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Muhammad Kashif Iqbal Khan,Abid Aslam Maan,Rana Muhammad Aadil,Akmal Nazir,Masood Sadiq Butt,Muhammad Imtiaz Rashid,Muhammad Inam Afzal 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.4
Onion and ginger are rich sources of bioactive compounds which are lost during conventional drying process. The present study was designed to optimize the novel Microwave Assisted Drying and Extraction technique (MADE) for simultaneous drying and extraction/recovery of bioactive compounds from model food products. The time required for drying of samples was 11 (onion) and 16 (ginger) minutes with recovery yield of 87% (onion) and 85% (ginger). The drying time was reduced to 100 times compared to hot air drying and moisture ratio of dried samples was best described by Midilli model. The diffusivities of onion and ginger slices were 1.27 e-11 and 1.43 e-11 m2/s, respectively. Moreover, microwave-based extraction was compared with conventional one. The results of antioxidant activity and total phenolic contents of condensates obtained through MADE were higher compared to conventional method. In short, MADE exhibited better yield of extraction and drying properties compared to conventional methods.
Perception Based Definition of Construction Quality in Pakistan
Awan, Muhammad Yousaf Sadiq,Awan, Dr Muhammad Maqbool Sadiq Korea Institute of Construction Engineering and Ma 2015 Journal of construction engineering and project ma Vol.5 No.2
The complexity arises in defining the construction quality due to its perception, based on inherent market conditions and their requirements, the diversified stakeholders itself and their desired output. A quantitative survey based approach was adopted in this constructive study. A questionnaire based survey was conducted, for the assessment of construction quality perception and expectations in the context of quality improvement technique. The survey feedback of professionals, from the leading construction organizations/companies of Pakistan were analyzed. The financial capacity, organizational structure, and construction experience of the construction firms formed basis for their selection. After statistical analysis of survey feedback it was found reliable and valid for the inferential purpose to the target population of construction professionals. The quality perception was found to be project scope oriented, considered as an excess cost for a construction project and keeping the rework minimum by qualifying the required quality tests, keeping the defects minimum by ensuring the specifications of supplied material. Any quality improvement technique was expected to address the financial aspects of the construction project for the employer and contractor, by increasing the profitability through reduction in overall cost, reduction in time, reduction in defects and improving the productivity in a construction project. The study is beneficial for the construction professionals to assess the prevailing construction quality perception and the expectations from implementation of any quality improvement technique in construction projects.
Sadiq Muhammad,Shinwari Riazullah,Usman Muhammad,Ozturk Ilhan,Maghyereh Aktham Issa 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.9
Nuclear energy has the potential to play an influential role in energy transition efforts than is now anticipated by many countries. Realizing sustainable human development and reducing global climate crises will become more difficult without significantly increasing nuclear power. This paper aims to probe the role of nuclear energy, external debt, and financial globalization in sustaining human development and environmental conditions simultaneously in BRICS (Brazil, Russia, India, China, and South Africa) countries. This study applied a battery of second-generation estimation approaches over the period from 1990 to 2019. These methods are useful and robust to cross-countries dependencies, slope heterogeneity, parameters endogeneity, and serial correlation that are ignored in conventional approaches to generate more comprehensive and reliable estimates. The empirical findings indicate that nuclear energy and financial globalization contribute to human development, whereas external debt inhibits it. Similarly, financial globalization accelerates ecological deterioration, but nuclear energy and external debt promote environmental sustainability. Moreover, the study reveals bidirectional feedback causalities between human development, carbon emissions and nuclear energy consumption. The study offers useful policy guidance on accomplishing sustainable and inclusive development in BRICS countries.
Sadiq Muhammad,Wen Fenghua,Dagestani Abd Alwahed 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.10
This study investigates the environmental footprint impacts of nuclear energy consumption in the presence of environmental technology and globalization of the ten largest ecological footprint countries from 1990 up to 2017. By considering a set of methods that can help solve the issue of cross-sectional dependence, we employ the Lagrange multiplier bootstrap cointegration method, Driscoll-Kraay standard errors for long-run estimation and feasible generalized least squares (FGLS) and panel-corrected standard errors (PCSE) for robustness. The finding revealed significant negative effects of nuclear energy consumption, environmental-related technology, population density and significant positive effects of globalization and economic growth on ecological footprint. These results are also robust by assessing the long-run impacts of predictors on carbon footprint and CO2 emissions as alternate ecological measures. These conclusions provide the profound significance of nuclear energy consumption for environmentally sustainable development in the top ten ecological footprint countries and serve as an important reference for ecological security for other countries globally.
