Antiglycation and antioxidant activity of four Iranian medical plant extracts

Safari, Mohammad Reza,Azizi, Omid,Heidary, Somayeh Sadat,Kheiripour, Nejat,Ravan, Alireza Pouyandeh KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.2

Objective: Diabetes mellitus (DM) is the most common metabolic disorder that defined by chronic hyperglycemia for the deficiency in insulin secretion or resistance. Hyperglycemia could induce non-enzymatic glycation of proteins. It has been suggested that some traditional plants can improve blood glucose and inhibit glycation process. This work evaluates and compares the anti-glycation activities of four Iranian plant extracts in vitro. Methods: The methanolic extract of "Fumaria officinalis, Stachys lavandulifolia, Salvia hydrangea and Rosa Damascene" was prepared in three different concentrations. Phenolic, flavonoids content and antioxidant activity were evaluated. The multistage glycation markers- fructosamines (early stage), protein carbonyls (intermediate stage) and ${\beta}$ aggregation of albumin were investigated in the bovine serum albumin (BSA)/ glucose systemt. Results: All plants showed the high potency of scavenging free radicals and glycation inhibition in the following order: Fumaria officinalis> Rosa Damascene> Stachys lavandulifolia > Salvia hydrangea. There was a significant correlation between antioxidant and anti-glycation activity. Also, the antioxidant and anti-glycation capacity of extracts correlated with total phenolic and flavonoids content. Conclusion: Our findings demonstrated that the studied plants are good sources of anti-glycation and antioxidant compounds and, these properties can primarily attributable to phenolics, particularly flavonoids.

Effects of abutment diameter, luting agent type, and re-cementation on the retention of implant-supported CAD/CAM metal copings over short abutments

Safari, Sina,Ghavam, Fereshteh Hosseini,Amini, Parviz,Yaghmaei, Kaveh The Korean Academy of Prosthodonitics 2018 The Journal of Advanced Prosthodontics Vol.10 No.1

PURPOSE. The aim of this study was to evaluate the effects of abutment diameter, cement type, and re-cementation on the retention of implant-supported CAD/CAM metal copings over short abutments. MATERIALS AND METHODS. Sixty abutments with two different diameters, the height of which was reduced to 3 mm, were vertically mounted in acrylic resin blocks with matching implant analogues. The specimens were divided into 2 diameter groups: 4.5 mm and 5.5 mm (n=30). For each abutment a CAD/CAM metal coping was manufactured, with an occlusal loop. Each group was sub-divided into 3 sub-groups (n=10). In each subgroup, a different cement type was used: resin-modified glass-ionomer, resin cement and zinc-oxide-eugenol. After incubation and thermocycling, the removal force was measured using a universal testing machine at a cross-head speed of 0.5 mm/min. In zinc-oxide-eugenol group, after removal of the coping, the cement remnants were completely cleaned and the copings were re-cemented with resin cement and re-tested. Two-way ANOVA, post hoc Tukey tests, and paired t-test were used to analyze data (${\alpha}=.05$). RESULTS. The highest pulling force was registered in the resin cement group (414.8 N), followed by the re-cementation group (380.5 N). Increasing the diameter improved the retention significantly (P=.006). The difference in retention between the cemented and recemented copings was not statistically significant (P=.40). CONCLUSION. Resin cement provided retention almost twice as strong as that of the RMGI. Increasing the abutment diameter improved retention significantly. Re-cementation with resin cement did not exhibit any difference from the initial cementation with resin cement.

Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos

Safari, Somayyeh,Faramarzi, Azita,Agha-Rahimi, Azam,Khalili, Mohammad Ali The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.3

The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B-C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.

Zinc (II) [tetra(4-methylphenyl)] Porphyrin: a Novel and Reusable Catalyst for Efficient Synthesis of 2,4,5-trisubstituted Imidazoles Under Ultrasound Irradiation

Safari, Javad,Khalili, Shiva Dehghan,Banitaba, Sayed Hossein,Dehghani, Hossein Korean Chemical Society 2011 대한화학회지 Vol.55 No.5

An efficient three-component one-step synthesis of 2,4,5-trisubstituted imidazoles by condensation reaction of 1,2-diketones or ${\alpha}$-hydroxyketones with aromatic aldehydes and ammonium acetate using Zinc (II) [tetra (4-methylphenyl)] porphyrin as a novel and reusable catalyst under ultrasound irradiation at ambient temperature is described. In this method, ${\alpha}$-hydroxyketones as well as 1,2-diketones were converted to their corresponding 2,4,5-trisubstituted imidazoles in excellent yields.

