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Antitumor activity of Trichosanthes kirilowii
Ryu, Shi Yong,Lee, Seung Ho,Choi, Sang Un,ee, Chung Ock,No, Zaesung,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The acitivity-directed fractionation upon the MeOH extract of the not of trichosanthes kirilowill led to the isolation of eight cucurbitane triterpenes namely cucurbitacin B(Ⅰ), isocucubitacin B(Ⅱ), cucurbitacin D (Ⅲ), isocucurbitacin D (Ⅳ, 3-epi-isocucurbitacin B(Ⅴ), dihydrocucurbitacin B(Ⅵ), dihydroisocucurbitacin B(Ⅶ) and dihydrocucurbitacin E(Ⅷ), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, SK-OV-3, 5K-MIL-2, XF-498 and HCT 15, with an exceptionally high potency.
Antitumor Activity of Psorelea corylifolia
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.
ALKBH5 gene is a novel biomarker that predicts the prognosis of pancreatic cancer
Sung Hwan Cho,Mihyang Ha,Yong Hoon Cho,Je Ho Ryu,Kwangho Yang,Kang Ho Lee,Myoung-Eun Han,Sae-Ock Oh,Yun Hak Kim 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: Discovery of new prognostic factors for cases in which the pancreatic cancer scoring and staging system does not result in a clear definition is imperative. We examined the role of Human AlkB homolog H5 (ALKBH5) as a prognostic marker for pancreatic cancer. Methods: Patient data were extracted from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). The prognostic value of ALKBH5 was confirmed via analysis of ALKBH5 and other clinical factors, such as age, sex, and stage, using the time-dependent area under the curve (AUC) of Unos C-index, the AUC value of the receiver operating characteristics (ROC) at three years, the Kaplan-Meier survival curve, and multivariate analysis. Results: ALKBH5 showed excellent prognosis prediction in comparison with existing markers in the two independent cohorts (n=262). Kaplan-Meier survival analysis showed that ALKBH5 expression was positively associated with overall survival (log-rank test, ICGC, p=0.001; TCGA, p=0.01). Notably, comparison of C-index and AUC values in ROC analysis showed that ALKBH5 was associated with high C-index and AUC values compared with other clinical variables (C-index: ICGC, 0.621; TCGA, 0.614 and AUC at three years: ICGC, 0.609; TCGA, 0.558). Multivariate analysis demonstrated that ALKBH5 is an independent prognostic factor (ICGC, p=0.0123; TCGA, p<0.001). Conclusions: These findings contribute to the study of RNA methylation in pancreatic cancer. We believe that ALKBH5 is a new prognostic marker for pancreatic cancer.
Decreasing Effect of LidocaineㆍHCl on the Thickness of the Neuronal and Model Membrane
Sung-Min Park,Jong-Sun Park,Jae-Han Kim,Jin-Hyun Baek,Tae-Gyun Yoon,Do-Keun Lee,Won-Hyang Ryu,In-Kyo Chung,Uy Dong Sohn,Hye-Ock Jang,Il Yun 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4
This study examined the mechanism of action of a local anesthetic, lidocaineㆍHCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used to determine the effect of lidocaineㆍHCl on the thickness (D) of the synaptosomal plasma membrane vesicles (SPMV) isolated from the bovine cerebral cortex, and liposomes of the total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. The thickness (D) of the intact SPMV, SPMVTL and SPMVPL were 1.044±0.008, 0.914±0.005 and 0.890±0.003 (arbitrary units, n=5) at 37<sup>o</sup>C (pH 7.4), respectively. LidocaineㆍHCl decreased the thickness of the neuronal and model membrane lipid bilayers in a dose-dependent manner with a significant decrease in the thickness, even at 0.1 mM. The decreasing effect of lidocaineㆍ HCl on the membrane thickness might be responsible for some, but not all of its anesthetic action.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi-Yong,Lee, Seung-Ho,Lee, Sang-Un,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The activity fractionation upon the MeOH extract of the root of trichosanthes kirilowii led to the isolation of eight cucurbitane tritepense namely cucurbitacin .betha. (I), isocucurbitacin .betha.(II), cucurbitacin D(III), isocucurbitacin D(IV), 3-epi-isocucurbitacin .betha(V), dihydrocucurbitain .betha. (VI), dihydroisocucurgbitachin .betha. (VII) and dihydrocucurbitacin E (VIII), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, Sk-OV-3, Sk-MEL-2, XF-498 and HCT 15, with an exceptionally high potency.
Ryu, Chung-Kyu,Jeong, Hyeh-Jean,Lee, Sang-Kook,You, Hee-Jung,Choi, Ko-Un,Shim, Ju-Yeon,Heo, Yeon-Hoi,Lee, Chong-Ock The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.5
Synthesized 6-arylamino-5,8-quinolinediones 4a-4j and 6-chloro-7-arylamino-5,8-isoquinolinediones 5a-5g were evaluated for effects on NAD(P)H quinone oxidoreductase (NQOl ) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. The compounds 4d, 5b, 5c, 5e and 5g were comparable modulators of NQO1 activity.
Ryu, Chung-Kyu,Jeong, Hyeh-Jean,Lee, Sang-Kook,Kang, Hye-Young,Ko, Kyung-Min,Sun, Yang-Jung,Song, Eun-Ha,Hur, Yeon-Hoe,Lee, Chong-Ock The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.6
Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQOl) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQOl activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQOl activity.
Ryu, Chung-Kyu,Lee, In-Kyung,Jung, Sung-Hee,Kang, Hye-Young,Lee, Chong-Ock 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
Antitumor Triterpense from Medicinal Plants
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Seung-Ho,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
Thirteen kinds of naturally occurring or derivatised thiterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells, i.e., A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15, in vitro. Ursonic acid III, betulinic acid VIII, betulonic acid X and glycrrhetinic acid XI were exhibitied a marked inhibition on cell growth.