개에서 발생한 폐수종의 치료 증례

김유수,심재현,김건우,김지용,이병희,송근호,이영원,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A 9 months intact male American bull dog with chief complaints of dry cough, dyspnea and fever was referred to the Veterinary Teaching Hospital, Chungnam National University. Based on the findings of physical examination, radiological examination, and blood and blood chemical examinations, the present patient was diagnosed into pulmonary edema secondary to primary bacterial and aspiration pneumonia. The patient was hospitalized and treated with buscopan, cephazolin and furosemide for 1 week. His activity and appetite was returned to normal and thoracic radiographs revealed that Jung was recovered to the normal condition after treatment for 7 days. The present patient was a case with pulmonary edema showed favorable therapeutic responses to proper medication.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

Treadmill 운동부하시 비만중년 여성의 유산소능력, 심근산소소비 및 심전도 ST의 변화

김종덕,최건식,황수관 대한스포츠의학회 1994 대한스포츠의학회지 Vol.12 No.2

The purpose of this study was to examine changes in aerobic capacity, MV´O_2, and ST segment at electrocardiography during treadmill exercise. Forty-six obese women, ranged in age from 40s-50s yr, were divided into four groups; 1) Contorl group 1(N=10, body fat < 35%), 2) Cotrol group 2(N=12, 25 < body fat <30%), 3) obese group 1(N=11, 30% < body fat <35%), and 4) Obese group 2(N=13, 35% < body fat). The findings of this study were as follows. 1. Subjects with higher percent of body fat showed lower LBM and percent of body fluid. 2. Every group showed a significant increase in HR after one minute of exercise, and gradual increase in HR during the first 2 of 3minutes of exercise. Increase in heart rate of obese group 2 was higher that that of other groups during exercise. 3. The blood pressure of obese groups both at rest and during exercise was higher than that of control group. 4. There was no big difference in V´O_2 between four groups at rest and before 5 minutes of exercise. After 5 minutes of exercise, V´O_2 of obese group 2 increased significantly. Subjects who had higher percent of body fat showed lower V´O_2max. 5. There was no big difference in energy expenditure between four groups at rest of during 5 minutes exercise. After 5 minutes of exercise, energy expenditure was significantly increased in obese group 2. 6. The MV´O_2 of each groups after one minute of exercise increased twice or more than that of the same group at rest. The MV´O_2 of obese groups was larger than that of control groups. 7. The Regression equations between HR per minute and SBP, V´O_2 and MV´O_2 were obtained from the study. The Regression equations of HR per minute was significantly correlated to SBP, V´O_2, and MV´O_2. 8. The ST level of each group. during exercise, decreased approximately 50% of the same group at rest, while the ST slope increased approximately twice of three times of the same group at rest. The study found two interesting facts: firstly, LBM and body fluid were inversely proportional to percent of body fat. Furthermore, there was a small difference between control groups and obese group 1, while big difference existed between control groups and obese group 2. It is noted that BP, V´O_2, and MV´O_2. could be measured only from HR per minute using regression equations. Moreover, ST level decreases while ST slope increases.

고기능 치재용 시멘트 및 세척용 화학용액 개발

김종수,송근호,오한기,이광래 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

치과용 도구세척을 위한 화학용액을 개발하기 위하여, 상용 치과재료용 화학용액의 주성분을 바탕으로 분해성능에 영향을 미치는 성분, 조성, 조건에 대한 연구를 수행하였다. 분해성능은 온도가 높을수록, 초음파의 세기가 클수록 향상되었다. 화학용액에 첨가된 계면활성제는 분해를 촉진시켰으며 계면활성제의 종류에 따라 부내성능에 큰 차이를 보였다. 알콜류는 분해성능을 저하시키는 나타났으며 시멘트류는 NaOHtndyddor에, 석고류는 sodium bicarbonate 수용액에서 뛰어난 분해성능을 보였다. Chemical solutions were prepared and the effects of chemical composition of decomposition ability of cleaning solution for dental instruments were studied. With high temperature and ultrasonic intensity, decomposition ability of cleaning solution were improved. Certain surfactants(Miwon Commercial Co. Ltd) such as amine oxides and alkanol amides accelerated decomposition rate of cleaning solution. Alcohols added to solution made worse the decomposition capability of cleaning solution. Dental cements and gypsums were well decomposed in sodium hydroxide aqueous solution and sodium bicarbonate aqueous solution respectively.

^(99m)TC Phytate 간스캔에 있어서 정량적 간외섭취율의 임상적 의의

김병수,문태용,김건일,남상화,한국상 부산의대 1991 부산의대잡지 - 부산대학교 의과대학 Vol.31 No.2

은유와 의미

김건수 한국강원영어영문학회 1998 영어영문학 Vol.17 No.1

The study on the metaphors has been analyzed on the basis of mainly Aristotle's rhetoric views in the literature, but since 1950, it has become as an important issue in the linguistics, too. The method on it has been approached by the way of semantic, philosophical and psychological aspects, and it is roughly divided into three categories: substitution theory, comparison theory, and interaction theory. In this paper, the comparison theory was focused on by the 'the comparative system of figurative' which I strongly compared as the speed of the automobile is controlled by the transirnission device(gear box). Namely all of the figures: similes, metonomies, synecdoches and metaphors are controlled by 'the comparative system of figure' in our linguistic competence. It could be a simple sentece like 'A is x', a simile of 'A is as ∼ as B or A is like B', or a metaphor like 'A is B'. Chapter 3 Ⅰ made interpretation rules of metaphors centering round the focused noun phrases. Namely, 'A is B' metaphors translated by the rules of (25), 'A does' metaphors by (28). and 'A does B' metaphors by (31).

건축공간에서 창에 의한 관념적 공간인지에 관한 연구

김정환,오건수 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

Concept of space is one of endless discussion topics and research's targets until now a days from ancient time. Concept of space in architecture was well-known in late 19th century, and was used as a important principle. Many architects made architectural space from the basis of these concept of space, and made ideation space through window. This study is to interpret existence and possibility of such space called ideological cognitive space which is shown through window.