Free vibration of electro-magneto-thermo sandwich Timoshenko beam made of porous core and GPLRC

Safari, Mohammad,Mohammadimehr, Mehdi,Ashrafi, Hossein Techno-Press 2021 Advances in nano research Vol.10 No.2

In this article, free vibration behavior of electro-magneto-thermo sandwich Timoshenko beam made of porous core and Graphene Platelet Reinforced Composite (GPLRC) in a thermal environment is investigated. The governing equations of motion are derived by using the modified strain gradient theory for micro structures and Hamilton's principle. The magneto electro are under linear function along the thickness that contains magnetic and electric constant potentials and a cosine function. The effects of material length scale parameters, temperature change, various distributions of porous, different distributions of graphene platelets and thickness ratio on the natural frequency of Timoshenko beam are analyzed. The results show that an increase in aspect ratio, the temperature change, and the thickness of GPL leads to reduce the natural frequency; while vice versa for porous coefficient, volume fractions and length of GPL. Moreover, the effect of different size-dependent theories such as CT, MCST and MSGT on the natural frequency is investigated. It reveals that MSGT and CT have most and lowest values of natural frequency, respectively, because MSGT leads to increase the stiffness of micro Timoshenko sandwich beam by considering three material length scale parameters. It is seen that by increasing porosity coefficient, the natural frequency increases because both stiffness and mass matrices decreases, but the effect of reduction of mass matrix is more than stiffness matrix. Considering the piezo magneto-electric layers lead to enhance the stiffness of a micro beam, thus the natural frequency increases. It can be seen that with increasing of the value of WGPL, the stiffness of microbeam increases. As a result, the value of natural frequency enhances. It is shown that in hc/h = 0.7, the natural frequency for WGPL = 0.05 is 8% and 14% less than its for WGPL = 0.06 and WGPL = 0.07, respectively. The results show that with an increment in the length and width of GPLs, the natural frequency increases because the stiffness of micro structures enhances and vice versa for thickness of GPLs. It can be seen that the natural frequency for aGPL = 25 ㎛ and hc/h = 0.6 is 0.3% and 1% more than the one for aGPL = 5 ㎛ and aGPL = 1 ㎛, respectively.

Investigation on Distillation Column Sequence and Heat Integration Effects in Methanol to Propylene Separation Unit: An Economic Optimization Study Based on Pinch and Exergy Analysis

Safari Davood,Kasiri Norollah,Khalili-Garakani Amirhossein,Mafi Mostafa 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.5

To study the simultaneous impacts of distillation column sequencing and heat integration on the Methanol to Propylene plant’s economy, diff erent distillation sequences for three components separation have been examined. In this study, optimization has been done by considering Total Annual Cost, TAC, as an objective function and the independent variables, including the number of trays, distillation column pressure, and temperature levels of refrigeration cycles, by using the Genetic Algorithm, GA. In order to provide an insight into heat integration’s detrimental eff ects on TAC, optimization has been performed with and without heat integration. Analysis of the optimization results indicates that heat integration can reduce the TAC of the separation unit by nearly 50%. Also, scrutinized interpretation of confi gurations over the optimization results leads to the proposition that the thermal coupling of the direct sequence, with TAC of 238,000$ would exhibit the utmost performance for light gas separations, which would be more than 10% improvement compared with the simple direct. Furthermore, the application of the proposed 4-component separation unit reduces TAC by around 10% compared with the industrial plant. In this regard, an optimization framework has been presented for the systematic design of integrated below-ambient temperature separation units.

New Synthesis of Perhydrotriazolotriazoles Catalyzed by TiCl₄ under Ambient Conditions

Safari, J.,Gandomi-Ravandi, S.,Ghotbinejad, M. Korean Chemical Society 2012 대한화학회지 Vol.56 No.1

Aromatic 2,3-diazabuta-1,3-dienes in glacial acetic acid with isothiocyanate in the presence of catalyst $TiCl_4$ at room temperature produced via criss-cross cycloaddition reactions the corresponding perhydro[1,2,4]triazolo[1,2-a][1,2,4] triazole-1,5-dithiones in relatively high yields and short reaction time.

