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      • Leukemia in Iran: Epidemiology and Morphology Trends

        Koohi, Fatemeh,salehiniya, Hamid,Shamlou, Reza,Eslami, Soheyla,Ghojogh, Ziyaeddin Mahery,Kor, Yones,Rafiemanesh, Hosein Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

        Background: Leukemia accounts for 8% of total cancer cases and involves all age groups with different prevalence and incidence rates in Iran and the entire world and causes a significant death toll and heavy expenses for diagnosis and treatment processes. This study was done to evaluate epidemiology and morphology of blood cancer during 2003-2008. Materials and Methods: This cross-sectional study was carried out based on re-analysis of the Cancer Registry Center report of the Health Deputy in Iran during a 6-year period (2003 - 2008). Statistical analysis for incidence time trends and morphology change percentage was performed with joinpoint regression analysis using the software Joinpoint Regression Program. Results: During the studied years a total of 18,353 hematopoietic and reticuloendothelial system cancers were recorded. Chi square test showed significant difference between sex and morphological types of blood cancer (P-value<0.001). Joinpoint analysis showed a significant increasing trend for the adjusted standard incidence rate (ASIR) for both sexes (P-value<0.05). Annual percent changes (APC) for women and men were 18.7 and 19.9, respectively. The most common morphological blood cancers were ALL, ALM, MM and CLL which accounted for 60% of total hematopoietic system cancers. Joinpoint analyze showed a significant decreasing trend for ALM in both sexes (P-value<0.05). Conclusions: Hematopoietic system cancers in Iran demonstrate an increasing trend for incidence rate and decreasing trend for ALL, ALM and CLL morphology.

      • KCI등재

        An extension of annihilating-ideal graph of commutative rings

        Mahtab Koohi Kerahroodi,Fatemeh Nabaei 대한수학회 2020 대한수학회논문집 Vol.35 No.4

        Let $R$ be a commutative ring with unity. The extension of annihilating-ideal graph of $R$, $\overline{\mathbb{AG}}(R)$, is the graph whose vertices are nonzero annihilating ideals of $R$ and two distinct vertices $I$ and $J$ are adjacent if and only if there exist $n,m\in\mathbb{N}$ such that $I^{n}J^{m}=(0)$ with $I^{n}, J^{m}\neq (0)$. First, we differentiate when $\mathbb{AG}(R)$ and $\overline{\mathbb{AG}}(R)$ coincide. Then, we have characterized the diameter and the girth of $\overline{\mathbb{AG}}(R)$ when $R$ is a finite direct products of rings. Moreover, we show that $\overline{\mathbb{AG}}(R)$ contains a cycle, if $\overline{\mathbb{AG}}(R)\neq\mathbb{AG}(R)$.

      • SCOPUSKCI등재

        AN EXTENSION OF ANNIHILATING-IDEAL GRAPH OF COMMUTATIVE RINGS

        Kerahroodi, Mahtab Koohi,Nabaei, Fatemeh Korean Mathematical Society 2020 대한수학회논문집 Vol.35 No.4

        Let R be a commutative ring with unity. The extension of annihilating-ideal graph of R, $^{\bar{\mathbb{AG}}}$(R), is the graph whose vertices are nonzero annihilating ideals of R and two distinct vertices I and J are adjacent if and only if there exist n, m ∈ ℕ such that I<sup>n</sup>J<sup>m</sup> = (0) with I<sup>n</sup>, J<sup>m</sup> ≠ (0). First, we differentiate when 𝔸𝔾(R) and $^{\bar{\mathbb{AG}}}$(R) coincide. Then, we have characterized the diameter and the girth of $^{\bar{\mathbb{AG}}}$(R) when R is a finite direct products of rings. Moreover, we show that $^{\bar{\mathbb{AG}}}$(R) contains a cycle, if $^{\bar{\mathbb{AG}}}$(R) ≠ 𝔸𝔾(R).

