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Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5
<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325–331. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>
Oh, K.S.,Heo, S.I.,Yun, J.C.,Yang, Y.C.,Han, K.S. The Korean Society for Composite Materials 2008 Advanced composite materials Vol.17 No.3
This study aims to optimize the mechanical and electrical properties of electrically conductive polymer composites (CPCs) for use as a material of bipolar plates for PEM fuel cells. The thin CPCs consisting of conductive fillers and polymer resin were fabricated by a preform molding technique. Expanded graphite (EG), flake-type graphite (FG) and carbon fiber (CF) were used as conductive fillers. This study tested two types of CPCs, EG/FG filled CPCs and EG/CF filled CPCs, to optimize the material properties. First, the characteristics of EG/FG filled CPCs were investigated according to the FG ratio for 7 and $100{\mu}m$ sized FG. CPCs using $100{\mu}m$ FG showed optimal material properties at 60 wt% FG ratio, which were an electrical conductivity of 390 S/cm and flexural strength of 51 MPa. The particle size was an important parameter to change the mechanical and electrical behaviors. The flexural strength was sensitive to the particle size due to the different levels of densification. The electrical conductivity also showed size-dependent behavior because of the different contributions to the conductive network. Meanwhile, the material properties of EG/CF filled CPCs was also optimized according to the CF ratio, and the optimized electrical conductivity and flexural strength were 290 S/cm and 58 MPa, respectively. The electrical conductivity of this case decreased similarly to the EG/FG filled case. On the other hand, the behavior of the flexural strength was more complicated than the EG/FG filled case, and the reason was attributed to the interaction between the strengthening effect of CF and the deterioration of voids.
Oh, M.J.,Hwang, H.H.,Kim, H.G.,Lee, G.H.,Cho, Y.S.,Lee, S.Y.,Kang, S.Y.,Cho, K.H.,Lee, Y.Y.,Lee, Y.J.,Jang, C.G.,Lee, S.Y. Excerpta Medica] ; Elsevier Science Ltd 2017 Clinical therapeutics Vol.39 No.7
Purpose: A fixed-dose combination (FDC) pill of amlodipine (relatively old calcium channel blocker as dihydropyridine) and olmesartan (relatively new angiotensin II receptor blocker) is used for hypertension that is not adequately controlled with a single-formulation drug. Because the FDC is a one-pill formulation, and amlodipine and olmesartan have different mechanisms of action, it is expected to improve patients' medication compliance and have an increased blood pressure-lowering efficacy. The purpose of this study was to assess the safety profile and the bioequivalence of two different FDC formulations [amlodipine besylate/olmesartan medoxomil 10/40 mg (reference product) and S-amlodipine nicotinate/olmesartan medoxomil 5/40 mg (test product)]. Methods: A randomized, open-label, single-dose, 2-treatment, 2-way, and 2-period crossover study, including a 3-week washout period, was performed in 32 healthy Korean male volunteers. To analyze the concentration of S-amlodipine or olmesartan, plasma samples were collected up to 144 hours after the dose for S-amlodipine and 48 hours after the dose for olmesartan. Pharmacokinetic parameters, including the C<SUB>max</SUB> and the area under the curve from time 0 to the last measurable concentration (AUC<SUB>0-last</SUB>) for the time versus concentration plot, were calculated. Analysis of variance for bioequivalence was conducted using C<SUB>max</SUB> and AUC<SUB>0-last</SUB> converted to log scale, and the mean ratios and 90% CIs were determined. Safety data included analysis of adverse events (AEs), vital signs, physical examinations, clinical laboratory test, and 12-lead ECGs. Findings: Of the 32 enrolled participants, 29 healthy volunteers completed the study. For both S-amlodipine and olmesartan, the main pharmacokinetic parameters were all within the acceptable range for regulatory bioequivalence. The 90% CIs for the geometric mean ratios of C<SUB>max</SUB> and AUC<SUB>0-last</SUB> were 0.8766 to 0.9760 and 0.8288 to 0.9224, respectively, for S-amlodipine and 0.9097 to 1.1229 and 0.8904 to 1.0407, respectively, for olmesartan. Hypotension was the most frequent AE, and it was observed in 4 volunteers with the test product and 7 volunteers with the reference product. Both the test and reference formulations were well tolerated. Implications: The present study demonstrates that the newly developed FDC product (test drug) and the conventional FDC product (reference drug) have comparable pharmacokinetic characteristics in healthy adult male volunteers. Both the test and reference products indicated good tolerance in this population, and no serious AEs were observed.
Characteristics of an Ultraviolet Dye Laser Pumped by an Improved HCP Device
S.J.Park,S.S.Suk,C.W.Lim,D.W.Choi,C.H.Oh,J.H.Lee 한국물리학회 2002 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.40 No.3
The conventional HCP (hypocycloidal pinch) device has been proven to have signicant advantages over traditional ashlamps in terms of output power, life expectancy and selectivity of spectra in the UV (ultraviolet) region. However, the conventional HCP device's electrical discharge was contaminated with dye cuvette due to vaporization of the electrodes and the insulators. As a result, we improved the electrode and the insulator of the conventional HCP device and investigated the electrical and the optical properties of the improved HCP device. The pumping light intensity of the improved HCP device was compared with that of the conventional HCP device. The optimum operating pressure of the HCP device was at 4 Torr. The maximum output power of the UV dye laser pumped by the HCP was 192 kW at input energy of 900 J. In addition, the untuned laser wavelength was 385 nm and the half width of the laser was 3 nm.
