An Uncommon Finding; Bleeding Extrahepatic Recurrence of Hepatocellular Carcinoma

( Gilbert Peh ),( David Gan ),( Padmaan Sankaran ),( Thanesh Ku ),( Mar Maiyauen ),( Mohd Sharifudin Sharif ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Introduction : Recurrence of Hepatocellular carcinoma (HCC) can mainly be divided into intrahepatic recurrence (IHR) and extrahepatic recurrence (EHR). EHR being the less common of the two. Results: In a post-hemihepatectomy patient with routine surveillance at 6 months, was noted to have elevated Alpha-Fetoprotein and complained of vague lower abdominal pain. CT scan revealed a 6cm heterogenous mass located at pelvis. During laparotomy for resection, the tumour was found to be bleeding. Conclusions: In conclusion, a high index of suspicion and early surgical intervention can help in detecting possible bleeding extrahepatic recurrence in the background of a patient with history of HCC.

Hemorrhagic extrahepatic recurrence of hepatocellular carcinoma

Gilbert Peh Voon Yeow,David Gan Eng Yeow,Padmaan Sankaran,Thanesh Maiyauen,Mohd Sharifudin Sharif 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.1

Effect of seasonal changes on fertility parameters of Holstein dairy cows in subtropical climate of Taiwan

Liu, Wen-Bor,Peh, Huo-Cheng,Wang, Chien-Kai,Mangwe, Mancoba Christopher,Chen, Chih-Feng,Chiang, Hsin-I Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6

Objective: The purpose of this retrospective study was to investigate the relationship between temperature-humidity index (THI), season, and conception rate (CR) of Holstein cows in central Taiwan. Methods: The mean performance and number of observations were statistically evaluated for various parameters, including age at first service, number of days open, gestation length, CR, and calving interval for different parities. Results: The results indicate that the mean age at first service was 493.2 days; the gestation length was similar across all cows of different parities, ranging from 275.1 to 280.7 days. The overall CR of all inseminations was significantly lower in multiparous cows ($47.26%{\pm}0.22%$) than in heifers ($57.14%{\pm}0.11%$) (p<0.05). At THI>72 and during the hot season (from June to November), CRs for multiparous cows were significantly reduced compared to that for heifers, while the ratio remained unchanged among heifers for all seasons. Conclusion: To achieve a high CR, lactating cows should be bred in winter and spring (from December to May) from the start of the seasonal breeding program, whereas the heifer should be allowed to breed in summer and fall under the subtropical climate in Taiwan.

Differences in Working Memory Profiles amongst Children with Low Versus Average Academic Performances

Kerry Lee,Yu Xi Peh 대한사고개발학회 2008 The International Journal of Creativity & Problem Vol.18 No.1

Previous studies showed working memory span predicted mathematical performance. However, it was unclear whether working memory span differed amongst children with poorer performances in mathematics (PM), English literacy (PL), or in both areas (PML). 150 Primary 5 pupils participated in the study. Assignment to performance groups was based on two standardised literacy measures and a mathematical problem solving task. Children scoring at or below the 25th percentile were classified as having performed poorly in that area. Working memory capacity was measured using the Working Memory Test Battery for Children. PML had similar working memory profiles as PL, but had lower scores than PM. Children classified as PM had similar profiles as did normally achieving children. These findings suggest children with difficulties in different topic areas may not benefit equally from working memory based intervention.

The Reproductive Characteristics of the Mare in Subtropical Taiwan

Ju, Jyh-Cherng,Peh, Huo-Cheng,Hsu, Jenn-Chung,Cheng, San-Pao,Chiu, Shaw-Ching,Fan, Yang-Kwang Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.4

The objectives of this study were to document the reproductive traits of mares as influenced by the month of the year in Taiwan. Reproductive records, lactation traits, foal birth weight (FBW) and foal height (FBH) were collected from Holi Equine Station of Taiwan. The effects of month on these parameters were analyzed. The length of estrus (LE) was shortest in December each year. The increasing trend was recorded from January to September with a significantly (p<0.05) longer period of $12.4{\pm}0.4$ days in September than in January and February. A gradual shortening in LE was observed from September to December ($10.1{\pm}0.6$ days, p<0.05), when the shortest period of the year was observed. Mares showed signs of estrus throughout the year, but more than 80% were found in estrus during March through October. The FBW was significantly (p<0.05) affected by the breeding month of the year. The lowest foal weights were recorded in both September ($36.7{\pm}0.7$ kg) and December ($36.8{\pm}0.9$ kg), which were also significantly lower than those in other months except in March, August, and November. A trend of lower FBH from September to December (93.5-93.8 cm) than those from January to August was observed. The greatest FBH was in June (96.2 cm). Breeding months and onset of estrus of the mares exerted a significant effect on the incidence of agalactia during the lactation period. These analyses provide fundamental information on adaptive processes in respect to reproductive characteristics of mares, which indicated an extent of acclimation by these animals in subtropical Taiwan.

