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Inhibition of Inducible Nitric Oxide Synthase by Agaricus bisporus Extract in RAW 264.7 Macrophages
Jiyun Ahn,Hyunjung Lee,Mikyung Moon,Suna Kim,Taeyoul Ha 한국식품영양과학회 2008 Preventive Nutrition and Food Science Vol.13 No.4
Agaricus bisporus, also known as white button mushroom, is one of the most popular mushrooms consumed in Korea. This mushroom contains high concentrations of flavanoids and exhibits antioxidant activity. In this study, we examined the effects of Agaricus bisporus ethanol extract (ABE) on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells. Nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) protein levels were assessed in cells treated with 100 μM LPS in the presence or absence of ABE. 0.5 ㎎/mL of ABE suppressed NO production significantly. Moreover, ABE inhibited levels of iNOS protein. Taken together, these results suggest that ABE exerts anti-inflammatory activity in LPS-induced inflammation in RAW 264.7 cells.
Lee, Jiyun,Morton, Y.T. Jade,Lee, Jinsil,Moon, Hee-Seung,Seo, Jiwon IEEE 2017 IEEE signal processing magazine Vol.34 No.5
<P>The ionosphere has been the most challenging source of error to mitigate within the community of global navigation satellite system (GNSS)-based safety-critical systems. Users of those systems should be assured that the difference between an unknown true position and a system-derived position estimate is bounded with an extremely high degree of confidence. One of the major concerns for meeting this requirement, known as integrity, is ionosphere-induced error or discontinuity of GNSS signals significant enough to threaten the safety of users. The potentially hazardous ionospheric anomalies of interest in this article are ionospheric spatial decorrelation and ionospheric scintillation under disturbed conditions. As the demand of safety-critical navigation - applications increases with the rapid growth of the autonomous vehicle sector, ionospheric monitoring and mitigation techniques become more important to support such systems.</P>