http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Suppressor Cell Activities of Peripheral Blood Mononuclear Cells in Type B Hepatitis in Korea
Kim, Boo Sung,Lee, Chang Don CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
To examine the possible contribution of cellular immune regulatory mechanism to pathogenesis and progression of type B hepatitis, we evaluated concanavalin A (con A) induced suppressor cell activities of peripheral blood mononuclear cells in patients with acute viral hepatitis (9 cases), chronic hepatitis (27 cases), liver cirrhosis (10 cases), hepatocellular carcinoma (8 cases) and in normal control subjects (25 cases). Con A stimulated suppressor cell activity was assessed in coculture with fresh allogenic peripheral blood mononuclear cells by percent inhibition of blast transformation stimulated by phrtohemagglutmm (PHA). The results were as follows: 1. In the controls (25 normal subjects), the activities of suppressor cells were 14.5±8.9%. No significant difference between sex and age were seen. 2. In acute hepatitis (9 cases), the activities of suppressor cells were 17.9 ± 5.8%. There was no significant difference compare to normal controls. 3. In chronic hepatitis (27 cases), the activities of suppressor cells were 4.2±10.2% (P< 0.005). In seventeen cases of chronic active hepatitis confirmed by histologic examination, the activities of suppressor cells in those with (9 cases) and without cirrhosis (8 cases) were = 2.6±8.7% and 9.2 ± 4.2% respectively. There were significant differences between each group(P<0.0001). The degree of activities of suppressor cells have no correlation with the value of serum alanine aminotransferase in group of chronic active hepatitis (r = 0.18). The activities of suppressor cells were decreased significantly in the group of hepatitis be antigen (HBe Ag) negative compare with those of HBe Ag positive (P<0.05). 4. In cirrhosis (10 cases), the activities of suppressor cells were 11.1±9.6%. There was no significant difference with the normal controls. 5. In hepatocellular carcinoma (8 cases), the activities of suppressor cells were 6.8 ± 11.6%. There was no significant difference with the normal controls. It suggested that the assessment of the suppressor cell activities induced by Con A might be playing an important role for prediction of histological status of patient with hepatitis type B. Furthermore the suppressor cell activity may have an important effect on immuno-modulation in chronic active hepatitis type B.
Prognostic Value of Pre- and Post-Treatment FDG PET/CT Parameters in Small Cell Lung Cancer Patients
Kim, Hyoungwoo,Yoo, Ie Ryung,Boo, Sun Ha,Park, Hye Lim,O, Joo Hyun,Kim, Sung Hoon 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.1
Purpose To evaluate the prognostic value of PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC. Methods Fifty-nine patients with initially diagnosed SCLC from 2009 to 2014 were included and had chemotherapy and/or concurrent chemoradiotherapy. FDG PET/CT examinations were performed before (PET1) and after (PET2) treatment to evaluate treatment response. A region of interest was placed over the primary lesion and metastatic lymph nodes within the thoracic cavity. PET parameters including change from PET1 to PET2 (${\Delta}$ in %) were acquired: SUVmax, SUVpeak, MTV2.5, TLG, ${\Delta}SUVmax$, ${\Delta}SUVpeak$, ${\Delta}MTV$ and ${\Delta}TLG$. Patient characteristics including staging, age, sex, LDH and response evaluation by RECIST were surveyed. Statistical analysis was done using Kaplan-Meier method and Cox regression analysis with respect to OS and PFS. Results The median follow-up was 9.6 months (2.5-80.5 months). 27 patients were LD and 32 were ED. Forty-six patients (78.0%) had died, and median OS was 8.6 months; 51 patients (86%) showed disease progression, and median PFS was 2.5 months. On univariate analysis, patients with ED, high interval change (${\Delta}SUVmax$ and ${\Delta}SUVpeak$) and low PET2 parameters showed longer OS and PFS. Multivariate analyses demonstrated that ${\Delta}SUVpeak$ (HR 2.6, P = 0.002) was an independent prognostic factors for OS, and MTV2.5 of PET2 (HR 2.8, P = 0.001), disease stage (HR 2.7, P = 0.003) and RECIST (HR 2.0, P = 0.023) were independent prognostic factors for PFS. Conclusions Metabolic and volumetric PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC have significant prognostic information.