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Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells
( Dong Wan Seo ),( Sam Yeol Hong ),( Jae Youl Cho ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin derivative with anti-tumor activity. However, the biochemical and molecular mechanisms of G-Rp1 on anti-tumor activity are not fully understood. In the present study, we report that G-Rp1 inhibits lung cancer cell proliferation, migration and adhesion in p53 wild-type A549 and p53-defi cient H1299 cells. Anti-proliferative activity of G-Rp1 in lung cancer cells is mediated by enhanced nuclear localization of cyclin-dependent kinase inhibitors including p27Kip1 and p21WAF1/Cip1, and subsequent inhibition of pRb phosphorylation. We also show that these anti-tumor activities of G-Rp1 in both A549 and H1299 cells appear to be mediated by suppression of mitogenic signaling pathways such as ERK, Akt and p70S6K. Taken together, these fi ndings suggest further development and evaluation of G-Rp1 for the treatment of lung cancers with mutated p53 as well as wild-type p53.
Halliwick 10 Point Program의 운동학습과정
서삼기,김태열,황태연,Seo, Sam-Ki,Kim, Tae-Youl,Hwang, Tae-Yeun 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.1
The Halliwick concept was developed by James McMillan over 50 years ago, and began as a method for teaching swimming to children with physical disables. After that the Halliwcik concept was developed as a specific strategy(called the Ten-Point Program) for teaching swimming to children with disabilities. Soon after the changes in the physical and emotional behavior were attributed to a unique teaching/learning philosophy and a psycho-sensory-motor learning program that is enhanced by hydrodynamics. Recognizing the therapeutic effects of the Ten-Pont Program adapted the program as a therapeutic intervention called Water Specific Therapy or the Logic Approach to Therapy in Water.
정상인의 자세와 시각 교란에 따른 정적 균형능력의 변화
서삼기,김수현,김태열,Seo, Sam-Ki,Kim, Soo-Hyun,Kim, Tae-Youl 대한물리치료학회 2009 대한물리치료학회지 Vol.21 No.4
Purpose: This study examined the difference in the static balance ability according to the visual cues and postural tasks in normal subjects. Methods: Thirty participants (12 male, 18 female; mean age $24.63\pm1.43$ years) stood barefoot on a force platform in a one-legged stance, tandem Romberg stance and tandem Romberg with neck extension stance with a visual cue open and closes. The static balance was assessed by the center of pressure (CoP), surface electromyography root mean square (RMS) of the leg muscles according to the stance position. Results: In the CoP tests, the difference in the unit path length and circumference area was affected by the visual cue according to the stance posture (p<0.01). In the RMS tests, the difference in the tibialis anterior and medial gastrocnemius muscle was affected by visual cue in accordance with the stance posture (p<0.01). Conclusion: The visual cue and postural task affect the balance ability in normal subjects. Therefore, this study provides clinical evidence that the balance and postural control can be improved. Therapeutic intervention, such as an obstacle course, and a lower leg muscle performance program with a change in the base of support can affect the balance and postural control.
Kim, Eun Yu,Park, Ki Youl,Seo, Young Sam,Kim, Woo Taek American Society of Plant Biologists 2016 PLANT PHYSIOLOGY - Vol.170 No.4
<P>Lipid droplets (LDs) act as repositories for fatty acids and sterols, which are used for various cellular processes such as energy production and membrane and hormone synthesis. LD-associated proteins play important roles in seed development and germination, but their functions in postgermination growth are not well understood. Arabidopsis (Arabidopsis thaliana) contains three SRP homologs (SRP1, SRP2, and SRP3) that share sequence identities with small rubber particle proteins of the rubber tree (Hevea brasiliensis). In this report, the possible cellular roles of SRPs in postgermination growth and the drought tolerance response were investigated. Arabidopsis SRPs appeared to be LD-associated proteins and displayed polymerization properties in vivo and in vitro. SRP-overexpressing transgenic Arabidopsis plants (35S:SRP1, 35S:SRP2, and 35S:SRP3) exhibited higher vegetative and reproductive growth and markedly better tolerance to drought stress than wild-type Arabidopsis. In addition, constitutive over-expression of SRPs resulted in increased numbers of large LDs in postgermination seedlings. In contrast, single (srp1, 35S:SRP2-RNAi, and srp3) and triple (35S:SRP2-RNAi/srp1srp3) loss-of-function mutant lines exhibited the opposite phenotypes. Our results suggest that Arabidopsis SRPs play dual roles as positive factors in postgermination growth and the drought stress tolerance response. The possible relationships between LD-associated proteins and the drought stress response are discussed.</P>
김건,서삼기,윤희종,김태열,이정우,Kim, Kun,Seo, Sam-Ki,Yoon, Hui-Jong,Kim, Tae-Youl,Lee, Jeong-Woo 대한물리치료학회 2008 대한물리치료학회지 Vol.20 No.1
Purpose: This study was designed to investigate the correlations between muscle strength of the ankle and balance, walking in the elderly. Methods: Thirty-nine subjects were selected from a population of female volunteers. Measurement of balance ability included evaluation of timed "up and go", functional reach, and a one leg standing test. Measurement of walking analysis included evaluation of cadence, stride length, step length, and walking speed. Maximal voluntary isometric contraction (MVIC) of the ankle muscle strength was measured by use of a dynamometer. Results: For balance, there were significant negative correlations between timed "up and go" and the MVIC of the ankle dorsiflexor. There were significant positive correlations between one leg standing with the eyes closed and the MVIC of the ankle dorsiflexor. For walking, there were significant positive correlations between cadence, walking speed and the MVIC of the ankle dorsiflexor. Conclusion: This study showed that there were close relationships between muscle strength of the ankle dorsiflexor and walking and balance in the elderly.