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AMI 계량데이터의 검증 신뢰성 및 추정 정확도 향상을 위한 VEE 알고리즘 개선 연구
이재관,신진호,주용재,노재구,박영배,정남준,Lee, Jaekwan,Shin, Jinho,Joo, Yongjae,Noh, Jaekoo,Park, YoungBae,Jung, Namjoon 한국전력공사 2016 KEPCO Journal on electric power and energy Vol.2 No.4
계량데이터 관리 시스템은 수용가에서 검침된 계량데이터를 수집하고 관리하는 시스템이다. 이 시스템에는 검침된 데이터의 오검침과 유효성을 판단하는 검증과 누락된 검침값이나 오검침으로 판단된 구간값을 추정하는 VEE 알고리즘이 있다. 그러나 기존의 VEE 알고리즘은 현장 데이터의 특성을 반영하지 않고 검증하고 추정하기 때문에 그만큼 신뢰성과 정확도가 낮아지는 단점이 있다. 본 논문에서는 검증 신뢰성과 추정 정확도를 향상시킬 수 있는 차세대 VEE 알고리즘을 제안한다.
Kim Sukyung,Han Song-Yi,Lee Jinyoung,Kim Na-Rae,Lee Bora,Kim Hyunmi,Kwon Mijeoung,Ahn Kangmo,Noh Youngbae,Kim Sang Jong,Lee Phyrim,Kim Dongki,Kim Byung Eui,김지현 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.5
Purpose: The beneficial effects of a combination therapy using Bifidobacterium longum and galactooligosaccharide (GOS) for the treatment of atopic dermatitis (AD) have not been elucidated. Methods: Gene expressions of interleukin (IL)-4 and IL-13 from peripheral blood mononuclear cells and fecal abundance of B. longum from 12-month-old infants were evaluated. Human primary epidermal keratinocytes (HEKs) and hairless mice were treated with B. longum, GOS, B. longum-derived extracellular vesicles (BLEVs), dinitrochlorobenzene (DNCB), or a synbiotic mixture of B. longum and GOS. Expression of epidermal barrier proteins and cytokines as well as serum immunoglobulin E (IgE) levels were analyzed in HEKs and mice. Dermatitis scores, transepidermal water loss (TEWL), epidermal thickness, and fecal B. longum abundance were evaluated in mice. Results: Fecal abundance of B. longum was negatively correlated with blood IL-13 expression in infants. B. longum or BLEVs increased expression of filaggrin (FLG) and loricrin (LOR) in HEKs. B. longum increased the efficacy of GOS to upregulate FLG and LOR expressions in HEKs. Oral administration of GOS increased fecal abundance of B. longum in mice. Oral administration of B. longum attenuated DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, and deficiency of epidermal barrier proteins. Moreover, the combination of B. longum and GOS showed greater effects to improve DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, serum IgE levels, IL-4 over-expression, and the deficiency of epidermal barrier proteins than the administration of B. longum alone. Conclusions: B. longum and GOS improve DNCB-induced skin barrier dysfunction and AD-like skin.