Association of mitochondrial DNA content in peripheral blood with cancer-related fatigue and chemotherapy-related cognitive impairment in early-stage breast cancer patients: a prospective cohort study

Chae, Jung-Woo,Chua, Peh Siang,Ng, Terence,Yeo, Angie Hui Ling,Shwe, Maung,Gan, Yan Xiang,Dorajoo, Sreemanee,Foo, Koon Mian,Loh, Kiley Wei-Jen,Koo, Si-Lin,Chay, Wen Yee,Tan, Tira Jing Ying,Beh, Sok Yu Springer-Verlag 2018 Breast cancer research and treatment Vol.168 No.3

<P>This is the first study to show that the reduction of mtDNA content in peripheral blood is associated with the onset of CRF in patients receiving chemotherapy. Further validation studies are required to confirm the findings.</P>

Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet

Kai Bin Liew,Kok Khiang Peh 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8

Orally disintegrating tablet (ODT) is a userfriendly and convenient dosage form. The study aimed toinvestigate the effect of polymers and wheat starch on thetablet properties of lyophilized ODT, with dapoxetine asmodel drug. Three polymers (hydroxypropylmethyl cellulose,carbopol 934P and Eudragit EPO) and wheat starchwere used as matrix forming materials in preparation oflyophilized ODT. The polymeric dispersion was casted intoa mould and kept in a freezer at -20 C for 4 h beforefreeze dried for 12 h. It was found that increasing in HPMCand Carbopol 934P concentrations produced tablets withhigher hardness and longer disintegration time. In contrast,Eudragit EPO was unable to form tablet with sufficienthardness at various concentrations. Moreover, HPMCseems to have a stronger effect on tablet hardness comparedto Carbopol 934P at the same concentration level. ODT of less friable was obtained. Wheat starch acted asbinder which strengthen the hardness of ODTs and prolongedthe disintegration time. ODT comprising of HPMCand wheat starch at ratio of 2:1 was found to be optimumbased upon the tablet properties. The optimum formulationwas palatable and 80 % of the drug was released within30 min in the dissolution study.

The Utility of FDG PET/CT in IgG4-Related Disease with a Focus on Coronary Artery Involvement

Huang, Hian L,Fong, Warren,Peh, Wee M,Niraj, Kasat A,Lam, Winnie W 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.1

Purpose Our case series aims to study the growing use of FDG PET/CT in diagnostic evaluation and follow up of IgG4-RD with emphasis on patients presenting with coronary artery involvement. Methods We conducted a search on the nuclear medicine and rheumatology service databases and identified patients with histologically proven IgG4-RD with FDG PET/CT performed at the Singapore General Hospital. The radiological, clinical, and laboratory findings of these patients were analyzed retrospectively. Results The series included ten male and two female patients. The commonest organ involved (five patients) was the pancreas. In three patients, coronary artery involvement manifested as soft tissue masses surrounding the arterial lumens. In these patients, histological diagnosis was established from alternative biopsy sites with abnormal metabolic activity on FDG PET/CT. Correlation between laboratory and metabolic imaging findings was not statistically significant in our series. Four patients had follow-up FDG PET/CT; three showed interval reduction in metabolic activity to baseline. One showed persistent abnormal metabolic activity before a rise in IgG4 levels. The metabolic imaging response was used to guide steroid dose. Conclusions FDG PET/CT is a useful tool in evaluation and follow-up of IgG4-RD, particularly in identifying alternative biopsy sites in patients who present with coronary artery involvement. Hypermetabolic coronary artery masses on FDG PET/CT should raise clinical suspicion of IgG4-RD. As the coronary artery masses may not show decrease in size after treatment, FDG PET/CT is also useful for metabolic response assessment.

