면양에 있어서 Cassia 와 Alfalfa 의 소화율 및 미생물 단백질 합성

안종호,R. Elliott 한국낙농학회 1991 韓國酪農學會誌 Vol.13 No.3

Cassia rotundifolia의 반추동물의 이용성에 관한 자료가 극히 드물고 또한 현장에서 가축의 채식 거부 현상이 관찰되었다는 보고가 있어 본 실험에서 Cassia의 반추동물의 사료로서 가치를 평가하고저 실시하였다. 제1위와 제4위에 fistula가 장치된 면양을 이용하여 Cassia rotundifolia 및 알팔파(Medicage sativa)를 각각 급여했을때 ^(51)Cr-EDTA, Na₂^(35)SO₄ 등의 등위원소를 지시제로 사용하여 제4위로 이전되는 단백질, 건물량 및 반추위에서의 미생물 단백질 생산량이 조사되었다. Cassia구에서의 미생물 생산량은 4gN/100g organic matter apparently digested in the rumen로서 알팔파구(6.5gN)에서보다 유의하게 낮았으나 화학성분에 기대되는 결과로 사료되었다. 2차실험에서는 알팔파와 Cassia를 35일간 면양에게 각각 급여하고 마지막 7일간 측정된 섭취량 및 소화율 시험의 결과 Cassia는 특정 유해물질을 함유하지 않았으며 1차실험의 미생물 단백질 생산량과 함께 Cassia는 그 화학성분에 기대되는 영양가와 사료섭취량을 보였다고 사료되었다. Microbial protein production in the rumen of abomasally fistulated sheep fed hay made from the legume Cassia rotundifolia and alfafa(Medicago sativa) was measured in this experiment. The yield of microbial protein from Cassia(4gN/100g organic matter apparently digested in the rumen) was significantly less than that recorded in sheep fed alfalfa. In anther experiment, wether sheep were fed alfalfa hay or Cassia hay for 35 days. Digestibility of DM and N balance was measured in these sheep over a 7 day period. Dry matter and N digestibilities were significantly greater in sheep fed alfalfa. It was concluded however that Cassia hay cut at a mature stage of growth had the expected nutritive value and voluntary intake based on its chemical composition and appeared to be free of anti-nutritive factors.

열대 두과 잡관목류의 탄닌 성분과 GEL FILTRATION 에 의한 탄닌분리

안종호(J . H . Ahn),R . Elliott(R . Elliott) 한국영양사료학회 1991 韓國營養飼料學會誌 Vol.15 No.4

Newer Methods for Insulin Delivery

Elliott, R.B. Medical Publications Korea 1986 Medical Progress Vol.8 No.6

흰쥐 생체 실험을 이용한 두과 식물의 유해물질 조사

안종호(J . H . Ahn),R . Elliott(R . Elliott) 한국영양사료학회 1991 韓國營養飼料學會誌 Vol.15 No.5

Asymmetric Mode of Ca ²⁺ -S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling

Elliott, Paul ,R.,Irvine, Andrew ,F.,Jung, Hyun ,Suk,Tozawa, Kaeko,Pastok, Martyna ,W.,Picone, Remigio,Badyal, Sandip ,K.,Basran, Jaswir,Rudland, Philip ,S.,Barraclough, Roger Cell Press 2012 Structure Vol.20 No.4

<P><B>Summary</B></P><P>Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca<SUP>2+</SUP>-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers. Our NMR structure shows that an S100A4 dimer binds to a single myosin heavy chain in an asymmetrical configuration. NMIIA in the complex forms a continuous helix that stretches across the surface of S100A4 and engages the Ca<SUP>2+</SUP>-dependent binding sites of each subunit in the dimer. Synergy between these sites leads to a very tight association (K<SUB>D</SUB> ∼1 nM) that is unique in the S100 family. Single-residue mutations that remove this synergy weaken binding and ameliorate the effects of S100A4 on NMIIA filament assembly and cell spreading in A431 human epithelial carcinoma cells. We propose a model for NMIIA filament disassembly by S100A4 in which initial binding to the unstructured NMIIA tail initiates unzipping of the coiled coil and disruption of filament packing.</P>

The impact of incontinence etiology on artificial urinary sphincter outcomes

Adam R. Miller,Brian J. Linder,Laureano J. Rangel,David Y. Yang,Daniel S. Elliott 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.4

