http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mihee Hong,Inhwan Kim,Jin-Hyoung Cho,Kyung-Hwa Kang,Minji Kim,Su-Jung Kim,Yoon-Ji Kim,Sang-Jin Sung,Young Ho Kim,Sung-Hoon Lim,Namkug Kim,Seung-Hak Baek 대한치과교정학회 2022 대한치과교정학회지 Vol.52 No.4
Objective: To investigate the pattern of accuracy change in artificial intelligence-assisted landmark identification (LI) using a convolutional neural network (CNN) algorithm in serial lateral cephalograms (Lat-cephs) of Class III (C-III) patients who underwent twojaw orthognathic surgery. Methods: A total of 3,188 Lat-cephs of C-III patients were allocated into the training and validation sets (3,004 Lat-cephs of 751 patients) and test set (184 Lat-cephs of 46 patients; subdivided into the genioplasty and non-genioplasty groups, n = 23 per group) for LI. Each C-III patient in the test set had four Lat-cephs: initial (T0), pre-surgery (T1, presence of orthodontic brackets [OBs]), post-surgery (T2, presence of OBs and surgical plates and screws [S-PS]), and debonding (T3, presence of S-PS and fixed retainers [FR]). After mean errors of 20 landmarks between human gold standard and the CNN model were calculated, statistical analysis was performed. Results: The total mean error was 1.17 mm without significant difference among the four timepoints (T0, 1.20 mm; T1, 1.14 mm; T2, 1.18 mm; T3, 1.15 mm). In comparison of two time-points ([T0, T1] vs. [T2, T3]), ANS, A point, and B point showed an increase in error (p < 0.01, 0.05, 0.01, respectively), while Mx6D and Md6D showeda decrease in error (all p < 0.01). No difference in errors existed at B point, Pogonion, Menton, Md1C, and Md1R between the genioplasty and non-genioplasty groups. Conclusions: The CNN model can be used for LI in serial Lat-cephs despite the presence of OB, S-PS, FR, genioplasty, and bone remodeling.
Sunjin Yim,Sungchul Kim,Inhwan Kim,Jae-Woo Park,Jin-Hyoung Cho,Mihee Hong,Kyung-Hwa Kang,Minji Kim,Su-Jung Kim,Yoon-Ji Kim,Young Ho Kim,Sung-Hoon Lim,Sang Jin Sung,Namkug Kim,Seung-Hak Baek 대한치과교정학회 2022 대한치과교정학회지 Vol.52 No.1
Objective: The purpose of this study was to investigate the accuracy of one-step automated orthodontic diagnosis of skeletodental discrepancies using a convolutional neural network (CNN) and lateral cephalogram images with different qualities from nationwide multi-hospitals. Methods: Among 2,174 lateral cephalograms, 1,993 cephalograms from two hospitals were used for training and internal test sets and 181 cephalograms from eight other hospitals were used for an external test set. They were divided into three classification groups according to anteroposterior skeletal discrepancies (Class I, II, and III), vertical skeletal discrepancies (normodivergent, hypodivergent, and hyperdivergent patterns), and vertical dental discrepancies (normal overbite, deep bite, and open bite) as a gold standard. Pre-trained DenseNet-169 was used as a CNN classifier model. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis, t-stochastic neighbor embedding (t-SNE), and gradientweighted class activation mapping (Grad-CAM). Results: In the ROC analysis, the mean area under the curve and the mean accuracy of all classifications were high with both internal and external test sets (all, > 0.89 and > 0.80). In the t-SNE analysis, our model succeeded in creating good separation between three classification groups. Grad-CAM figures showed differences in the location and size of the focus areas between three classification groups in each diagnosis. Conclusions: Since the accuracy of our model was validated with both internal and external test sets, it shows the possible usefulness of a one-step automated orthodontic diagnosis tool using a CNN model. However, it still needs technical improvement in terms of classifying vertical dental discrepancies.
