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ACCase 저해 제초제 cyhalofop-butyl에 대한 경남지방 수집종 피의 저항성
원종찬,원옥재,하준,임일빈,강광식,변종영,박기웅,이증주,Won, Jong Chan,Won, Ok Jae,Ha, Jun,Im, Il-Bin,Kang, Kwang Sik,Pyon, Jong Yeong,Park, Kee Woong,Lee, Jeung Joo 한국잡초학회한국잔디학회 2018 Weed & Turfgrass Science Vol.7 No.2
Repeated use of ACCase inhibiting herbicides for a long time has resulted in increases of resistant Echinochloa oryzicola populations in paddy fields in middle west area of Korea. This study aims to investigate current status of herbicide resistant E. oryzicola in Gyeongsangnam-do, in which there is less information about herbicide resistance. For resistance frequency and dose-response study, seeds from 100 individual plants of E. oryzicola in Gyeongsangnam-do were collected and tested with cyhalofop-butyl. Seven percent of plants from Gyeongsangnam-do was resistant at a recommended rate of cyhalofop-butyl. $GR_{50}$ values (herbicide rates required to reduce plant growth 50%) for one representative resistant populations and five susceptible populations were $738g\;a.i.\;ha^{-1}$ and 66-234 (average 147)$g\;a.i.\;ha^{-1}$, respectively, indicating average 5 times difference in resistance. Although lower rate of frequency of herbicide resistance in Gyeongsangnam-do than in Jeollabuk-do, increases of herbicide resistance are expected in this area because of increases of direct seeded rice fields and increases of dependence on a specific herbicide. Therefore, it is necessary to monitor herbicide resistance regularly and conduct integrated herbicide resistance management in this area. 경남지역 제초제 저항성 피의 발생현황과 저항성 정도를 알아보기 위하여 벼 재배 논에서 100개체의 피 종자를 수집하여 ACCase 저해제인 cyhalofop-butyl에 대한 약량반응 실험을 수행한 결과, 수집한 피의 7%가 저항성으로 조사되었다. 선발된 감수성 5개체의 $GR_{50}$값은 평균 $147g\;a.i.\;ha^{-1}$로 나타났고, 함양 지역의 저항성 개체의 $GR_{50}$값은 $738g\;a.i.\;ha^{-1}$ 로 R/S (ratio of resistance to sensitivity)값은 5.01배로 나타났다. 현재 경남지역에서의 저항성 피의 발생 수준은 낮은 것으로 나타났지만, 저항성 피의 확산을 지연시키거나 막기 위해서는 주기적인 저항성 피의 모니터링과 체계적인 저항성 잡초 관리방안을 마련하여 수행할 필요가 있다.
Pascua, Philippe Noriel Q.,Song, Min-Suk,Kwon, Hyeok-Il,Lim, Gyo-Jin,Kim, Eun-Ha,Park, Su-Jin,Lee, Ok-Jun,Kim, Chul-Joong,Webby, Richard J.,Webster, Robert G.,Choi, Young-Ki American Society for Microbiology 2013 Journal of virology Vol.87 No.19
<P>We previously reported that influenza A/swine/Korea/1204/2009(H1N2) virus was virulent and transmissible in ferrets in which the respiratory-droplet-transmissible virus (CT-Sw/1204) had acquired simultaneous hemagglutinin (HA<SUB>D225G</SUB>) and neuraminidase (NA<SUB>S315N</SUB>) mutations. Incorporating these mutations into the nonpathogenic A/swine/Korea/1130/2009(H1N2, Sw/1130) virus consequently altered pathogenicity and growth in animal models but could not establish efficient transmission or noticeable disease. We therefore exploited various reassortants of these two viruses to better understand and identify other viral factors responsible for pathogenicity, transmissibility, or both. We found that possession of the CT-Sw/1204 tripartite viral polymerase enhanced replicative ability and pathogenicity in mice more significantly than did expression of individual polymerase subunit proteins. In ferrets, homologous expression of viral RNA polymerase complex genes in the context of the mutant Sw/1130 carrying the HA<SUB>225G</SUB> and NA<SUB>315N</SUB> modifications induced optimal replication in the upper nasal and lower respiratory tracts and also promoted efficient aerosol transmission to respiratory droplet contact ferrets. These data show that the synergistic function of the tripartite polymerase gene complex of CT-Sw/1204 is critically important for virulence and transmission independent of the surface glycoproteins. Sequence comparison results reveal putative differences that are likely to be responsible for variation in disease. Our findings may help elucidate previously undefined viral factors that could expand the host range and disease severity induced by triple-reassortant swine viruses, including the A(H1N1)pdm09 virus, and therefore further justify the ongoing development of novel antiviral drugs targeting the viral polymerase complex subunits.</P>
Diagnostic challenges of nonodontogenic toothache
Park, Hyung-Ok,Ha, Jung-Hong,Jin, Myoung-Uk,Kim, Young-Kyung,Kim, Sung-Kyo The Korean Academy of Conservative Dentistry 2012 Restorative Dentistry & Endodontics Vol.37 No.3
The objective of this article was to present two nonodontogenic conditions that may mimic odontogenic toothache: trigeminal neuralgia and burning mouth syndrome. Two cases are presented in which one is related to the upper left second premolar and the other is related to the upper left first molar. Both showed pain when chewing. These two cases highlight the complexities involved in diagnosing nonodontogenic toothache. This article demonstrates the importance of having a thorough knowledge of both odontogenic and nonodontogenic toothache, as well as the need for careful evaluation of the nature of the pain and history, clinical and radiographic examinations.
