A Comparative Study on the Bioethics Consciousness of University Students on the Life-sustaining Treatment Decision Act

Junghyun Kim(Junghyun Kim),Dae-Eun Kim(Dae-Eun Kim),Eunseok Park(Eunseok Park),Dae-Jin Kim(Dae-Jin Kim),Hwanhee Kim(Hwanhee Kim) 한국보건의료윤리학회 2023 한국보건의료윤리학회지 Vol.2 No.1

Background: The purpose of this study is to provide basic data on the necessity and direction of education to establish a desirable bioethics view by identifying bioethics awareness of the Life-sustaining Treatment Decision Act among biomedical laboratory science student and nursing students attending K University. Methods: From October 30 to November 5, 2022, the final 279 people (144 in biomedical laboratory science and 135 in nursing) were analyzed through a structured survey of 29 questions. Results: As a result of comparing the presence or absence of learning and the degree of awareness of the life-sustaining treatment decision act, the presence or absence of learning p<.001. There was a statistically significant difference in cognitive degree p<.001. Conclusion: It is suggested that continuous research should be conducted to confirm the perception of biomedical ethics of Biomedical laboratory science students and nursing students and to find the need and direction of education to establish a desirable bioethics.

Enhanced solubility of galangin based on the complexation with methylated microbial cyclosophoraoses

Kim, Hwanhee,Choi, Jae Min,Choi, Youngjin,Tahir, Muhammad Nazir,Yang, Yung-Hun,Cho, Eunae,Jung, Seunho Springer-Verlag 2014 Journal of inclusion phenomena and macrocyclic che Vol.79 No.3

Changes in epidemiology of parainfluenza virus and respiratory syncytial virus infection during coronavirus disease 2019 pandemic in Korea

Kim Kyung-Ran,Park Hwanhee,Kim Doo Ri,김예진 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.6

.

고혈관성 종양으로 오인된 Trichophyton verrucosum에 의한 두피 백선종창 1례

Kim Kyung-Ran,Park Hwanhee,Kim Doo Ri,Yoon Yoonsun,Jeon Chiman,Lee Sanghoon,Lim So Young,Kim Ji Hye,Kim Yae-Jean 대한소아감염학회 2022 Pediatric Infection and Vaccine Vol.29 No.2

A dermatophyte is a zoonotic infection that causes infection on the skin, hair, and nails and is transmitted through contact. The species of Microsporum, Trichophyton, and Epidermophyton are the major dermatophytes that infect humans. Tinea capitis is a dermatophyte infection in the scalp, and it may progress to kerion celsi, including severe redness, swelling, and pus formation. Kerion celsi is sometimes misdiagnosed as a bacterial infection or a tumor. Trichophyton verrucosum is a zoophilic dermatophyte that mainly causes infection in cattle. It can be spread to dairy farmers or ranchers who have frequent contact with infected cattle. We report a pediatric case who received scalp tumor excision and a split-thickness skin graft for extensive and severe inflammatory scalp tumors that occurred after contact with cattle with ringworm. Finally, the patient was diagnosed with kerion celsi caused by T. verrucosum infection. This was based on the patient’s medical history, clinical manifestations, and histopathologic findings. 피부사상균은 접촉을 통해 피부, 모발, 손발톱 등에 감염을 일으키며, 심한 경우 백선종창으로 진행되기도 한다. 건강했던 4세 여자 환자가 심한 두피병변으로 내원하여 세균, 진균감염뿐만 아니라 고혈관성 종양도 의심되어 두피 종양 절제술과 피부이식까지 받았다. 저자들은 면밀한 병력청취와 신체 진찰 및 임상양상을 토대로 Trichophyton verrucosum을 의심하여, 최종적으로 조직병리검사 소견을 종합하여 T. verrucosum에 의한 백선종창으로 진단 및 치료한 증례 1 례를 보고하는 바이다.

Digital operating tip-enhanced Raman spectroscopy

Kim Hwanhee,Moon Taeyoung,Lee Hyeongwoo,Koo Yeonjeong,Kang Mingu,Park Kyoung-Duck,An Sangmin 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.6

Tip-enhanced Raman spectroscopy (TERS) can investigate structural and optical characteristics of a range of materials with high optical sensitivity. However, it is not widely deployable due to the complicated hardware confguration of atomic-force microscopy (AFM) part, which is required for TERS. Here, we present a digital operating TERS by replacing the conventional instruments, such as a function generator, a lock-in amplifer, and a PID controller, with the digital algorithms in computer to simplify the confguration. We verify the comparable performance of the digital AFM and the conventional analog AFM by performing control experiments, e.g., frequency response curves, approach curves, and topography measurements. In addition, we demonstrate the simple digital processes to decrease the AFM noise level by optimizing the time constant and the data sampling rate. Furthermore, we demonstrate the gap-dependent and time-dependent TERS spectra for brilliant cresyl blue molecules, which confrms the robust acquisition of nano-spectroscopic responses in ambient conditions. This work provides a facile way to easily build tip-enhanced nano-spectroscopy with a compact apparatus.

