델파이기법을 활용한 국가 공공(公共)백신 연구개발 정책수립 기초조사

이소민 ( Somin Lee1 ),여상구 ( Sanggu Yeo ),강신정 ( Shinjung Kang ),한순영 ( Soonyoung Han ),이상원 ( Sangwon Lee ) 한국보건행정학회 2015 보건행정학회지 Vol.25 No.2

Background: Vaccination is the most powerful and useful preparation against infectious diseases. However, developing vaccines costs a lot and requires extensive long-term efforts. Therefore, the government should research and develop vaccines with a national-level policy. To greatly enhance the success rate of vaccine development, the policy should be set up considering priorities such as the current status of domestic research, the importance for public health, the urgency of research. Methods: The Delphi technique was utilized to draft this survey, through a brainstorming stage, then two inquiries, and finally the final panel meeting where unresolved items were discussed, to draw the conclusion. Results: Among the results, firstly, the highest ranked item on centralized fields for vaccine development by the Ministry of Health was ‘self-sufficiency of vaccines.’ Secondly, ‘emerging infectious disease’ was most highly ranked in prioritized fields of vaccine development and research. Thirdly, for the vaccine that needs to be improved and developed further by the government to improve its efficacy and safety, BCG (Bacille de Calmette) for tuberculosis was ranked the highest on both types (intradermal and subcutaneous injection) from National Immunization Programme (NIP) and non-NIP. As for the high risk pathogens, ‘anthrax’ and ‘smallpox’ were first and second, consecutively. Lastly, ‘development and control of vaccine candidates’ was ranked the highest for the area in need for technique development in order to improve domestic vaccine’s research level. Conclusion: The results of this study will be put to good use as basic data for the national vaccine research and development (R&D) policy of the country. This study was first step and more studies should be carried out for the final decision of the national vaccine R&D priority.

Dissipation patterns of acrinathrin and metaflumizone in Aster scaber

Lee Somin,Ko Rakdo,Lee Kwanghun,Kim Jinchan,Kang Seokhyeon,Lee Jiho 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.1

The establishment of preharvest residue limits (PHRLs) is important to minimize damage to producer and consumers caused by agricultural products which pesticide residue exceeds maximum residue limits (MRLs). Dissipation patterns of acrinathrin and metaflumizone in Aster scaber in greenhouse were studied during 10 days in order to determine a pre-harvest interval after application. Acrinathrin and metaflumizone were applied in two different greenhouse, located in Taean-gun (field 1) and Gwangyang-si (field 2). Samples were collected at 0, 1, 2, 3, 5, 7, and 10 days after insecticides application. The recoveries of two insecticides analyzed by LC–MS/MS and HPLC–DAD were ranged from 77.1 to 111.3%. The half-lives of acrinathrin and metaflumizone residues respectively were 3.8 and 5.9 days in field 1 and 9.2 and 4.5 days in field 2. The PHRLs 10 days before harvesting A. scaber were 0.610 mg/kg (field 1), 0.946 mg/kg (field 2) for acrinathrin, and 5.930 mg/kg (field 1), 5.147 mg/kg (field 2) for metaflumizone. This results can be used as basic data for the establishment of PHRL in A. scaber. The establishment of preharvest residue limits (PHRLs) is important to minimize damage to producer and consumers caused by agricultural products which pesticide residue exceeds maximum residue limits (MRLs). Dissipation patterns of acrinathrin and metaflumizone in Aster scaber in greenhouse were studied during 10 days in order to determine a pre-harvest interval after application. Acrinathrin and metaflumizone were applied in two different greenhouse, located in Taean-gun (field 1) and Gwangyang-si (field 2). Samples were collected at 0, 1, 2, 3, 5, 7, and 10 days after insecticides application. The recoveries of two insecticides analyzed by LC–MS/MS and HPLC–DAD were ranged from 77.1 to 111.3%. The half-lives of acrinathrin and metaflumizone residues respectively were 3.8 and 5.9 days in field 1 and 9.2 and 4.5 days in field 2. The PHRLs 10 days before harvesting A. scaber were 0.610 mg/kg (field 1), 0.946 mg/kg (field 2) for acrinathrin, and 5.930 mg/kg (field 1), 5.147 mg/kg (field 2) for metaflumizone. This results can be used as basic data for the establishment of PHRL in A. scaber .

