PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis

( Juyoung Kim ),( Kyung Hee Jung ),( Jaeho Yoo ),( Jung Hee Park ),( Hong Hua Yan ),( Zhenghuan Fang ),( Joo Han Lim ),( Seong-ryul Kwon ),( Myung Ku Kim ),( Hyun-ju Park ),( Soon-sun Hong ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.2

Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory processes. However, limited studies have reported the involvement of PI3KC2γ in RA, and the underlying mechanism remains largely unknown. Therefore, we investigated the role of PI3KC2γ as a novel therapeutic target for RA and the effect of its selective inhibitor, PBT-6. In this study, we observed that PI3KC2γ was markedly increased in the synovial fluid and tissue as well as the PBMCs of patients with RA. PBT-6, a novel PI3KC2γ inhibitor, decreased the cell growth of TNFmediated synovial fibroblasts and LPS-mediated macrophages. Furthermore, PBT-6 inhibited the PI3KC2γ expression and PI3K/ AKT signaling pathway in both synovial fibroblasts and macrophages. In addition, PBT-6 suppressed macrophage migration via CCL2 and osteoclastogenesis. In CIA mice, it significantly inhibited the progression and development of RA by decreasing arthritis scores and paw swelling. Three-dimensional micro-computed tomography confirmed that PBT-6 enhanced the joint structures in CIA mice. Taken together, our findings suggest that PI3KC2γ is a therapeutic target for RA, and PBT-6 could be developed as a novel PI3KC2γ inhibitor to target inflammatory diseases including RA.

Induced Magnetism and Giant Perpendicular Magnetic Anisotropy of Transition Metal Doped Topological Insulator Bi(111)

Juyoung Jung,Youngjun Kim,Purev Taivansaikhan,Dorj Odkhuu 한국자기학회 2017 한국자기학회 학술연구발표회 논문개요집 Vol.2017 No.5

Clinical and Radiological Characteristics of Angiomatous Meningiomas

( Juyoung Hwang ),( Doo-sik Kong ),( Ho Jun Seol ),( Do-hyun Nam ),( Jung-il Lee ),( Jung Won Choi ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2

Background Angiomatous meningioma is a rare histological subtype of meningioma. Therefore, this specific medical condition is rarely reviewed in the literature. In the present work, we report the clinical and radiological features with postoperative outcomes of angiomatous meningioma. Methods This retrospective study included the patients who were pathologically diagnosed with angiomatous meningioma after surgical resection between February 2010 and September 2015 in our institute. We analyzed the clinical data, radiological manifestation, treatment and prognosis of all patients. Results The 15 patients (5 males and 10 females) were diagnosed with angiomatous meningioma during the study period. The median age of patients at the time of surgery was 63 years (range: 40 to 80 years). According to Simpson classification, 7, 5, and 3 patients achieved Simpson grade I, II, and IV resection, respectively. In the follow-up period, recurrence was noted in one patient. Ten out of the 15 patients showed homogeneous enhancement. Two patients demonstrated cystic changes. There was no occurrence of calcification or hemorrhage in our patients. Characteristically, 14 out of 15 patients showed signal voids of vessels. Significant peritumoral edema was observed in the majority of tumors (67%). Conclusion Angiomatous meningiomas are rare benign meningioma. Brain images of angiomatous meningioma usually demonstrate signal void signs and peritumoral edema. In the present study, angiomatous meningiomas showed good prognosis after surgical resection.

Warping effects in the band and angular-momentum structures of the topological insulator Bi2Te3

Jung, Wonsig,Kim, Yeongkwan,Kim, Beomyoung,Koh, Yoonyoung,Kim, Chul,Matsunami, Masaharu,Kimura, Shin-ichi,Arita, Masashi,Shimada, Kenya,Han, Jung Hoon,Kim, Juyoung,Cho, Beongki,Kim, Changyoung American Physical Society 2011 Physical review. B, Condensed matter and materials Vol.84 No.24

Precise precursor rebalancing for isoprenoids production by fine control of <i>gapA</i> expression in <i>Escherichia coli</i>

