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Chung, Ill-Min,Abdul Rahuman, Abdul,Marimuthu, Sampath,Kirthi, Arivarasan Vishnu,Anbarasan, Karunanithi,Padmini, Parthasarathy,Rajakumar, Govindasamy D.A. Spandidos 2017 Experimental and therapeutic medicine Vol.14 No.1
<P>The present study outlines the development of a method to synthesize copper nanoparticles (CuNPs) by mixing copper acetate solution with leaf extract of <I>Eclipta prostrata</I> without using any surfactant or external energy. <I>E. prostrata</I> leaf extract function as an excellent reducing agent of copper ions, and the biosynthesized CuNPs are safer for the environment. The powder X-ray diffraction (XRD) pattern provided evidence for the formation of face-centered cubic structure ranging from 23 to 57 nm, with an average size of 31±1.2 nm. Fourier transform infrared spectroscopy (FTIR) was used to identify the biomolecules and capping reagents in the <I>E. prostrata</I> leaf extract that may be responsible for the reduction of copper ions and the stability of the bioreduced nanoparticles. The biosynthesized CuNPs displayed considerable antioxidant capacity. Similarly, <I>in vitro</I> anticancer studies demonstrated the cytotoxicity value of synthesized CuNPs against tested HepG2 cells. The findings of the present study suggested that biosynthesized CuNPs that utilize extracts of <I>E. prostrata</I> may be used for therapeutic application, and thus are a promising nanomaterial.</P>