Antiglycation and antioxidant activity of four Iranian medical plant extracts

Safari, Mohammad Reza,Azizi, Omid,Heidary, Somayeh Sadat,Kheiripour, Nejat,Ravan, Alireza Pouyandeh KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.2

Objective: Diabetes mellitus (DM) is the most common metabolic disorder that defined by chronic hyperglycemia for the deficiency in insulin secretion or resistance. Hyperglycemia could induce non-enzymatic glycation of proteins. It has been suggested that some traditional plants can improve blood glucose and inhibit glycation process. This work evaluates and compares the anti-glycation activities of four Iranian plant extracts in vitro. Methods: The methanolic extract of "Fumaria officinalis, Stachys lavandulifolia, Salvia hydrangea and Rosa Damascene" was prepared in three different concentrations. Phenolic, flavonoids content and antioxidant activity were evaluated. The multistage glycation markers- fructosamines (early stage), protein carbonyls (intermediate stage) and ${\beta}$ aggregation of albumin were investigated in the bovine serum albumin (BSA)/ glucose systemt. Results: All plants showed the high potency of scavenging free radicals and glycation inhibition in the following order: Fumaria officinalis> Rosa Damascene> Stachys lavandulifolia > Salvia hydrangea. There was a significant correlation between antioxidant and anti-glycation activity. Also, the antioxidant and anti-glycation capacity of extracts correlated with total phenolic and flavonoids content. Conclusion: Our findings demonstrated that the studied plants are good sources of anti-glycation and antioxidant compounds and, these properties can primarily attributable to phenolics, particularly flavonoids.

Zinc (II) [tetra(4-methylphenyl)] Porphyrin: a Novel and Reusable Catalyst for Efficient Synthesis of 2,4,5-trisubstituted Imidazoles Under Ultrasound Irradiation

Safari, Javad,Khalili, Shiva Dehghan,Banitaba, Sayed Hossein,Dehghani, Hossein Korean Chemical Society 2011 대한화학회지 Vol.55 No.5

An efficient three-component one-step synthesis of 2,4,5-trisubstituted imidazoles by condensation reaction of 1,2-diketones or ${\alpha}$-hydroxyketones with aromatic aldehydes and ammonium acetate using Zinc (II) [tetra (4-methylphenyl)] porphyrin as a novel and reusable catalyst under ultrasound irradiation at ambient temperature is described. In this method, ${\alpha}$-hydroxyketones as well as 1,2-diketones were converted to their corresponding 2,4,5-trisubstituted imidazoles in excellent yields.

Effects of abutment diameter, luting agent type, and re-cementation on the retention of implant-supported CAD/CAM metal copings over short abutments

Safari, Sina,Ghavam, Fereshteh Hosseini,Amini, Parviz,Yaghmaei, Kaveh The Korean Academy of Prosthodonitics 2018 The Journal of Advanced Prosthodontics Vol.10 No.1

PURPOSE. The aim of this study was to evaluate the effects of abutment diameter, cement type, and re-cementation on the retention of implant-supported CAD/CAM metal copings over short abutments. MATERIALS AND METHODS. Sixty abutments with two different diameters, the height of which was reduced to 3 mm, were vertically mounted in acrylic resin blocks with matching implant analogues. The specimens were divided into 2 diameter groups: 4.5 mm and 5.5 mm (n=30). For each abutment a CAD/CAM metal coping was manufactured, with an occlusal loop. Each group was sub-divided into 3 sub-groups (n=10). In each subgroup, a different cement type was used: resin-modified glass-ionomer, resin cement and zinc-oxide-eugenol. After incubation and thermocycling, the removal force was measured using a universal testing machine at a cross-head speed of 0.5 mm/min. In zinc-oxide-eugenol group, after removal of the coping, the cement remnants were completely cleaned and the copings were re-cemented with resin cement and re-tested. Two-way ANOVA, post hoc Tukey tests, and paired t-test were used to analyze data (${\alpha}=.05$). RESULTS. The highest pulling force was registered in the resin cement group (414.8 N), followed by the re-cementation group (380.5 N). Increasing the diameter improved the retention significantly (P=.006). The difference in retention between the cemented and recemented copings was not statistically significant (P=.40). CONCLUSION. Resin cement provided retention almost twice as strong as that of the RMGI. Increasing the abutment diameter improved retention significantly. Re-cementation with resin cement did not exhibit any difference from the initial cementation with resin cement.