소아 신장이식 환자에서 발생한 파르보바이러스 B19에 의한 심한 빈혈에 대한 증례 보고 및 문헌 고찰

Kim Kyung-Ran,Park Hwanhee,Kim Doo Ri,Cho Heeyeon,Lee Sanghoon,Lee Suk-Koo,Kim Yae-Jean 대한소아감염학회 2021 Pediatric Infection and Vaccine Vol.28 No.3

Anemia commonly occurs in kidney transplantation (KT) recipients. Many factors such as viral infection, bleeding, erythropoietin deficiency, and immunosuppressants are the causes of chronic anemia in KT recipients. We report 2 cases who developed severe anemia caused by parvovirus B19 infection and were successfully treated with intravenous immunoglobulin in pediatric KT recipients. 신장이식 환자에서 만성 빈혈은 치료 과정 중 발생하는 합병증으로 바이러스 감염, 적혈구형성호르몬결핍, 출혈, 면역억제제의 부작용 등과 관련이 있다. 신장이식 환자에서 파르보바이러스 B19에 의한 빈혈은 초감염 혹은 기존 감염의 재활성화로 발생할 수 있으며, 아직 이에 대한 치료법은 정립이 되어 있지 않다. 특히, 소아청소년 신장이식 환자에 대한 보고나 자료는 더욱 드물다. 저자들은 소아청소년 신장이식 환자에서 발생한 심각한 빈혈을 파르보바이러스 B19 PCR 검사법으로 진단하고, 정맥내글로불린으로 재발 없이 성공적으로 치료한 두 증례와 문헌 고찰을 보고하는 바이다.

Complications of the Central Nervous System in Pediatric Patients With Common Cold Coronavirus Infection During 2014–2019

Park Hwanhee,Kim Kyung-Ran,Huh Hee Jae,Yoon Yoonsun,Park Esther,Cho Joongbum,Lee Jiwon,Lee Jeehun,Kim Ji Hye,Kim Yae-Jean 대한의학회 2023 Journal of Korean medical science Vol.38 No.46

Background: In pediatric patients, the common cold coronavirus (ccCoV) usually causes mild respiratory illness. There are reports of coronavirus causing central nervous system (CNS) infection in experimental animal models. Some immunocompromised patients have also been reported to have fatal CNS infections with ccCoV. The aim of this study was to investigate the clinical characteristics of CNS complications related to ccCoV infection. Methods: From January 2014 to December 2019, a retrospective analysis was performed of medical records from hospitalized patients under 19 years of age whose ccCoV was detected through polymerase chain reaction in respiratory specimens. The CNS complications were defined as clinically diagnosed seizure, meningitis, encephalopathy, and encephalitis. Results: A total of 436 samples from 420 patients were detected as ccCoV. Among the 420 patients, 269 patients were immunocompetent and 151 patients were immunocompromised. The most common type of ccCoV was OC43 (52% in immunocompetent, 37% in immunocompromised). CNS complications were observed in 9.4% (41/436). The most common type of CNS complication was the fever-provoked seizure under pre-existing neurologic disease (42% in immunocompetent and 60% in immunocompromised patients). Among patients with CNS complications, two immunocompetent patients required intensive care unit admission due to encephalitis. Three patients without underlying neurological disease started anti-seizure medications for the first time at this admission. There was no death related to ccCoV infection. Conclusion: ccCoV infection may cause severe clinical manifestations such as CNS complications or neurologic sequelae, even in previously healthy children.

제석사지 폐기유적의 시기와 형성에 대한 재검토

김환희(Kim, Hwanhee),이나은(Lee, Naeun),우상은(Woo, Sangeun),조지현(Cho, Jihyun) 한국고고학회 2021 한국고고학보 Vol.- No.118

