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柳光洙 충남대학교 공업기술개발연구소 1975 工業技術開發硏究所論文集 Vol.2 No.2
This research tries to formulate a criterion for better perspective drawing by surveying the distribution and variation of perceptual preference among the different groups. For the systematic analysis of the preference test the various perspective drawings are aggregated into three formats based upon the distance, height and direction of the station point. For easy comparison and realistic understanding a general house is adopted as a sample object of the perspective drawing. As expected some variation of preference among the different groups and within the same group are observed, but the variations are not so high that it may be possible to expect some possibility of man's perceptual consensus on better perspectives.
Mi-Kyoung You,Jin Rhuy,Kyu Shik Jeong,Mi-Ae Bang,Myung-Seok Kim,Hyeon-A Kim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.3
BACKGROUND/OBJECTIVES: This study was conducted to assess the potential of St. John’s Wort (Hypericum perforatum) to prevent obesity and abnormalities in lipid metabolism induced by ovariectomy in a rat model without stimulatory activity on uterus. MATERIALS/METHODS: Ovariectomized (OVX) rats were treated for 6 weeks with 70% ethanol extracts of Hypericum perforatum [HPEs: whole plant (WHPE) and flower and leaves (FLHPE)], β-estradiol-3-benzoate at a dose of 50 μg/kg/day (E2) or vehicle (distilled water). RESULTS: As expected, OVX increased body weight gain and adiposity and showed higher food efficacy ratio. OVX also increased the serum cholesterol as well as insulin resistance, while reducing uterus weight and uterine epithelial proliferation rate. HPEs (WHPE and FLHPE) showed estrogen-like effect on body weight gain, adipose tissue weight and food efficacy ratio in OVX rats. HPEs prevented hypercholesterolemia induced by OVX more effectively than E2. E2 increased uterus weight and epithelial proliferation rate in OVX rats, while HPEs maintained them at the level of the sham-operated animals. CONCLUSIONS: Our finding demonstrates that HPEs can be considered as an effective agent to prevent OVX-induced obesity without stimulatory activity on uterus.
Kim, Min-Sook,You, Mi-Kyoung,Rhuy, Dong-Young,Kim, Yung-Jae,Baek, Hum-Young,Kim, Hyeon-A The Korean Nutrition Society 2009 Nutrition Research and Practice Vol.2 No.3
We examined the inhibitory effects of loquat methanol extract on the adhesion, migration, invasion and matrix metalloproteinase (MMP) activities of MDA-MB-231 human breast cancer cell line. Cells were cultured with DMSO or with 10, 25, or 50 ${\mu}g/ml$ of loquat methanol extract. Both leaf and seed extracts significantly inhibited growth of MDA-MB-231 cells in a dose-dependent manner, although leaf extract was more effective. Adhesion and migration were significantly inhibited by loquat extracts in a dose-dependent manner. Loquat extract also inhibited the invasion of breast cancer cells in a dose-dependent manner and leaf extract was more effective than seed extract. MMP-2 and MMP-9 activities were also inhibited by loquat extract. Our results indicate that methanol extracts of loquat inhibit the adhesion, migration and invasion of human breast cancer cells partially through the inhibition of MMP activity and leaf extract has more anti-metastatic effects in cell based assay than seed extract. Clinical application of loquat extract as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.