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Health and Social Media: Perfect Storm of Information
Luis Fernández-Luque,Teresa Bau 대한의료정보학회 2015 Healthcare Informatics Research Vol.21 No.2
Objectives: The use of Internet in the health domain is becoming a major worldwide trend. Millions of citizens are searching online health information and also publishing content about their health. Patients are engaging with other patients in online communities using different types of social media. The boundaries between mobile health, social media, wearable, games, and big data are becoming blurrier due the integration of all those technologies. In this paper we provide an overview of the major research challenges with the area of health social media. Methods: We use several study cases to exemplify the current trends and highlight future research challenges. Results: Internet is exploding and is being used for health purposes by a great deal of the population. Social networks have a powerful influence in health decisions. Given the lack of knowledge on the use of health social media, there is a need for complex multidisciplinary research to help us understand how to use social networks in favour of public health. A bigger understanding of social media will give health authorities new tools to help decision-making at global, national, local, and corporate level. Conclusions: There is an unprecedented amount of data that can be used in public health due the potential combination of data acquired from mobile phones, Electronic Health Records, social media, and other sources. To identify meaningful information from those data sources it is not trial. Moreover, new analytics tools will need to be developed to analyse those sources of data in a way that it can benefit healthcare professionals and authorities.
Zhu, Huihui,Liu, Ao,Luque, Hector Lopez,Sun, Huabin,Ji, Dongseob,Noh, Yong-Young American Chemical Society 2019 ACS NANO Vol.13 No.4
<P>Although organic-inorganic halide perovskites continue to generate considerable interest due to great potentials for various optoelectronic devices, there are some critical obstacles to practical applications, including lead toxicity, relatively low field-effect mobility, and strong hysteresis during operation. This paper proposes a universal approach to significantly improve mobility and operational stability with reduced dual-sweep hysteresis for perovskite-based thin film transistors (TFTs) by coupling low-dimensional lead-free perovskite material (C<SUB>6</SUB>H<SUB>5</SUB>C<SUB>2</SUB>H<SUB>4</SUB>NH<SUB>3</SUB>)<SUB>2</SUB>SnI<SUB>4</SUB> (hereafter abbreviated as (PEA)<SUB>2</SUB>SnI<SUB>4</SUB>) with embedded conjugated polymer wrapped semiconducting carbon nanotubes (semi-CNTs). In (PEA)<SUB>2</SUB>SnI<SUB>4</SUB>/semi-CNT hybrid TFTs, semi-CNTs can provide highway-like transport paths, enabling smoother carrier transport with less trapping and scattering. We also demonstrate the performance of (PEA)<SUB>2</SUB>SnI<SUB>4</SUB>/semi-CNT hybrid phototransistors with ultrahigh photoresponsivity (<I>R</I>) of 6.3 × 10<SUP>4</SUP> A/W and detectivity (<I>D*</I>) of 1.12 × 10<SUP>17</SUP> Jones, which is about 2 or 3 orders of magnitude higher than that of the best devices available to date. The results indicate promising potentials for solution-processed perovskite/semi-CNT hybrid platforms, and the developed strategy can be applied for high-performance perovskite nanomaterial optoelectronics.</P> [FIG OMISSION]</BR>
Wilfredo Flores-Paredes,Nestor Luque,Roger Albornoz,Nayade Rojas,Manuel Espinoza,Maria J. Pons,Joaquim Ruiz 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3
Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among the most relevant causes of hospital infections. In Peru, few studies, often focused in a single ESKAPE microorganism, have been performed, but none providing an overall and comprehensive long-time analysis of the antibiotic resistance of ESKAPE microorganisms. In the present study, the evolution of antimicrobial resistance levels of ESKAPE microorganisms isolated during 2009 - 2010 (Period 1) and 2012 - 2014 (Period 2) in a IV-level hospital in Lima was analyzed. Materials and Methods: ESKAPE microorganisms were isolated from inpatients clinical samples. Bacterial identification, as well as antimicrobial susceptibility levels for up to 29 antimicrobial agents and presence of Extended-Spectrum β-Lactamases (only established in K. pneumoniae) were determined using automatic methods. Results: Of 9,918 clinical isolates, 1,917/3,777 (50.8%) [JAN/2009-JUN/2010 (Period 1)] and 4764/6141 (46.4%) [JAN/2012-DEC/2014 (Period 2)] belonged to the ESKAPE group (P <0.0001). ESKAPE were more frequent in the intensive care unit (ICU) (P <0.0001). E. faecium decreased from 5.1% to 4.1% (P <0.5), S. aureus from 10.5% to 7.0% (P <0.05), and P. aeruginosa from 12.9% to 11.6% (P <0.05), while, A. baumannii increased from 5.0% to 6.7% (P <0.05), mainly related to an increase in ICU isolates (8.4% vs. 17.1%; P <0.05). Overall, high levels of antimicrobial resistance were detected, but with few exceptions (e.g. vancomycin in E. faecium), antibiotic resistance levels remained stable or lower in Period 2. Contrarily, A. baumannii showed significantly increased resistance to different cephalosporins, carbapenems and amoxicillin plus sulbactam. Conclusion: The introduction of a successful extensively drug-resistant A. baumannii clone in the ICU is suspected. The isolation of ESKAPE and levels of antibiotic resistance levels have reduced over time.
