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Phylogenetic Analysis of Astrovirus and Kobuvirus in Korean Dogs
CHOI, Sarah,LIM, Seong-In,KIM, Yong Kwan,CHO, Yoon-Young,SONG, Jae-Young,AN, Dong-Jun The Japanese Society of Veterinary Science 2014 The Journal of veterinary medical science Vol.76 No.8
<P><B>ABSTRACT</B></P><P>Astroviruses and kobuviruses are frequently found in mammalian feces, including that of humans. The present study examined fecal samples from 91 Korean dogs suffering from diarrhea. Canine astroviruses (CAstVs) and canine kobuviruses (CKoVs) were identified in 2 (2.1%) and 46 (50.6%) dogs, respectively. Nucleotide sequence analysis coupled with phylogenetic analysis using the neighbor-joining method showed that CAstVs clustered into four genetically diverse groups. Two Korean CAstVs belonged to group 2 alongside strains isolated in Italy and France. Twelve of the Korean CKoVs belonged to a single clade, along with strain UK003 identified in the UK and six CKoVs identified in the USA. Thus, the results suggest that the Korean strain of CAstV is closely related to strains isolated in Europe. Surely, CKoV in South Korea could identify the circulation among dogs population.</P>
Soh, Sarah,Shim, Jae-Kwang,Ha, Yoon,Kim, Young-Sam,Lee, Hyelin,Kwak, Young-Lan RAVEN PRESS PUBLISHERS 2018 JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY Vol.30 No.3
BACKGROUND:: Spinal surgery in the prone position is accompanied by increased intrathoracic pressure and decreased respiratory compliance. This study investigated whether intraoperative lung protective mechanical ventilation improved lung function evaluated with pulmonary function tests in patients at risk of postoperative pulmonary complications (PPCs) after major spinal surgery in the prone position. METHODS:: Seventy-eight patients at potential risk of PPCs were randomly assigned to the protective group (tidal volume; 6 mL/kg predicted body weight, 6 cm H2O positive end-expiratory pressure with recruitment maneuvers) or the conventional group (10 mL/kg predicted body weight, no positive end-expiratory pressure). The primary efficacy variables were assessed by pulmonary function tests, performed before surgery, and 3 and 5 days afterward. RESULTS:: Postoperative forced vital capacity (2.17±0.1 L vs. 1.91±0.1 L, P=0.213) and forced expiratory volume in 1 second (1.73±0.08 L vs. 1.59±0.08 L, P=0.603) at postoperative day (POD) 3 in the protective and conventional groups, respectively, were similar. Trends of a postoperative decrease in forced vital capacity (P=0.586) and forced expiratory volume in 1 second (P=0.855) were similar between the groups. Perioperative blood-gas analysis variables were comparable between the groups. Patients in the protective and conventional groups showed similar rates of clinically significant PPCs (8% vs. 10%, P>0.999). CONCLUSIONS:: In patients at potential risk of developing PPCs undergoing major spinal surgery, we did not find evidence indicating any difference between the lung protective and conventional ventilation in postoperative pulmonary function and oxygenation.
Soh, Sarah,Shim, Jae-Kwang,Song, Jong-Wook,Kim, Keung-Nyun,Noh, Hyun-Young,Kwak, Young-Lan Wolters Kluwer Health, Inc. All rights reserved 2017 Journal of neurosurgical anesthesiology Vol.29 No.4
<P>Background: Perioperative cerebral hypoperfusion/ischemia is a major inciting factor of postoperative delirium, which is coupled with adverse outcome in elderly patients. Cerebral oximetry enables non-invasive assessment of the regional cerebral oxygen saturation (rSO(2)). This study aimed to investigate whether perioperative rSO(2) variations were linked to delirium in elderly patients after spinal surgery. Materials and Methods: Postoperative delirium was assessed for 48 hours postsurgery in 109 patients aged over 60 years without a prior history of cerebrovascular or psychiatric diseases by the Confusion Assessment Method for the intensive care unit and the intensive care delirium screening checklist. The rSO(2) values immediately before and throughout surgery were acquired. The preoperative cognitive functions, patient characteristics, and perioperative data were recorded. Results: During the 48-h postoperative period, 9 patients (8%) exhibited delirium. The patients with delirium showed similar perioperative rSO(2) values as those without, in terms of the median lowest rSO(2) values (55% vs. 56%; P = 0.876) and incidence (22%, both) and duration of decline of rSO(2) < 80% of the baseline values. The serially assessed hemodynamic variables, hematocrit levels, and blood gas analysis variables were also similar between the groups, except for the number of hypotensive events per patient, which was higher in the patients with delirium than in those without (4, interquartile range [IQR] 3 to 6 vs. 2, IQR: 1 to 3; P = 0.014). Conclusions: The degree and duration of decrease of the perioperative rSO(2) measurements were not associated with delirium in elderly patients after spinal surgery.</P>
Immediate loading on mandibular edentulous patient with SFI Bar$^{(R)}$ overdenture
Kim, Ha-Young,Kim, Jin-Young-Ryan,Qadeer, Sarah,Jeong, Chang-Mo,Shin, Sang-Wan,Huh, Jung-Bo The Korean Academy of Prosthodonitics 2011 The Journal of Advanced Prosthodontics Vol.3 No.1
Despite the greater retention and low maintenance of bar attachment system, the longer clinical time and increased number of visits were the assignments to overcome in bar attachment system. This case report describes SFI-Bar$^{(R)}$ (Cendres et Me$\'{e}$taux, Biel/Bienne, Switzerland) to be solve those problems. A 65-year-old female, who had severely absorbed mandible, hoped to wear a stable mandibular denture without pain. As soon as two implants were placed on mandible, a tube bar was connected to two adaptors connected to each implant. The length of the tube bar was adjusted considering inter implant distance, and reconnected to the adaptors. Finally a female part was seated beneath the denture. This case report showed that a satisfactory clinical result was achieved by delivering bar overdenture immediately after implant placement without laboratory procedure.
