A comprehensive review on phytochemistry, bioactivity and medicinal value of bioactive compounds of pomegranate (Punica granatum)

Muhammad Modassar Ali Nawaz Ranjha,Bakhtawar Shafique,Lufeng Wang,Shafeeqa Irfan,Muhammad Naeem Safdar,Mian Anjum Murtaza,Muhammad Nadeem,Shahid Mahmood,Ghulam Mueen-ud-Din,Hafiz Rehan Nadeem 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.1

Pomegranate (Punica granatum) acts as a therapeutic fruit possessing different bioactive compounds. Different compartments of pomegranate (P. granatum) like seed, peel, juice and leaves are rich in potential bioactive compounds. Pomegranate contains sinapyl, coniferyl, ellagic acid, cinnamic acid, genistein, linoleic acid, anthocyanin, gallic acid, catechin, quercetin, rutin, kaempferol, cyanidin, punicalin, delphinidin, punicalagin, chlorogenic acid, coumaric acid, luteolin and pelletierine alkaloids, flavonoids, anthocyanin and caffeic acid. Pomegranate also exhibits significant anti-oxidative, anti-hypertensive, cardioprotective and anti-diabetic properties and anti-carcinogenic possessions including prevention of prostate cancer; reduction in colon inflammation, prevention of skin tumorigenesis, improvement in renal function and reduction in metastatic melanoma growth. This review summarizes the current available data on the phytochemistry, bioavailability and therapeutic importance of potential bioactive compounds of pomegranate.

Vibration analysis of submerged thin FGM cylindrical shells

Muhammad Nawaz Naeem,Madiha Gamkhar,Shahid Hussain Arshad,Abdul Ghafar Shah 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.3

This study gives a brief work on vibration characteristics of cylindrical shells submerged in an incompressible fluid. The shell is presumed to be structured from functionally graded material. The effect of the fluid is introduced by using the acoustic wave equation. Love’s first order thin shell theory is utilized in the shell dynamical equations. The problem is framed by combining shell dynamical equations with the acoustic wave equation. Fluid-loaded terms are associated with Hankel function of second kind. Wave propagation approach is employed to solve the shell problem. Some comparisons of numerical results are performed for the natural frequencies of simply supported-simply supported, clamped-clamped and clamped-simply supported boundary conditions of isotropic as well as functionally graded cylindrical shells to check the validity of the present approach. The influence of fluid on the submerged functionally graded cylindrical shells is noticed to be very pronounced.

Instability analysis of microfilaments with and without surface effects using Euler theory

Taj, Muhammad,Khadimallah, Mohamed A.,Hussain, Muzamal,Mahmood, Shaid,Safeer, Muhammad,Rashid, Yahya,Ahmad, Manzoor,Naeem, M. Nawaz,Asghar, Sehar,Ponnore, Joffin,Al Qahtani, Abdelaziz,Mahmoud, S.R.,Al Techno-Press 2021 Advances in nano research Vol.10 No.6

The study of cell components has been an active area of research since the last few decades. Cytoskeleton of the cell which gives shape and provides structure to the cell has three main components, microtubules, microfilaments and intermediate filaments. Each of the cytoskeletal components is surrounded by various filamentous or the other cytoskeletal components act as a surface layer on these filaments. The stability of these components affected when cell perform various functions in the body and as a result these filaments buckle, vibrate and bend. In the present study the buckling behavior of microfilament is discussed with the effects of surface by using Euler Bernoulli beam theory and the obtained results for free and surrounded microfilament are shown in the tables and figures.

Thermal stress effects on microtubules based on orthotropic model: Vibrational analysis

Taj, Muhammad,Khadimallah, Mohamed A.,Hussain, Muzamal,Fareed, Khurram,Safeer, Muhammad,Khedher, Khaled Mohamed,Ahmad, Manzoor,Naeem, M. Nawaz,Qazaq, Amjad,Qahtani, Abdelaziz Al,Mahmoud, S.R.,Alwabli, Techno-Press 2021 Advances in concrete construction Vol.11 No.3

Vibration of protein microtubules is investigated based upon Orthotropic Elastic Shell Model, considering the effect of thermal stresses. The complete analytical formulas of thermal vibration for microtubules are obtained. It is observed that the effects of thermal stresses on the vibrational frequency mode are more significant when the longitudinal and circumferential wave vectors are large enough. But when the length of wave vector reduces to 5 nm, these effects have no significant effects. The present results well agree with the lattice vibrations of microtubules. Moreover, the results show that the effects of thermal stresses due to small change in temperature are not so significant but with the increase in temperature its effects are obvious.

