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Rajesh,K.Kaneto 한국물리학회 2005 Current Applied Physics Vol.5 No.2
A conducting polymer film of N-amino substituted pyrrole monomer has been prepared for covalent immobilization of enzyme for biosensing applications, illustrated by tyrosinase (PPO).The tyrosinase enzyme retains its bioactivity when being immobilized on N-substituted pyrrole polymer film by covalent bonding.The enzyme electrode was characterized by UV.Vis and infrared spectroscopy.Phenolic compounds were quantitatively estimated by the direct electrochemical reduction of enzymatically liberated quinone species at 0.2 V vs. Ag/AgCl. The results of amperometric response measurements conducted on enzyme electrode show sensitivity of 57.6, 71.4 and 45.8 mAM1cm2 and a linear response range of 1.8.170.2, 1.3.110.1 and 2.1.168 lM for phenol, catechol and p-cresol, respectively. The biosensor exhibits a lowest detection limit of 0.9, 0.7 and 1.1 lM, for phenol, catechol and p-cresol, respectively and a period of stable sensitivity of 3 months at 4.5 C.
Rajesh,S.S. Pandey,W. Takashima,K. Kaneto 한국물리학회 2005 Current Applied Physics Vol.5 No.2
A conducting polypyrrole lm has been prepared on indium tin oxide coated glass plate by electropolymerization of pyrrole in anaqueous solution of enzyme, tyrosinase (PPO), and a redox mediator potassium hexacyanoferrate (II). The enzyme retains its bio-activity well within the polymer lm. Phenol concentration in aqueous solution was quantitatively estimated by monitoring the elec-tron exchange occurring in redox mediator within the polymer matrix i.e. direct reduction of Fe (III) to Fe (II) ion at +0.12V vs. Ag/AgCl. The results of amperometric response measurements conducted on enzyme electrode (PPO/Fe2+/PPY/ITO) show a sensitivityof 0.33 AM. 1 cm. 2 and a linear response range of 4.5107.4l M for phenol in aqueous medium. The electrode exhibits a responsetime of about 80 second and is stable for 4 months at 4.C..
G. Lakshmi Vara Prasad,Venkatagurunatham Naidu Kollu,M. Sailaja,S. Radhakrishnan,K. Jagan Mohan,A. Kishore Reddy,G. Rajesh Chandra 한국전기전자재료학회 2024 Transactions on Electrical and Electronic Material Vol.25 No.1
In this paper, we delve into the intriguing realm of Pseudo-morphic High Electron Mobility Transistors (pHEMTs) composed of InAs∕In0.3Al0.7As∕InSb∕In0.3Al0.7As layers, utilizing Silvaco-TCAD for simulation. Our focus centers on the assessment of RF and analog electrical characteristics, with a keen eye on the high-temperature eff ects. The influence of temperature on device performance is meticulously evaluated in comparison to a reference device operating at room temperature. Traditionally, the critical parameters such as threshold voltage ( Vth ), transconductance ( gm ), and Ion∕Ioff ratio have been calculated within the temperature range spanning from 300 K to 700 K. The primary pHEMT device in our study exhibits impressive attributes, featuring a drain current of 950 mA, a threshold voltage of -1.75 V, a high transconductance ( gm ) value of 650 mS/mm, an Ion∕Ioff ratio of 1 × 106 , a transition frequency ( ft ) soaring to 790 GHz, and a maximum frequency ( fmax ) reaching a staggering 1.4 THz. However, as we traverse the temperature spectrum, our findings unveil a compelling narrative. The impact of rising temperature is unequivocal, triggering a cascade of transformations within the device. Notably, as the temperature escalates, we observe a noticeable decrease in current, a reduction in transconductance ( gm ), and a diminishing Ion∕Ioff ratio. To unravel the intricacies of these temperature-induced effects, we introduce the infusion of Machine Learning (ML) into our analysis.
