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Kashmiri Deka,Anupam Guleria,Dinesh Kumar,Jayeeta Biswas,Saurabh Lodha,Som Datta Kaushik,Suman Dasgupta,PRITAM DEB 한국물리학회 2020 Current Applied Physics Vol.20 No.1
Single mode (either T1 or T2) contrast agents employed during magnetic resonance imaging owe their advantage over their dual counterparts to the fact that they do not involve any quenching caused by interference between the two modes. The chemistry involving oxides of manganese is highly significant due to their applicability as MRI contrast agents. Manganese oxides are usually known to display a dominant T1 relaxation enhancement. But, in this work, an engineered structure of manganese oxide (Mn2O3) nanoparticles encapsulated within mesoporous carbon frameworks was developed which exhibited dominant T2 contrast enhancement, through regulation of contact between the magnetic ion and water. Microstructural characterization revealed that the mesoporous carbon frameworks were spherical in shape and the nanoparticles within them had an average size of 40–50 nm. Relaxivity measurement, MRI experiments and cell viability assay convincingly established the system as a new class of biocompatible T2 based magnetic resonance imaging agent.
Acharya Shankar,Khanna Varun,Chahal Rupinder Singh,Kalra Kashmiri Lal,Vishwakarma Gayatri 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.5
Study Design: This is a retrospective cohort study.Purpose: This study aimed to identify the clinicoradiological risk factors associated with the inability to achieve minimum clinically important difference (MCID) on the modified Japanese Orthopaedic Association (mJOA) Scale in operated cases of cervical spondylotic myelopathy (CSM).Overview of Literature: Only a few studies have evaluated the outcomes of surgery performed for CSM using MCID on the mJOA scale.Methods: We analyzed 124 operated CSM cases from March 2019 to April 2021 for preoperative clinical features, cervical sagittal radiographic parameters, and magnetic resonance imaging (MRI) signal intensities (SI). The risk factors associated with missing the MCID (poor outcome) on mJOA at the final follow-up were identified using binary logistic regression. Multivariate analysis was used to find significant risk factors, and odds ratios (OR) were computed.Results: A total of 110 men (89.2%) and 14 women (10.8%) with an average age of 53.5±13.2 years were included in the analysis. During the last follow-up, 89 cases (72.1%) achieved MCID (meaningful gains following surgery) while 35 (27.9%) could not. The final model identified the following parameters as significant risk factors for poor outcome: increased duration of symptoms (OR, 6.77; <i>p</i>=0.001), lower preoperative mJOA scale (OR, 0.75; <i>p</i>=0.029), the presence of multilevel T2-weighted (T2W) MRI SI (OR, 4.79; <i>p</i>=0.004), and larger change in cervical sagittal vertical axis (ΔcSVA) (OR, 1.06; <i>p</i>=0.013). Also, an increase in cSVA postoperatively correlated with a reduced functional recovery rate (<i>r</i>=−0.4, <i>p</i><0.001).Conclusions: Surgery for CSM leads to significant functional benefits. However, poorer outcomes are observed in cases of greater duration of symptoms, higher preoperative severity with multilevel T2W MRI SI, and a larger increase in the postoperative cSVA (sagittal imbalance).
Yoon, Sun Ok,Lee, Tae Sup,Kim, Sang Jick,Jang, Myung Hee,Kang, Young Jun,Park, Jae Hyun,Kim, Keun-Soo,Lee, Hyun Sil,Ryu, Chun Jeih,Gonzales, Noreen R.,Kashmiri, Syed V. S.,Lim, Sang Moo,Choi, Chang Wo American Society for Biochemistry and Molecular Bi 2006 The Journal of biological chemistry Vol.281 No.11