외과적수술에서 Naloxone이 혈장 Prolactin치 및 LH치의 변동에 미치는 영향

한세준,오승진,송창훈,박석현,나윤정,김왕수,송경언,황순철 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.8

각종 대, 소수술과 NAL 투여에 따른 혈장 PRL치와 LH치의 변동상황을 알기 위하여 남성 10명, 여성 16녕 도합 26명을 대상으로 하여 방사면역측정용 kit로서 이들 hormone치를 측정하였다. 그 결과, 1. 수술환자의 혈청 PRL치는 수술시작전 62.31±26.55ng/ml에서 수술시작후 15분에서 203.42±52.50ng/ml로 크게 증가하고(P$lt;0.01) 수술시작후 45분에서는 별반 변동없이 207.76±57.93ng/ml를 보였다. 2. 대수술의 경우에는 혈장 PRL치가 수술시작후 15분에 115.40±25.42ng/ml로 증가하였고 수술시작후 45분에서도 계속 증가하여 206.20±107.23ng/ml로서 대조군의 수치에 도달하였다. 3. 소수술의 경우에는 혈장 PRL치가 수술시작후 15분에서 최고치인 257.81±117.23ng/ml를 보였다가 수술시작후 45분에서는 226.18±68.33ng/ml로 감소하기 시작하였다. 4. NAL을 투여한 경우에는 혈장 PRL치가 수술시작후 15분과 45분에서 각각 186.93±71.94ng/ml와 111.53±24.52ng/ml로서 15분후에 일단 peak에 도달하였다가 감소하기 시작하였다. 5. NAL을 투여한 경우에는 혈장 PRL치가 15분후에서 228.63±78.88ng/ml이었고 45분후에서는 364.36±121.58ng/ml로서 계속 증가하여 45분후에 peak에 도달하였다.(P$lt;0.05). 6. 수술환자의 혈청 LH치는 수술전에 52.52±37.71ng/ml이었던 것이 15분후와 45분후에 각 130.39±33.43ng/ml ,133.22±34.53ng/ml로서 15분치의 LH치가 45분후까지 그대로 유지되었다. 7. 대수술의 경우에서는 혈창 LH치가 15분후와 45분후에 각각 51.29±41.04ng/ml, 43.47±34.15ng/ml로서 증가하지 않아 수술전치와 별반 변동이 없었다. 8. 소수술의 경우에는 15분후에 179.83±44.41ng/ml. 45분후에 189.31±47.38ng/ml로서 계속적으로 증가하였다. (P$lt;0.01). 9. NAL을 투여하지 않으면 혈장 LH치가 15분후에 83.86±31.38ng/ml, 45분후에 103.14±41.41ng/ml로 점차 증가하며 NAL을 투여하면 혈장 LH치가 15분후에 193.85±63.45ng/ml에 달하고 45분후에는 174.24±58.98ng/ml로 감소하여 혈장 LH치는 NAL에 의하여 증가하였다. The concentrations of plasma PRL were increased at 15 minutes and 45 minutes after surgery. In the minor surgery the plasma PRL levels were more significantly increased, than those in the major surgery. In the administration of Naloxone Chloride or not, the latter levels of plasma PRL more significantly increased comparing to those of the former levels. The concentrations of plasma LH did not change at 15minutes and 45minutes after surgery comparing to presurgery levels. In the major surgery, the plasma LH levels did not increased, but in the minor surgery at the time of 15 minutes and 45 minutes after surgery plasma LH levels were significantly increased. At the administration of NAL, plasma LH levels were significantly increased than those without administration. We conclude that the plasma PRL and LH levels may be more significantly increased in the minor surgery at administration of NAL. However, those mechanisms are obscure.

Detennination of 129I in simulated radioactive wastes using distiIlation technique

Ke Chon Choi,Byung Cheol Song,Sun Ho Han,Yong Joon Park,Kyuseok Song 한국방사성폐기물학회 2011 방사성폐기물학회지 Vol.9 No.3

Eddy Loss Analysis and Parameter Optimization of the WPT System in Seawater

Ke-Han Zhang,Zheng-Biao Zhu,Luo-Na Du,Bao-Wei Song 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3

Magnetic resonance wireless power transfer (WPT) in the marine environment can be utilized in many applications. However, energy loss in seawater through eddy loss (EL) is another consideration other than WPT in air. Therefore, the effect of system parameters on electric field intensity (EFI) needs to be measured and ELs calculated to optimize such a system. In this paper, the usually complicated analytical expression of EFI is simplified to the product of frequency, current, coil turns, and a coefficient to analyze the eddy current loss (ECL). Moreover, as the calculation of ECL through volume integral is time-consuming, the equivalent eddy loss impedance (EELI) is proposed to help designers determine the optimum parameters quickly. Then, a power distribution model in seawater is conceived based on the introduction of EELI. An optimization flow chart is also proposed according to this power distribution model, from which a prototype system is developed which can deliver 100 W at 90% efficiency with a gap of 30 mm and a frequency of 107.1 kHz.

