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Sang‑Wook Kim,Hyeon‑Woo Son,Taek‑Kyun Jung,Young‑Bum Chun,Yi‑Hyun Park,Ji‑Woon Lee,Soong‑Keun Hyun 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4
The hot deformation behavior of advanced reduced-activation alloy (ARAA) was investigated using hot torsion tests. Thefl ow stress decreased as deformation temperature increased and as strain rate decreased. The fl ow behavior demonstratedthe typical dynamic recrystallization (DRX). Based on the constitutive analysis of peak stress, the activation energy for hotdeformation was found to be 330.3 kJ mol −1 . Peak stress was analyzed as a function of the Zener–Hollomon parameter, andcalculated and experimental values were in good agreement. A DRX kinetic model for ARAA was derived with deformationconditions based on the Avrami-type model. It was confi rmed that the volume fraction of dynamically recrystallized grainsincreased as deformation temperature increased and as strain rate decreased. The necklace structure and grain boundarybulging were observed in the deformed microstructure of ARAA. The suggested DRX mechanism for ARAA during hotworking is discontinuous DRX.
산업단지 및 일반생활 지역의 공기 중 톨루엔에 대한 개인노출 및 생체시료의 상관성 분석
이병준(Byoungjun Lee),허 정(Jung Heo),정다영(Dayoung Jung),김순신(Sunshin Kim),류현수(Hyeon-Su Ryu),최민지(Min-Ji Choi),솨이지엔페이(Jian-Fei Shuai),임성국(Sung-Guk Im),양원호(Wonho Yang) 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.4
Objectives: The purpose of this study was to assess the correlation relationship between personal exposure and urinary hippuric acid in biological monitoring for airborne toluene in an industrial complex and in general environments. Methods: Personal exposure to toluene and its metabolite, hippuric acid, in urine were simultaneously measured in occupational environments area near an industrial complex and in general environments. The study subjects were divided into three types: 137 workers who use organic solvents in the workplace, 210 residents living near a dyeing industrial complex, and 379 residents living in general environments. The toluene exposures of workers and residents were measured by a passive sampler for four days. The urine of participants was sampled when the passive samplers of personal exposure were collected. Results: The toluene and hippuric acid concentrations of workers were the highest, followed by the concentrations of residents living near a dyeing industrial complex and residents living in general environments. The coefficient of correlation between the concentrations of toluene and hippuric acid among workers was 0.749 (p<0.01) in the workplace. On the contrary, correlations between the concentrations of toluene and hippuric acid among residents living near a dyeing industrial complex and residents living in general environments were all not significant. The relationship between the concentrations of hippuric acid and toluene in three types could be described by the exponential growth model. Conclusions: This study analyzed the relationships between toluene exposure and the concentrations of hippuric acid in urine in high, middle, and low exposure environments, and could be described by the exponential growth model.
Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Successful treatment of granuloma annulare with UVA-1 photothrapy
( Sang Hwa Han ),( Kang Hoon Lee ),( Joon Hee Kim ),( Myeong Hyeon Yang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Granuloma annulare (GA) is a benign, granulomatous skin disease that presents clinically as papules and plaques, often in an annular configuration. The histopathologic findings of GA show central core of altered collagen surrounded by a wall of palisaded histiocytes or interstitial, nonpalisaded pattern of inflammation with histiocytes infiltrating among fragmented collagen bundles. Ultraviolet (UV) radiation has been used for decades to treat variable skin diseases. The therapeutic effect of UVA-1 is related to T-cell apoptosis, increased collagenase activity, and it penetrates the dermis more deeply than UVB and PUVA. A 73-year-old female patient presented with multiple erythematous annular plaques and patches on the trunk. Histopathologic findings showed intact epidermis, palisading infiltrate of inflammatory cells with degeneration of collagen, and swollen and intensely eosinophilic collagen fibers with dense interstitial histiocytic infiltrate. On the basis of these clinical and histological findings, the diagnosis of granuloma annulare was made. The patient was treated with medium-dose (65 J/cm2) UVA-1 phototherapy 3-4 times a week. A significant improvement in skin lesions was achieved after 17th UVA-1 phototherapy. Herein, we report a case of granuloma annulare successfully treated with UVA-1 phototherapy.