Low-Cost Fabrication of Transparent Hard Replica Molds for Imprinting Lithography
Kim, Joohee,Kim, Mihee,Lee, Min Jung,Lee, Ji Soo,Shin, Kyusoon,Kim, Youn Sang WILEY-VCH Verlag 2009 Advanced Materials Vol.21 No.40
<B>Graphic Abstract</B> <P>A new and cost-effective replica fabrication method for transparent and hard molds used in imprinting lithography is presented. The process uses a polymer copy as a carrier. Replicated hard molds eliminate the need for direct contact between the master and the patterned polymer on the substrate, and thus reduce contamination of the master. <img src='wiley_img/09359648-2009-21-40-ADMA200803243-content.gif' alt='wiley_img/09359648-2009-21-40-ADMA200803243-content'> </P>
Kim, Eunjung,Kim, Changhwan,Yang, Bokyung,Kim, Mihee,Kang, Jingu,Lee, Jiun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.4
Eosinophilic pleural effusion (EPE) is defined as a pleural effusion that contains at least 10% eosinophils. EPE occurs due to a variety of causes such as blood or air in the pleural space, infection, malignancy, or an autoimmune disease. Undifferentiated connective tissue disease (UCTD) associated with eosinophilic pleural effusion is a rare condition generally characterized by the presence of the signs and symptoms but not fulfilling the existing classification criteria. We report a case involving a 67-year-old man with UCTD and EPE, who has been successfully treated with a single intrapleural corticosteroid injection.
Mihee Kim,TaeHyung Kim,Seo-Yeon Ahn,Jun Hyung Lee,Ju Heon Park,Myung-Geun Shin,Sung-Hoon Jung,Ga-Young Song,Deok-Hwan Yang,Je-Jung Lee,Seung Hyun Choi,Mi Yeon Kim,Jae-Sook Ahn,Hyeoung-Joon Kim,Dennis 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.4
Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy. Methods: A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We analyzed the dynamics of variant allele frequency (VAF) in 49 available follow-up samples after the fourth cycle of decitabine. The 58.6% VAF clearance (Δ, [VAF at diagnosis − VAF at follow-up] × 100 / VAF at diagnosis) was the optimal cut-off for predicting overall survival (OS). Results: The overall response rate was 34.1% (eight patients with complete remission [CR], six of CR with incomplete hematologic recovery, 22 with partial responses, and six with morphologic leukemia-free status). Responders (n = 42) had significantly better OS compared with non-responders (n = 42) (median, 15.3 months vs. 6.5 months; p < 0.001). Of the 49 patients available for follow-up targeted NGS analysis, 44 had trackable gene mutations. The median OS of patients with ΔVAF ≥ 58.6% (n=24) was significantly better than that of patients with ΔVAF < 58.6% (n = 19) (20.5 months vs. 9.8 months, p = 0.010). Moreover, responders with ΔVAF ≥ 58.6% (n = 20) had a significantly longer median OS compared with responders with VAF < 58.6% (n = 11) (22.5 months vs. 9.8 months, p = 0.004). Conclusions: This study suggested that combining ΔVAF ≥ 58.6%, a molecular response, with morphologic and hematologic responses can more accurately predict OS in elderly AML patients after decitabine therapy.
