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DBD 반응기에서 플라즈마 방전형태에 따른 PFC_(s) 가스의 분해 특성
김관태,김용호,차민석,송영훈,김석준,류정인 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.5
Perfluorocompounds(PFC_(s)), such as tetrafluoromethane (CF₄) and hexafluoroethane (C₂F_(6)), have been widely used as plasma etching and chemical vapor deposition (CVD) gases for semiconductor manufacturing processes. Since these PFC_(s) are known to cause a greenhouse effect intensively, there has been a growing interest in reducing PFC_(s) emissions. Among various CF₄ decomposing techniques, a dielectric barrier discharge (DBD) is considered as one of a promising candidate because it has been successfully used for generating ozone (O₃) and decomposing nitrogen oxide (NO). Firstly, optimal concentration of oxygen for CF₄ decomposition was found to figure out how many primary and secondary reactions are associated with DBD process. Secondary, to find effective discharge method for CF₄ decomposition, a streamer and a glow mode in DBD are experimentally compared, which includes (ⅰ) coaxialcylinder DBD, (ⅱ) DBD reactor packed with glass beads. and (ⅲ) a glow mode operation with a helium gas. The test results showed that optimal concentration of oxygen was ranged 500 ppm~1% for treating 500 ppm of CF₄ and helium glow discharge was the most efficient one to decompose CF₄.
Kim, Hee Jeong,Lee, Moo Hyun,Lee, Jeong Eon,Park, Seho,Lee, Eun Sook,Kang, Yong Joon,Shin, Hae Na,Kim, Seung Il,Lee, Jun Ho,Im, Seock Ah,Ahn, Sei Hyun,Lee, Keun Seok,Sohn, Joohyuk,Kim, Seonok,Nam, Seo Elsevier 2018 Clinical breast cancer Vol.18 No.5
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Receipt of a gonadotropin-releasing hormone (GnRH) agonist has been reported to protect against ovarian failure. We sought to determine the oncologic effect of a GnRH agonist with chemotherapy for breast cancer patients.</P> <P><B>Patients and Methods</B></P> <P>Data from 1160 patients aged 20 to 40 years with stage I to III breast cancer who received chemotherapy from 5 hospitals in Korea from 2002 to 2012 were reviewed. A GnRH agonist was provided to 406 patients for ovarian protection during chemotherapy, and 754 patients received chemotherapy without ovarian protection. An individual score-matching strategy was used to create sets matched by age, tumor stage, hormone receptor status, neoadjuvant or adjuvant chemotherapy, and institute.</P> <P><B>Results</B></P> <P>Survival analysis by Cox regression showed that the GnRH agonist group had better distant metastasis-free survival (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.39-0.89) and disease-free survival (HR, 0.72; 95% CI, 0.52-0.99) than the chemotherapy-alone group. Among patients with hormone receptor–positive breast cancer, the benefit was significant for distant metastasis-free survival (HR, 0.53; 95% CI, 0.29-0.99) and disease-free survival (HR, 0.58; 95% CI, 0.35-0.96).</P> <P><B>Conclusion</B></P> <P>Ovarian protection using a GnRH agonist can be safely considered for premenopausal breast cancer patients for whom chemotherapy is planned.</P>
RpS3 translation is repressed by interaction with its own mRNA
Kim, Hag Dong,Kim, Tae-Sung,Joo, Yoo Jin,Shin, Hyun-Seock,Kim, Sang-Hwa,Jang, Chang-Young,Lee, Cheol Eui,Kim, Joon Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.110 No.2
<P>Ribosomal protein S3 (RpS3) is a well-known multi-functional protein mainly involved in protein biosynthesis as a member of the small ribosomal subunit. It also plays a role in repairing various DNA damage acting as a repair UV endonuclease. Most of the rpS3 pool is located in the ribosome while the minority exists in free form in the cytoplasm. We here report an additional function of rpS3 in which it represses its own translation by binding to its cognate mRNA. Through RT-PCR of the RNAs co-immunoprecipitated with ectopically expressed rpS3, rpS3 protein was found to interact with various RNAs—endogenous rpS3, 18S rRNA. The S3-C terminal domain was shown to be the major mRNA binding domain of rpS3, independent of the KH domain. This interaction was shown to occur in cytoplasmic fractions rather than ribosomal fractions, and then is involved in its own mRNA translational inhibition by in vitro translation. Furthermore, when Flag-tagged rpS3 was transiently transfected into 293T cells, the level of endogenous rpS3 gradually decreased regardless of transcription. These results suggest that free rpS3 regulates its own translation via a feedback mechanism. J. Cell. Biochem. 110: 294–303, 2010. © 2010 Wiley-Liss, Inc.</P>
Kim, Tae-Sung,Kim, Hag Dong,Shin, Hyun-Seock,Kim, Joon American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.32
<P>It has been shown previously that ribosomal protein S3 (rpS3) has an endonuclease activity, which is increased by protein kinase Cdelta (PKCdelta)-dependent phosphorylation. However, the reciprocal mechanism for rpS3 dephosphorylation is not known. In this study, we examined phosphatases involved in rpS3 dephosphorylation, and we determined that rpS3 is specifically dephosphorylated by protein phosphatase 2A (PP2A). By immunoprecipitation assay, rpS3 only interacted with PP2Ac but not with protein phosphatase 1. The interaction between rpS3 and PP2Ac occurred only in the nuclear fraction. Moreover, the PP2Ac association with rpS3 was identified in cells transfected with wild-type rpS3 but not with mutant rpS3 lacking PKCdelta phosphorylation sites. PP2A inhibition using okadaic acid induced rpS3 phosphorylation. The level of phosphorylated rpS3 in cells was decreased by the overexpression of PP2Ac and was increased by the down-regulation of PP2Ac. Taken together, these results suggest that oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta and blocking the PP2A interaction with rpS3.</P>
이준우(Joon Woo Lee),이주장(Ju Jang Lee),박경택(Kyoung Taik Park),김석준(Seock Joon Kim),김두형(Doo-hyeong Kim),김한메(Han Me Kim) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
For a special working environment such as painting work or transportation work of burden in heavy industral field, application of WML(wearable multi-link) system is very helpful for decreasing work load of workers. In the design of WML system, since WML system imitates the motion of human body, it is important to consider the DOF(degree of freedom) of human body. In addition, it is important to consider the power required, structural efficiency, and economic feasibility of WML system before making WML system. Thus, to achieve the design purposes of WML system, this paper deals with mechanical design analysis of WML system through computer simulation.