Diurnal Variations in Milk and Blood Urea Nitrogen and Whole Blood Ammonia Nitrogen in Dairy Cows

Hwang, Sen-Yuan,Lee, Mei-Ju,Peh, Huo-Cheng Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.12

The levels of urea nitrogen both in blood (BUN) and milk (MUN), and milk protein (MP) reflect protein and energy intake in dairy herd feeding. Blood and milk constituents may be changes rhythmically and influence by different sampling time within a day and after feeding. Trials were conducted using five dietary treatments in both lactating and dry cows to study the effects of sampling time on concentrations of BUN, MUN and whole blood ammonia nitrogen (BAN) in practical dairy cow feeding in Taiwan. The conventional feed ingredients and forages including corn silage, alfalfa hay, timothy or pangola hay and corn grain were used as major source of the diet to follow practical dairy cow feeding. Five different diets were varying in amounts (low=L; standard=S; high=H) of crude protein (P) and energy (E) according to the NRC (1989). The energy to protein ratios in kcal/kg for the PSES, PLES, PHES, PSEH and PSEL were 10.82, 12.54, 9.41, 12.53 and 9.13 in lactating cows, and 11.38, 13.33, 9.78, 13.28 and 9.74 in dry cows, respectively. Results showed that after feeding at 9:30, BUN reached peak at 13:30 and was significantly higher than those to that sampled at 14:30 to 18:30 (p<0.05) in dry cows. Therefore the best blood sampling time for urea nitrogen assay in dry cows is 4 hours after morning feeding. In lactating cows, BUN of 13:30 was significantly higher than those of 8:30 to 11:30 (p<0.05), but there were no significant difference between the BUN values of other sampling time. Hence the suitable blood sampling time for BUN value in lactating cows was located on 3 to 8 hours after morning feeding, but the best time was 4 hours after morning feeding. MUN content is significantly higher in the afternoon collected bulk milk than the fore-strip morning milk (p<0.05), therefore the best sampling time for MUN is from afternoon collected bulk milk. Diurnal BAN changed without traceable rhythmic pattern and was negatively correlated to the BUN (r = -0.78). It is suggested that BAN may not be a good indicator for monitoring dairy cow feeding.

The Effects of Endurance Training on the Hemogram of the Horse

Fan, Y.K.,Hsu, J.C.,Peh, H.C.,Tsang, C.L.,Cheng, S.P.,Chiu, S.C.,Ju, J.C. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.9

The purpose of this study was to evaluate the changes and readjustment capacity in the hematological characteristics of the horse during and after a prolonged training program. One pony and two hot-blooded horses were used in this study. Resting or basal blood parameters were assessed by collecting blood samples of the animals for 1 to 2 months prior to start of the training program. Each animal was subjected to arbitrary exercise for 30 min by an automatic hot trotter and was bled at 0, 15, 30, 45 (15 min of recovery), 60 (30 min of recovery), and 75 min (45 min of recovery) after onset of exercise. All animals were exercised 3 times a week over a fivemonth period. Hematological parameters including average white blood cell counts (WBC, ${\times}$$10^3$/$\mu$l), erythrocyte concentrations (RBC, ${\times}$$10^6$/$\mu$l), hematocrit (HCT, %), mean corpuscular volume (MCV, fl), number of platelets (PLT, ${\times}$$10^4$/$\mu$l), hemoglobin concentration (Hb, g/dl), mean corpuscular hemoglobin (MCH, pg), and mean corpuscular hemoglobin concentration (MCHC, g/dl) were analyzed using an automatic cell counter. All animals showed that RBC, WBC, and HCT were significantly (p<0.05) increasing from 7.09, 8.55, and 43.5 to 8.11, 9.67, and 49.5, respectively, during the 30 min of exercise and were back to or lower than the initial basis (resting and 0 min) 30 min after exercise. However, no significant differences were detected in MCV (50.3-51.3 fl), MCH (17.2-17.4 pg), and MCHC (33.7-34.4 g/dl) values (p>0.05) regardless of the training periods. Similar trends were observed after 1, 3, 4, and 5 months of training when compared to the resting state. When these parameters were analyzed by the effect of training periods (month), mean WBC concentrations significantly reduced in the fourth and fifth month after onset of training compared to that in resting condition or the first month of training program (p<0.05). The RBC values elevated at the second month (9.40) and reaching a significantly low level (p<0.001) at the fifth month (8.62) after training compared to the first month of training (7.89). In conclusion, a mild training program enhances blood parameters gradually in both the horse and the pony. Therefore, an optimized training program is beneficial in promoting the endurance performance of the horse.