Microfluidic-based vascularized microphysiological systems

Lee, Somin,Ko, Jihoon,Park, Dohyun,Lee, Seung-Ryeol,Chung, Minhwan,Lee, Younggyun,Jeon, Noo Li The Royal Society of Chemistry 2018 Lab on a chip Vol.18 No.18

<P>Microphysiological systems have emerged in the last decade to provide an alternative to <I>in vivo</I> models in basic science and pharmaceutical research. In the field of vascular biology, in particular, there has been a lack of a suitable <I>in vitro</I> model exhibiting a three-dimensional structure and the physiological function of vasculature integrated with organ-on-a-chip models. The rapid development of organ-on-a-chip technology is well positioned to fulfill unmet needs. Recently, functional integration of vasculature with diverse microphysiological systems has been increasing. This recent trend corresponds to emerging research interest in how the vascular system contributes to various physiological and pathological conditions. This innovative platform has undergone significant development, but adoption of this technology by end-users and researchers in biology is still a work in progress. Therefore, it is critical to focus on simplification and standardization to promote the distribution and acceptance of this technology by the end-users. In this review, we will introduce the latest developments in vascularized microphysiological systems and summarize their outlook in basic research and drug screening applications.</P>

Five newly recorded foraminifera from off the southern coast of Jeju Island, Korea

Lee, Somin,Lee, Wonchoel The National Institute of Biological Resources 2020 Journal of species research Vol.9 No.4

In this study, we briefly describe five newly recorded foraminiferal species from off the southern coast of Jeju Island: Ammolagena clavata, Neoeponides bradyi, Nodosaria lamnulifera, Rhabdammina abyssorum, and Uvigerina schwageri. Ammolagena clavata and Rhabdammina abyssorum are the first reports of the genera Ammolagena and Rhabdammina in Korea. In addition, R. abyssorum is reported from a depth of 103 m, which is a relatively shallow record within the distribution depth range for this agglutinated deep-sea species. Ammolagena clavata also shows interesting characteristics that the test usually attaches to substrates including shell fragments, sediment particles, or other foraminiferal tests. All other three species have typical calcareous and hyaline tests. The present report on unrecorded species improves the understanding of foraminiferal species diversity in Korean waters and confirms the need for the further research on foraminifera in the adjacent seas of Korea.

Thirty new records of marine benthic Foraminifera from Korean waters

Lee, Somin,Frontalini, Fabrizio,Lee, Wonchoel The National Institute of Biological Resources 2017 Journal of species research Vol.6 No.no.spc

As a part of a survey of indigenous biological resources of Korea, 30 marine benthic foraminiferal species belonging to 24 genera and seven orders (Astrorhizida, Lagenida, Lituolida, Miliolida, Robertinida, Rotaliida and Textulariida) were identified. Bottom sediment samples were collected from eight stations on the west and east coast of South Korea, in April 2015 and May 2016, respectively. Ten species belonging to nine genera and five orders (Lagenida, Lituolida, Robertinida, Rotaliida, Textulariida) were identified in the Yellow Sea. Among these taxa, Rotaliida was the dominant order, represented by four species: Evolvocassidulina tenuis (Phleger & Parker, 1951), Cibicides mabahethi Said, 1949, Cibicides pseudolabatulus Perelis & Reiss, 1975 and Cibicidoides barnetti Bermudez, 1949. Twenty species belonging to 15 genera and five orders (Astrorhizida, Lagenida, Lituolida, Miliolida, and Rotaliida) were identified from the East Sea and the Lagenida was the dominant order, represented by 11 species: Lagena strumosa Reuss, 1858, Lagena nebulosa (Cushman, 1923), Lagena striata var. semiornata Reuss, 1863, Procerolagena cylindrocostata Albani & Yassini, 1989, Fissurina bispinata $Ujii{\acute{e}}$, 1963, Oolina laevigata d'Orbigny, 1839, Polymorphina amplissima McCulloch, 1977, Polymorphina subelliptica McCulloch, 1977, Guttulina succincta McCulloch, 1977, Guttulina neoproblema McCulloch, 1977 and Lagenosolenia obtecta McCulloch, 1977. The findings described here increased the number of foraminiferal species in Korea to approximately 1060, and contribute to our understanding of the diversity of foraminifera in Korean waters.

