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Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7
Lili Kong,Hongyue Wang,Chenhao Li,Huiyan Cheng,Yan Cui,Li Liu,Ying Zhao 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.6
Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. Bone morphologic protein 7 (BMP-7) has been shown to reduce renal fibrosis induced by transforming growth factor-beta1. The aim of this study was to investigate the epigenetic effect of SFN on BMP-7 expression in diabetes-induced renal fibrosis.Methods: Streptozotocin (STZ)-induced diabetic mice and age-matched controls were subcutaneously injected with SFN or vehicle for 4 months to measure the in vivo effects of SFN on the kidneys. The human renal proximal tubular (HK11) cell line was used to mimic diabetic conditions in vitro. HK11 cells were transfected to over-express HDAC2 and treated with high glucose/palmitate (HG/Pal) to explore the epigenetic modulation of BMP-7 in SFN-mediated protection against HG/Pal-induced renal fibrosis.Results: SFN significantly attenuated diabetes-induced renal fibrosis in vivo. Among all of the HDACs we detected, HDAC2 activity was markedly elevated in the STZ-induced diabetic kidneys and HG/Pal-treated HK11 cells. SFN inhibited the diabetes-induced increase in HDAC2 activity which was associated with histone acetylation and transcriptional activation of the BMP-7 promoter. HDAC2 over-expression reduced BMP-7 expression and abolished the SFN-mediated protection against HG/Pal-induced fibrosis in vitro.Conclusion: Our study demonstrates that the HDAC inhibitor SFN protects against diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7.
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Jing Huang,Lili Zheng,Fang Wang,Yuan Su,Hongfang Kong,Hong Xin 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
Preeclampsia is an inflammatory disease whichcan induce oxidative stress in placenta. Oxidative stressin preeclampsia is regulated by the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. Mangiferin, an anti-oxidative molecule,is reported to ameliorate oxidative stress in the kidney andbrain through activating the PI3K/Akt/mTOR pathway. Weaimed to investigate the effects of mangiferin in a mousemodel of preeclampsia, which was induced by phosphatidylserine/dioleoyl-phosphatidycholine (PS/PC) from day 5to 17 of pregnancy. The female pregnant mice were dividedinto five groups according to drug treatment. Animalsreceived mangiferin orally at doses of 10, 20, 40 mg/kg/dayfrom day 0.5 to 17. In preeclampsia mouse model, elevatedsystolic blood pressure and proteinuria were ameliorated bymangiferin treatment. Mangiferin attenuated fms-like tyrosinekinase-1 and placental growth factor expression andoxidative stress in both blood and placenta of preeclampsiamice. The suppressed PI3K/Akt/mTOR pathway in placentawas activated by mangiferin treatment. This study demonstratesthat mangiferin ameliorates placental oxidative stressand activates PI3K/Akt/mTOR pathway in a mouse modelof preeclampsia.
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Singapore s Chinatown:Nation Building and Heritage Tourism in a Multiracial City
Brenda S. A. Yeoh,Lily Kong 부산대학교 한국민족문화연구소 2012 Localities Vol.- No.2
This paper focuses on the pivotal role played by the state in refashioning the Chinatown landscape as part of both nation-building and heritage tourism projects, and the ensuing cultural politics. After a brief history of the creation of Singapore’s Chinatown, the paper discusses, first, Chinatown’s place in Singapore’s post-independence nation-building project and, second, the reconfiguration of the Chinatown landscape as a tourism asset. The final section reflects on the changing politics of place as Chinatown gains legitimacy in state discourses on heritage, tourism and multiculturalism, as well as in the popular imagination as an ethnic precinct par excellence.
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Shuimiao Fan,Bingfu Jin,Wei Yue,Lili Dang,Mengyao Wang,Qingxiang Kong 한국지질과학협의회 2021 Geosciences Journal Vol.25 No.5
Electronic probe analyses were performed on 343 and 406 sedimentary amphibole single-mineral samples extracted from five sampling points in the Huanghe River estuary and six in the Changjiang River estuary. The profiles of amphibole single-mineral major elements were determined for the two rivers using these samples. The cation coefficients and related parameters of 749 amphiboles were calculated based on 23 oxygen standards, and their crystal structure molecular formulae and related characteristic crystallochemical values were determined. The results show that the sedimentary amphiboles of the two estuaries belong to the calcic amphibole subgroup, where the majority is Magnesiohornblende, accounting for more than 70%, followed by Tschermakite. A genetic mineralogical analysis was carried out on the genesis type, magmatic source, and crystallization temperature and pressure environment of the amphiboles in the Huanghe River and Changjiang River estuaries, showing that most of the calcic amphiboles in these estuaries originated from metamorphic rocks, followed by magmatic rocks. Amphiboles of magmatic genesis in the Huanghe River and Changjiang River estuaries were largely crust-mantle type. Most of the metamorphic amphiboles originated in a metamorphic environment below moderate temperature and pressure. The amphiboles of the Huanghe River estuary mainly originate from the orogenic belt in the Northern Loess Plateau. The amphiboles of the Changjiang River estuary mainly originate from the middle and upper reaches of the Changjiang River, where the amphiboles mainly form as a result of magmatic and hydrothermal activity, as well as metamorphism. The chemical composition and characteristic values of sedimentary amphiboles in the Huanghe River and Changjiang River estuaries are stable, and can be used as standardized substances for terrestrial sediments.
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