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Influence of Al2O3 Content and Cooling Rate on Crystallization in Fe2O3–CaO–SiO2–Al2O3 Systems
Tae Jun Park,Joon Sung Choi,Dong Joon Min 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9
The behavior of silico-ferrite of calcium and aluminum (SFCA) phases and the influence of sintered ore quality were investigatedusing a confocal laser scanning microscope to understand how the Al2O3content of iron ore affects the sintered orestructure and the crystallization behavior of SFCA in a Fe2O3–CaO–Al2O3–SiO2 pseudo-quaternary system. The experimentalresults were used to inform simulations of the heterogeneous dynamic behavior in response to the rapid temperature changesand various chemical compositions typically encountered in actual sintering processes. Increasing the Al2O3content in theFe2O3–CaO–Al2O3–SiO2 pseudo-quaternary system led to the hematite content decreasing, which affects the reducibilityof the sintered ore. The correlation between the creation of SFCA and the cooling effect associated with varying the Al2O3is discussed in detail.
Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6
<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>
LNT를 통해 분석한 국립공원 탐방목적과 산행 윤리 의식의 상관성 : 내장산국립공원 백양사지구와 남창지구를 중심으로
최형철(Choi Hyung Chul),박재철(Park Jae Chul),노재현(Roh Jae Hyun),신상섭(Shin Sang Sup),허준(Huh Joon) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.3
본 연구는 LNT 항목의 분석을 통해서 산행 목적과 산행윤리의식 사이의 차이를 규명하기 위하여 수행되었다. 이를 위해서, 내장산국립공원의 백양사지구와 남창지구를 사례로 연구를 수행하였다. 이를 통해 국립공원 방문목적에 따라서 윤리 의식이 유의한 차이가 있음을 확인할 수 있었다. 다시 말하면, 산행목적의 탐방객이 행락 목적의 탐방객보다 윤리 의식이 높은 것을 확인할 수 있었다. This study was performed to identify the difference between purpose and ethics consciousness of national park visit through analysis of LNT(Leave No Trace) items. For this, case study was performed in the Baekyangsa and Namchang district in Naejang national park. Study methods were questionnaire and statistic analyses. Through these, the difference of Ethics Consciousness of national park visit according to visit purpose of one was identified. In other words, it was identified that visitors for climbing purpose had higher than those for pleasure-making in Ethics Consciousness of National Park Visit.
Clinical and Genetic Characteristics of Retinal Capillary Hemangioblastoma in Korean Patients
Sang Ha Lee(Sang Ha Lee),Kyu Hyung Park(Kyu Hyung Park),Se Joon Woo(Se Joon Woo),Sang Jun Park(Sang Jun Park),Kwangsic Joo(Kwangsic Joo) 대한안과학회 2022 Korean Journal of Ophthalmology Vol.36 No.6
Purpose: We investigated the clinical features of Korean patients with retinal capillary hemangioblastoma (RCH) and genetic variants of the von Hippel-Lindau (VHL) gene. Methods: A retrospective analysis was performed on patients with RCH from 2003 to 2021 at Seoul National University Bundang Hospital. Sporadic and hereditary RCH associated with VHL disease were classified based on the specific tumors and family history. Clinical features, including the location and number of RCH and bilateral involvement, were investigated. Multiplex ligation-dependent probe amplification and direct sequencing targeting the VHL gene were performed for six RCH cases associated with VHL disease. Results: A total of 18 patients (23 eyes) were enrolled in this study. The mean age at diagnosis was 37 ± 15 years. Twelve patients had hereditary RCH associated with VHL disease, and six patients had sporadic RCH. All five patients with bilateral RCH were clinically diagnosed with VHL disease, and 13 patients had unilateral RCH. Juxtapapillary RCH was only observed in patients with VHL. The most common complication of RCH was the epiretinal membrane, followed by the subretinal fluid. Pathogenic variants were identified in four patients. All three patients with type 1 VHL had the well-known missense mutation p.Glu70Lys, and one patient with type 2 VHL had the nonsense mutation p.Trp88Ter. Conclusions: In Korean patients with RCH, bilateral involvement and juxtapapillary RCH are highly likely to be associated with VHL disease. Because RCH may be the first clinical manifestation in patients with VHL, active genetic testing of the VHL gene and systemic evaluation are required.