굴 껍질 연용에 의한 토양의 이화학적 특성변화

이기상(Ke-Sang Lee),이용복(Yong-Bok Lee),허재영(Jae-Young Heo),이영한(Young-Han Lee),이성태(Seong-Tae Lee),홍광표(Kwang-Pyo Hong),송원두(Won-Doo Song) 한국토양비료학회 2008 한국토양비료학회 학술발표회 초록집 Vol.2008 No.9

Eddy Loss Analysis and Parameter Optimization of the WPT System in Seawater

Zhang, Ke-Han,Zhu, Zheng-Biao,Du, Luo-Na,Song, Bao-Wei The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3

Magnetic resonance wireless power transfer (WPT) in the marine environment can be utilized in many applications. However, energy loss in seawater through eddy loss (EL) is another consideration other than WPT in air. Therefore, the effect of system parameters on electric field intensity (EFI) needs to be measured and ELs calculated to optimize such a system. In this paper, the usually complicated analytical expression of EFI is simplified to the product of frequency, current, coil turns, and a coefficient to analyze the eddy current loss (ECL). Moreover, as the calculation of ECL through volume integral is time-consuming, the equivalent eddy loss impedance (EELI) is proposed to help designers determine the optimum parameters quickly. Then, a power distribution model in seawater is conceived based on the introduction of EELI. An optimization flow chart is also proposed according to this power distribution model, from which a prototype system is developed which can deliver 100 W at 90% efficiency with a gap of 30 mm and a frequency of 107.1 kHz.

Prescribed Performance-tangent Barrier Lyapunov Function for Adaptive Neural Backstepping Control of Variable Stiffness Actuator with Input and Output Constraints

Yu Xia,Jun-Yang Li,Yan-Kui Song,Jia-Xu Wang,Yan-Feng Han,Ke Xiao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3

Due to the complexity of modeling and the strong transmission coupling, the rich background of rigid actuator control has not been transferred to variable stiffness actuator (VSA). Therefore, most model-based control techniques developed for VSA require feedback linearization first. Alternatively, VSA can use non-model-based control techniques such as PD control, but it does not show strong robustness under disturbances. This paper is concerned with designing a novel adaptive neural network backstepping control scheme without using feedback linearization for a special VSA with saturation inputs, output constraints, and disturbances. Firstly, for ensuring the VSA with lower tracking error and higher security, the prescribed performance-tangent barrier Lyapunov function (PP-TBLF) is introduced to handle the prescribed output performance constraints. Subsequently, the Chebyshev neural network and the Nussbaum-type function are exploited to approximate the unknown nonlinearities and unknown gains. Meanwhile, the inverse hyperbolic sine function tracking differentiator is utilized to solve the “explosion of complexity” caused by the differentiation of virtual inputs and also approximate the complex partial derivatives caused by the auxiliary control signals. Finally, the stability of the whole scheme is proved by the Lyapunov criterion. The simulation results illustrate the raised control scheme’s feasibility and show a better closed-loop behavior relative to that obtained using a classic PD controller.

CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA

Jian Son,Hong-Li Wang,Ke-Han Song,Zhi-Wen Ding,Hai-Lian Wang,Xiao-Sheng Ma,Fei-Zhou Lu,Xin-Lei Xia,Ying-Wei Wang,Fei-Zou,Jian-Yuan Jiang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

This study was carried out to explore the roles of circular RNAs (circRNAs) in nucleus pulposus (NP) tissues in intervertebral disc degeneration (IDD). Differentially expressed circRNAs in IDD and normal NP tissues were identified based on the results of microarray analysis. Bioinformatics techniques were employed to predict the direct interactions of selected circRNAs, microRNAs (miR), and mRNAs. CircRNA_104670 was selected as the target circRNA due to its large multiplier expression in IDD tissues. After luciferase reporter and EGFP/RFP reporter assays, we confirmed that circRNA_104670 directly bound to miR-17-3p, while MMP-2 was the direct target of miR-17-3p. The receiver-operating characteristic (ROC) curve showed that circRNA_104670 and miR-17-3p had good diagnostic significance for IDD (AUC circRNA_104670 = 0.96; AUC miRNA-17-3p = 0.91). A significant correlation was detected between the Pfirrmann grade and expression of circRNA_104670 (r = 0.63; p = 0.00) and miR-17-3p (r = −0.62; p = 0.00). Flow-cytometric analysis and the MTT assay showed that interfering with circRNA_104670 using small interfering RNA (siRNA) inhibited NP cell apoptosis (p < 0.01), and this inhibition was reduced by interfering with miR-17-3p. Interfering with circRNA_104670 suppressed MMP-2 expression and increased extracellular matrix (ECM) formation, which were also reduced by interfering with miR-17-3p. Finally, an MRI evaluation showed that circRNA_104670 inhibition mice had a lower IDD grade compared with control mice (p < 0.01), whereas circRNA_104670 and miRNA-17-3p inhibition mice had a higher IDD grade compared with circRNA_104670 inhibition mice (p < 0.05). CircRNA_104670 is highly expressed in the NP tissues of IDD and acts as a ceRNA during NP degradation.