Photocatalytic degradation of methyl tert-butyl ether (MTBE) by Fe-TiO2 nanoparticles

Mojtaba Safari,Manouchehr Nikazar,Mitra Dadvar 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.5

Nowadays, since the underground waters are known as the main source for supplying the drinking water, their pollution to the organic contaminants such as methyl tert-butyl ether (MTBE) is a very significant issue. Therefore, in this study, photocatalytic degradation of MTBE was investigated in the aqueous soloution of Fe-TiO2 nanoparticale under UV irradiation (wavelenght 254 nm) in a batch reactor. The Fe-TiO2 mixed oxides were prepared by sol–gel impregnation method. The samples were characterized by X-ray diffraction (XRD), UV–vis diffuse reflectance spectroscopy (DRS), scanning electron microscopy (SEM) and BET specfic surface area. Then, the effect of various operational parameters namely pH, catalyst loading, molar ratio of [H2O2]0/[MTBE]0 and UV light intensity on degradation of aqueous MTBE were evaluated in a batch reactor. The optimal condition to achieve the best degradation for the initial concentration of 75 ppm MTBE was found at pH 7, catalyst concentration 2 g/L, molar ratio of [H2O2]0/[MTBE]0 4, and UV irradiation 24 W. Total degradation of MTBE with initial concentration of 75 ppm was reached in optimal condition after 70 min. In addition, investigations were also carried out to determine the appropriate kinetics of MTBE degradation using UV/Fe-TiO2/H2O2process in optimal condition.

Synthesis of amidoalkyl naphthols by nano-Fe3O4 modified carbon nanotubes via a multicomponent strategy in the presence of microwaves

Javad Safari,Zohre Zarnegar 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

Fe3O4-CNTs composites are synthesized using simple chemical coprecipitation which is confirmed with XRD, VSM, TEM and EDS. Fe3O4-CNTs as a magnetically active catalyst catalyze one-pot multicomponent condensation of b-naphthol with aromatic and aliphatic aldehydes and amide derivatives under solventfree conditions and microwave-irradiation to afford the corresponding amidoalkyl naphthols in excellent yields. This catalyst provides clean conversion; greater selectivity and easy workup make this protocol practical and economically attractive.

The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers

Farhad Safari,Ali Dabbagh,Mansour Sharifnia 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.6

Background: There are a number of adjuvants to be used for local anesthetics in spinal block. The aim of this study was to demonstrate the possible effect of intrathecal midazolam compared with bupivacaine as adjuvants in spinal anesthesia with bupivacaine in chronic opium abuses. Methods: In a double blind, randomized clinical trial, 90 opium abuser patients undergoing lower limb orthopedic surgery were selected and randomly assigned into 3 groups (30 cases each). The patients received 15 mg plain bupivacaine, or 15 mg bupivacaine plus 25 mcg fentanyl or 15 mg bupivacaine plus 1 mg midazolam, intrathecally. Results: The duration of anesthesia was much longer in the bupivacaine-midazolam group than the bupivacaine-fentanyl group; both were longer than the plain bupivacaine group (P < 0.05). Conclusions: Subarachnoid injection of adjuvant midazolam or fentanyl with plain 0.5% bupivacaine in opium abusers in lower limb orthopedic surgery increases the duration of sensory block. Therefore midazolam is more effective than fentanyl in such cases. Background: There are a number of adjuvants to be used for local anesthetics in spinal block. The aim of this study was to demonstrate the possible effect of intrathecal midazolam compared with bupivacaine as adjuvants in spinal anesthesia with bupivacaine in chronic opium abuses. Methods: In a double blind, randomized clinical trial, 90 opium abuser patients undergoing lower limb orthopedic surgery were selected and randomly assigned into 3 groups (30 cases each). The patients received 15 mg plain bupivacaine, or 15 mg bupivacaine plus 25 mcg fentanyl or 15 mg bupivacaine plus 1 mg midazolam, intrathecally. Results: The duration of anesthesia was much longer in the bupivacaine-midazolam group than the bupivacaine-fentanyl group; both were longer than the plain bupivacaine group (P < 0.05). Conclusions: Subarachnoid injection of adjuvant midazolam or fentanyl with plain 0.5% bupivacaine in opium abusers in lower limb orthopedic surgery increases the duration of sensory block. Therefore midazolam is more effective than fentanyl in such cases.