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Kaneko, Shiho,Matsumoto, Kazumasa,Minamida, Satoru,Hirayama, Takahiro,Fujita, Tetsuo,Kodera, Yoshio,Iwamura, Masatsugu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
We investigated the urinary levels of 14-3-3 protein beta/alpha to evaluate their diagnostic significance with regard to clear cell renal cell carcinoma (ccRCC) and angiomyolipoma (AML). Urine samples from 91 patients with ccRCC, 16 patients with AML and 24 healthy volunteers were assessed. We used an enzyme-linked immunosorbent assay (ELISA) to quantify 14-3-3 protein beta/alpha levels in urine. Values were higher in patients with ccRCC than in those with AML and in healthy volunteers. High levels were associated with pathologic stage, lymph node status, distant metastasis and poor survival. Urinary levels of 14-3-3 protein beta/alpha were significantly increased in patients with small-sized carcinoma, irrespective of being less than 4.0 cm and 2.0 cm, compared with levels in patients with AML. This study is the first to report that increased expression of 14-3-3 protein beta/alpha in urine is associated with advanced stage and poor survival in patients with ccRCC. In addition, urinary 14-3-3 protein beta/alpha may differentiate AML from RCC, even when small sized. These results suggest that examination of urinary 14-3-3 protein beta/alpha could serve as a diagnostic and prognostic marker in patients with ccRCC.
Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies
Kaneko, Kimihiko,Sato, Douglas Kazutoshi,Nakashima, Ichiro,Nishiyama, Shuhei,Tanaka, Satoru,Marignier, Romain,Hyun, Jae-Won,Oliveira, Luana Michelli de,Reindl, Markus,Seifert-Held, Thomas,Sepulveda, M BMJ 2016 Journal of neurology, neurosurgery and psychiatry Vol.87 No.11
Wang, Yue,Kaneko, Osamu,Sattabongkot, Jetsumon,Chen, Jun-Hu,Lu, Feng,Chai, Jong-Yil,Takeo, Satoru,Tsuboi, Takafumi,Ayala, Francisco J,Chen, Yong,Lim, Chae Seung,Han, Eun-Taek Allen Press, etc.] 2011 The American journal of tropical medicine and hygi Vol.84 No.2
<P>Abstract. Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P. vivax merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor-like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P. yoelii, P. berghei, and P. falciparum during their evolutionary history. Full-length sequences of the msp1p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.</P>
Consideration of a Face Recognition System with Real-time and Robustness
Hitoshi Horiuchi,Satoru Kaneko,Mie Sato,Koichi Ozaki,Masao Kasuga 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
Capability of recognition, collision avoidance and communication with humans in natural is required for robots coexisting with humans. It is important that real-time and robust image processing for face recognition in a real environment. In this paper, we have developed a method of face recognition no depending on direction and size of human faces on various images. This method is include preprocess of a pattern matching algorithm based on the HSV color coordinate system and a rapid search algorithm by using the Genetic Algorithm (GA). For accurate face recognition, extracted images by an edge filter are used when a value of fitness on GA is evaluated. As a result, this system extracted face with about 65% accuracy.
Sakamoto, Hirokazu,Takeo, Satoru,Takashima, Eizo,Miura, Kazutoyo,Kanoi, Bernard N.,Kaneko, Takamasa,Han, Eun-Taek,Tachibana, Mayumi,Matsuoka, Kazuhiro,Sattabongkot, Jetsumon,Udomsangpetch, Rachanee,Is Elsevier 2018 Parasitology international Vol.67 No.2
<P><B>Abstract</B></P> <P>The target molecules of antibodies against falciparum malaria remain largely unknown. Recently we have identified multiple proteins as targets of immunity against <I>Plasmodium falciparum</I> using African serum samples. To investigate whether potential targets of clinical immunity differ with transmission intensity, we assessed immune responses in residents of low malaria transmission region in Thailand. Malaria asymptomatic volunteers (Asy: n=19) and symptomatic patients (Sym: n=21) were enrolled into the study. Serum immunoreactivity to 186 wheat germ cell-free system (WGCFS)-synthesized recombinant <I>P. falciparum</I> asexual-blood stage proteins were determined by AlphaScreen, and subsequently compared between the study groups. Forty proteins were determined as immunoreactive with antibody responses to 35 proteins being higher in Asy group than in Sym group. Among the 35 proteins, antibodies to MSP3, MSPDBL1, RH2b, and MSP7 were significantly higher in Asy than Sym (unadjusted p<0.005) suggesting these antigens may have a protective role in clinical malaria. MSP3 reactivity remained significantly different between Asy and Sym groups even after multiple comparison adjustments (adjusted p=0.033). Interestingly, while our two preceding studies using African sera were conducted differently (e.g., cross-sectional vs. longitudinal design, observed clinical manifestation vs. functional activity), those studies similarly identified MSP3 and MSPDBL1 as potential targets of protective immunity. This study further provides a strong rationale for the application of WGCFS-based immunoprofiling to malaria vaccine candidate and biomarker discovery even in low or reduced malaria transmission settings.</P> <P><B>Highlights</B></P> <P> <UL> <LI> WGCFS generated <I>P. falciparum</I> recombinant proteins are immunoreactive to human sera from low endemic Thailand. </LI> <LI> Four <I>P. falciparum</I> antigens are plausible targets of clinical immunity. </LI> <LI> WGCFS and AlphaScreen system are invaluable tools for malaria vaccine candidate and biomarker discovery. </LI> </UL> </P>