임준범 ( Joon Bum Lim ),이수범 ( Soo Beom Lee ),성정곤 ( Jung Gon Sung ),박준태 ( Jun Tae Park ) 한국안전학회(구 한국산업안전학회) 2012 한국안전학회지 Vol.27 No.4
This research has analyzed factors affecting customers` satisfaction when they use parking lots of big retailers so that, in case of constructing, operating or managing such retailers, proper measures can be come up with. The analysis has been implemented on the basis of survey, and influence factors including entry/exit lamp, parking cars`` traffic flow, parking type, pedestrians`` movement after parking and safety. Parking lot users`` satisfaction has been analyzed by using the Structural Equation Modelling and, as a result of it, in case of a detached or single building, pedestrians movement flow after parking contributed the most to the users`` satisfaction, while, in case of multipurpose complex, parking cars traffic flow has the most influential factor. It is interpreted that users of a single building put a bigger emphasis on entry to the shop and their way back to the parked area after their shopping while customers of multipurpose complex might have various purposes of visiting the place and there are relatively more cars so that they put more emphasis on traffic counterflow, other cars and pedestrians.
S-405 Calcitonin in Wash-Out Fluid from Fine-Needle Aspiration Biopsy in Medullary Thyroid Cancer
( Sang Joon Park ),( Hye Jeong Kim ),( Kyung Sook Kim ),( Hyeong Kyu Park ),( Dong Won Byun ),( Kyoil Suh ),( Myung Hi Yoo ),( Jae Wook Kim ),( In Ho Choi ),( So-young Jin ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Fine-needle aspiration cytology is the current diagnostic approach in identifying medullary thyroid cancer (MTC) neck lymph node metastases. However, it is not frequently proposed as a routine procedure in patients with high-serum calcitonin (CT) because of its low sensitivity and specificity. A few study evaluated CT measurement in wash-out fluid from fine-needle aspiration biopsy (CT-FNAB), a promising tool for the detection of metastatic lymph node in MTC. We describe two cases of MTC patients with neck lymph node recurrence who were identified by elevation of CT-FNAB and confirmed on surgical pathology. Metastatic lymph nodes from one patient had both positive CT-FNAB and conventional cytology for MTC recurrence, while another patient showed positive CT-FNAB and negative cytology specimen for lymph node metastases. CT-FNAB can be a highly sensitive and reliable diagnostic procedure to identify recurrent/metastatic MTC.
Reaction Kinetics of Carbon Dioxide with Diethanolamine in Polar Organic Solvents
Park, Sang‐,Wook,Lee, Joon‐,Wook,Choi, Byoung‐,Sik,Lee, Jae‐,Wook Taylor Francis 2005 Separation science and technology Vol.40 No.9
<P>The chemical absorption rate of carbon dioxide with diethanoamine was measured in such nonaqueous solvents as methanol, ethanol, n‐propanol, n‐butanol, ethylene glycol, propylene glycol, and propylene carbonate, and in water at 298 K and 101.3 kPa using a semibatch stirred tank with a plane gas‐liquid interface. The overall reaction rate constant obtained under the condition of fast reaction regime from the measured rate of absorption was used to get the elementary reaction rate constants in complicated reactions represented by reaction mechanism of carbamate formation and the order of overall reaction of CO 2 with amine. Correlation between the elementary reaction rate constant and the solubility parameter of the solvent was presented.</P>
Sung-Soo Park,Hee-Je Kim,Tong Yoon Kim,Joon yeop Lee,Jong Hyuk Lee,Gi June Min,Silvia Park,Jae-Ho Yoon,Sung-Eun Lee,Byung-Sik Cho,Ki-Seong Eom,Yoo-Jin Kim,Seok Lee,Dong-Wook Kim 대한혈액학회 2021 Blood Research Vol.56 No.3
Background Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative treatment option for acute leukemia. We aimed to identify the comorbidity factors affecting survival outcomes after alloSCT and develop a new comorbidity index tool for predicting overall survival (OS). Methods A Korean nationwide cohort of 3,809 adults with acute leukemia treated with alloSCT between January 2002 and December 2018 was analyzed as the development cohort. A retrospective cohort comprising 313 consecutive adults with acute leukemia who underwent alloSCT between January 2019 and April 2020 was analyzed as the validation cohort. Results In the development cohort, advanced age, male sex, and comorbidities such as previous non-hematologic malignancy, hypertension, and coronary or cerebral vascular disease were significantly related to poor OS. Subsequently, a new comorbidity scoring system was developed, and risk groups were created, which included the low-risk (score ≤0.17), intermediate-risk (0.17< score ≤0.4), high-risk (0.4< score ≤0.55), and very high-risk (score >0.55) groups. The 1-year OS rates were discriminatively estimated at 73.5%, 66.2%, 61.9%, and 50.9% in the low-risk, intermediate-risk, high-risk, and very high-risk groups in the development cohort, respectively (P<0.001). The developed scoring system yielded discriminatively different 1-year OS rates and 1-year incidence of non-relapse mortality according to the risk group (P=0.085 and P=0.018, respectively). Furthermore, the developed model showed an acceptable performance for predicting 1-year non-relapse mortality with an area under the curve of 0.715. Conclusion The newly developed predictive scoring system could be a simple and reliable tool helping clinicians to assess risk of alloSCT in adults with acute leukemia.