Investigation on Distillation Column Sequence and Heat Integration Effects in Methanol to Propylene Separation Unit: An Economic Optimization Study Based on Pinch and Exergy Analysis

Safari Davood,Kasiri Norollah,Khalili-Garakani Amirhossein,Mafi Mostafa 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.5

To study the simultaneous impacts of distillation column sequencing and heat integration on the Methanol to Propylene plant’s economy, diff erent distillation sequences for three components separation have been examined. In this study, optimization has been done by considering Total Annual Cost, TAC, as an objective function and the independent variables, including the number of trays, distillation column pressure, and temperature levels of refrigeration cycles, by using the Genetic Algorithm, GA. In order to provide an insight into heat integration’s detrimental eff ects on TAC, optimization has been performed with and without heat integration. Analysis of the optimization results indicates that heat integration can reduce the TAC of the separation unit by nearly 50%. Also, scrutinized interpretation of confi gurations over the optimization results leads to the proposition that the thermal coupling of the direct sequence, with TAC of 238,000$ would exhibit the utmost performance for light gas separations, which would be more than 10% improvement compared with the simple direct. Furthermore, the application of the proposed 4-component separation unit reduces TAC by around 10% compared with the industrial plant. In this regard, an optimization framework has been presented for the systematic design of integrated below-ambient temperature separation units.

Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos

Safari, Somayyeh,Faramarzi, Azita,Agha-Rahimi, Azam,Khalili, Mohammad Ali The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.3

The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B-C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.

Free vibration of electro-magneto-thermo sandwich Timoshenko beam made of porous core and GPLRC

Safari, Mohammad,Mohammadimehr, Mehdi,Ashrafi, Hossein Techno-Press 2021 Advances in nano research Vol.10 No.2

In this article, free vibration behavior of electro-magneto-thermo sandwich Timoshenko beam made of porous core and Graphene Platelet Reinforced Composite (GPLRC) in a thermal environment is investigated. The governing equations of motion are derived by using the modified strain gradient theory for micro structures and Hamilton's principle. The magneto electro are under linear function along the thickness that contains magnetic and electric constant potentials and a cosine function. The effects of material length scale parameters, temperature change, various distributions of porous, different distributions of graphene platelets and thickness ratio on the natural frequency of Timoshenko beam are analyzed. The results show that an increase in aspect ratio, the temperature change, and the thickness of GPL leads to reduce the natural frequency; while vice versa for porous coefficient, volume fractions and length of GPL. Moreover, the effect of different size-dependent theories such as CT, MCST and MSGT on the natural frequency is investigated. It reveals that MSGT and CT have most and lowest values of natural frequency, respectively, because MSGT leads to increase the stiffness of micro Timoshenko sandwich beam by considering three material length scale parameters. It is seen that by increasing porosity coefficient, the natural frequency increases because both stiffness and mass matrices decreases, but the effect of reduction of mass matrix is more than stiffness matrix. Considering the piezo magneto-electric layers lead to enhance the stiffness of a micro beam, thus the natural frequency increases. It can be seen that with increasing of the value of WGPL, the stiffness of microbeam increases. As a result, the value of natural frequency enhances. It is shown that in hc/h = 0.7, the natural frequency for WGPL = 0.05 is 8% and 14% less than its for WGPL = 0.06 and WGPL = 0.07, respectively. The results show that with an increment in the length and width of GPLs, the natural frequency increases because the stiffness of micro structures enhances and vice versa for thickness of GPLs. It can be seen that the natural frequency for aGPL = 25 ㎛ and hc/h = 0.6 is 0.3% and 1% more than the one for aGPL = 5 ㎛ and aGPL = 1 ㎛, respectively.