Risk Factors of Cardiovascular Disease according to Alcohol Behavioral Change after Cancer Diagnosis
Eun Mi Bae,In Young Cho,Ji-Hye Jun,Kiheon Lee,Ju Young Kim,Woo Kyung Bae,이혜진,Jong-Soo Han,Se Young Jung,Kee Hyuck Lee,Sarah Kim,Hye Yeon Koo,Sang Jin Cho,Houbuem Lee,Chuelmin Paek 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.4
Background: Problem drinking increases the incidence of all-cause mortality and specific cancers, and persistent drinking is associated with cardiovascular disease in certain cancer survivors. This study analyzed the cardiovascular risk factors before and after diagnosis in Korean cancer survivors. Methods: Data for the period between 2002 and 2013 were collected from the National Health Insurance Service Health-Examinee Cohort Database. Among the 27,835 patients included, those with moderate alcohol consumption before and after cancer diagnosis were excluded. Problem drinking was defined as males under 65 years consuming over 14 glasses a week, and males over 65 years or females consuming over seven glasses a week. A t-test, chi-square test, and linear regression analysis were performed for differences in cardiovascular risk factors and differences according to cancer types. Results: There was a difference in the body mass index, systolic and diastolic blood pressure, and total cholesterol among patients who became moderate drinkers after diagnosis, but fasting blood glucose did not show any significant changes. Risk factors for cardiovascular disease were analyzed in patients with liver, stomach, rectal, and breast cancer with improved drinking behavior, and there were significant differences in body mass index, systolic and diastolic blood pressure, fasting blood glucose, and total cholesterol in stomach cancer patients. Conclusion: Moderate drinking can lower cardiovascular risk in cancer survivors, and among the many drinkingrelated cancers, stomach cancer patients demonstrated significantly reduced cardiovascular risk factors.
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer
Han, Jinil,Choi, Yoon-La,Kim, Haein,Choi, Jun Young,Lee, Se Kyung,Lee, Jeong Eon,Choi, Joon-Seok,Park, Sarah,Choi, Jong-Sun,Kim, Young Deug,Nam, Seok Jin,Nam, Byung-Ho,Kwon, Mi Jeong,Shin, Young Kee Springer US 2017 Breast cancer research and treatment Vol.164 No.1
<P><B>Purpose</B></P><P>More accurate prediction of patient outcome based on molecular subtype is required to identify patients who will benefit from specific treatments.</P><P><B>Methods</B></P><P>We selected novel 16 candidate prognostic genes, including 10 proliferation-related genes (p-genes) and 6 immune response-related genes (i-genes), from the gene list identified in our previous study. We then analyzed the association between their expression, measured by quantitative real-time reverse transcription-PCR in formalin-fixed, paraffin-embedded tissues, and clinical outcome in 819 breast cancer patients according to molecular subtype.</P><P><B>Results</B></P><P>The prognostic significance of clinical and gene variables varied according to the molecular subtype. Univariate analysis showed that positive lymph node status was significantly correlated with the increased risk of distant metastasis in all subtypes except the hormone receptor-negative, HER2-positive (HR−/HER2<B>+</B>) subtype. Most p-genes were significantly associated with poor prognosis in patients with the HR<B>+</B>/HER2− subtype, whereas i-genes correlated with a favorable outcome in patients with HR−/HER2<B>+</B> breast cancer. In HR−/HER2+ breast cancer, four genes (three i-genes <I>BTN3A2</I>, <I>CD2</I>, and <I>TRBC1</I> and the p-gene <I>MMP11</I>) were significantly associated with distant metastasis-free survival (DMFS). A new prognostic model for HR−/HER2+ breast cancer based on the expression of <I>MMP11</I> and <I>CD2</I> was developed and the DMFS for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group. Multivariate analyses revealed that our risk score is an independent prognostic factor for DMFS. Moreover, C-index showed that our risk score has a superior prognostic performance to traditional clinicopathological factors.</P><P><B>Conclusions</B></P><P>Our new prognostic model for HR−/HER2+ breast cancer provides more accurate information on the risk of distant metastasis than traditional clinical prognostic factors and may be used to identify patients with a good prognosis in this aggressive subtype of breast cancer.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s10549-017-4234-4) contains supplementary material, which is available to authorized users.</P>