Computer-aided approach for modelling of FG cylindrical shell sandwich with ring supports

Muzamal Hussain,Muhammad Nawaz Naeem,Muhammad Shabaz Khan,Abdelouahed Tounsi 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.5

In this paper, the shell material has been taken as functionally graded material and their material quantity is located by the exponential volume fraction law. Moreover, the impact of ring supports around the shell circumference has been examined for their various positions along the shell axial length. These rings support restraints the radial displacement in the transverse direction. While the axial modal deformation functions have been estimated by characteristic beam functions and nature of materials used for construction of cylindrical shells. The fundamental natural frequency of cylindrical shell of parameter versus ratios of length- and height-to-radius for a wide range has been reported and investigated through the study. In addition, by increasing height-to-radius ratio resulting frequencies also increase and frequencies decrease on ratio of length-toradius. Though the trends of frequency values of both ratios are converse to each other with three different boundary conditions. Also it is examined the position of ring supports with length-to radius ratio, height-to-radius ratio and varying the exponent of volume fraction. MATLAB software package has been utilized for extracting shell frequency spectra. The obtained results are confirmed by comparing with available literature.

Creation of 3D Maps for Satellite Communications to Support Ambulatory Rescue Operations

Nakajima, Isao,Nawaz, Muhammad Naeem,Juzoji, Hiroshi,Ta, Masuhisa Korea Multimedia Society 2019 The journal of multimedia information system Vol.6 No.1

A communications profile is a system that acquires information from communication links to an ambulance or other vehicle moving on a road and compiles a database based on this information. The equipment (six sets of HDTVs, fish-eye camera, satellite antenna with tracking system, and receiving power from the satellite beacon of the N-star) mounted on the roof of the vehicle, image data were obtained at Yokohama Japan. From these data, the polygon of the building was actually produced and has arranged on the map of the Geographical Survey Institute of a 50 m-mesh. The optical study (relationship between visibility rate and elevation angle) were performed on actual data taken by fish-eye lens, and simulated data by 3D-Map with polygons. There was no big difference. This 3D map system then predicts the communication links that will be available at a given location. For line-of-sight communication, optical analysis allows approximation if the frequency is sufficiently high. For non-line-of-sight communication, previously obtained electric power data can be used as reference information for approximation in certain cases when combined with predicted values calculated based on a 3D map. 3D maps are more effective than 2D maps for landing emergency medical helicopters on public roadways in the event of a disaster. Using advanced imaging technologies, we have produced a semi-automatic creation of a high-precision 3D map at Yokohama Yamashita Park and vicinity and assessed its effectiveness on telecommunications and ambulatory merits.

Simulating vibration of single-walled carbon nanotube using Rayleigh-Ritz's method

Hussain, Muzamal,Naeem, Muhammad Nawaz,Taj, Muhammad,Tounsi, Abdelouahed Techno-Press 2020 Advances in nano research Vol.8 No.3

In this paper, a new method based on the Sander theory is developed for SWCNTs to predict the vibrational behavior of length and ratio of thickness-to-radius according to various end conditions. The motion equation for this system is developed using Rayleigh-Ritz's method. The proposed model shows the vibration frequencies of armchair (5, 5), (7, 7), (9, 9), zigzag (12, 0), (14, 0), (19, 0) and chiral (8, 3), (10, 2), (14, 5) under different support conditions namely; SS-SS, C-F, C-C, and C-SS. The solutions of frequency equations have been given for different boundary condition, which have been given in several graphs. Several parameters of nanotubes with characteristic frequencies are given and vary continuously in length and ratio of thickness-to-radius. It has been illustrated that an enhancing the length of SWCNTs results in decreasing of the frequency range. It was demonstrated by increasing of the height-to-radius ratio of CNTs, the fundamental natural frequency would increase. Moreover, effects of length and ratio of height-to-radius with different boundary conditions have been investigated in detail. It was found that the fundamental frequencies of C-F are always lower than that of other conditions, respectively. In addition, the existence of boundary conditions has a significant impact on the vibration of SWCNTs. To generate the fundamental natural frequencies of SWCNTs, computer software MATLAB engaged. The numerical results are validated with existing open text. Since the percentage of error is negligible, the model has been concluded as valid.