New Synthesis of Perhydrotriazolotriazoles Catalyzed by TiCl₄ under Ambient Conditions

Safari, J.,Gandomi-Ravandi, S.,Ghotbinejad, M. Korean Chemical Society 2012 대한화학회지 Vol.56 No.1

Aromatic 2,3-diazabuta-1,3-dienes in glacial acetic acid with isothiocyanate in the presence of catalyst $TiCl_4$ at room temperature produced via criss-cross cycloaddition reactions the corresponding perhydro[1,2,4]triazolo[1,2-a][1,2,4] triazole-1,5-dithiones in relatively high yields and short reaction time.

Development of a metamodel assisted sampling approach to aerodynamic shape optimization problems

Amir Safari,Adel Younis,Gary Wang,Hirpa Lemu,Zuomin Dong 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.5

A new metamodel-assisted sampling search approach applied to the aerodynamic shape optimization of turbomachinery airfoils is presentedin this paper. The proposed methodology integrates a non-uniform rational B-spline (NURBS) geometry representation, a twodimensionalflow analysis, and an improved metamodel driven optimization algorithm named approximated promising region identifier(APRI), which represents a momentous advancement of the existing space exploration techniques specifically for the high-dimensionalexpensive black-box (HEB) problems. The novel optimization method prospects the whole design space by generating sample points,reporting evaluating information using a surrogate model, and then focusing the search in the most promising region by deploying moreagents. Using the integration of these adaptive tools and methods, the optimization results are considerably promising in terms of computationalefficiency and performance enhancement of the turbomachinery blade airfoil shape in both design and off-design conditions.

A Hybrid Rough Set Theory-PSO Technique for Solving of Non-convex Economic Load Dispatch

Amin Safari,Davoud Moghaddam Sheibai 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.12

This paper applies a novel hybrid rough set theory-particle swarm optimizer technique, namely rough particle swarm optimization (RPSO) algorithm, for solving non-convex economic load dispatch (NELD) problem. The RPSO algorithm is based on the notion of rough patterns that uses rough values defined with upper and lower intervals in which represent a set of values. This RPSO method is suggested to deal with the practical constraints such as valve point loading effect, generation limitation, ramp rate limits and prohibited operating zones in the NELD problems. Simulations were performed on four different power systems with 3, 6, 15 and 40 generating units and the results are compared with classical PSO and crazy PSO algorithms. The results of this study reveal that the proposed approach is able to find appreciable NELD solutions than those of previous algorithms.

Forced vibration of a sandwich Timoshenko beam made of GPLRC and porous core

Mohammad Safari,Mehdi Mohammadimehr,Hossein Ashrafi 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.1

In this study, forced vibration behavior of a piezo magneto electric sandwich Timoshenko beam is investigated. It is assumed a sandwich beam with porous core and graphene platelet reinforced composite (GPLRC) in facesheets subjected to magneto-electro-elastic and temperature-dependent material properties. The magneto electro platelets are under linear function along with the thickness that includes a cosine function and magnetic and electric constant potentials. The governing equations of motion are derived using modified strain gradient theory for microstructures. The effects of material length scale parameters, temperature change, different distributions of porous, various patterns of graphene platelets, and the core to face sheets thickness ratio on the natural frequency and excited frequency of a sandwich Timoshenko beam are scrutinized. Various size-dependent methods effects such as MSGT, MCST, and CT on the natural frequency is considered. Moreover, the final results affirm that the increase in porosity coefficient and volume fractions lead to an increase in the amount of natural frequency; while vice versa for the increment in the aspect ratio. From forced vibration analysis, it is understood that by increasing the values of volume fraction and the length thickness of GPL, the maximum deflection of a sandwich beam decreases. Also, it is concluded that increasing the temperature, the thickness of GPL, and the initial force leads to a decrease in the maximum deflection of GPL. It is also shown that resonance phenomenon occurs when the natural and excitation frequencies become equal to each other. Outcomes also reveal that the third natural frequency owns the minimum value of both deflection and frequency ratio and the first natural frequency has the maximum.