Vahid Khakyzadeh,Amir Ehsani,Rafael Luque 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
A novel highly ordered network based on shed snakeskin has been employed as a sustainable/naturaltemplate, to fabricate efficient heterogeneous cobalt composite as catalyst by a nano-casting process. Characterization of the Cobalt nano-catalyst was investigated by several analysis methods includingTEM, FESEM-EDS mapping, XRD, XPS, TGA, ICP, Raman, ATR, and N2 sorption and results verified thepreparation of a nano-catalyst with highly ordered perforated structure, uniform pore size distribution,high surface area, and high stability. The nano-cobalt particles were uniformly disposed on the supportwith a particle size of about 100 nm, validated by various analysis methods. The catalytic performance ofthe synthesized catalyst was evaluated in the Suzuki-Miyaura reaction for Csp2 –Csp2 bond formation in highyields (up to 97%) and excellent reactivity. The catalyst could also be recycled for at least 10 reaction runswithout almost losing its activity (less than 10% after 10 runs).
Juristo Fonolla,Jose A Maldonado-Lobón,Roberto Luque,Carlos Rodríguez,Óscar Bañuelos,Jose L López-Larramendi,Mónica Olivares,Ruth Blanco-Rojo 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.5
Hydroxytyrosol (HT) from olives and polyphenols from almond skin (ASPs) possess cardioprotective properties. This pilot study evaluates the effect of supplementation with a combination of olive fruit and almond skin extracts on low-density lipoprotein (LDL) cholesterol oxidation, lipid homeostasis, and inflammatory parameters in adults with moderate hypercholesterolemia. A randomized, parallel, double-blind, placebo-controlled pilot study of 8 weeks was performed. The extract group (EG) received the supplement with 7.5 mg HT +210 mg ASPs, and the control group (CG) received a placebo composed of maltodextrin. Oxidized LDL (oxLDL) levels and the oxLDL/LDL ratio were lower in the EG than in the CG after 8 weeks of treatment (18.76 ± 3.91 vs. 10.34 ± 4.22, P < .001 and 0.151 ± 0.025 vs. 0.08 ± 0.023, P < .001, respectively). Interleukin-1β levels were significantly higher in the CG than in the EG at week 4 (P = .004), IL-6 was significantly higher in the CG than in the EG at week 4 (P = .049), and IL-10 was significantly increased at week 4 in both groups (P = .002 for CG and P = .001 for EG). In conclusion, daily consumption of a combination of an olive fruit extract and an almond skin extract for 8 weeks seems to protect LDL from oxidation and to prevent inflammatory status in moderately hypercholesterolemic subjects.
Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Sánchez-Fdez Adrián,Matilla-Almazán Sofía,Del Carmen Sofía,Abad Mar,Arconada-Luque Elena,Jiménez-Suárez Jaime,Chinchilla-Tábora Luis Miguel,Ruíz-Hidalgo Mª José,Sánchez-Prieto Ricardo,Pandiella Atanas 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Sarcomas constitute a heterogeneous group of rare and difficult-to-treat tumors that can affect people of all ages, representing one of the most common forms of cancer in childhood and adolescence. Little is known about the molecular entities involved in sarcomagenesis. Therefore, the identification of processes that lead to the development of the disease may uncover novel therapeutic opportunities. Here, we show that the MEK5/ERK5 signaling pathway plays a critical role in the pathogenesis of sarcomas. By developing a mouse model engineered to express a constitutively active form of MEK5, we demonstrate that the exclusive activation of the MEK5/ERK5 pathway can promote sarcomagenesis. Histopathological analyses identified these tumors as undifferentiated pleomorphic sarcomas. Bioinformatic studies revealed that sarcomas are the tumors in which ERK5 is most frequently amplified and overexpressed. Moreover, analysis of the impact of ERK5 protein expression on overall survival in patients diagnosed with different sarcoma types in our local hospital showed a 5-fold decrease in median survival in patients with elevated ERK5 expression compared with those with low expression. Pharmacological and genetic studies revealed that targeting the MEK5/ERK5 pathway drastically affects the proliferation of human sarcoma cells and tumor growth. Interestingly, sarcoma cells with knockout of ERK5 or MEK5 were unable to form tumors when engrafted into mice. Taken together, our results reveal a role of the MEK5/ERK5 pathway in sarcomagenesis and open a new scenario to be considered in the treatment of patients with sarcoma in which the ERK5 pathway is pathophysiologically involved.
A Probabilistic Approach for Testing Feedback Controllers with Application to Congestion Control
José M. Maestre,Teresa Alvarez,Teodoro Alamo,Anuar Salim del Río,Amalia Luque 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.4
Prompted by an application in congestion control of computer networks, this paper presents a methodology to certify with a certain degree of confidence whether a given controller satisfies a pre-defined set of specifications. The methodology is applied to testing AQM controllers for efficiency in congestion control, by repeating detailed simulations under a variety of network configurations.