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Cytotoxic Constituents from Angelicae Sinensis Radix
Quan Cheng Chen,JongPill Lee,WenYi Jin,윤의중,HongJin Kim,Ik Soo Lee,XinFeng Zhang,송경식,성연희,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1- yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 µM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ± 0.19 and 9.87 ± 0.14 µM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 µM, respectively.
Analysis of Shooting Consistency in Archers: A Dynamic Time Warping Algorithm-Based Approach
Quan, Cheng-Hao,Mohy-Ud-Din, Zia,Lee, Sangmin Hindawi Limited 2017 Journal of sensors Vol.2017 No.-
<P>The shooting consistency of an archer is commonly perceived to be an important determinant of successful scores. Four (n=4) elementary level archers from a middle school in Korea participated in this study. In order to quantify shooting consistency, movement of the bow forearm was measured with an inertia sensor during archery shooting. The shooting consistency was calculated and defined by the dynamic time warping (DTW) algorithm as the distance between two time sequences of acceleration data. Small distance values indicate that the archer has maintained high-level shooting consistency while archery shooting repetitively. To verify the shooting consistency metric, the relationship between scores and shooting consistency is evaluated. The results show that the higher the scores achieved by the archer, the higher is the level of shooting consistency demonstrated.</P>
Quan Cheng Chen,Su Jin Jeong,Gwi Seo Hwang,Kyeong Ho Kim,Jong Seong Kang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
A chiral mobile phase HPLC method is described for chiral separation and determination of chlorpheniramine (CP) enantiomers in various commercial preparations. Chromatographic separation was achieved on a conventional ODS column with a mixture of aqueous sodium phosphate (5 mM) containing 0.5 mM carboxymethyl-β-cyclodextrin, methanol and triethylamine (73:25:2, v/v/v, pH 4.3) as the mobile phase. The flow rate of isocratic elution was 0.24 mL/min and peaks were detected at 224 nm. The method was applied to nine commercial CP preparations in six dosage forms and CP enantiomers were well separated without any disturbance of other ingredients or impurities present. The results showed that only one preparation was d-CP and the others were dl-CP preparations. The contents of all the preparations were found to be in the range of 97%-104% of labeled contents. This method was economical and convenient, affording sufficient accuracy, precision and reproducibility, as well as sensitivity and selectivity.
Cheng Quan,Sang Su Lee 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.96 No.3
Purpose: A prospective study was conducted to compare radiation exposure to different parts of an endovascular surgeon’s body when using a mobile C-arm with that in a hybrid room. Methods: Exposure during individual procedures performed on 39 patients with a mobile C-arm and 42 patients in a hybrid room, from July 2016 to December 2016, was evaluated. Results: The procedures performed, fluoroscopy time, and dose-area product were not significantly different between groups. The dose-area product per second in the hybrid room group appeared greater than in the C-arm group (4.5 μGym2/ sec vs. 3.1 μGym2/sec). In the C-arm group, the peak skin dose on the right neck (1.77 mSv) and shoulder (1.48 mSv) appeared higher than those on their left side (0.32 mSv, 0.53 mSv, respectively) and the counterparts of the hybrid room group (0.88 mSv, 0.20 mSv, respectively). Conclusion: The peak skin dose in the hybrid room appeared highest for the lower part of the protective apron. The dosearea product per second seemed to be greater in the hybrid room than when using the C-arm. Thus, attention should be focused on protecting the surgeon’s upper body when using the C-arm and the lower body when using the hybrid room