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A Systematic Review of the Economic Evaluation of Telemedicine in Japan
Miki Akiyama,유병광 대한예방의학회 2016 예방의학회지 Vol.49 No.4
Objectives: There is no systematic review on economic evaluations of telemedicine in Japan, despite over 1000 trials implemented. Our systematic review aims to examine whether Japan’s telemedicine is cost-saving or cost-effective, examine the methodological rigorousness of the economic evaluations, and discuss future studies needed to improve telemedicine’s financial sustainability. Methods: We searched five databases, including two Japanese databases, to find peer-reviewed articles published between January 1, 2000 and December 31, 2014 in English and Japanese that performed economic evaluations of Japan’s telemedicine programs. The methodological rigorousness of the economic analyses was assessed with a well-established checklist. We calculated the benefit-to-cost ratio (BCR) when a reviewed study reported related data but did not report the BCR. All cost values were adjusted to 2014 US dollars. Results: Among the 17 articles identified, six studies reported on settings connecting physicians for specialist consultations, and eleven studies on settings connecting healthcare providers and patients at home. There are three cost-benefit analyses and three cost-minimization analyses. The remaining studies measured the benefit of telemedicine only, using medical expenditure saved or users’ willingness-to-pay. There was substantial diversity in the methodological rigorousness. Studies on teledermatology and teleradiology indicated a favorable level of economic efficiency. Studies on telehomecare gave mixed results. One cost-benefit analysis on telehomecare indicated a low economic efficiency, partly due to public subsidy rules, e.g., a too short budget period. Conclusions: Overall, telemedicine programs in Japan were indicated to have a favorable level of economic efficiency. However, the scarcity of the economic literature indicates the need for further rigorous economic evaluation studies.
( Miki Hirabayashi ) 아세아여성법학연구소 2008 아세아여성법학 Vol.11 No.-
In Japan, under Article 772 of Civil Code, a baby born within 300 days of its mother`s divorce will be regarded as the child of the previous husband, even if the child`s biological father is the mother`s current husband. So the government do not accept baby` birth registration as it stipulated that its mother`s current husband is the baby`s father. The children denied baby`s birth registration can not have it`s passport and accept various benefit. Many woment and her children face such problems. It is called "The 300 Days Problem" in Japan. Even if a woman can prove that her current husband is her baby`s biological father, she has to clear a legal hurdle to record the baby in his family register. She has to ask her previous husband to testify in court the baby is not his child. But not every ex-husband is cooperative. So such women and children urge the government to improve the situation as so as possible. For example, now, the Ministry of Foreign Affairs of Japan issues passport for such children. However the name on passport in not biological but their mother`s previous husband`s. And the Ministry of Justice recognizes babies born within 300 days of the mother`s divorce as those of their new spouses or as illegitimate children, provided the mothers can prove they became pregnant after divorce. As such, the presumend legitimate father of the child can be changed without a trial. However, even the ministry suspects that only 10 percent of such children were saved. The radical solution is to revise the Civil Law. However, to do so, various other problems arise. If we abolish Article 772, we cannot give baby ist father without DNA test. It is an unfortunate decision for majority of children. Therefore we should maintain and make the most of the current system. If a woman wants to record her child in its biological father`s family register, she gets him to go through a legal procedure to recognize the child as his own, This trial does not need participate of her previous husband.
Synthesis of some pyridinethione derivatives and their biological activity
Miky, Jehane A.A.,Zahkoug, Samir A.M. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
Aminolysis, hydrazinolysis and alkylation of 4-methoxy and 4,9-dimethoxy-6-cyano-7-thione-5-methyl-7H furo [3,2-g] [1] benzopyridine (1 a-b) yielded 7N-substituted furobenzopyridine derivatives (2 a-e or the possible isomers 3 a-e and 4 a-b), (5 a,b and 6 a,b) and the ester (8 a,b). Hydrolysis of (la) with acetic acid gave the corresponding pyridone derivatives (7). Furobenzopyridinyl-7-thioacetyl hydrazide (9 a,b) have been prepared via alkylation of furobenzopyridine thione (1 a-b) with ethyl chloroacetate followed by condensation with hydrazine hydrate. Schiff base (11) was prepared by reacting (9a) with p. N,N-dimethyl aminobenzaldehyde in boiling ethanol. Treatment of (8a) with anthranilic acid gave the corresponding 7-substituted-4H-3,1-benzoxazine-4-one (10). We found that compound (11) increased bleeding, coagulating time, the total count of white blood cells, blood glucose level (cause hyperglycemia), enzymes (GOT, GPT) activities, concentration of urea and creatinine. On the other hand it decreased red blood cells number, haemoglobin content and haematocrite value.
Miki, Daiki,Kubo, Michiaki,Takahashi, Atsushi,Yoon, Kyong-Ah,Kim, Jeongseon,Lee, Geon Kook,Zo, Jae Ill,Lee, Jin Soo,Hosono, Naoya,Morizono, Takashi,Tsunoda, Tatsuhiko,Kamatani, Naoyuki,Chayama, Kazuak Nature Publishing Group, a division of Macmillan P 2010 Nature genetics Vol.42 No.10
Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 ? 10<SUP>??11</SUP>, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 ? 10<SUP>??12</SUP>, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.
Miki Hiroki,Hori Chinatsu,Nagae Masahiro,Yoshio Tetsuo 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Y-type barium ferrite ( Me=Zn, Co, Cu) expected as an electromagnetic wave absorber were prepared by the glass-ceramic method. The glasses with composition of were prepared. Single-phase powders of Y type barium ferrite were obtained with the composition . The shape of Y-type crystals depended strongly on the heating temperature and changed from a plate-like hexagon to a complex polyhedron with increasing heating temperature. Correlation was recognized between saturation magnetization and crystal shape. Electromagnetic wave absorption characteristics was affected by the saturation magnetization and crystal shape.
Review : Proposal of Cooperative Study Toward Establishing Asiacatalyst
( Miki Niwa ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Cooperative studies on $quot;Reference Catalyst$quot; in Japan have proven to be very important and useful not only for characterization of catalysts but also for standardization of characterization techniques. This recognition has motivated us to propose $quot;Asiacatalyst$quot;, an extended version of Reference Catalyst, for similar cooperative activities in Asian countries.
Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity
Miki Okada-Iwabu,Masato Iwabu,Kohjiro Ueki,Toshimasa Yamauchi,Takashi Kadowaki 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.5
Obesity associated with unhealthy diet and lack of exercise is shown to contribute to the onset and/or aggravation of the metabolic syndrome and diabetes, thus placing affected individuals at increased risk of cardiovascular disease and cancer. Plasma adiponectin levels are decreased in obesity, which causes insulin resistance and diabetes. Therefore, we identified adiponectin receptors (AdipoRs) as the therapeutic target. It was suggested that, similarly to caloric restriction and exercise, activation of the AdipoRs may have the potential not only to improve lifestyle-related diseases but to contribute to prolonged the shortened lifespan on a high caloric unhealthy diet. To this end, we have identified “AdipoRon” as an adiponectin receptor agonist. Indeed, AdipoRon ameliorated diabetes associated with obesity as well as to increase exercise endurance, thus prolonging shortened lifespan of obese mice fed on a high fat diet. Additionally, we have recently determined the crystal structures of the human AdipoRs. The seven-transmembrane helices of AdipoRs are structurally distinct from those of G-protein coupled receptors. It is expected that these findings will contribute not only to the elucidation of the AdipoR-related signal transduction but to the development and optimization of AdipoR-targeted therapeutics for obesity-related diseases such as diabetes.