Safety evaluation of cricket(Gryllus bimaculatus) extract in Sprague-Dawley rats

Lee, Somin,Ahn, Kyu Sup,Ryu, Hyeon Yeol,Kim, Hye Jin,Lee, Jin Kyu,Cho, Myung-Haing,Ahn, Mi Young,Song, Kyung Seuk Korean Society of Sericultural Science 2016 International Journal of Industrial Entomology Vol.32 No.1

Recently, research investment in the improvement of food safety as a food source and specializing of nutritional source of edible insects is being actively conducted. Cricket especially has been attracting considerable interest in entomophagy; however, research on the safety assessment of cricket is limited. This study investigated the effects of cricket ethanol extract when orally administrated in Sprague-Dawley rats. Here, we performed a 4 wk repeated oral dose toxicity test in Sprague-Dawley rats following the Organization for Economic Cooperation and Development test guidelines 407 under Good Laboratory Practice regulation. Rats were randomly allocated 4 groups: vehicle control, 250, 500, 1,000 mg/kg test groups and administrated based on body weight for 28 d. The animals were observed for mortalities and clinical signs, body weight changes, food and water consumption. At the end of treatment period, blood and urine were collected and analyzed. Subsequently, the animals were sacrificed and subjected to gross pathological examination and organ weight measurement. The organs were preserved for histopathological examination. The results showed that there were no systemic toxicological effects related with the cricket ethanol extract in the 4 wk oral repeated dose toxicity study. It is considered that NOAEL of cricket ethanol extract is greater than 1,000 mg/kg/d and there was no target organ detected.

Three new records of recent benthic Foraminifera from Korea

Lee, Somin,Lee, Wonchoel The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.4

Foraminifera are protists that inhabit diverse marine environments and show high abundance and diversity. However, previous studies on foraminifera in Korea mostly focused on geological and paleoecological fields and were conducted in a limited area. Therefore, there is a high possibility for discovering new and unrecorded species. Here we describe three newly recorded foraminiferal species from the southwestern part of Jeju Island during a survey on the meiofaunal community, which belongs to three different genera (Ammobaculites, Cylindroclavulina, Saracenaria), three families (Lituolidae, Vaginulinidae, Valvulinidae), and three orders (Lituolida, Textulariida, Vaginulinida): Ammobaculites formosensis Nakamura, 1937, Cylindroclavulina bradyi (Cushman, 1911), and Saracenaria hannoverana (Franke, 1936). These species have been reported from Chinese region in the East China Sea, however this is the first report from Korean waters. Particularly, Cylindroclavulina bradyi is the first report of the genus Cylindroclavulina in Korean waters. The present study supports the diversity of foraminiferal species in Korea, and the necessity of further surveys in Korean waters.

Drug-Eluting Bead Transarterial Chemoembolization Versus Radiofrequency Ablation as an Initial Treatment of Single Small (≤ 3 cm) Hepatocellular Carcinoma

Lee Somin,Jeong Yong Yeon,Lee Byung Chan,Shin Sang Soo,Heo Suk Hee,Kim Hyoung Ook,Park Chan,Jeong Won Gi 대한의학회 2023 Journal of Korean medical science Vol.38 No.42

