Effect of eucalyptus oil inhalation on pain and inflammatory responses after knee replacement

Purum Kang,Sun Seek Min,Geun Hee Seol 한국성인간호학회 2013 성인간호학회 학술대회 Vol.2013 No.5

<i>Citrus bergamia</i> Risso Elevates Intracellular Ca ^<b>2+</b> in Human Vascular Endothelial Cells due to Release of Ca ^<b>2+</b> from Primary Intracellular Stores

Kang, Purum,Han, Seung Ho,Moon, Hea Kyung,Lee, Jeong-Min,Kim, Hyo-Keun,Min, Sun Seek,Seol, Geun Hee Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-

<P>The purpose of the present study is to examine the effects of essential oil of <I>Citrus bergamia</I> Risso (bergamot, BEO) on intracellular Ca<SUP>2+</SUP> in human umbilical vein endothelial cells. Fura-2 fluorescence was used to examine changes in intracellular Ca<SUP>2+</SUP> concentration [Ca<SUP>2+</SUP>]<SUB>i</SUB> . In the presence of extracellular Ca<SUP>2+</SUP>, BEO increased [Ca<SUP>2+</SUP>]<SUB>i</SUB> , which was partially inhibited by a nonselective Ca<SUP>2+</SUP> channel blocker La<SUP>3+</SUP>. In Ca<SUP>2+</SUP>-free extracellular solutions, BEO increased [Ca<SUP>2+</SUP>]<SUB>i</SUB> in a concentration-dependent manner, suggesting that BEO mobilizes intracellular Ca<SUP>2+</SUP>. BEO-induced [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase was partially inhibited by a Ca<SUP>2+</SUP>-induced Ca<SUP>2+</SUP> release inhibitor dantrolene, a phospholipase C inhibitor U73122, and an inositol 1,4,5-triphosphate (IP<SUB>3</SUB>)-gated Ca<SUP>2+</SUP> channel blocker, 2-aminoethoxydiphenyl borane (2-APB). BEO also increased [Ca<SUP>2+</SUP>]<SUB>i</SUB> in the presence of carbonyl cyanide m-chlorophenylhydrazone, an inhibitor of mitochondrial Ca<SUP>2+</SUP> uptake. In addition, store-operated Ca<SUP>2+</SUP> entry (SOC) was potentiated by BEO. These results suggest that BEO mobilizes Ca<SUP>2+</SUP> from primary intracellular stores via Ca<SUP>2+</SUP>-induced and IP3-mediated Ca<SUP>2+</SUP> release and affect promotion of Ca<SUP>2+</SUP> influx, likely via an SOC mechanism.</P>

(-)-Linalool inhibits vascular contraction in mouse aorta by activating guanylyl cyclase and K+ channels

Purum Kang,Geun Hee Seol 한국성인간호학회 2013 성인간호학회 학술대회 Vol.2013 No.5

Antioxidant Activity of Linalool in Patients with Carpal Tunnel Syndrome

Purum Kang,Geun-Hye Seol,Hui Su Lee,Geun Hee Seol 한국간호과학회 2015 한국간호과학회 학술대회 Vol.2015 No.10

The essential oil of Citrus bergamia?Risso induces vasorelaxation of the mouse aorta by activating K(+) channels and inhibiting Ca(2+) influx.

Kang, Purum,Suh, Suk Hyo,Min, Sun Seek,Seol, Geun Hee Pharmaceutical Society of Great Britain 2013 Journal of pharmacy and pharmacology Vol.65 No.5

<P>The aim of this study was to explore the effect of the essential oil of Citrus bergamia?Risso (bergamot) on mouse blood vessels and to analyse the mechanism of this effect from a pharmacological perspective.</P>

Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K(+) channels.