Ray, Schindra Kumar,Adhikari, Rajesh,Joshi, Bhupendra,Gyawali, Gobinda,Kshetri, Yuwaraj K.,Regmi, Chhabilal,Tripathi, Khagendra,Lee, Soo Wohn American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.11
<P>BaMoO4, co-doped with Er3+, Yb3+ and K+, microcrystals were synthesized by the microwave hydrothermal process. The crystal structure and particle morphology were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. The XRD pattern revealed the tetragonal scheelite structure of BaMoO4. In addition, octahedron microcrystals around 0.5-2 mu m were found by SEM analysis. Compositional analysis and the chemical states of the samples were analyzed by X-ray photoelectron spectroscopy (XPS). UV-Vis diffuse reflectance spectra and luminescence properties were also analyzed by UV-Vis diffuse reflectance spectroscopy and photoluminescence spectroscopy. Two strong green emission peaks (526 nm and 554 nm) and one weak red emission peak (661 nm) were observed, which are related to the H-2(11/2) -> I-4(15/2), S-4(3/2) -> I-4(15/2) and F-4(9/2) -> I-4(15/2) transitions of the Er3+ ions, respectively, under 980 nm (CW) laser diode excitation. The green upconversion luminescence intensity was enhanced two times with the KCl addition.</P>
Molecular insights into the role of genetic determinants of congenital hypothyroidism
Kollati, Yedukondalu,Akella, Radha Rama Devi,Naushad, Shaik Mohammad,Patel, Rajesh K.,Reddy, G. Bhanuprakash,Dirisala, Vijaya R. Korea Genome Organization 2021 Genomics & informatics Vol.19 No.3
In our previous studies, we have demonstrated the association of certain variants of the thyroid-stimulating hormone receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (TG) genes with congenital hypothyroidism. Herein, we explored the mechanistic basis for this association using different in silico tools. The mRNA 3'-untranslated region (3'-UTR) plays key roles in gene expression at the post-transcriptional level. In TSHR variants (rs2268477, rs7144481, and rs17630128), the binding affinity of microRNAs (miRs) (hsa-miR-154-5p, hsa-miR-376a-2-5p, hsa-miR-3935, hsa-miR-4280, and hsa-miR-6858-3p) to the 3'-UTR is disrupted, affecting post-transcriptional gene regulation. TPO and TG are the two key proteins necessary for the biosynthesis of thyroid hormones in the presence of iodide and H<sub>2</sub>O<sub>2</sub>. Reduced stability of these proteins leads to aberrant biosynthesis of thyroid hormones. Compared to the wild-type TPO protein, the p.S398T variant was found to exhibit less stability and significant rearrangements of intra-atomic bonds affecting the stoichiometry and substrate binding (binding energies, ΔG of wild-type vs. mutant: -15 vs. -13.8 kcal/mol; and dissociation constant, K<sub>d</sub> of wild-type vs. mutant: 7.2E<sup>-12</sup> vs. 7.0E<sup>-11</sup> M). The missense mutations p.G653D and p.R1999W on the TG protein showed altered ΔG(0.24 kcal/mol and 0.79 kcal/mol, respectively). In conclusion, an in silico analysis of TSHR genetic variants in the 3'-UTR showed that they alter the binding affinities of different miRs. The TPO protein structure and mutant protein complex (p.S398T) are less stable, with potentially deleterious effects. A structural and energy analysis showed that TG mutations (p.G653D and p.R1999W) reduce the stability of the TG protein and affect its structure-functional relationship.
