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Samantha E. Russell(Samantha E. Russell ),David R. Skvarc(David R. Skvarc ),Mohammadreza Mohebbi(Mohammadreza Mohebbi ),David Camfield(David Camfield ),Linda K. Byrne(Linda K. Byrne ),Alyna Turner(Aly 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: N -acetylcysteine (NAC) is a novel therapeutic agent with multiple mechanisms of action in the central nervous system and a favourable side effect profile. Clinical evidence indicates that adjunctive NAC may reduce the severity of depressive symptoms in individuals with major depressive disorder (MDD). Methods: A 12-week randomised controlled trial of 2,000 mg/day adjunctive NAC for MDD found no significant improvement at the primary endpoint (week 12) but did see improvements at the post-discontinuation interview (week 16). Within the context of patient-centered treatment, mixed-methods qualitative analysis was also included to explore factors that may determine individual responses to adjunctive NAC treatment. These data were drawn, under blinded conditions, from clinician notes recorded in the case report form. Using the DSM-5 symptom profile for MDD as the initial framework, themes were developed and explored. Frequencies were compared between placebo and NAC groups. Results: Per protocol analysis of individual themes across the six interviews revealed group differences in favour of NAC for overall depressive affect, optimism, relationships and reduced functional impairment. Conclusion: This study provides further evidence for the utility of the mixed methods approach complimenting the primary findings using traditional quantitative analyses, as well as being able to capture additional, often more subtle, evidence of individual symptom-level change that reflects improvement in functional abilities in response to NAC supplementation. The use of mixed methods to explore outcomes from psychiatric studies should be considered in future to work towards improved patient-centred care and both confirm quantitative findings and generate novel hypotheses.
Protection and Presentation : An Ongoing Battle of The American Civil War
Russell E,Brayley 세계문화관광학회 2011 Conference Proceedings Vol.12 No.-
Major battlefields from the American Civil War are protected in the National Park system and preserved as hallowed grounds. As places of interest and importance to the public battlefields are also presented for educational and interpretive purposes. Political and management conflict arises over the apparent contradiction between preservation as protection and preservation for presentation. Like other sacred sites the battlefields require formal designation protection and control to preserve their sanctity. However they also need to be understood appreciated and visited by those for whom the sites are an important part of their heritage. Interpretive activities such as large-scale battle re-enactments often emphasize the challenges of providing both protection and interpretive presentation.
Home ranges and activity patterns of Sunda pangolins Manis javanica (Pholidota: Manidae) in Vietnam
Russell J. Gray,Dung Van Le,Huyen Thi Thanh Nguyen,Long Nhat Cau,Tan Van Nguyen,Thong Van Pham,Daniel Willcox,Tiffany Chen,Thai Van Nguyen 국립중앙과학관 2023 Journal of Asia-Pacific Biodiversity Vol.16 No.3
This study provides an update on the movement ecology of the Sunda pangolin (Manis javanica) in threedistinct ecoregions of Vietnam. Using radio telemetry, we tracked 12 pangolins rescued from the illegalwildlife trade and translocated to protected areas. We found that the average home range of translocatedSunda pangolins was 1.58 km2 and did not vary significantly between sexes, mass, or habitat. However,there was a marked decrease in range size with decreasing sizes of suitable forest space and terrain, or alocalized abundance of resources in some locations. Pangolins were most active from 03:00 to 04:00. Thestudy highlights the need for further research to fully understand the ecology of this unique and enig matic species.
Gastric Xanthoma in the Pediatric Population: A Possible Herald for Malignancy?
Russell, Joseph D.,Peck, Jacquelin,Phen, Claudia,Linehan, Janna L.,Karjoo, Sara,Nguyen, Johnny,Wilsey, Michael J. The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.1
Gastric xanthoma is frequently an incidental finding on upper endoscopy in adults. Gastric xanthomas (GX) can be mistaken for malignancies and warrant prompt histologic diagnosis. The underlying etiology is not fully understood; however, it has been linked to Helicobacter pylori gastritis and gastric cancer. GX in the pediatric population is largely unreported in the literature. Because of the relative rarity, documentation with case reports are essential to provide as much data as possible to see if there is a correlation between GX and malignant potential in the pediatric population. Our group is reporting two cases, a 10-year-old male and a 7-year-old male, both who presented with chronic dysphagia, upper abdominal pain, nausea, vomiting, and loss of appetite. Upper endoscopies for both patients revealed small polypoid lesions located in the antrum with foamy histiocytes on histology, leading to the diagnosis of gastric xanthoma.
Application of Information Value Chain in Gout Management
Russell Maranda,Kim Sujin 한국성인간호학회 2022 성인간호학회지 Vol.34 No.4
Purpose: This study introduces information value chain analysis by identifying essential information for use in gout care management. Part I reviews the essential concepts of information value chain analysis first introduced by Porter. Part II applies the analysis to determine the information values of patient health information and explores ways in which health information technologies can be best utilized to provide that information to patients with gout. Methods: We combined value chain analysis with natural language processing and machine learning techniques to develop algorithms that can identify patients with gout flares using clinical notes. As one of the first signs that the disease was not being controlled, variables found to be associated with gout flares were considered valuable information for patients with gout. Results: The best performing model, in terms of both gout flare prediction and association identification, was the comprehensive model that not only included concepts from all stages of the value chain but also designated natural language processing concepts from every care stage as surrogate variables. Additionally, all administrative codes traditionally associated with gout and its treatment were included as surrogate outcome variables. Conclusion: This study introduced information value chain analysis and applied it to develop a computer-based method with theoretical underpinnings to identify the concepts associated with gout flares. The findings can be used as a starting point for filtering the vast amounts of information patients must go through and identifying the most valuable information for patient with gout to adequately manage their symptoms.
Morphing anthropomorphism: An update
Russell Belk,Maria Kniazeva 한국마케팅과학회 2018 마케팅과학연구 Vol.28 No.3
This is an update of a 2010 paper we published on anthropomorphic consumer perception of brands and marketer attempts to humanize brands through packaging. Since that time a great deal of academic and business attention to the topic of anthropomorphism has resulted in the related work on brand mascots, brand personality, marketplace mythologies, and anthropomorphism in product design and advertising. In addition, new arenas of anthropomorphism have emerged with developments in projective research methods, digital avatars, robot design, digital self-presentation, and conversational digital assistants like Amazon’s Alexa and Apple’s Siri. Such novel directions have prompted new research questions and further studies. This paper offers a brief update of the evolving issues in the co-creation of anthropomorphic objects and brand interpretations by consumers, designers, roboticists, engineers, and marketers.