Kang, Purum,Seol, Geun Hee Pharmaceutical Society of Great Britain 2015 Journal of pharmacy and pharmacology Vol.67 No.5

<P>ObjectivesThe aim of this study was to investigate the cardiovascular relaxing properties of monoterpene alcohol (-)-linalool (LIN), a principal component of several aromatic plants. MethodsWe assessed the effects of LIN on vascular contractility in mouse aortae and evaluated its underlying mechanisms of action. Key findingsWe found that LIN dose-dependently relaxed the vascular tonus of mouse thoracic aortae induced by prostaglandin F-2 alpha (PGF(2), 3m). This effect, however, was reduced by pretreatment with the nitric oxide synthase inhibitor L-NAME (30m). Treatment with the inhibitor of soluble guanylyl cyclase ODQ (2m) or the K+ channel blocker TEA (10mM) partially blocked LIN-induced vasorelaxation. Moreover, addition of TEA after incubation of the rings with L-NAME and ODQ partially blocked LIN-induced vasorelaxation. Furthermore, LIN was able to partially antagonize CaCl2-induced contractions in high potassium (80mM) Krebs' solution, whereas LIN did not affect Ca2+ release from endoplasmic reticulum Ca2+ stores. ConclusionOur findings indicate that LIN may induce endothelium-dependent vasorelaxation in mouse thoracic aortae by activating soluble guanylyl cyclase and K+ channels.</P>

바질 에센셜 오일 향흡입이 척추수술 전 만성요통환자에서 통증, 불안 및 활력징후에 미치는 효과

강푸름(Purum Kang),정금미(Kum Mi Jung),민선식(Sun Seek Min),설근희(Geun Hee Seol) 대한스트레스학회 2012 스트레스硏究 Vol.20 No.3

Ocimum basilicum L.은 민간요법에서 통증, 염증 및 고혈압을 치료하는데 사용되어 온 식물로 알려져 있다. Ocimum basilicum L.에서 추출된 바질 에센셜 오일을 사용하여 만성 요통으로 척추수술을 받기 위해 입원 중인 환자를 모집단으로 하여 농도에 따른 바질 에센셜 오일 향흡입이 척추수술 전 통증, 불안 및 활력징후에 미치는 효과를 규명하기위해 이중맹검법을 이용한 무작위 대조군 전?후 실험설계로 검증한 연구이다. 연구대상자는 0.1%, 1%, 5%의 바질에센셜 향흡입군 및 대조군으로 무작위 배치되었으며 통증, 불안, 기분상태(profile of mood states), 수축기 혈압, 이완기 혈압, 맥박 및 호흡수를 바질 에센셜 오일 향흡입 전·후에 측정하였다. 연구결과 0.1%와 1%의 바질 에센셜 오일을 흡입한 군은 대조군에 비해 유의미한 통증의 감소를 나타내었으며(p=.022, p=.022, respectively) 5%의 바질 에센셜 오일을 향흡입한 군에서는 대조군에 비해 이완기 혈압을 유의미하게 감소시켰다(p=.023). 반면에 수축기 혈압 및 맥박, 호흡수, 기분상태 및 불안은 대조군에 비해 실험군에서 감소하는 경향은 보였으나 네 그룹 간 유의미한 차이를 나타내지 않았다. 따라서, 본 연구 결과로 미뤄볼 때 바질 에센셜 오일 향흡입은 농도 비의존적으로 특정 농도에서 통증 완화 및 이완기 혈압을 조절시키는 효과가 있음을 알 수 있었으며 이러한 연구결과는 향후 임상에서 아로마요법 시행 시 아로마 에센셜 오일의 적정 농도 선별이 선행되어야함을 시사하고 있다. Ocimum basilicum L. (basil essential oil, BEO) is a plant used in traditional folk medicine for the treatment of pain, inflammation and hypertension. BEO-inhalation was used to examine the effects of the odor of BEO and BEO concentration dependency on pain and anxiety before spine surgery in patients with chronic low back pain. A total of sixty patients were randomly assigned to one of the four study groups (control, 0.1%, 1%, 5% BEO-inhalation group). Pain-visual analog scale (P-VAS), anxiety-visual analog scale (A-VAS), profile of mood states (POMS) test, blood pressure, heart rate, and respiratory rate were measured before and after inhalation of the odors for five minutes. Inhalation of BEO at 0.1%, 1% concentration caused significant decreases in P-VAS compared with control (p=.022, p=.022, respectively), meanwhile 5% BEO-inhalation significantly reduced in diastolic blood pressure compared with control (p=.023). However, there was no significant difference among the four groups in systolic blood pressure, heart rate, respiratory rate, A-VAS, POMS test. In patients with chronic low back pain before spine surgery, 0.1% and 1% BEO-inhalation is effective in alleviating pain and 5% BEO-inhalation reduce diastolic blood pressure. In conclusion, BEO-inhalation at specific concentrations can be useful method for the relief of pain and blood pressure control for patients with chronic low back pain before spine surgery. (Korean J Str Res 2012;20:169∼178)