On mixing the Rayleigh-Ritz formulation with Hankel's function for vibration of fluid-filled functionally graded cylindrical shell

Hussain, Muzamal,Naeem, Muhammad Nawaz,Shahzad, Aamir,Taj, Muhammad,Asghar, Sehar,Fatahi-Vajari, Alireza,Singh, Rahul,Tounsi, Abdelouahed Techno-Press 2020 Advances in computational design Vol.5 No.4

In this paper, a cylindrical shell is immersed in a non-viscous fluid using first order shell theory of Sander. These equations are partial differential equations which are solved by approximate technique. Robust and efficient techniques are favored to get precise results. Employment of the Rayleigh-Ritz procedure gives birth to the shell frequency equation. Use of acoustic wave equation is done to incorporate the sound pressure produced in a fluid. Hankel's functions of second kind designate the fluid influence. Mathematically the integral form of the Lagrange energy functional is converted into a set of three partial differential equations. Throughout the computation, simply supported edge condition is used. Expressions for modal displacement functions, the three unknown functions are supposed in such way that the axial, circumferential and time variables are separated by the product method. Comparison is made for empty and fluid-filled cylindrical shell with circumferential wave number, length- and height-radius ratios, it is found that the fluid-filled frequencies are lower than that of without fluid. To generate the fundamental natural frequencies and for better accuracy and effectiveness, the computer software MATLAB is used.

Nonlocal effect on the vibration of armchair and zigzag SWCNTs with bending rigidity

Hussain, Muzamal,Naeem, Muhammad Nawaz,Tounsi, Abdelouahed,Taj, Muhammad Techno-Press 2019 Advances in nano research Vol.7 No.6

Vibration analysis of carbon nanotubes (CNTs) is very essential field owing to their many promising applications in tiny instruments. In current study, the Eringen's nonlocal elasticity theory with clamped-clamped and clamped-free end conditions is utilized for the vibration analysis of armchair and zigzag SWCNTs. The Fourier method is utilized to solve the ordinary differential equation. The motion equation for this system is developed using a novel wave propagation method. Complex exponential functions have been used and the axial model depends on BCs that has been described at the edges of CNTs. The behavior of different nonlocal parameters is considered to find the vibrational frequency of SWCNTs. It is exhibited that the effect of frequencies against aspect ratio by varying the bending rigidity. It has been investigated that by increasing the nonlocal parameter decreases the frequencies and on increasing the aspect ratio increases the frequencies for both the tubes. To generate the fundamental natural frequencies of SWCNTs, computer software MATLAB engaged. The numerical results are validated with existing open text. Since the percentage of error is negligible, the model has been concluded as valid.

Colorectal carcinoma and chronic inflammatory demyelinating polyneuropathy: is there a possible paraneoplastic association?

Adnan Malik,Faisal Inayat,Muhammad Hassan Naeem Goraya,Gul Nawaz,Ahmad Mehran,Atif Aziz,Saad Saleem 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.2

A plethora of paraneoplastic syndromes have been reported as remote effects of colorectal carcinoma (CRC). However, there is a dearth of data pertaining to the association of this cancer with demyelinating neuropathies. Herein, we describe the case of a young woman diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Treatment with intravenous immunoglobulins and prednisone did not improve her condition, and her neurological symptoms worsened. Subsequently, she was readmitted with exertional dyspnea, lightheadedness, malaise, and black stools. Colonoscopy revealed a necrotic mass in the ascending colon, which directly invaded the second part of the duodenum. Pathologic results confirmed the diagnosis of locally advanced CRC. Upon surgical resection of the cancer, her CIDP showed dramatic resolution without any additional therapy. Patients with CRC may develop CIDP as a type of paraneoplastic syndrome. Clinicians should remain cognizant of this potential association, as it is of paramount importance for the necessary holistic clinical management.