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Kwon Nayeon,Lee Siyun,Jang Moonbong,Lee Jin-Ho,Park Chulhwan,Lee Taek 한국바이오칩학회 2024 BioChip Journal Vol.18 No.1
Yellow fever virus (YFV) is an acute infectious virus with high morbidity and mortality risks during the toxic phase. Early diagnosis and suppression are essential because YFV has no precise treatment. With the aim of detecting YFV, we fabricated a highly sensitive electrochemical biosensor comprised with a truncated DNA aptamer/MXene heterolayer. The synthesized DNA aptamer was prepared by systematic evolution of ligands using the exponential enrichment (SELEX) technique, which can specifically detect the YFV NS1 protein. MXenes increase the electrical sensitivity and the possibility of attachment of aptamers by widening the surface area. The aptamer-cutting process which called a truncation process can reduce the production cost of biosensors. The biosensor performance was evaluated using electrochemical methods, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The limit of detection (LOD) was 2.757 pM for YFV diluted in phosphate-buffered saline (PBS) and 2.366 pM for YFV diluted in 10% human serum, proving that the biosensor specifically binds to YFV through selectivity evaluation. This biosensor can be a valuable tool for the early diagnosis of YFV, enabling timely intervention as well as facilitating the control and prevention of yellow fever outbreaks.
On Fisher’s dispersion test for integer-valued autoregressive Poisson models with applications
Lee, Sangyeol,Park, Siyun,Chen, Cathy W. S. Informa UK (TaylorFrancis) 2017 Communications in Statistics Vol.46 No.20
<P>The integer-valued autoregressive (INAR) model has been widely used in diverse fields. Since the task of identifying the underlying distribution of time-series models is a crucial step for further inferences, we consider the goodness-of-fit test for the Poisson assumption on first-order INAR models. For a test, we employ Fisher's dispersion test due to its simplicity and then derive its null limiting distribution. As an illustration, a simulation study and real data analysis are conducted for the counts of coal mining disasters, the monthly crime data set from New South Wales, and the annual numbers of worldwide earthquakes.</P>
On entropy goodness-of-fit test based on integrated distribution function
Lee, Sangyeol,Park, Siyun,Kim, Byungsoo Informa UK (TaylorFrancis) 2018 JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION Vol.88 No.12
<P>In this study, we consider an entropy-type goodness-of-fit (GOF) test based on integrated distribution functions. We first construct the test for the simple vs. simple hypothesis and then extend it to the composite hypothesis case. It is shown that under regularity conditions, the null limiting distribution of the proposed test is a function of a Brownian bridge. A bootstrap method is also considered and is shown to be weakly consistent. A simulation study and real data analysis are conducted for illustration.</P>
Ethyl Acetate를 유기탄소원으로 이용한 혼합영양배양에서의 Oscillatoria sp.의 성장특성 연구
고시원(Siyun Gao),홍가이(Kai Hong),이태윤(Tae-Yoon Lee) 한국생물공학회 2018 KSBB Journal Vol.33 No.3
The purpose of this study was to determine optimum value of aeration rate for the cultivation of Oscillatoria sp. and to find adequate acetate types and concentration as organic carbon source. The highest specific growth rate of 0.287 day-1 was obtained at the aeration of 0.55 vvm. Among four different acetate compounds, ammonium acetate and ethyl acetate were effective for Oscillatoria cultivation. For 30 mM ethyl acetate usage, the highest maximum specific growth rate (0.347 day<SUP>-1</SUP>), maximum biomass productivity (0.214 g L<SUP>-1</SUP> d<SUP>-1</SUP>), and maximum concentration (2.05 g/L) were obtain. For the effective cultivation of Oscillatoria, aeration and dosage of more than 20 mM of ethyl acetate is recommended.
Shin Jaehyeok,Noh Siyun,Lee Jinseong,Kim Jin Soo,Choi Ilgyu,Ahn Ho-Kyun 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.10
We discuss the structural and electrical characteristics of an ultra-thin Si-doped GaN flm, regrown on a patterned GaN/ sapphire substrate with square-shaped patterns, at an extremely low growth rate. The Si-doped GaN regrowth (RG-GaN) flms were grown by systematically varying V/III ratio (183, 241, 306, and 417) and growth temperature (880, 890, 900, and 910 ℃). Field-emission scanning electron microscope (FE-SEM) and atomic force microscope (AFM) images of the RG-GaN flm show that its surface morphology was improved with increasing V/III ratio up to 306, and then slightly degraded with further increasing the ratio. In addition, the surface morphology of the RG-GaN flm was improved with increasing growth temperature up to 900 ℃, and then slightly degraded with further increasing the growth temperature. The root-mean-square value of the surface roughness evaluated from the AFM image of the RG-GaN flm was measured to be 3.44 nm, which is much better than those of the previous reports. When the thickness of an epitaxial flm is ultra-thin, its surface roughness is typically high because of poor surface planarization. However, the surface uniformity of the RG-GaN thin flm in this work was signifcantly improved even with ultra-thin thickness. When the surface morphology of the Si-doped RG-GaN flm was improved, its electrical resistance was efectively lowered.
Recent Progress in Rapid Biosensor Fabrication Methods: Focus on Electrical Potential Application
Yoon Yejin,Kwon Yein,Park Hanbin,Lee Siyun,Park Chulhwan,Lee Taek 한국바이오칩학회 2024 BioChip Journal Vol.18 No.1
The coronavirus disease pandemic has led to an urgent need for rapid and accurate viral diagnosis. Therefore, rapid biosen- sors, not only for viruses but also for the detection of bacteria, disease diagnosis, and environmental monitoring, have been actively researched. Biosensors analyze the binding of biomolecules and target substances mainly based on electrochemical, electrical, or optical methods. To achieve precise and rapid diagnosis, it is crucial to reduce the time required for biomolecule– target substance binding. Typically, biomolecules reach the target substances through random diffusion, and to overcome the limitations associated herewith, biosensors have been integrated with alternating current (AC) electrokinetics (ACEK) technology. ACEK, through the application of alternating voltages, converts electrical energy into fluid motion, inducing pumping, mixing, concentration, and separation of the fluid. Its low power consumption makes it highly promising as a point-of-care diagnostic device. In this paper, we review the advancements in three ACEK technologies: AC electrothermal flow, AC electro-osmosis, and AC di-electrophoresis, to discuss the development of rapid biosensor fabrication methods based on electrical potential applications. The coronavirus disease pandemic has led to an urgent need for rapid and accurate viral diagnosis. Therefore, rapid biosen- sors, not only for viruses but also for the detection of bacteria, disease diagnosis, and environmental monitoring, have been actively researched. Biosensors analyze the binding of biomolecules and target substances mainly based on electrochemical, electrical, or optical methods. To achieve precise and rapid diagnosis, it is crucial to reduce the time required for biomolecule– target substance binding. Typically, biomolecules reach the target substances through random diffusion, and to overcome the limitations associated herewith, biosensors have been integrated with alternating current (AC) electrokinetics (ACEK) technology. ACEK, through the application of alternating voltages, converts electrical energy into fluid motion, inducing pumping, mixing, concentration, and separation of the fl uid. Its low power consumption makes it highly promising as a point-of-care diagnostic device. In this paper, we review the advancements in three ACEK technologies: AC electrothermal flow, AC electro-osmosis, and AC di-electrophoresis, to discuss the development of rapid biosensor fabrication methods based on electrical potential applications.