Gill, S.S.,Oh, H.W.,Lee, D.W.,Roh, J.Y.,Park, H.W.,Jin, B.R.,Je, Y.H.,Kang, S.K. 東亞大學校附設遺傳工學硏究所 1998 遺傳工學硏究 Vol.- No.5
J.Y.ROH,H.W.PARK,Y.H.JE,D.W.LEE,B.R.JIN, H.W.OH,S.S.GILL AND S.K.KANG.1997. Bacillus thuringiensis NTB-1 isolated from soil samples in Korea produces ovoidal parasporal inclusions with proteins of approximately 24-40kDa in size. Although serological study indicated that the isolate has a flagella (H) antigen identical with subsp. israelensis, it seemed to be non-insecticidal against Lepidoptera and Coleoptera as well as Diptera. To investigate the activity of non-insecticidal B.thuringiensis transformed with insecticidal crystal protein genes, cryIVD and cytA genes of B. thuringiensis subsp. morrisoni PG-14, highly toxic to mosquito larvae, were introduced into the isolate NTB-1. The expression of mosquitocidal crystal protein genes in NTB-1 was characterized by SDS-PAGE analysis and electron microscopy. The results showed that crystalline inclusions of host, CryIVD and CytA were stably expressed in the transformant. However, the mosquitocidal activity of transformant was similar to that of B. thuringiensis subsp. kurstaki Cry-B harbouring cryIVD and cytA genes, demonstrating that a synergistic effect by an interaction of both introduced insecticidal and resident non-insecticidal crystal proteins was not observed.
Oh, C.Y.,Nam, H.S.,Kim, Y.J.,Ainsworth, R.A.,Budden, P.J. Pergamon Press ; Elsevier Science Ltd 2014 Engineering fracture mechanics Vol.124 No.-
Objective: This paper provides validation of R6 elastic-plastic J-estimation methods, via elastic-plastic finite element analyses for circumferentially cracked pipes under combined mechanical and thermal loads. Materials method: In the FE analyses, the relative magnitudes of the mechanical and thermal loads, types of thermal loads, the crack sizes and material hardening are systematically varied. Loading sequence effects for the mechanical and thermal loads are also considered. The FE elastic-plastic J values are compared with those derived using R6 elastic-plastic J-estimation methods. Results: It is shown that there are significant load order effects on elastic-plastic J for large secondary stress cases, but these are conservatively estimated using newly proposed methods in R6.
Park, E.W.,Kim, J.H.,Lim, H.T.,Seo, B.Y.,Cho, I.C.,Lee, J.G.,Oh, S.J.,Cheong, I.C.,Lee, J.H.,Jeon, J.T. S. Karger AG 2004 CYTOGENETIC AND GEN0ME RESEARCH Vol.108 No.4
<P> </P><P>Copyright © 2005 S. Karger AG, Basel</P>
Kim, J.H.,Lee, Y.S.,Park, E.W.,Seo, B.Y.,Cho, I.C.,Lee, J.G.,Oh, S.J.,Lee, J.H.,Jeon, J.T. S. Karger AG 2004 CYTOGENETIC AND GEN0ME RESEARCH Vol.108 No.4
<P> </P><P>Copyright © 2005 S. Karger AG, Basel</P>
Yun, S.M.,Woo, S.H.,Oh, S.T.,Hong, S.E.,Choe, T.B.,Ye, S.K.,Kim, E.K.,Seong, M.K.,Kim, H.A.,Noh, W.C.,Lee, J.K.,Jin, H.O.,Lee, Y.H.,Park, I.C. North-Holland 2016 Molecular and cellular endocrinology Vol.422 No.-
Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Melatonin enhanced the ATO-induced apoptotic cell death via changes in the protein levels of Survivin, Bcl-2, and Bax, thus affecting cytochrome c release from the mitochondria to the cytosol. Interestingly, we found that the cell death induced by co-treatment with melatonin and ATO was mediated by sustained upregulation of Redd1, which was associated with increased production of reactive oxygen species (ROS). Combined treatment with melatonin and ATO induced the phosphorylation of JNK and p38 MAP kinase downstream from Redd1 expression. Rapamycin and S6K1 siRNA enhanced, while activation of mTORC1 by transfection with TSC2 siRNA suppressed the cell death induced by melatonin and ATO treatment. Taken together, our findings suggest that melatonin enhances ATO-induced apoptotic cell death via sustained upregulation of Redd1 expression and inhibition of mTORC1 upstream of the activation of the p38/JNK pathways in human breast cancer cells.
Effect of Filament Configuration on Critical Current Density of Bi2212/Ag Wires With Low Ag Ratio
Kim, S.-C.,Ha, D.-W.,Oh, S.-S.,Han, I.-Y.,Oh, J.-G.,Sohn, H.-S. IEEE 2008 IEEE transactions on applied superconductivity Vol.18 No.2
<P>Effect of filament configuration and heat treatment of Bi2212/Ag round wire with low Ag ratio on the engineering critical current density (J<SUB>e</SUB>) was reported. We have fabricated 557, 85 7, and 121 7 wires with different Ag ratio and evaluated at various wire diameters. We have also changed the parameters of heat treatment. The effects of maximum process temperature (T<SUB>max</SUB>)and soaking time at T<SUB>max</SUB> and average filament diameter on the J<SUB>e</SUB> were also studied. 121 7 wire of 0.95 mm diameter heat-treated at showed J<SUB>e</SUB> of 858mm<SUP>2</SUP> at 4.2K, 0 T.</P>