제석사지 폐기유적은 제석사가 639년 뇌우로 인해 불탄 후 발생한 폐기물을 일시에 버렸던 장소로 알려져있다. 그러나 3년간 진행된 발굴조사 결과 폐기는 일시에 이루어진 것이 아니라 최소 2차례 이루어졌다는 사실이 확인되어, 기존의 논의를 재검토할 필요가 대두되었다. 또한 제석사보다 고도가 높은 곳에 위치한 제석사지 폐기유적의 입지상 비효율성을 어떻게 해석하고 받아들일 것인지에 대한 이견도 여전히 존재한다. 이에 본고에서는 제석사지 폐기유적의 발굴조사에서 보고된 폐기양상의 면밀한 검토, 출토유물의 과학적 분석, 시대별 지형 분석, 국내외 고대 사찰의 폐기장소 유사 사례 검토 등 다각적인 접근을 통해 유적의 시기, 성격, 형성 과정 등을 규명하였다. 먼저 층위양상 검토와 출토유물 분석 결과, 1차 폐기층 형성 → 1호 석곽묘 조성 → 1호 석곽묘 훼손 및 노출 → 2차 폐기층 형성이라는 4단계의 변화 과정을 거쳐 형성되었음을 확인하였다. 특히 2차 폐기 원인으로는 제석사 재건과 관련된 대지 정리 작업에서 나타난 것으로 추정하였다. 다음으로 출토유물의 과학적 분석을 통해 가마가 아닌 화재로 인하여 발생한 2차 피열임을 확인하여 유적의 성격이 폐기유적임을 규명하였다. 마지막으로 지형 분석 결과, 폐기유적이 곡부가 시작되는 끝자락에 입지한 점을 통해 시각적으로 폐기물을 감추기 최적화한 곳으로 추정하였다. 또한, 두 유적을 직접 잇는 서쪽의 도로가추가로 확인되어 폐기물 운반의 새로운 루트와 효율성을 확인하였다. 또한 국내외 고대 사찰의 폐기장소 유사 사례를 검토한 결과, 폐기행위는 규칙성 없이 상황에 따라 취사선택되어 형성된 것임을 파악하였다. It has been known, based on reviews of literature records and the results of excavation research, that the Jeseoksa Dump-site was a place where waste that was produced as a result of the fire started by the thunderstorm of 639 was disposed of. However, the results of excavations that took place over three years has revealed that the act of disposal did not take place over one occasion but took place twice. It has therefore become necessary to review existing discussions that have taken place on this topic. Different opinions still exist over how to interpret the Jeseoksa Dump-site, as well as how to come to terms with the inefficient location of the Dump-site, which was located at a higher altitude than the Jeseoksa Temple site. In an effort to investigate the formation process, period, and nature of the feature, this study conducted a multi-faceted review which included an analysis of the topography of the area where the Dump-site had been located according to period, an examination of the disposal patterns confirmed through excavation, the undertaking of scientific analysis on the artifacts excavated at the site, and a review of similar cases from home and abroad. The topographic analysis results revealed an additional road to the west that connected to the Jeseoksa Dump-site, which leads to the suggestion that road conditions had been suitable enough to enable transportation in the area. In addition, the Dump-site stood at the end of the curved section where the road started, which suggests that its location had been chosen due to its suitability for hiding the Dump-site. A review of the stratigraphy and an analysis of the excavated artifacts indicates that disposal took place over four stages in the following order of formation: the first disposal layer, the construction of the first stone-lined tomb, the damage and exposure of the first stone-lined tomb, and formation of the second disposal layer. In particular, it was estimated that the cause of the second disposal event was the clearing of the site related to the reconstruction of Jeseoksa Temple site. The scientific analysis results of the excavated artifacts demonstrate that the second instance of heating had been caused by a fire rather than a kiln. Finally, the study reviewed similar cases from home and abroad and found that similar acts of disposal took place according to emerging needs in an irregular fashion.

Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification.

Oh, Hwanhee,Ryu, Je-Hwang,Jeon, Jimin,Yang, Siyoung,Chun, Churl-Hong,Park, Hongryeol,Kim, Hyung Joon,Kim, Woo-Shin,Kim, Hong-Hee,Kwon, Young-Guen,Chun, Jang-Soo Mary Ann Liebert, Inc 2012 Journal of bone and mineral research Vol.27 No.6

<P>Developing cartilage serves as a template for long-bone development during endochondral ossification. Although the coupling of cartilage and bone development with angiogenesis is an important regulatory step for endochondral ossification, the molecular mechanisms are poorly understood. One possible mechanism involves the action of Dickkopf (DKK), which is a family of soluble canonical Wnt antagonists with four members (DKK1-4). We initially observed opposite expression patterns of Dkk1 and Dkk2 during angiogenesis and chondrocyte differentiation: downregulation of Dkk1 and upregulation of Dkk2. We examined the in vivo role of Dkk1 and Dkk2 in linking cartilage/bone development and angiogenesis by generating transgenic (TG) mice that specifically express Dkk1 or Dkk2 in chondrocytes, hypertrophic chondrocytes, or endothelial cells. Despite specific expression pattern during cartilage development, chondrocyte- and hypertrophic chondrocyte-specific Dkk1 and Dkk2 TG mice showed normal developmental phenotypes. However, Dkk1 misexpression in endothelial cells resulted in defects of endochondral ossification and reduced skeletal size. The defects are caused by the inhibition of angiogenesis in developing bone and subsequent inhibition of apoptosis of hypertrophic chondrocytes and cartilage resorption.</P>

