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( Hohyun Kim ),( Jae Hun Kim ),( Gil Hwan Kim ),( Hyun-woo Sun ),( Chan Ik Park ),( Sung Jin Park ),( Chan Kyu Lee ),( Suk Kim ) 대한외상학회 2020 大韓外傷學會誌 Vol.33 No.2
Traumatic abdominal wall hernias (TAWHs) are uncommon and the incidence of this, which is rarely encountered in clinical practice, has been estimated at 1%. Furthermore, blunt transection of the entire abdominal wall musculature caused by seatbelt is a very rare complication. We report a case of adult with a complete disruption of the entire anterolateral abdominal wall muscle following the seatbelt injury. A 32-year-old male was wearing a seat belt in a high speed motor vehicle collision. Abdominal computed tomography (CT) scan revealed the complete disruption of bilateral abdominal wall musculatures including TAWH without visceral injury. However, injuries of small bowel and sigmoid colon were observed in the intra-operative field. The patient underwent the repair by primary closure of the defect with absorbable monofilament sutures. This case suggests that especially in TAWH patients, even if a CT scan is normal, clinicians should keep the possibility of bowel injury in mind, and choose a treatment based on the clinical findings.
Hohyun Kim,Chan Yong Park,Jae Hyuk Lee,Jung Chul Kim,Chol-Kyoon Cho,Hee Jun Kim 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.4
Purpose: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer. Methods: Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression. Results: Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403?528.135; P = 0.029). Conclusion: The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.
Clinical Significance of Malnutrition Risk in Severe Trauma Patients: A Single-Center Study
( Hohyun Kim ),( Kum-Hee Hong ),( Inah Choi ),( Kyung-a Lee ),( Geun Am Song ) 한국정맥경장영양학회 2021 한국정맥경장영양학회지 Vol.13 No.2
Purpose: A suboptimal nutritional status is often observed among hospitalized patients across all medical/surgical specialties. The objective of the present study was to (1) analyze the prevalence of malnutrition in severe trauma patients and (2) evaluate the relationship between malnutrition and select clinical outcomes. Materials and Methods: This retrospective study was conducted between October 2015 and March 2017 at the Pusan National University Hospital Trauma Center. Of a total of 3,560 patients, 945 were enrolled in this study. Patients were checked for malnutrition using a nutrition assessment tool by the hospital nutrition support team. The parameters assessed included serum albumin, the ratio of actual body weight to ideal body weight (%), total lymphocyte count, appetite, and gastrointestinal problems. Clinical outcomes under consideration included 1) mortality, 2) length of hospitalization, and 3) length of stay in the intensive care unit (ICU). Results: The total prevalence of malnutrition in hospitalized trauma patients was 55.0% (n=520). Malnutrition risk was the independent prognostic factor of mortality in severe trauma patients (adjusted odds ratio [OR]=3.440; 95% confidence interval [CI]=1.401~8.447, P=0.007). Risk factors of malnutrition were age over 65 years (adjusted OR=2.393; 95% CI=1.699~3.370, P<0.001), injury severity score (adjusted OR=1.034, 95% CI=1.012~1.056, P=0.002), length of hospitalization (adjusted OR=1.104; 95% CI=1.007~1.020, P<0.001), and length of stay in the ICU (adjusted OR=1.050; 95% CI=1.029~1.072, P<0.001). Conclusion: Malnutrition is widespread in hospitalized patients with severe trauma and results in suboptimal clinical outcomes. Thus, patients at high risk of malnutrition should be monitored carefully during hospitalization.
Kim, Choon Ok,Oh, Eun Sil,Kim, Hohyun,Park, Min Soo Dove Medical Press 2017 Drug design, development and therapy Vol.11 No.-
<P>To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK) interactions between these two drugs in healthy males and to explore the effect of <I>SLCO1B1</I> and <I>CYP2C9</I> polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part. All subjects (n=24) completed part 1, and 22 subjects completed part 2. A total of 38 subjects among the participants of the PK interaction studies were enrolled in the genotype study to analyze their <I>SLCO1B1</I> and <I>CYP2C9</I> polymorphisms retrospectively (n=22 in part 1, n=16 in part 2). Comparison of the PK and safety of each drug alone with those of the drugs in combination showed that both glimepiride and rosuvastatin did not interact with each other and had tolerable safety profiles in all subjects. However, with regard to glimepiride PK, the <I>SLCO1B1 521TC</I> group had a significantly higher maximum plasma concentration (C<SUB>max,ss</SUB>) and area under the plasma concentration–time curve during the dose interval at steady state (AUC<SUB>τ,ss</SUB>) for glimepiride in combination with rosuvastatin than those for glimepiride alone. However, other significant effects of the <I>SLCO1B1</I> or <I>CYP2C9</I> polymorphism on the interaction between the two drugs were not observed. In conclusion, there were no significant PK interactions between the two drugs; however, the exposure to glimepiride could be affected by rosuvastatin in the presence of the <I>SLCO1B1</I> polymorphism.</P>
Kim, Yunjoong,Kim, Mingu,Han, Bumku,Kim, Youdan,Shin, Hohyun The Korean Society for Aeronautical and Space Scie 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2
The optimum design of an SAR (Synthetic Aperture Radar) satellite constellation is developed herein using a genetic algorithm. The performance of Earth observations using a satellite constellation can be improved by minimizing the maximum revisit time. Classical orbit design using analytic methods has limitations when addressing orbit dynamics due to various disturbances. To overcome this issue, an optimization technique based on a genetic algorithm is used. STK (Systems Tool Kit) is utilized to propagate the satellite orbit when considering external disturbances, and the maximum revisit time on the earth observation area is calculated. By minimizing the performance index using a genetic algorithm, the optimum orbit of the satellite constellation is designed. Numerical results are provided to demonstrate the performance of the proposed method.