      • KCI등재

        Catalytic Cracking of Polystyrene and Low-Density Polyethylene over Synthesized Zeolite Na-A with Optimized Crystallinity

        Sakaki Seyyed Alireza,Dadvand Koohi Ahmad,Rashidzadeh Mehdi,Sheykhan Mehdi 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.3

        Nowadays, waste plastics made a signifi cant environmental problems. Chemical converting of the polymers to valuable liquids is a promising method to solve the problem and make excellent benefi t. This study investigates the utilization of kaolin, a natural resource, for synthesizing zeolite Na-A and signifi cance of the catalyst crystallinity on the catalytic cracking of a 50:50 mixture of polystyrene (PS) and low-density polyethylene (LDPE). This research aims to identify the optimal hydrothermal conditions for producing crystalline zeolite Na-A and evaluate the eff ect of crystallinity of synthesized zeolite Na-A on production of liquids. A central composite design (CCD) model is employed to achieve this, selecting three independent variables: hydrothermal temperature (80, 85, 90, 95 and 100 °C), the molarity of the alkaline solution (NaOH concentration = 1,2,3,4 and 5 molar), and hydrothermal time (8, 10.43, 14, 17.56 and 20 h). Fourier transform infrared spectroscopy (FTIR) determines the functional groups which proves the presence of sodium aluminosilicate in the synthesized zeolite. The crystallinity of the produced zeolite Na-A is evaluated through X-ray diff raction (XRD) analysis, optimizing the results using the CCD model. Scanning electron microscopy (SEM) reveals well-formed cubic crystalline structures of zeolite Na-A. The optimum conditions for polymer cracking are determined as hydrothermal temperature of 89 °C, a hydrothermal time of 13 h, and a NaOH molarity of 2.8, while predicted liquid production was obtained 81%. The analysis of ANOVA indicates that the designed model based on CCD calculations is valid for prediction of the process. Finally, gas chromatography with fl ame ionization detection (GC-FID) is employed to characterize the main resulting value-added components (styrene, toluene, and ethylbenzene) under optimum conditions.

      • SCIEKCI등재

        Molecular Characterization of a Novel Putative Partitivirus Infecting Cytospora sacchari, a Plant Pathogenic Fungus

        Peyambari, Mahtab,Habibi, Mina Koohi,Fotouhifar, Khalil-Berdi,Dizadji, Akbar,Roossinck, Marilyn J. The Korean Society of Plant Pathology 2014 Plant Pathology Journal Vol.30 No.2

        Three double-stranded RNAs (dsRNAs), approximately 1.85, 1.65 and 1.27 kb in size, were detected in an isolate of Cytospora sacchari from Iran. Partial nucleotide sequence revealed a 1,284 bp segment containing one ORF that potentially encodes a 405 aa protein. This protein contains conserved motifs related to RNA dependent RNA polymerases (RdRp) that showed similarity to RdRps of partitiviruses. The results indicate that these dsRNAs represent a novel Partitivirus that we tentatively designate Cytospora sacchari partitivirus (CsPV). Treatment of the fungal strain by cyclohexamide and also hyphal tip culture had no effect on removing the putative virus. Phylogenetic analysis of putative RdRp of CsPV and other partitiviruses places CsPV as a member of the genus Partitivirus in the family Partitiviridae, and clustering with Aspergillus ochraceous virus 1.

      • KCI등재

        Computational Study of Solvent Effects on Characterizations of (E)-3-X-Indoline-2-thiones Derivatives as Antivirus and Anticancer Compounds

        S. Zahra Sayyed-Alangi,Maryam Koohi,Hadi Sajjadi-Ghotabadi 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.8

        (E)-3-X-Indoline-2-thione derivatives (X = phenyl, furan-2-yl, 1H-pyrrole-2-yl, and thiophene-2-yl, I–IV , respectively) are considered as potent and selective inhibitors against different receptor tyrosine kinases. A particularly interesting issue for these biologically active compounds is how their stability is affected by solvation. Here we have tackled this issue using the self-consistent reaction field theory for I– IV , in the gas phase as well as solution including: toluene, CH2Cl2 , MeOH, and H2O. The highest observed total free energy difference between liquid (l) and gas (g) phase (∆E l–g) relates to structure III in water, whereas the lowest ∆E l–g is associated with II in toluene. Thus, III is the most solvent sensitive and enjoys maximum stabilization in water. On the other extreme, II is the least solvent sensitive and its stability is least affected by solvation in toluene. Moreover, stability of each solute (I– IV ) depends on the dielectric constant of the solvent and the possibility of the hydrogen bonding. In going from gas phase to different solvents, considerable changes of nucleophilicity as well as electrophilicity occur for scrutinized structures. The six- and five-membered rings in indoline skeleton for all species show aromatic and nonaromatic property, respectively. Finally, the substituent rings appear the most aromatic property. These phenomena are confirmed by the succeeding geometrical parameters.