Background: In this study, we aimed to compare the long-term therapeutic outcomes of drug-eluting bead transarterial chemoembolization (DEB-TACE) with those of radiofrequency ablation (RFA) for the initial treatment of a single small (≤ 3 cm) hepatocellular carcinoma (HCC). Methods: From January 2010 to December 2021, 259 consecutive patients who underwent DEB-TACE (67 patients) or RFA (192 patients) as a first-line treatment for a single small HCC were enrolled in this retrospective study. The therapeutic outcomes, including cumulative intrahepatic local tumor progression (LTP), progression-free survival (PFS), and longterm overall survival (OS) rates, were compared between the two groups before and after propensity score (PS) matching. Multivariate Cox proportional hazard models were used to evaluate the prognostic factors and differences in OS and PFS between the two groups for all 92 patients after PS matching. Results: After PS matching, the 1-, 2-, 3-, and 5-year LTP rates were lower in the RFA group than those in the DEB-TACE group (P < 0.001), and the 1-, 2-, 3-, and 5-year PFS rates in the RFA group were higher than those in the DEB-TACE group (P = 0.007). However, the 1-, 2-, 3-, and 5-year OS rates were not significantly different between the RFA and DEB-TACE groups (P = 0.584). Moreover, the OS was not significantly different between the RFA and DEB-TACE groups in the univariate and multivariate analyses, with a hazard ratio (HR) of 0.81. The PFS was significantly higher in the RFA group than that in the DEB-TACE group in the univariate analyses, with a HR of 0.44 (P = 0.009). Multivariate Cox regression analysis showed that albumin (P = 0.019) was an independent prognostic factor for OS. Additionally, the major complication rates were not significantly different between the DEB-TACE and RFA groups (P = 1.000). Conclusion: The LTP and PFS rates of RFA were superior to those of DEB-TACE in the initial treatment of single small HCC after PS matching. However, the OS rates were not significantly different between RFA and DEB-TACE. Therefore, DEB-TACE may be considered an efficient substitute for RFA in some patients with a single small HCC who are ineligible for RFA.

Silk fibroin-coated polyamide thin-film composite membranes with anti-scaling properties

Somin Lee,Kyeong Yeon Park,Hee-Jun Kim,Miao Tian,Gilson Kang,Hyun-Woo Kim,Tae-Hyun Ba,Jaewoo Lee 한국막학회 2022 한국막학회 총회 및 학술발표회 Vol.2022 No.11

The relationship between nurse managers’ leadership and patient safety and quality of care: A systematic review

Somin Sang,Nowon Kwon,Hyunjie Lee,Seung Eun Lee 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): To examine the relationship between nurse managers’ leadership and patient safety and quality of care in hospital settings. Method(s): Online literature search was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, besides manual searching. On four databases, the search terms used were: “nurse leadership,” “nurse manager,” “nurse administrator,” “patient safety,” “patient outcome,” “quality of care,” “care quality,” and “hospital*.” The inclusion criteria for this review were studies that examined nurse managers’ leadership, investigated patient safety or quality of care as outcome variables, comprised samples of nurses working in hospital settings, employed quantitative study designs, and were published in the English language between 2011 and 2021. Result(s): This review included 12 studies. Two studies were conducted in Canada, two in Iran, two in the United States, and one each in Brazil, Ghana, Jordan, Pakistan, the Philippines, and South Korea. Three studies used a theoretical framework. Transformational leadership was positively related to quality of care, and negatively to frequency of adverse patient outcomes. Ethical leadership was negatively associated with frequency of nursing errors and positively with frequency of error reporting. Authentic leadership was positively related to quality of care but was insignificant to frequency of adverse patient outcomes. Transactional leadership and toxic leadership had negative association with quality of care. Toxic leadership was also associated with an increased frequency of adverse patient outcomes. Studies measuring non-specific leadership—such as nursing managers’ ability and support—and team leadership reported inconsistent results. Conclusion(s): The use of transactional and toxic leadership should be avoided while reinforcing transformational and ethical leadership of nurse managers that positively affect patient safety and quality of care. Future research is needed to elucidate the systematic mechanism between leadership and patient safety and quality of care based on theoretical frameworks.