Kim, Jin Chul,Jung, Jungwoon,Rho, Yecheol,Kim, Mihee,Kwon, Wonsang,Kim, Heesoo,Kim, Ik Jung,Kim, Jung Ran,Ree, Moonhor American Chemical Society 2011 Biomacromolecules Vol.12 No.7
<P>Two new DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)ethylene] (PECH-AS). These polymers were found to be thermally stable up to 220 °C and could be applied easily by conventional coating processes to produce good quality films. Interestingly, both brush polymers formed molecular multibilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. However, the high hydrophilicity and good water sorption characteristics of the PECH-AS film suggest that this brush polymer is better suited to applications requiring good biocompatibility and reduced chance of bacterial infection compared with the PECH-AP film.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-7/bm200572t/production/images/medium/bm-2011-00572t_0012.gif'></P>
Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus
( Mihee Hong ),( Hee Yeon Kim ),( Hannah Seok ),( Chang Dong Yeo ),( Young Soo Kim ),( Jae Yen Song ),( Young Bok Lee ),( Dong-hee Lee ),( Jae-im Lee ),( Tae-kyu Lee ),( Hyo-suk Ahn ),( Yoon Ho Ko ),( 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.5
Background/Aims: This study examined prevalence and risk factors of periodontitis in representative samples of Korean adults, with and without diabetes mellitus (DM). Methods: Data from the 2012 Korean National Health and Nutritional Examination Survey were analyzed. A total of 4,477 adults (≥ 30 years old) were selected from 8,057 individuals who completed a nutrition survey, a self-reported general health behavior questionnaire, an oral examination, an oral hygiene behaviors survey, and laboratory tests. DM was defined as a fasting plasma glucose ≥ 126 mg/dL, or self-reported diagnosed diabetes, or current use of oral hypoglycemic agents and/or insulin. The community periodontal index was used to assess periodontitis status and comparisons between the periodontitis and the non-periodontitis group, were performed, according to the presence of DM. Risk factors for periodontitis in adults with DM and without DM were evaluated by multiple logistic regression analysis. Results: The prevalence of periodontitis was significantly higher in adults with DM (43.7%) than in those without DM (25%, p < 0.001). In adults without DM, risk factors for periodontitis were older age, male, urban habitation, waist circumference, smoking, oral pain, and less frequent tooth brushing. Significant risk factors for periodontitis in adults with DM were the smoking, oral pain, and not-using an oral hygiene product. Conclusions: Adults with DM have an increased risk of periodontitis than those without DM. Current smoking and oral pain increase this risk. Using an oral hygiene product can reduce risk of periodontal disease in adults with DM.
Kim, Mihee,Kim, Jin Chul,Rho, Yecheol,Jung, Jungwoon,Kwon, Wonsang,Kim, Heesoo,Ree, Moonhor The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.37
<P>In this study we synthesized a series of well-defined brush polymers, poly(oxy(11-(3-sulfonylpropyltrimethylglycinyl)undecylesterthiomethyl)ethylene-<I>co</I>-oxy(<I>n</I>-dodecylthiomethyl)-ethylene)s (PECH-DMAPS<I>m</I>, where <I>m</I> is the mol% of DMAPS (sulfobetaine) end group). The thermal properties and phase transitions of these polymers were investigated. The polymers were thermally stable up to 185 °C. The polymers were found to form favorably into multi-bilayer structures, always providing hydrophilic, zwitterionic sulfobetaine end groups at the film surface. For the films, water sorption behavior was examined. In addition, surface energy components were determined for the polymer films and the bacterial cells deposited on cellulose acetate membranes. The brush polymer films were found to suppress bacterial adherence significantly. An understanding of the suppression of bacterial adherence was attempted in terms of surface energies and thermodynamics. The results collectively indicate that the sulfobetaine-containing brush polymers are suitable for use in biomedical applications that require the reduced possibility of post-operative infection.</P> <P>Graphic Abstract</P><P>The adherences of bacteria on self-assembled films of sulfobetaine-containing brush polymers were quantitatively investigated in aspects of surface characteristics and thermodynamics. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm15912k'> </P>
( Mihee Kim ),( Hyun-jin Bang ),( Ga-Young Song ),( Seo-Yeon Ahn ),( Sung-hoon Jung ),( Yong-su Song ),( Jae-sook Ahn ) 대한전해질학회 2021 Electrolytes & Blood Pressure Vol.19 No.2
Combination treatment with hypomethylating agents (HMAs) and venetoclax is being used increasingly in elderly patients with acute myeloid leukemia (AML). Venetoclax with HMAs has been reported to be associated with tumor lysis syndrome (TLS) in AML patients with high leukemic burden. We present a case of an elderly AML patient with low leukemic burden who developed TLS while receiving venetoclax and azacitidine (AZA). A 74-year-old man with newly diagnosed AML with NPM1 mutation received combination therapy with venetoclax and AZA in an outpatient clinic. Within 12 hours after starting venetoclax and AZA, the patient was admitted to the emergency room with fever, general weakness, and laboratory findings consistent with TLS. Based on our results, we recommend monitoring at the start of the treatment with venetoclax and HMAs to prevent and control TLS regardless of the leukemic burden and favorable genetic risk.