      • SCIESCOPUSKCI등재

        Effect of Cholesterol-loaded-cyclodextrin in Presence and Absence of Egg Yolk during Freezing Step on Quality of Markhoz Buck's Spermatozoa

        Farshad, A.,Amidi, F.,Khor, A. Koohi,Rashidi, A. Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.2

        Cryopreservation protocols induce partially irreversible damage to mammalian sperm plasma membranes. Previous studies have indicated that adding cholesterol to the plasma membrane, as cholesterol-loaded-cyclodextrins, improves cryosurvival of sperm. Therefore, the purpose of this study was to determine if treating sperm of Markhoz bucks with cholesterol-loaded-cyclodextrins (CLC) (0, 0.75, 1.5, 2.25 and 3 mg/ml diluted $240{\times}10^6$ sperm/ml) in Tris-citric acid-glucose diluents with and without egg yolk (containing 5% glycerol) would improve the post-thaw sperm quality. The motion characteristics were evaluated with a Computer Assisted System Analyzer (CASA); acrosome integrity and vitality were measured with the triple-stain technique. Samples were recovered before and after freezing by means of putting straws into $37^{\circ}C$ water for 30 sec and then parameters were assessed. The results showed that the treatments significantly affected motility, progressive motility, recovery rate, curvilinear velocity, beat cross frequency, live sperm with reacted acrosome, live sperm with unreacted acrosome, dead sperm with reacted acrosorne, and dead sperm with unreacted acrosome during freezing (p<0.05). However; no significant differences were found for average path velocity, straight line velocity, amplitude of lateral head displacement, straightness and linearity (p>0.05). The best results were observed for extender containing 2.25 mg/ml ($240{\times}10^6$ sperm/ml) CLC supplemented with 2.6% egg yolk. In conclusion, the findings of this study indicate improved Markhoz sperm viability and motility following treatment in the presence of egg yolk.

      • KCI등재

        Transplantation of Neural Stem Cells Cultured in Alginate Scaffold for Spinal Cord Injury in Rats

        Seyed Mojtaba Hosseini,Ali Sharafkhah,Omid Koohi-Hosseinabadi,Maryam Semsar-Kazerooni 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.4

        Study Design: This study investigated the effects of transplantation of alginate encapsulated neural stem cells (NSCs) on spinal cord injury in Sprague-Dawley male rats. The neurological functions were assessed for 6 weeks after transplantation along with a histological study and measurement of caspase-3 levels. Purpose: The aim of this study was to discover whether NSCs cultured in alginate transplantation improve recovery from spinal cord injury. Overview of Literature: Spinal cord injury is one of the leading causes of disability and it has no effective treatment. Spinal cord injury can also cause sensory impairment. With an impetus on using stem cells therapy in various central nervous system settings, there is an interest in using stem cells for addressing spinal cord injury. Neural stem cell is one type of stem cells that is able to differentiate to all three neural lineages and it shows promise in spinal injury treatment. Furthermore, a number of studies have shown that culturing NSCs in three-dimensional (3D) scaffolds like alginate could enhance neural differentiation. Methods: The NSCs were isolated from 14-day-old rat embryos. The isolated NSCs were cultured in growth media containing basic fibroblast growth factor and endothelial growth factor. The cells were characterized by differentiating to three neural lineages and they were cultured in an alginate scaffold. After 7 days the cells were encapsulated and transplanted in a rat model of spinal cord injury. Results: Our data showed that culturing in an alginate 3D scaffold and transplantation of the NSCs could improve neurological outcome in a rat model of spinal cord injury. The inflammation scores and lesion sizes and also the activity of caspase-3 (for apoptosis evaluation) were less in encapsulated neural stem cell transplantation cases. Conclusions: Transplantation of NSCs that were cultured in an alginate scaffold led to a better clinical and histological outcome for recovery from spinal cord injury in a rat model.

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