A note on vertex pair sum $k$-zero ring labeling
Antony Sanoj Jerome,K.R. Santhosh Kumar,T.J. Rajesh Kumar 한국전산응용수학회 2024 Journal of applied mathematics & informatics Vol.42 No.2
Let $G=(V,E)$ be a graph with $p$-vertices and $q$-edges and let $R^{\circ}$ be a finite zero ring of order $n$. An injective function $f:V(G)\to \{r_1,r_2,\ldots,r_k\}$, where $r_i\in R^\circ$ is called vertex pair sum $k$-zero ring labeling, if it is possible to label the vertices $x\in V$ with distinct labels from $R^{\circ}$ such that each edge $e=uv$ is labeled with $f(e=uv)=[f(u)+f(v)] \pmod n$ and the edge labels are distinct. A graph admits such labeling is called vertex pair sum $k$-zero ring graph. The minimum value of positive integer $k$ for a graph $G$ which admits a vertex pair sum $k$-zero ring labeling is called the vertex pair sum $k$-zero ring index denoted by $\psi_{pz}(G)$. In this paper, we defined the vertex pair sum $k$-zero ring labeling and applied to some graphs.
Spectroscopic, Redox and Biological Studies of Push-Pull Porphyrins and Their Metal Complexes
K. Rajesh,A. Kalilur Rahiman,K. Shanmuga Bharathi,S. Sreedaran,V. Gangadevi,V. Narayanan 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.9
We have synthesized a series of push-pull porphyrins containing both donor and acceptor substituents at the mesopositions and have examined their spectral and biological properties. The push-pull porphyrins containing both strong donor NH2 and acceptor NO2 at meso-positions, in which donor group condensed with the ligand, (2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formlyphenol (L) to form imine linkages with porphyrin. The Schiff base ligand 5-[4-(2,6-bis(4-methylpiperazine-1-yl-methyl)-4-iminomethylphenol)phenyl]-10,15,20-tris(4-nitrophenyl) porphyrin [an3(TPP)L] can be synthesized from 2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formylphenol (L) and 5-(4-aminophenyl)-10, 15,20-tris(4-nitrophenyl)porphyrin. The push-pull porphyrin [an3(TPP)L] was metallated to get copper,nickel and zinc complexes. The spectral, electrochemical, antibacterial, antifungal and cytotoxicity properties of all the donor- acceptor push-pull porphyrins and their complexes were characterized and studied.
Spectroscopic, Redox and Biological Studies of Push-Pull Porphyrins and Their Metal Complexes
Rajesh, K.,Rahiman, A. Kalilur,Bharathi, K. Shanmuga,Sreedaran, S.,Gangadevi, V.,Narayanan, V. Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.9
We have synthesized a series of push-pull porphyrins containing both donor and acceptor substituents at the mesopositions and have examined their spectral and biological properties. The push-pull porphyrins containing both strong donor $NH_2$ and acceptor $NO_2$ at meso-positions, in which donor group condensed with the ligand, (2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formlyphenol (L) to form imine linkages with porphyrin. The Schiff base ligand 5-[4-(2,6-bis(4-methylpiperazine-1-yl-methyl)-4-iminomethylphenol)phenyl]-10,15,20-tris(4-nitrophenyl) porphyrin [$an_3$(TPP)L] can be synthesized from 2,6-bis(4-methylpiperazine-1-yl-methyl)-4-formylphenol (L) and 5-(4-aminophenyl)-10, 15,20-tris(4-nitrophenyl)porphyrin. The push-pull porphyrin [$an_3$(TPP)L] was metallated to get copper, nickel and zinc complexes. The spectral, electrochemical, antibacterial, antifungal and cytotoxicity properties of all the donor- acceptor push-pull porphyrins and their complexes were characterized and studied.
K. Rajesh Kumar,Kiran Kumar Dama,Vaddi Venkata Satyanarayana 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.3
Friction stir welding of AZ 91D magnesium alloy has been undertaken with boron powder application at the interface. Multiresponses are measured with different characteristics. The responses are analyzed with variable weightages employing TOPSISTaguchi method. Optimal parameter condition has been identified and found that weld speed is playing major role incontrolling all the responses. The performance is computed for the optimum case and also the ANOM and ANOVA test isconducted to show the performance improvement.