간호·간병통합서비스 병동 간호사가 경험하는 입원 환자와의 관계: 현상학적 접근

강푸름(Kang, Purum),강지원(Kang, Jiwon) 한국간호행정학회 2021 간호행정학회지 Vol.27 No.3

Purpose: The purpose of this study was to explore the experiences of the relationship between nurses working on comprehensive nursing care service wards and the inpatients on those wards. Methods: The phenomenological research method was used. Participants in the study were seven women. Data were collected through individual in-depth interviews from December, 2018 to January, 2019 Results: Five theme clusters were extracted that described nurses’ patient experiences for comprehensive nursing care service wards. They are “Expansion of relationship formation”, “Transition of place to provide nursing care”, “Expansion of communication”, “Maintaining professional boundaries” and “Realization of professional nursing”. Conclusion: The results of this study provide a deep understanding and insight in to the nature for nurses on comprehensive nursing care service wards and patients" relationships. It is thought that active development of strategies to support positive relationships will enhance the quality of the comprehensive nursing care service wards and help improve patient care outcomes.

<i>Trans</i>-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats

Seo, Eunhye,Kang, Purum,Seol, Geun Hee Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.102 No.-

<P><B>Abstract</B></P> <P>Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether <I>trans</I>-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and <I>trans</I>-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of <I>trans</I>-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of <I>trans</I>-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and <I>trans</I>-anethole reduced both blood pressure and vascular tone. These findings are the first to show that <I>trans</I>-anethole can prevent hypertension, suggesting that <I>trans</I>-anethole may be useful as a prophylactic antihypertensive agent.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

<i>Foeniculum vulgare</i> Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-kB Activation

Hui Su Lee,Purum Kang,Ka Young Kim,Geun Hee Seol 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2

<i>Foeniculum vulgare</i> Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflam-matory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7∼10). In five groups, the mice were intraperitoneally injected with 1% Tween 80-saline (vehicle), fennel (125, 250, 500<i>μ</i>l/kg), or dexame-thasone (1 mg/kg), followed 1 h later by intratracheal instillation of LPS (1.5 mg/kg). In two groups, the mice were intraperitoneally injected with vehicle or fennel (250<i>μ</i>l/kg), followed 1 h later by intra-tracheal instillation of sterile saline. Mice were sacrificed 4 h later, and bronchoalveolar lavage fluid (BALF) and lung tissues were obtained. Fennel significantly and dose-dependently reduced LDH activity and immune cell numbers in LPS treated mice. In addition fennel effectively suppressed the LPS-induced increases in the production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, with 500<i>μ</i>l/kg fennel showing maximal reduction. Fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (NO). Assessments of the involvement of the MAPK signaling pathway showed that fennel significantly decreased the LPS-induced phosphorylation of ERK. Fennel effectively blocked the inflammatory processes induced by LPS, by regulating pro-inflammatory cytokine production, transcription factors, and NO.