Purpose: To evaluate the impact of incontinence etiology on artificial urinary sphincter (AUS) device outcomes. Materials and Methods: We identified 925 patients who underwent primary AUS placement from 1983 to 2011. The etiology of incontinence was categorized as radical prostatectomy alone, radical prostatectomy with radiation, benign prostate resection, and those with cryotherapy as a salvage prostate cancer treatment. Hazard regression and competing risk analyses were used to determine the association of the etiology of incontinence with device outcomes. Results: The distribution of the 4 etiologies of incontinence included: 598 patients (64.6%) treated with prostatectomy alone, 206 (22.2%) with prostatectomy and pelvic radiation therapy, 104 (11.2%) with benign prostate resection, and 17 (1.8%) with prior cryotherapy. With a median follow-up of 4.9 years (interquartile range, 1.2–8.8 years), there was significant difference in the cumulative incidence of device infection/urethral erosion events between the four etiologies (p=0.003). On multivariable analysis, prior cryotherapy (reference prostatectomy alone; hazard ratio [HR], 3.44; p=0.01), older age (HR, 1.07; p=0.0009) and history of a transient ischemic attack (HR, 2.57; p=0.04) were associated with an increased risk of device infection or erosion. Notably, pelvic radiation therapy with prostatectomy was not associated with an increased risk of device infection or erosion (reference prostatectomy alone, p=0.30). Conclusions: Compared to prostatectomy alone, prior treatment with salvage cryotherapy for recurrent prostate cancer was associated with an increased risk of AUS infection/erosion, whereas radiation (in addition to prostatectomy) was not.

3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren’s surgery

Benjamin H Miranda,Charlotte Elliott,Christopher C Kearsey,David N Haughton,Mark R Webb,Ian Harvey,Fahmy S Fahmy 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.6

Background Numerous Dupuytren’s fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren’s disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren’s disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3−5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer (5.0±0 years vs. 4.0±0.2 years; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease- free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren’s flexion deformity.

3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren's surgery

Miranda, Benjamin H,Elliott, Charlotte,Kearsey, Christopher C,Haughton, David N,Webb, Mark R,Harvey, Ian,Fahmy, Fahmy S Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.6

Background Numerous Dupuytren's fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren's disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren's disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3-5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer ($5.0{\pm}0years$ vs. $4.0{\pm}0.2years$; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease-free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren's flexion deformity.

Self-Reported Sleep Latency in Postmenopausal Women

Girardin Jean Louis,Melville R Klauber,Doo Heum Park,Daniel F Kripke,Jeffrey A Elliott,Katharine M Rex,Arja Tuunainen,Robert D Langer 대한의학회 2007 Journal of Korean medical science Vol.22 No.6

What is the fate of artificial urinary sphincters among men undergoing repetitive bladder cancer treatment?

S. Mitchell Heiner,Boyd R. Viers,Marcelino E. Rivera,Brian J. Linder,Daniel S. Elliott 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.1

Purpose: Functional characteristics and durability of the artificial urinary sphincter (AUS) among patients who develop bladder cancer has been poorly characterized. We sought to evaluate AUS outcomes among patients subsequently diagnosed with bladder cancer, in order to describe device survivability when subject to diagnostic and therapeutic procedures such as cystoscopy, transurethral resection, and cystectomy. Materials and Methods: We retrospectively reviewed 1,803 male patients treated with AUS surgery at a single institution between 1983–2014. We describe AUS device outcomes among patients undergoing surveillance and treatment for bladder cancer. Results: Following AUS placement, 14 (0.8%) patients were subsequently diagnosed with and treated for bladder cancer and 4 patients with bladder cancer undergoing treatment and screening, subsequently received AUS placement. The median follow-up from device placement was 7.2 years (interquartile range [IQR], 2.8–11.5), and the median time from AUS placement to bladder cancer diagnosis was 6 (IQR, 0–9). There were a total of 8 primary and 1 secondary devices failures. Despite a median of 2 diagnostic cystoscopies (IQR, 1–6) and 0 bladder tumor resections (IQR, 0–0) per patient following device implantation, only 1 (5.6%) patient experienced an iatrogenic erosion related to urethral manipulation. Among those undergoing cystectomy (n=4), 1 device was left in situ without complication. Conclusions: Bladder cancer surveillance and treatment with an AUS device in place appears to confer minimal additional risk to AUS survival. Careful attention should be given to device deactivation and use of the smallest caliber instruments available to minimize the risk of iatrogenic urethral erosion.