Successful treatment of cutaneous polyarteritis nodosa with pentoxifylline
( Sang Hwa Han ),( Kang Hoon Lee ),( Joon Hee Kim ),( Myeong Hyeon Yang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Cutaneous polyarteritis nodosa (PAN) is a vasculitis of small-to-medium-sized arteries with chronic benign course without systemic involvement. Clinically, tender subcutaneous nodule, livedo reticularis, and cutaneous ulcers can be seen. Histopathologically, degeneration of the arterial wall with deposition of fibrinoid material, complete occlusion of the lumen with thrombus, and fibroblastic proliferation into the perivascular area can be seen. Systemic steroid and non-steroidal anti-inflammatory drugs have formed the mainstay of treatment of cutaneous PAN, and pentoxifylline also can be used. Pentoxifylline is a synthetic xanthine derivative with hemorheological properties. A 34-year-old male patient presented with multiple brownish subcutaneous nodules on the lower legs. Histopathologic findings showed deep perivascular inflammation, degeneration of the arterial wall with deposition of fibrinoid material, and infiltrate of neutrophils, lymphocytes, and histiocytes within and around the arterial wall. On the basis of these clinical and histological findings, the diagnosis of cutaneous PAN was made. The patient was treated with pentoxifylline, resulting in a significant improvement in skin lesions. The improvement of blood flow and the anti-inflammatory effects of pentoxifylline may have played role in the resolution of the disease in this patient. Herein, we report a case of cutaneous PAN successfully treated with pentoxifylline.
A case of cervical chondrocutaneous branchial remnants
( Sang Hyeon Hwang ),( Jae Yun Lim ),( Ju Yeon Choi ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Cervical chondrocutaneous branchial remnants are rare developmental anomalies of the brachial apparatus which appear as a firm, protruding papule or nodule on the neck along the line of anterior border of the sternocleidomastoid muscle. Primitive branchial embryonic tissues migrate into the final lateral facial position to form the adult derivatives of head and neck. However, failure of proper migration, fusion, or maturation of the branchial apparatus components results in a variety of congenital defects. Most branchial cysts and fistulae are considered to be derived from the first and second branchial clefts. Of these, cervical chondrocutaneous branchial remnants are infrequent, whereas branchial cysts and sinuses are relatively more common. Our patient, a 9-month-old girl, presented with a solitary skin-colored about 0.4 cm sized soft papule on the lower third of the left neck. The lesion had been presented at birth and physical examination revealed no remarkable findings except for the skin lesion. The histopathologic examination revealed normal epidermis and characteristic cartilage core in the dermis without connection to the epidermis. The histopathological features were consistent with cervical chondrocutaneous branchial remnants.
Sung Soo-Eun,Seo Min-Soo,Kang Kyung-Ku,Choi Joo-Hee,Lee Si-Joon,Lim Ju-Hyeon,양승윤,Kim Seul-Ki,Lee Gun Woo 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2
Study Design: An experimental study with extracellular vesicles (EVs) from mesenchymal stem cell (MSC) of the epidural fat (EF) of the spine. Purpose: This study aims to isolate the exosomes from epidural fat-derived mesenchymal stem cells (EF-MSCs) and fully characterize the EF-MSC-EVs. Overview of Literature: EF-MSCs were reported in 2019, and a few studies have shown the positive outcomes of using EF-MSCs to treat specific spine pathologies. However, MSCs have significant limitations for conducting basic studies or developing therapeutic agents. Although EVs are an emerging research topic, no studies have focused on EVs, especially exosomes, from EF and EF-MSCs. Methods: In this study, we isolated the exosomes using the tangential flow filtration (TFF) system with exosome-depleted fetal bovine serum and performed the characterization tests via western blotting, reverse transcription–polymerase chain reaction, nanoparticle tracking analysis (NTA), and transmission electron microscopy. Results: In transmission electron microscopy, the exosome had a diameter of approximately 100–200 nm and had a spherical shape, whereas in the NTA, the exosome had an average diameter of 142.8 nm with a concentration of 1.27×1010 particles/mL. The flow cytometry analysis showed the expression of CD63 and CD81. The western blotting analysis showed the positive markers. Conclusions: These findings showed that isolating the exosomes via TFF resulted in high-quality EF-MSC exosome yield. Further studies with exosomes from EF-MSC are needed to evaluate the function and role of the EF tissue.