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Study on Young's Modulus of Geomaterials used in Korean Railway Infrastructures
Lee, Sung Jin,Lee, Seong Hyeok,Lee, Il Wha,Hwang, Su Beom,Kim, Ki Jae The Korean Society for Railway 2013 International Journal of Railway Vol.6 No.2
In this study, cyclic triaxial tests were carried out with the coarse granular materials used in Korean railway infrastructure (reinforced trackbed, gravel of transition zone, upper subgrade of railway) and Young's modulus for the target materials in small strain level were suggested. And the result of elastic modulus suggested in this study is expected to be effectively applied to dynamic analysis of the railway embankment structure using similar material, since the grain size distributions and unit weight of the material tested in this study are specified in Korean Railway Design Criteria.
Lee, Juhie,Ban, Ju Yeon,Won, Kyu Yeoun,Kim, Gyo-Yong,Lim, Sung-Jig,Lee, Sun,Kim, Youn Wha,Park, Yong-Koo,Lee, Sang Sook National Hellenic Research Foundation 2008 Oncology reports Vol.20 No.4
<P>This study investigated the useful morphologic and immunophenotypic findings for the diagnosis of Castleman's disease (CD). We focused on the distribution and expression of follicular dendritic cells (FDC) in lymphoid follicles from patients with CD. Eleven CD cases of the hyaline vascular (HV) variant and six cases of the plasma cell (PC) variant were studied using tissue microarray and paraffin resistant monoclonal antibodies CD21, CD35, and EGFR, a new novel marker of FDC, as well as an antibody against human herpes virus 8 (HHV8). Epstein-Barr virus (EBV) was detected by means of in situ hybridization with a fluorescein isothiocyanate-labeled EBV-encoded RNA (EBER) specific oligonucleotide. The FDC network of the PC variant (n=4) was similar to that seen in normal or reactive germinal centers. In contrast, all HV variants and 2 cases of the PC variant were either expanded, disrupted, or exhibited multiple tight collections of FDC both in germinal centers and in mantle zone lymphocytes. The expanded mantle zone lymphocytes were CD20+, Bcl2+, PAX5+, and MUM1- with less number of CD3+ T cells admixed. Other features of the HV variant included follicular regression and vascular ingrowth of the germinal centers, whereas features of the PC variant were follicular hyperplasia and interfollicular plasmacytosis. In addition, EBV infection was positive in three CD cases, and one case had co-expression of HHV8 and EBV infection. Taken together, we found immunophenotypic differences of mantle zone lymphocytes and FDC network patterns of lymphoid follicles in CD. Thus, we conclude that these differences are relevant for the differential diagnosis of the two histopathologic variants of CD.</P>
Lee, Sang-Guk,Yim, Ye Seal,Lee, Yong-ho,Lee, Byung-Wan,Kim, Hyon-Suk,Kim, Kyung-Sup,Lee, Yong-Wha,Kim, Jeong-Ho Elsevier 2018 Diabetes research and clinical practice Vol.140 No.-
<P>Conclusions: The increase in fasting serum AAs can be an early manifestation of insulin resistance. Increased muscle proteolysis induced by insulin resistance and inflammatory cytokines can be a possible mechanism for the rise in serum AA levels. (C) 2018 Elsevier B.V. All rights reserved.</P>
Lee, Sang Heon,Derby, Richard,Sul, Dong geun,Hong, Jung wha,Kim, Gon Ho,Kang, Seok,Kim, Nack Hwan,Yoo, Seung Han,Lee, Seok Jun,Hong, Young Ki,Lee, Jeong Eun Blackwell Publishing Inc 2011 Pain medicine Vol.12 No.3
<P><B>Abstract</B></P><P><B>Study Design. </B> An institutional, prospective clinical data analysis.</P><P><B>Objective. </B> To evaluate the safety and efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with lumbar disc herniation with radicular pain.</P><P><B>Methods and Outcome Measures. </B> We performed disc decompressions using L'DISQ on 27 patients with persistent disabling back and leg pain for 1 month or longer (average 6.48 months) due to a herniated lumbar intervertebral disc. Baseline data were prospectively gathered before the index procedure and at 1, 4, 12, and 24 weeks post‐procedure. Data included pain intensity (visual analog scale [VAS]), measure of disability (Oswestry Disability Index [ODI] and Rolando–Morris Questionnaire [RM]), health‐related quality of life (Bodily Pain Scale of Short Form‐36 version 2 [SF‐36 BP]), and passive straight leg raising test (SLR).</P><P><B>Results. </B> The VAS fell from 7.08 ± 1.22 to 1.84 ± 0.99 scores at 24 weeks post‐procedure. At 24 weeks, the ODI had fallen from 41.88 ± 10.61 to 16.66 ± 8.55% and the RM from 11.52 ± 3.91 to 2.68 ± 1.97 points. The SF‐36 BP dropped significant improvement from 32.89 ± 5.83 to 49.57 ± 4.96 scales. In the SLR test, the angular change of 24 weeks showed considerable improvement from 60.20 ± 20.02 to 83.00 ± 14.29 degrees. No major complication occurred, although two cases developed a disc reherniation 1 month post‐procedure.</P><P><B>Conclusions. </B> The L'DISQ device is specifically designed to remove herniated disc using a wand that can be navigated into a disc protrusion or extrusion. Following decompression, we measured clinically significant pain improvement and decreased disability for patients with both radicular and axial pain caused by protruded and extruded discs.</P>
Lee, Sang-Jun,Oh, Sumi,Kim, Mi-Ja,Sim, Gun-Sub,Moon, Tae Wha,Lee, JaeHwan The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Background: Explosive puffing can induce changes in the chemical, nutritional, and sensory quality of red ginseng. The antioxidant properties of ethanolic extracts of red ginseng and puffed red ginseng were determined in bulk oil and oil-in-water (O/W) emulsions. Methods: Bulk oils were heated at $60^{\circ}C$ and $100^{\circ}C$ and O/W emulsions were treated under riboflavin photosensitization. In vitro antioxidant assays, including 2,2-diphenyl-1-picrylhudrazyl, 2,2'-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid, ferric reducing antioxidant power, total phenolic content, and total flavonoid content, were also performed. Results: The total ginsenoside contents of ethanolic extract from red ginseng and puffed red ginseng were 42.33 mg/g and 49.22 mg/g, respectively. All results from above in vitro antioxidant assays revealed that extracts of puffed red ginseng had significantly higher antioxidant capacities than those of red ginseng (p < 0.05). Generally, extracts of puffed red and red ginseng had high antioxidant properties in riboflavin photosensitized O/W emulsions. However, in bulk oil systems, extracts of puffed red and red ginseng inhibited or accelerated rates of lipid oxidation, depending on treatment temperature and the type of assay used. Conclusion: Although ethanolic extracts of puffed red ginseng showed stronger antioxidant capacities than those of red ginseng when in vitro assays were used, more pro-oxidant properties were observed in bulk oils and O/W emulsions.