송산리 29호분의 시기와 계통에 대한 검토: 최신 조사·연구 성과를 바탕으로

김환희(Kim Hwanhee),이나은(Lee Naeun) 한국고고학회 2021 한국고고학보 Vol.- No.120

송산리 29호분은 구조적으로 전통적인 석실에 새로운 전실의 요소가 가미된 구조로, 당시 사회·문화상이 장례문화에 직접적으로 영향을 주고 있음을 보여준다. 송산리고분군의 가계는 북동쪽 구릉에 위치한 1~4호분을 문주왕-삼근왕계로, 남서쪽 구릉에 위치한 무령왕릉, 5·6·29호분을 무령왕계로 정리하였다. 고분의 축조 순서는 입지적 특징과 구조, 출토유물(관정) 등을 검토한 결과, 2~4호분 → 1호분 →무령왕릉→6호분→5호분→29호분으로 추정하였다. 다음으로 일제강점기에 조사 보고되었던 내용과 최근 실시된 29호분의 재발굴조사 성과를 종합하여, 29 호분의 시기와 계통에 대한 검토를 진행하였다. 시기를 파악할 수 있는 중요한 단서는 29호분에서 출토된 화형두정, 반구형원두정, 평방두정이었다. 화형두정과 평방두정의 경우 웅진기에도 계속 사용되지만, 반구형원두정의 경우 사비천도를 전후한 시기인 6세기 중엽에 등장한 것으로 편년되어서, 유물 간의 시기 차이가 확인된다. 즉 29호분에서 출토된 반구형원두정도 6세기 중엽으로 편년할 수 있으며, 반구형원두정과 평방두정이조합된 목관B는 6세기 중엽, 즉 사비기 초에 추가장된 것으로 추정된다. 마지막으로 29호분의 피장자가 누구인지(계통)를 추정하였다. 29호분의 피장자는 무령왕계의 혈족으로, 가계의 마지막 단계에 매장된 것으로 파악하였다. 또한 앞서 검토한 여러 내용들을 종합하여 당시 29호분의매장 상황을 그려보면, 웅진기 말에 사망한 왕족 여성이 목관A에 입관되어 서쪽 관대에 안치된 이후, 6세기 중엽, 즉 사비기 초에 사망한 왕족 남성이 목관B에 입관된 후 동쪽 관대에 안치된 것으로 추정된다. S ongsan-ri Tomb No. 29 represents a merging of the use of brick with the traditional stone chamber tomb architecture, illustrating that the social and cultural aspects had direct impact on the burial culture of the time. The tombs of Songsan-ri have been established as follows: Tombs No. 1 to No. 4 located along the northeast hill belong to the line of King Munju to King Samgeun; the Tomb of King Muryeong and Tombs No. 5, No. 6, No. 29, located along the southwest hill belong to the line of King Muryeong. An examination of their construction order, based on location, structural features, and artifacts (in particular, coffin nails), can be suggested as follows: Tombs No. 2 to No. 4 were first built, followed by Tomb No. 1, the Tomb of King Muryeong, and Tombs No. 6, No. 5 and No. 29, in that order. This study then reviewed the temporal position and genealogy of Tomb No. 29 by putting together the survey reports dating to the period of Japanese Occupation and the recent re-excavation survey of the tomb. Important clues for figuring out the time period of construction were found in the coffin nails with flower-shaped head, semi-globular head, and square head excavated in Tomb No. 29. It is presumed that the coffin nails with flower- shaped and square heads were used during the Ungjin period, whereas coffin nails with semi-globular heads were seemingly produced in the middle of the sixth century, around the time of the relocation of the capital to Sabi. This suggests that wooden coffin B from Tomb No. 29, featuring a combination of coffin nails with semi-globular and square heads, was added to the tomb in the middle sixth century, in the early part of the Sabi period. Finally, this study explored the identity (geneaolgy) of the deceased buried in Tomb No. 29. It was suggested that one of King Muryeong’s kin was buried in the tomb at the last stage. In considering together various lines of evidence previously discussed, it was established that after a royal female had passed away at the end of Ungjin period, was put into wooden coffin A, and placed upon the western coffin bed, a royal male had passed away in the middle of the sixth century, the early Sabi period, was put into woodden coffin B, and placed upon the eastern coffin bed.