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Abhilash Vasanth,Shilpa M Patel,Ruchi Arora,Chetana D Parekh,Pariseema Dave,Bijal M Patel,Priyanka Vemanamandhi 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2
Objective: To study clinical characters and outcomes in patients of malignant ovarian germcell tumor (MOGCT) undergoing surger y following neoadjuvant chemotherapy (NACT). Methods: Retrospective study of patients undergoing surger y following NACT for MOGCT atour institute. Platinum based chemotherapy was given in all patients in NACT. Results: Between March 2013 and Februar y 2023, 30 patients had surger y after NACT. Patient’s median age was 22 years (range, 12 to 35 years) and median follow up 42months(range, 6 to 132 months). Majority had endodermal sinus tumor (n=12), dysgerminoma (n=9)and mixed GCT (n=7). All had either International Federation of Gynecology and Obstetrics(FIGO) stage 3 (n=19) or FIGO stage 4 disease (n=11). Complete response to NACT seen in5 patients and 23 patients had partial response. Fertility sparing surger y in 18 patients andcomplete surger y in 12 patients. Suboptimal surger y was seen in 4 patients. Currently, 20of 30 patients are alive and disease free, 3 lost for follow up and 7 patients had progressionafter adjuvant therapy. Five patients had mortality—4 with progression and 1 with bleomycintoxicity. Fifteen of 17 eligible patients have resumed menstruation and one had successfulpregnancy. Prognostic factors noted in study are stage, optimal surger y and viable tumor inhistopathology. Dysgerminoma had better outcome than other histology. Conclusion: NACT may be a reasonable option in patients with extensive unresectable diseaseor in whom fertility sparing is not possible or in the poor general condition. Fertility sparingsurger y can be attempted post neoadjuvant chemotherapy without adversely affecting prognosis.
( Pabashi Poddar ),( Shilpa Patel ),( Ruchi Arora ),( Chetana Parekh ),( Pariseema Dave ),( Sangeetha Amin ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.2
Objective This study aimed to study the patterns of recurrence in surgically treated cases of vulvar cancer (VC) and determine the factors associated with recurrence, with a special emphasis on lymph node ratio (LNR). Methods This retrospective study examined VC patients primarily treated with surgery at our institute from January 2005 to December 2015. Demographic data, clinical characteristics, surgicohistopathological data, adjuvant treatment, follow up, and recurrence site and treatment were studied. Results Among the 111 cases treated, a recurrence rate of 18.9% was noted. Recurrence was most commonly local (61.9%). On univariate and multivariable analyses of clinicopathological parameters, an LNR >20 had the highest hazard ratio for recurrence. Conclusion LNR may provide useful prognostic information in VC patients with positive inguinal lymph node status.
Human papillomavirus: footprints in the population of western India
Ashi Robert Thobias,Kinjal Ankit Patel,Supreet Dhananjay Bhatt,Kruti Ashvinkumar Mehta,Chetana Deepal Parekh,Pariseema Sharad Dave,Prabhudas Shankarbhai Patel 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Cancer is a multi-factorial disease, with various intrinsic and environmental factors contributing to its occurrence. Human papillomavirus (HPV) has been associated with the occurrence of many cancers. India severely suffers from 3 HPV-associated cancers (cervical cancer, oral cancer, and oropharyngeal cancer). Hence, the present study aimed to evaluate the HPV burden in these 3 cancers among patients from the western region of India. METHODS: DNA was isolated from samples from 400 cervical cancer, 127 oral cancer, and 75 oropharyngeal cancer patients. Polymerase chain reaction was performed using degenerate primers for HPV infection. RESULTS: Overall, HPV infection was observed in 87% of cervical cancer cases, 12.5% of oral cancer cases, and 26.7% of oropharyngeal cancer cases when analyzed with a cumulative detection method using the MY 09/11, GP 5+/6+, and CP I/II primer sets. CONCLUSIONS: A significant prevalence of HPV infection was detected in all 3 cancers using the degenerate primer sets. This finding implies that testing for HPV infection using multiple primer sets is crucial for determining its actual prevalence in various malignancies.