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Kim, Eun Ji,Choi, Mi-Ran,Park, Heesook,Kim, Minhee,Hong, Ji Eun,Lee, Jae-Yong,Chun, Hyang Sook,Lee, Ki Won,Yoon Park, Jung Han BioMed Central 2011 Breast cancer research Vol.13 No.4
<P><B>Introduction</B></P><P>High-fat diets (HFDs) are known to cause obesity and are associated with breast cancer progression and metastasis. Because obesity is associated with breast cancer progression, it is important to determine whether dietary fat <I>per se </I>stimulates breast cancer progression in the absence of obesity. This study investigated whether an HFD increases breast cancer growth and metastasis, as well as mortality, in obesity-resistant BALB/c mice.</P><P><B>Methods</B></P><P>The 4-week-old, female BALB/c mice were fed HFD (60% kcal fat) or control diet (CD, 10% kcal fat) for 16 weeks. Subsequently, 4T1 mammary carcinoma cells were injected into the inguinal mammary fat pads of mice fed continuously on their respective diets. Cell-cycle progression, angiogenesis, and immune cells in tumor tissues, proteases and adhesion molecules in the lungs, and serum cytokine levels were analyzed with immunohistochemistry, Western blotting, and enzyme-linked immunosorbent assay (ELISA). <I>In vitro </I>studies were also conducted to evaluate the effects of cytokines on 4T1 cell viability, migration, and adhesion.</P><P><B>Results</B></P><P>Spleen and gonadal fat-pad weights, tumor weight, the number and volume of tumor nodules in the lung and liver, and tumor-associated mortality were increased in the HFD group, with only slight increases in energy intake and body weight. HF feeding increased macrophage infiltration into adipose tissues, the number of lipid vacuoles and the expression of cyclin-dependent kinase (CDK)2, cyclin D1, cyclin A, Ki67, CD31, CD45, and CD68 in the tumor tissues, and elevated serum levels of complement fragment 5a (C5a), interleukin (IL)-16, macrophage colony-stimulating factor (M-CSF), soluble intercellular adhesion molecule (sICAM)-1, tissue inhibitors of metalloproteinase (TIMP)-1, leptin, and triggering receptor expressed on myeloid cells (TREM)-1. Protein levels of the urokinase-type plasminogen activator, ICAM-1, and vascular cell adhesion molecule-1 were increased, but plasminogen activator inhibitor-1 levels were decreased in the lungs of the HFD group. <I>In vitro </I>assays using 4T1 cells showed that sICAM-1 increased viability; TREM-1, TIMP-1, M-CSF, and sICAM-1 increased migration; and C5a, sICAM-1, IL-16, M-CSF, TIMP-1, and TREM-1 increased adhesion.</P><P><B>Conclusions</B></P><P>Dietary fat increases mammary tumor growth and metastasis, thereby increasing mortality in obesity-resistant mice.</P>
( Yoo-kyung Lee ),( Kyung-a So ),( Mi-kyung Kim ),( In-ho Lee ),( Tae-jin Kim ),( Kyung-taek Lim ),( Ki-heon Lee ),( Sung Ran Hong ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Objective: Regression rates for atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) range widely, from 30% to 80%. The objective of this study was to investigate the predictive value of p16/Ki-67 dual-stained cytology for the progression of disease. 방법: Method: Cytology p16/Ki-67 dual-staining test was performed on 691 liquid-based residual samples from a cohort of women with ASC-US/ LSIL and co-testing human papillomavirus (HPV) positive. Among them, 250 women were followed up for at least a year. Study end points were HSIL detection in 1 and 2 year’s follow-up. 결과: Results: Positivity of p16/Ki-67 dual stained cytology was well correlated to progression of disease compared with positivity of HPV 16/18. During 1 year follow-up, 23 of 250 women experienced progression of disease into HSIL. For positivity of p16/Ki-67 dual stained cytology, Sensitivity (60.9%) for the detection of HSIL or specificity (81.5%) for normal or low grade cytology was higher than those of HPV 16/18 tests (13.0% and 89.0%, respectively) (p<0.001). During 2 years follow-up, 11 of 190 women experienced progression of disease into HSIL. For positivity of p16/Ki-67 dual stained cytology, Sensitivity (45.5%) for the detection of HSIL or specificity (82.1%) for normal or low grade cytology was higher than those of HPV 16/18 tests (18.2% and 89.9%, respectively) (p=0.025). 결론: Conclusions: p16/Ki-67 dual stained cytology could provide both high sensitivity and specificity for the prediction of HSIL in Pap cytology in the future. Positive p16/Ki-67 dual-stained cytology in low grade cytology was highly associated with the progression of disease in 1 or 2 years follow- up. Therefore, in cases of positive dual-stained cells morphologically showing benign atypical features, further follow-up would be necessary.
A New Phalaenopsis Hybrid "White Angel" with white Petals and Red Rip
Mi Seon Kim,Young Ran Lee,Hae Ryong Cho,Hye Kyung Rhee,Jin Hee Lim,Hak Ki Shin 한국육종학회 2007 한국육종학회지 Vol.39 No.3
A new Phalaenopsis hybrid “White Angel” was selected from the progenies derived from self-pollination of collection, “PN 3005 in 1995 at National Horticultural Research Institute (NHRI) Rural Development Administration. Final selection was applied in 2003 after the investigation of the characteristics for five years (1999-2003). “White Angel” has white flower with red rip and is a medium sized Phalaenopsis variety with semi-upright leaf and high PLBs (Protocorm ike bodies) formation ability of 70%. “White Angel” has white flower with red rip and is a medium sized (Flower width is 8.3 cm and leaf length is 25 cm) Phalaenopsis variety with semi-upright leaf and high PLBs (Protocorm like bodies) formation ability of 70%. Strong sunlight and over irrigation should be avoided for the appropriate growth.
Mi Seon Kim,Hae Ryong Cho,Hye Kyung Rhee,Jin Hee Lim,Young Ran Lee,Hak Ki Shin 한국육종학회 2009 한국육종학회지 Vol.41 No.3
A New Cymbidium variety "Yellow Evening" was developed from a cross between "Oji" and "Valley Flower Cherry Life" followed by seedling and line selections at the National Institute of Horticultural and Herbal Science (NIHHS), Rural Development Administration (RDA) in 2004. After investigation of the characteristics and selection for 9 years (1996-2004), it has been selected specifically pot orchid flower. "Yellow Evening" has medium plant height and semi-erect peduncle. It has medium flowering habit and brownish yellow flowers (RHS, Y11B: petal and sepal) with grayed purple GP183A) spot on lip, when fully opened. Each peduncle has 15.3 flowers with diameter of about 7.4 cm. It has adequate peduncle height, with some curved and spreading petal and sepals. Under optical culture conditions, it started to bloom early-winter (November).