Improvement on Mechanical Properties of a bcc Matrix Al8(FeCuCrMn)92 High-Entropy Alloy by Phase Modulation of Interstitial Carbon Element

Conghui Hu,Jianlei Zhang,Yunhu Zhang,Ke Han,Changjiang Song,Qijie Zhai 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2

High-entropy alloys (HEAs) are novel multi-element alloys based on five or more constituent elements in a range of 5–35 at%. Here we present a method to improve strength of a body-centered cubic (bcc) matrix HEA without loss of ductility. Theimprovement was achieved by phase modulation combined other strengthening effect of interstitial carbon addition. Carbonaddition can enhance strength and retain good ductility in some steels because carbon increases the volume fraction offace-centered cubic (fcc) phase. We used the same principle to design and fabricate a set of Al8(FeCuCrMn)92Cx (x = 0, 1,2, 3, 4 at%) HEAs under near-rapid solidification. Our results showed that carbon addition modulated constituent phases byincreasing the volume fraction of fcc phase and carbides. As a result, addition of carbon increased yield strength of this bccmatrix HEA. But the ductility decreased, especially when carbon content was higher than 3 at%, which was ascribed to unevendistribution of Cu-rich fcc phase and carbides precipitated in bcc phase region. After annealing at 1173 K for 2 h, additionof 1 at% carbon improved yield strength without compressive fracture. It demonstrated that a proper carbon content additionwith annealing can enhance the yield strength without loss of ductility for this bcc matrix HEA. Thus, interstitial carbon additionis a meaningful method to improve the mechanical properties by phase modulation combined other strengthening effect.

증류법을 이용한 모의 방사성폐기물 중 ¹²⁹I 의 정량

최계천,송병철,한선호,박용준,송규석,Choi, Ke-Chon,Song, Byung-Cheol,Han, Sun-Ho,Park, Yong-Joon,Song, Kyu-Seok 한국방사성폐기물학회 2011 방사성폐기물학회지 Vol.9 No.3

방사성폐기물이 처분장에 인도 될 때 주요 방사성 핵종의 방사능 농도를 규명 하도록 방사성폐기물 인도 규정에 명시되어 있다. 저준위 방사성폐기물 시료의 경우 측정된 방사능 농도가 최소검출 방사능 농도(MDA: Minimum dectable activity) 이하의 값을 나타낼 경우가 많으며, MDA는 시료의 양, 바탕 값, 계측시간 및 계측효율 등에 따라서 달라지므로 MDA를 낮추기 위하여 가능한 많은 양의 시료를 취할 필요가 있다. 모의 잡고체 시료에 첨가된 요오드의 회수율을 결정하기 위한 방법으로서 모의 시료 중 비 방사성 요오드를 비휘발성 산으로 침출시킨 후 침출액을 직접 증발시키는 방법과 음이온 교환수지를 이용하I-를 흡착하여 분리하는 칼럼용리방법으로 측정하여 회수율을 비교한 결과, 증류법과 칼럼용리방법의 회수율은 각각 $86.5{\pm}0.9%$, $87.3{\pm}2.7%$로 나타났다. 증류법에 의한 모의 방사성 시료 중 $^{129}I$ 요오드의 회수율 및 MDA는 $84.6{\pm}1.6%$, $1.2{\times}10^{-4}Bq/g$로 각각 나타났으며, 분리공정을 단순화하고 많은 양의 시료를 취함으로써, 칼럼용리 방법의 단점을 보완하고 10배 이상 MDA를 낮출 수 있는 결과를 얻을 수 있었다. It is clarified in the radioactive waste transfer regulation that the concentration of radioactive waste for the major radio nuclide has to be examined when radioactive waste is guided to the radioactive waste stores. In case of the low level radioactive waste sample, the analytical results of radioactive waste concentration frequently show a value lower than minimum detectable activity (MDA). Since the MDA value basically depends on the amount of a sample, background value, measurement time, counting efficiency, and etc, it would be necessary to increase a sample amount with a intention of minimizing MDA. In order to measure a concentration of $^{129}I$ in low and medium level radioactive waste, $^{129}I$ was collected by using a distillation technique after leaching the simulated radioactive waste sample with a non-volatile acid. The recovery of $^{129}I$ measured was compared with that measured with column elution technique which is a conventional method using an anion-exchange resin. The recovery of inactive iodide by using the distillation method and column elution were found as $86.5{\pm}0.9%$ and $87.3{\pm}2.7%$, respectively. The recovery and MDA value calculated for distillation technique when 100 g of extracted solution of $^{129}I$ was taken, were found to be $84.6{\pm}1.6%$ and $1.2{\times}10^{-4}Bq/g$, respectively. Consequently, the proposed technique with simplified process lowered the MDA value more than 10 times compared to the column elution technique that has a disadvantage of limited sampling amount.

잠아(蠶兒)와 송충(松蟲)과의 경화병균(硬化病菌) 전염시험성적(傳染試驗成績)

박병희 ( Byong Hee Park ),한수용 ( Ke Yong Han ),조성일 ( Song Ill Cho ) 한국잠사학회 1960 한국잠사곤충학회지 Vol.1 No.-