http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
알코올성 췌장염 환자에서 CYP2E1 유전자형의 다형성
김일환,염윤기,채석,권준택,김형기,박상흠 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Cytochrome P4502E1(CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine(NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, flouorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predispodition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans with alcoholic pancreatitis patients. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 64 alcoholic pancreatitis patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroforn extraction method. The allelic frequencies of c1 and c2 in healty volunteers were 0.85 and 0.15, respectively. The allelic frequencies of c1 and c2 in alcoholic pancreatitis patients were 0.8 and 0.2, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 and 0.031 (p<0.001) in healthy volunteers and alcoholic pancreatitis patients, respectively. However, the CYP2E1 genotype showed no significant relation to the alcoholic pancreatitis patients. It was suggested that the risk of alcoholic pancreatitis diagnosed clinically seem to be not associated with the CYP2E1 genotype.
한국인에서의 CYP2C19 돌연변이 유전자형의 다형성에 관한 연구
채석,채상우,양동규,김형기,권준택,염윤기 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). Recent studies have found a third (CYP2C19*4) and forth (CYP2C19*5) mutations in Caucasians. In the present study, we genotyped 536 healthy unrelated Koreans for functionally defective alleles, CYP2C19*2, CYP2C19*3, CYP2C19*4, and CYP2C19*5. Detection of the normal (CYP2C19*1) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19*1) and CYP2C19*2 were 72.6% and 27.4%, and the wild-type (CYP2C19*1) and CYP2C19*3 were 85.1% and 14.9%, respectively. For each CYP2C19*2 and CYP2C19*3 the observed number of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19*2, CYP2C19*3 and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). The mutated CYP2C19*4 and CYP2C19*5 alleles were not detected in this study. These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians, and we founded the racial variability of the frequencies of the CYP2C19*4 and CYP2C19*5 alleles in the Orientals.
최창진,이영행,이채호,김쌍오,채규윤 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.2
The reaction of N-benzyl β-amino acids with benzensulfonyl chloride in a chloroform-water bilayer system in the present of 15 mole % of tetrabutylammonium hydrogen sulfate gives the corresponding β-lactams in good yields.
Ventriculitis Associated with Invasive Klebsiella Pneumoniae Syndrome: A Case Report
Kim Chai Yoon,Hur Jin Woo,Kim Jeong Gyun,Lee Jong Won,Yun Il-Gyu,Lee Hyun Koo 대한말초신경학회 2023 The Nerve Vol.9 No.1
Invasive Klebsiella pneumoniae syndrome is defined as community-acquired liver abscess and metastatic infections in the lung, soft tissue, and central nervous system (CNS) caused by hypervirulent Klebsiella pneumoniae. Metastatic CNS infection in invasive Klebsiella pneumoniae syndrome shows rapid clinical deterioration and a high mortality rate. We present a case of ventriculitis caused by invasive Klebsiella pneumoniae syndrome successfully treated with a timely diagnosis, immediate surgical intervention, and administration of antibiotics.
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency
Kim, Yunha,Kang, Young-Sook,Lee, Na-Young,Kim, Ki Yoon,Hwang, Yu Jin,Kim, Hyun-Wook,Rhyu, Im Joo,Her, Song,Jung, Min-Kyung,Kim, Sun,Lee, Chai-Jin,Ko, Seyoon,Kowall, Neil W,Lee, Sean Bong,Lee, Junghee LANDES BIOSCIENCE 2015 AUTOPHAGY Vol.11 No.5
Kim Jaehwan,Kim Chai Yoon,Kim Jeong Gyun,Kim Hakyung,Sheen Seung Hun,Han In-bo,Sohn Seil 대한말초신경학회 2023 The Nerve Vol.9 No.1
Objective: This nationally matched longitudinal study aimed to investigate the relationship between acute myocardial infarction (AMI) and ossification of the posterior longitudinal ligament (OPLL) in Korea.Methods: We collected patient data from January 1, 2004 to December 31, 2015 from the National Health Insurance Service Health Screening Cohort. Patients with OPLL were defined as patients with the International Classification of Diseases, Tenth Revision code M48.8 (other specified spondylopathies) and were newly diagnosed through computed tomography imaging. The OPLL group had a total of 1,289 patients. The control group included 6,445 people. Utilizing the Kaplan-Meier technique, The incidence of AMI in both groups was estimated. A Cox proportional-hazards regression analysis was used to compute the AMI hazard ratio.Results: After controlling for age and sex, the hazard ratio of AMI in the OPLL group was 2.065 (95% confidence interval [CI], 1.228-3.474). The adjusted hazard ratio in the OPLL group was 2.209 after restricting the sample for demographics and concomitant medical conditions (95% CI, 1.311-3.721). In a subgroup analysis, the incidence of AMI was substantially greater in the OPLL group, which included women younger than 65 years and without hypertension, diabetes, or dyslipidemia.Conclusion: This nationwide longitudinal study found that patients with OPLL were at higher risk of AMI.
김채미(Chai Mee Kim),김명호(Myoung Ho Kim),이윤준(Yoon Joon Lee) 한국정보과학회 1992 한국정보과학회 학술발표논문집 Vol.19 No.2
객체 지향 데이타베이스 시스템에서는 복합객체에 대한 검색 성능을 향상시키기 위해 여러가지 색인기법들에 관한 연구가 진행되어 왔다. 그러나 이와 같은 방법들은 단일키 질의에 적합한 색인 방법이므로 다중키 제안 질의(multikey constraint query)를 효율적으로 처리하기에는 부적합하다. 이를 위해서는 복합객체를 구성하는 클래스 복합 계층 구조상의 클래스들의 여러 attrubute들을 키로 복합객체를 색인할 필요가 있다. 본 논문에서는 복합객체에 대한 다중키 제한 질의를 효율적으로 처리하기 위한 다중키 색인 방법을 제안한다. 그리고 제안된 다중키 색인 방법들을 다양한 복합객체에 대해 저장공간, 검색시간 및 갱신비용의 관점에서 성능 평가를 하였다. 그 결과를 통해 복합객체에 가장 적합한 다중키 색인 방법을 선택하여 색인을 구성할 수 있으며 이를 이용하여 검색 성능을 향상시킬 수 있다.