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- 저자 : K Arivarasan (검색결과 5 건)
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Biologics for the treatment of pyoderma gangrenosum in ulcerative colitis
K Arivarasan,Vaishali Bhardwaj,Sukrit Sud,Sanjeev Sachdeva,Amarender Singh Puri 대한장연구학회 2016 Intestinal Research Vol.14 No.4
Pyoderma gangrenosum (PG) is an uncommon extra-intestinal manifestation of inflammatory bowel disease (IBD). Despitelimited published literature, biologics have caused a paradigm shift in the management of this difficult-to-treat skin condition. The clinical data and outcomes of three patients with active ulcerative colitis and concurrent PG treated with biologics (infliximabtwo and adalimumab one) are reviewed in this report. Biologics were added because of the sub-optimal response of thecolonic symptoms and skin lesions to parenteral hydrocortisone therapy. All three patients showed a dramatic response to theaddition of the biologics. In view of the rapid healing of the skin lesions, superior response rate, and the additional benefit of improvementin the underlying colonic disease following treatment, anti-tumor necrosis factor blockers should be considered asa first line therapy in the management of PG with underlying IBD.
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Ayyalusamy, Anantharaman,Vellaiyan, Subramani,Subramanian, Shanmuga,Ilamurugu, Arivarasan,Satpathy, Shyama,Nauman, Mohammed,Katta, Gowtham,Madineni, Aneesha The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.2
Purpose: The aim is to study the dependence of deformable based auto-segmentation of head and neck organs-at-risks (OAR) on anatomy matching for a single atlas based system and generate an acceptable set of contours. Methods: A sample of ten patients in neutral neck position and three atlas sets consisting of ten patients each in different head and neck positions were utilized to generate three scenarios representing poor, average and perfect anatomy matching respectively and auto-segmentation was carried out for each scenario. Brainstem, larynx, mandible, cervical oesophagus, oral cavity, pharyngeal muscles, parotids, spinal cord, and trachea were the structures selected for the study. Automatic and oncologist reference contours were compared using the dice similarity index (DSI), Hausdroff distance and variation in the centre of mass (COM). Results: The mean DSI scores for brainstem was good irrespective of the anatomy matching scenarios. The scores for mandible, oral cavity, larynx, parotids, spinal cord, and trachea were unacceptable with poor matching but improved with enhanced bony matching whereas cervical oesophagus and pharyngeal muscles had less than acceptable scores for even perfect matching scenario. HD value and variation in COM decreased with better matching for all the structures. Conclusion: Improved anatomy matching resulted in better segmentation. At least a similar setup can help generate an acceptable set of automatic contours in systems employing single atlas method. Automatic contours from average matching scenario were acceptable for most structures. Importance should be given to head and neck position during atlas generation for a single atlas based system.
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Anantharaman Ayyalusamy,Subramani Vellaiyan,Shanmuga Subramanian,Arivarasan Ilamurugu,Shyama Satpathy,Mohammed Nauman,Gowtham Katta,Aneesha Madine 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.2
Purpose: The aim is to study the dependence of deformable based auto-segmentation of head and neck organs-at-risks (OAR) on anatomy matching for a single atlas based system and generate an acceptable set of contours. Methods: A sample of ten patients in neutral neck position and three atlas sets consisting of ten patients each in different head and neck positions were utilized to generate three scenarios representing poor, average and perfect anatomy matching respectively and auto-segmentation was carried out for each scenario. Brainstem, larynx, mandible, cervical oesophagus, oral cavity, pharyngeal muscles, parotids, spinal cord, and trachea were the structures selected for the study. Automatic and oncologist reference contours were compared using the dice similarity index (DSI), Hausdroff distance and variation in the centre of mass (COM). Results: The mean DSI scores for brainstem was good irrespective of the anatomy matching scenarios. The scores for mandible, oral cavity, larynx, parotids, spinal cord, and trachea were unacceptable with poor matching but improved with enhanced bony matching whereas cervical oesophagus and pharyngeal muscles had less than acceptable scores for even perfect matching scenario. HD value and variation in COM decreased with better matching for all the structures. Conclusion: Improved anatomy matching resulted in better segmentation. At least a similar setup can help generate an acceptable set of automatic contours in systems employing single atlas method. Automatic contours from average matching scenario were acceptable for most structures. Importance should be given to head and neck position during atlas generation for a single atlas based system.
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( Jatinderpal Singh ),( Amarender S Puri ),( Sanjeev Sachdeva ),( Puja Sakhuja ),( Kulandaivelu Arivarasan ) 대한장연구학회 2016 Intestinal Research Vol.14 No.2
Tumor necrosis factor-α inhibitors are now considered as standard therapy for patients with severe inflammatory bowel disease who do not respond to corticosteroids, but they carry a definite risk of reactivation of tuberculosis. We present a case in which a patient with inflammatory bowel disease developed a de novo tuberculosis infection after the start of anti-tumor necrosis factor-α treatment despite showing negative results in tuberculosis screening. Although there are many case reports of pleural, lymph nodal and disseminated tuberculosis following infliximab therapy, we present the first case report of rectal tuberculosis following infliximab therapy. (Intest Res 2016;14:183-186)
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Chung, Ill-Min,Abdul Rahuman, Abdul,Marimuthu, Sampath,Kirthi, Arivarasan Vishnu,Anbarasan, Karunanithi,Padmini, Parthasarathy,Rajakumar, Govindasamy D.A. Spandidos 2017 Experimental and therapeutic medicine Vol.14 No.1
<P>The present study outlines the development of a method to synthesize copper nanoparticles (CuNPs) by mixing copper acetate solution with leaf extract of <I>Eclipta prostrata</I> without using any surfactant or external energy. <I>E. prostrata</I> leaf extract function as an excellent reducing agent of copper ions, and the biosynthesized CuNPs are safer for the environment. The powder X-ray diffraction (XRD) pattern provided evidence for the formation of face-centered cubic structure ranging from 23 to 57 nm, with an average size of 31±1.2 nm. Fourier transform infrared spectroscopy (FTIR) was used to identify the biomolecules and capping reagents in the <I>E. prostrata</I> leaf extract that may be responsible for the reduction of copper ions and the stability of the bioreduced nanoparticles. The biosynthesized CuNPs displayed considerable antioxidant capacity. Similarly, <I>in vitro</I> anticancer studies demonstrated the cytotoxicity value of synthesized CuNPs against tested HepG2 cells. The findings of the present study suggested that biosynthesized CuNPs that utilize extracts of <I>E. prostrata</I> may be used for therapeutic application, and thus are a promising nanomaterial.</P>
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