경우 GFP가 소포체의 세포질 표면에 위치함을 확인할 수 있었다. 또한, FRB/rapamycin/FKBP시스템을 이용한 실험에서 rapamycin이 처리되지 않은 경우는 mRFP-FKBP가 세포질에 위치하다가 rapamycin이 처리되면 C4orf32-GFP-FR가 위치하는 소포체로 이동함을 확인할 수 있었다. 이러한 사실은 C4orf32의 C-말단이 소포체의 세포질쪽 면에 위치한다는 사실을 말해준다. 이러한 연구를 통해 C4orf32는 Type I 소포체 막단백질에 속한다는 사실을 확인할 수 있었다. Membrane topology is a key characteristic of membrane proteins. We previously reported the cloning of the chromosome 4 open-reading frame 32 (C4orf32) gene as a potential membrane protein; however, the cellular localization and membrane topology of C4orf32 was as yet unknown. In this study, we found that green fluorescent protein (GFP) fused to the C-terminus of C4orf32 (C4orf32-GFP) was localized to the endoplasmic reticulum (ER). We applied three tools to identify determinants of C4orf32 topology: protease protection, fluorescence protease protection (FPP), and an inducible system using the ternary complex between FK506 binding protein 12 (FKBP), rapamycin, and the rapamycin-binding domain of mTOR (FRB) (the FRB-rapamycin-FKBP system). Using protease protection and FPP assays, we found that the GFP tag in C4orf32-GFP was localized to the cytoplasmic surface of the ER membrane of HeLa cells. Protease protection and FPP assays are useful and complimentary tools for identifying the topology of GFP fusion membrane proteins. The FRB-rapamycin-FKBP system was also used to study the topology of C4orf32. In the absence of rapamycin, a monomeric red fluorescent protein–FKBP fusion (mRFP-FKBP) and C4orf32-GFP-FRB were localized to the cytoplasm and the ER membrane, respectively. However, in the presence of rapamycin, the mRFP-FKBP was shifted from the cytoplasm to the ER and colocalized with the C4orf32-GFP-FRB. These results indicate that the FRB moiety is facing the cytoplasmic surface of ER membrane. Overall, our results clearly suggest that C4orf32 belongs to the family of type I ER resident membrane proteins.

Power Quality Monitoring System with a New Distributed Monitoring Structure

Won, Dong-Jun,Chung, Il-Yop,Kim, Joong-Moon,Ahn, Seon-Ju,Moon, Seung-Il,Seo, Jang-Cheol,Choe, Jong-Woong The Korean Institute of Electrical Engineers 2004 KIEE International Transactions on Power Engineeri Vol.a4 No.4

Power quality monitoring is the cornerstone for power quality analysis, diagnosis and improvement. The measurement of power quality (PQ) evolves from instantaneous metering to continuous monitoring. Furthermore, recent technologies enable us to construct more flexible, reliable, rapid and economical power quality monitoring system (PQMS). Therefore, this paper presents an improved PQMS with a new distributed monitoring structure. The proposed PQMS consists of a PQ meter, PQ analyzer and GUI. The PQ meter only collects raw data and the PQ analyzer performs power quality analysis. It has several advantages compared to conventional structures in economic efficiency, modularity, speed, etc. PQ monitoring algorithms to catch steady-state trends and to detect PQ events are also adapted to the proposed structure. Using the proposed structure and monitoring algorithm, a prototype PQMS is constructed and real-time testing is performed.

Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer

( Seung Hun Jang ),( Dong Yoon Lee ),( Jihyeon Jeong ),( Won-il Choi ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4

Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic effects of EGFR-tyrosine kinase inhibitor (TKI) and other treatment modalities. Therefore, we compared the survival outcomes of patients treated with EGFR-TKIs versus those treated with other treatment modalities. Methods: Patient data were collected from the Korean National Health Insurance Database, National Health Insurance Service-National Sample Cohort 2002 to 2015, which was released by the Korean National Health Insurance Service in 2015. The lung cancer group included patients (n = 2,003) initially diagnosed with lung cancer between January 2010 and December 2013. The main outcome was all-cause mortality. A Cox proportional hazard regression analysis was used to calculate the relative risk of mortality. Results: Among the newly diagnosed lung cancer cases, 1,004 (50.1%) were included in the analysis. A 15.1-month median survival benefit was observed in the EGFR-TKI group than that of the multimodality therapy group. The risk of mortality was as follows: EGFR-TKI treatment group (n = 142; hazard ratio [HR], 5.29; 95% confidence interval [CI], 3.57 to 7.86) and multimodality therapy group (n = 326; HR, 7.42; 95% CI, 5.19 to 10.63) compared to surgery only (n = 275). Conclusions: Patients with advanced lung cancer harbouring EGFR mutations treated with EGFR-TKIs showed better median survival and lower risk of mortality than those in the multimodality therapy group. In the case of EGFR-mutated advanced lung cancer, there is room for downstaging in the TNM classification.

Overexpression of Recombinant Glucoamylase from Deinococcus geothermalis by E. coli and Its High Acido-stable Capability

Seung-Won JANG,Deok-Ho KWON,Suk-Jin HA,Jong-Hyun JUNG,Sang-Yong LIM 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.10