( Muhammad Sadiq ),( Iftikhar Ahmad ),( Jamila Shuja ),( Zubair Ahmad ),( Riyasat Ahmed ),( Khushnaseeb Ahmad ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2017 Brain Tumor Research and Treatment Vol.5 No.2
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm<sup>2</sup>) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i.e., within 24 hours of surgery). Histopathological examination revealed neoplastic lesion exhibiting perivascular pseudo-rosettes with centrally hyalinized blood vessel and focal nuclear pleomorphism. Immunohistochemistry staining illustrated reactivity for glial fibrillary acidic protein and inte-grase interactor 1 (INI-1). These features rendered the diagnosis of astroblastoma. A comprehensive re-view of the current literature to summarize the clinicopathological and radiological characteristics, prog-nostic factors and current treatment strategies of astroblastomas is also presented. Our study would expand the pool of this uncommon tumor towards its better understanding and optimal treatment.
Mehboob Muhammad Yasir,Ma Benjiang,Sadiq Muhammad,Zhang Yunsheng 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1
This research examined consumption-based carbon emission reduction by nuclear energy consumption and environmental tax while considering the context of trade globalization in the highest five emitter nations from 1990 to 2020. This study used various empirical methodologies, including preliminary analysis to check the stationarity and cointegration, the CS-ARDL for long-run analysis, CCEMG, AMG for robustness, and the D-H causality test for short-term pairwise causation. The results indicated that nuclear energy consumption, environmental tax, and trade globalization help to mitigate consumption-based carbon emissions while economic growth and population density boost carbon emissions. Furthermore, the results also found two-way casual connection exists between nuclear energy consumption, population density, and consumption-based carbon emissions. Thus, the results emphasize the need for government policies that encourage nuclear energy and environmental tax as a strategy to reduce carbon emissions and achieve and maintain environmental development.
Butt, Abdul Rehman Sadiq,Abbasi, Muhammad Athar,Aziz-ur-Rehman, Muhammad Athar,Siddiqui, Sabahat Zahra,Raza, Hussain,Hassan, Mubashir,Shah, Syed Adnan Ali,Shahid, Muhammad,Seo, Sung-Yum Elsevier 2019 Bioorganic chemistry Vol.86 No.-
<P><B>Abstract</B></P> <P>The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, <B>9a-n</B>, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques such as <SUP>1</SUP>H NMR, <SUP>13</SUP>C NMR, and EI-MS along with elemental analysis. The inhibitory effects of these bi-heterocyclic acetamides (<B>9a-n</B>) were evaluated against tyrosinase and all these molecules were recognized as potent inhibitors relative to the standard used. The Kinetics mechanism was analyzed by Lineweaver-Burk plots which explored that compound, <B>9h</B>, inhibited tyrosinase competitively by forming an enzyme-inhibitor complex. The inhibition constants K<I> <SUB>i</SUB> </I> calculated from Dixon plots for this compound was 0.0027 µM. The computational study was coherent with the experimental records and these ligands exhibited good binding energy values (kcal/mol). The hemolytic analysis revealed their mild cytotoxicity towards red blood cell membranes and hence, these molecules can be pondered as nontoxic medicinal scaffolds for skin pigmentation and related disorders.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of novel bi-heterocyclic acetamides and their tyrosinase inhibition to overwhelm the problem of melanogenesis. </LI> <LI> <I>In vitro</I> and <I>in silico</I> analysis were performed to check their inhibitory potential against tyrosinase enzymes. </LI> <LI> The molecules with small sized methyl group/s at <I>ortho</I>-position/s in aryl part or a flexible phenethyl group, generally inhibited the tyrosinase in an excellent manner. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>