( Ha-young Park ),( In-jae Oh ),( Bo Gun Kho ),( Tae-ok Kim ),( Hong-joon Shin ),( Cheol Kyu Park ),( Yong-soo Kwon ),( Yu-il Kim ),( Sung-chul Lim ),( Young-chul Kim ),( Yoo-duk Choi ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Programmed death-ligand 1 (PD-L1), a transmembrane protein, binds to the programmed death-1 (PD- 1) receptor, and anti-PD-1 therapy enables immune responses against tumors. This study aimed to assess clinical characteristics of PD-L1 expression using immunohistochemistry among Korean patients with lung cancer. Methods: We retrospectively reviewed the data of patients with pathologically proven lung cancer from a single institution. PD-L1 expression determined by Tumor Proportion Score (TPS) was detected using 22C3 pharmDx (Agilent Technologies) and SP263 (Ventana Medical Systems) assays. Results: From July 2016 to July 2017, 267 patients were enrolled. The main histologic type was adenocarcinoma (69.3%). Most participants were smokers (67.4%) and had clinical stage IV disease (60.7%). In total, 116 (42%) and 58 (21%) patients had TPS ≥1% and ≥50%, respectively. The patients were significantly older in TPS ≥1% group than in TPS <1% group (64.83 ± 9.38 years vs. 61.73 ± 10.78 years, p=0.014), not in TPS ≥50% cutoff value (64.69 ± 9.39 vs. 62.36 ± 10.51, p= 0.178). Regarding histologic grade, higher proportions of poorly differentiated tumor were observed in the TPS ≥1% (40.8% vs. 25.8%, p=0.020) and TPS ≥50% groups (53.2% vs. 27.2%, p=0.004). Among 34 patients examined with 22C3 and SP263 assays, 27 had positive results in both assays, with a cutoff of TPS ≥1% (r=0.826; 95% confidence interval, 0.736-0.916). Conclusion: PD-L1 expression, defined as TPS ≥1%, was related to older age and poorly differentiated histology. There was a similar distribution of PD-L1 expression in both 22C3 and SP263 results.
Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord
Ha, Sun-Ok,Yoo, Hea-Jin,Park, So-Yun,Hong, Hae-Sook,Kim, Dong-Sun,Cho, Hee-Jung 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1
The effects of capsaicin systemically administered in adult rats, with the major focus on the expression of brain-derived neurotropic factor(BDNF) and its mRNA in the dorsal root ganalion(DRG) and spinal code, has been investigated by means of immuno-histochemistry and reverse transcriptase-polymerase chain reactions.The percentage of BDNF-immunoreative neurons in the L5 DRG was found to increase significantly 1 day after capsaicin injection. Subsequently, it decreased slowly returning to near normal levels 1 week later.Four weeks post-injection, a significant reduction to below normal levels was observed. The temporal pattern of BDNF mRNA expression in the DRG was similar to BDNF-immnmoreactivity. In the spinal cord, 1 and 3 days post-injection, no changes in the expression of the BDNF-immunoreactive axonal fibers was noted. However, the expression had decreased significantly after 1 and 4 weeks. The mechanism by which capsaician induces changes in expression of BDNF in DRG neurons and the functional significance of the rapid increase in BDNF levels in the DRG is discussed briefly.
