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Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
Mulyadi Tanjung 한국생약학회 2023 Natural Product Sciences Vol.29 No.4
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and high-resolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL).
Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata
Mulyadi Tanjung,Intan Nurmalasari,Aisyah Kanti Wilujeng,Ratih Dewi Saputri,Fida Rachmadiarti,Tjitjik Srie Tjahjandarie 한국생약학회 2018 Natural Product Sciences Vol.24 No.4
A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with IC50 15.42 mM.
A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall.
Mulyadi Tanjung,Tjitjik Sri Tjahjandarie,Ratih Dewi Saputri,Andre Harsono,Muhammad Fajar Aldin 한국생약학회 2020 Natural Product Sciences Vol.26 No.1
A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.
Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.
Mulyadi Tanjung,Muhammad Fajar Aldin,Tjitjik Srie Tjahjandarie,Devina Oktari Rahayu,Alfiah Nur Irza Gunawan,Ratih Dewi Saputri 한국생약학회 2021 Natural Product Sciences Vol.27 No.3
Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 µg/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.
Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm
Mulyadi Tanjung 한국생약학회 2023 Natural Product Sciences Vol.29 No.1
Two xanthones and 4-phenylcoumarins were isolated from the twigs of Mesua beccariana (Baill.) Kosterm. Among them, one new xanthone, beccarianin A (1), along with 7-isoprenyl-jacareubin (2), mammea A/AA cyclo F (3), and mammea A/BA cyclo F (4). These structures were determined by spectrometric and spectroscopic methods, HRESIMS data, NMR, and UV spectra. Two xanthones (1-2) and two 4-phenyl- coumarins (3-4) were evaluated for their cytotoxic effect on the HeLa cells. Compound 1 showed active activity (IC50 = 8.2 µM), and compounds 3-4 showed moderate activity (IC50 = 12.3 and 15.6 µM, respectively).
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Mulyadi Tanjung,Tjitjik Srie Tjahjandarie,Shola Mardhiyyah,Ghinsha Zakatina Rahman,Muhammad Fajar Aldin,Ratih Dewi Saputri,Norizan Ahmat 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 µM.
Design of Music Learning Assistant Based on Audio Music and Music Score Recognition
Mulyadi, Ahmad Wisnu,Machbub, Carmadi,Prihatmanto, Ary S.,Sin, Bong-Kee Korea Multimedia Society 2016 멀티미디어학회논문지 Vol.19 No.5
Mastering a musical instrument for an unskilled beginning learner is not an easy task. It requires playing every note correctly and maintaining the tempo accurately. Any music comes in two forms, a music score and it rendition into an audio music. The proposed method of assisting beginning music players in both aspects employs two popular pattern recognition methods for audio-visual analysis; they are support vector machine (SVM) for music score recognition and hidden Markov model (HMM) for audio music performance tracking. With proper synchronization of the two results, the proposed music learning assistant system can give useful feedback to self-training beginners.
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Tanjung, Mulyadi,Tjahjandarie, Tjitjik Srie,Mardhiyyah, Shola,Rahman, Ghinsha Zakatina,Aldin, Muhammad Fajar,Saputri, Ratih Dewi,Ahmat, Norizan The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC<sub>50</sub> value of 11.2 μM.
Rahmad Mulyadi,Pungky Permata Putri,Handoko;Ramdinal Aviesena Zairinal,Joedo Prihartono 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4
Purpose: This systematic review aims to assess and summarize the clinical values of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameter changes as early biomarkers of tumor responses following radiation therapy (RT) in patients with spinal metastases. Materials and Methods: A systematic search was conducted on five electronic databases: PubMed, Scopus, Science Direct, Cochrane, and Embase. Studies were included if they mentioned DCE-MRI parameter changes before and after RT in patients with spinal metastases with a correlation to tumor responses based on clinical and imaging criteria. The Quality Assessment of Diagnostic Accuracy Studies 2 was used to assess study quality. Results: This systematic review included seven studies involving 107 patients. All seven studies evaluated the transfer constant (Ktrans), six studies evaluated the plasma volume fraction (Vp), three studies evaluated the extravascular extracellular space volume fraction, and two studies evaluated the rate constant. There were variations in the type of primary cancer, RT techniques used, post-treatment scan time, and median follow-up time. Despite the variations, however, the collected evidence generally suggested that significant differences could be detected in DCE-MRI parameters between before and after RT, which might reflect treatment success or failures in long-term follow-up. Responders showed higher reduction and lower values of Ktrans and Vp after RT. DCE-MRI parameters showed changes and detectable recurrences significantly earlier (up to 6 months) than conventional MRI with favorable diagnostic values. Conclusion: The results of this systematic review suggested that DCE-MRI parameter changes in patients with spinal metastases could be a promising tool for treatment-response assessment following RT. Lower values and higher reduction of Ktrans and Vp after treatment demonstrated good prediction of local control. Compared to conventional MRI, DCE-MRI showed more rapid changes and earlier prediction of treatment failure.