Effectiveness of Bleomycin microneedle treatment for recalcitrant wart
( Ha Ryeong Ryu ),( Jeong Soo Kim ),( Chul Hyun Yun ),( Ji Hoon Kim ),( Han Sol Lee ),( Jin Ok Beak ),( Jong Rok Lee ),( Jung Hwan Park ),( Joo Young Rho ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Wart is common skin disease caused by the HPV infection. Most treatment involving physicaldestruction of the infected cells has been used, such as cryotherapy. But intense pain, failure or recurrences may be substantial problems.Intralesional bleomycin has been used in the treatment of viral warts. It has been suggested that bleomycin induces cytotoxic or virucidal actions, breakages in the DNA strand and produce superoxide free radicals. Objectives: We performed pilot study to apply bleomycin coated microneedle into wart lesion to evaluate the treatment efficacy. Methods: Ten patients with warts were applied bleomycin microneedle at interval of 2 weeks. Treatment efficacy was assessed by Physician``s Global Assessment (PGA) and Patient``s Global Assessment (PaGA), and mean percentage of size reduction. Results: The mean treatments duration was 14.6 weeks.The mean PGA and PaGA were 1.4 and 2.0, respectively. All of them revealed apparently improved lesion more than 80% size reduction compared to the base line. No adverse reaction or pain, bleeding and discomforts were observed. One patient with two warts applied cryotherapy and microneedle, respectively. The effectiveness of bleomycin microneedle was similar to conventional cryotherapy. Conclusion: Bleomycin microneedle might be suggested as a new treatment modality for the patients who have unable to tolerate painful treatment. Further study with larger number of patients and comparison with conventional treatment is mandatory.
Anti-inflammatory Effect of Flower Bud and Fruit of Sweet Persimmon, Diospyros kaki T.
Park, Yeo Ok,Lee, Jeong Ah,Park, Seong Moon,Ha, Min Hee,Joo, Woo Hong,Kim, Dong Wan 대한의생명과학회 2020 Biomedical Science Letters Vol.26 No.2
Various beneficial effects of sweet persimmon (Diospyros kaki T.) including anti-oxidation, anti-bacteria and viruses, anti-allergy were widely reported previously. However, the anti-inflammatory effect and its molecular mechanisms are not clear. In this study, the anti-inflammatory effect of the extracts of flower bud and fruit of sweet persimmon was investigated in LPS-treated RAW264.7 cells. Both extracts of flower bud and fruit showed strong inhibitory effect on the LPS-induced NF-κB activation. IκBα, the inhibitor of NF-κB, was increased and the expressions of NF-κB target genes, COX-2 and iNOS, were suppressed by the treatment with the extracts of flower bud and fruit. The expressions of pro-inflammatory cytokines, IL-1β, IL-6, TNF-α were also suppressed by the extracts. In addition, the LPS-induced wnt/β-catenin pathway and its related gene expressions including cyclin D1, wnt 3a, wnt 5a were suppressed by the extracts. The extracts also showed anti-oxidant activity and suppressive effect on the LPS-induced apoptosis of RAW264.7 cells. These results suggest that the flower bud and fruit of sweet persimmon display strong anti-inflammatory effect through inhibiting the pro-inflammatory signaling pathways in the cells.
HA, Eun-Suk,LEE, Eun-Ok,YOON, Taek-Joon,KIM, Jin-Hyung,PARK, Jong-Oh,LIM, Nak-Cheol,JUNG, Sung-Ki,YOON, Byung-Soo,KIM, Sung-Hoon WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Spatholobi Caulis has been used in Oriental medicine to treat cancer and blood stasis. In this study, the methylene chloride fraction of Spatholobi Caulis (MCSC) was examined to determine if it possesses anti-cancer activity via its apoptosis-inducing activity. MCSC exhibited a strong cytotoxic effect against human monocyte leukemia U937 cells (IC_(50)=15.1 μg/ml). A TUNEL assay showed that the MCSC caused a characteristic ladder pattern of discontinuous DNA fragments and apoptotic bodies. Flow cytometric analysis confirmed that MCSC significantly increases the number of apoptotic cells stained by annexin V^(+)/PI^(-) cells. Western blotting revealed that MCSC activated caspase-3 expression and cleaved poly (ADP-ribose) polymerase (PARP) in a concentration-dependent manner. An enzyme-linked immunosorbent assay (ELISA) demonstrated that MCSC significantly activated the caspase-3 activity compared with the untreated control by. Taken together, these results suggest that MCSC can induce apoptosis in U937cells via the caspase dependent pathway.