Jung, Juyoung,Lim, Jae Hyung,Kim, Se Yeon,Im, Dae-Kyun,Seok, Joo Yeon,Lee, Seung-Jae V.,Oh, Min-Kyu,Jung, Gyoo Yeol Academic Press 2016 Metabolic engineering Vol.38 No.-

<P><B>Abstract</B></P> <P>Biosynthesis of isoprenoids via the 1-deoxy-<SMALL>D</SMALL>-xylulose-5-phosphate (DXP) pathway requires equimolar glyceraldehyde 3-phosphate and pyruvate to divert carbon flux toward the products of interest. Here, we demonstrate that precursor balancing is one of the critical steps for the production of isoprenoids in <I>Escherichia coli</I>. First, the implementation of the synthetic lycopene production pathway as a model system and the amplification of the native DXP pathway were accomplished using synthetic constitutive promoters and redesigned 5′-untranslated regions (5′-UTRs). Next, fine-controlled precursor balancing was investigated by tuning phosphoenolpyruvate synthase (PpsA) or glyceraldehyde 3-phosphate dehydrogenase (GAPDH). The results showed that tuning-down of <I>gapA</I> improved the specific lycopene content by 45% compared to the overexpression of <I>ppsA</I>. The specific lycopene content in the strains with down-regulated <I>gapA</I> increased by 97% compared to that in the parental strain. Our results indicate that <I>gapA</I> is the best target for precursor balancing to increase biosynthesis of isoprenoids.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of precursor balancing for the biosynthesis of isoprenoids was explored through fine-control of <I>ppsA</I> and <I>gapA</I>. </LI> <LI> Precise down-regulation of <I>gapA</I> showed a better lycopene production than up-regulation of <I>ppsA</I>. </LI> <LI> A novel target (<I>gapA</I>) to balance precursor pool for biosynthesis of isoprenoids was demonstrated for the first time. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Advanced Redox Rebalancing for the Optimization of Butanoate Pathway in Escherichia coli

Juyoung JUNG,Jae Hyung LIM,Gyoo Yeol JUNG 한국생물공학회 2014 한국생물공학회 학술대회 Vol.2014 No.10

『가장 푸른 눈』에 나타난 시선과 권력의 상관성

정주영(JuYoung Jung) 대한문학치료학회 2023 대한문학치료연구 Vol.12 No.1

토니 모리슨의 『가장 푸른 눈』은 탈식민주의와 페미니즘 등 다양한 관점에서 연구되고 있으나 본 논문은 시서관 권력의 상관성에 초점을 맞추었다. 본 연구는 헤겔의 인정투쟁과 푸코의 생체 권력 및 미시 권력 개념을 바탕으로 논지를 전개한다. 『가장 푸른 눈』에서 백인들은 흑인들에게 부적절한 시선을 보냄으로써 권력을 행사한다. 예를 들어, 젊은 시절에 촐리 브리드러브가 여자 친구와 성관계를 할 때 백인 남자 두 명에게 그 장면을 목격당한다. 이 경우, 그들의 시선은 푸코의 판-옵티콘처럼 감시자의 권력으로 기능한다. 게다가, 피콜라와 그녀의 어머니 폴린 브리드러브도 백인들에 의한 시선의 거부를 경험한다. 그러나 브리드러브 가족 구성원들 중에서 피콜라의 고통이 가장 심각하다. 가족 구성원 모두가 여러 방면에서 백인에 의해 희생되는데, 그들은 외부의 시선을 내면화하였고 나이와 성별에 있어서 가장 약자인 피콜라를 보호할 수 없었기 때문이다. 그러나 시간이 지나면서 촐리는 아내와 딸 피콜라에게 폭력을 행사하며, 심지어 그는 딸을 강간한다. 이는 푸코의 관점에서는 성은 권력의 한 표현이므로 의미심장한 사건이다. 처음에 그 가족들은 백인의 “타자”였으나 시간이 지나면서 백인 우월주의를 내면화하였으며, 마침내 그들 스스로의 타자가 된다. 그 결과 자기 소외가 일어난다. 소설의 전반부에서 백인들과 흑인들은 서로 대항한다. 그러나 후반부에서는 상대적으로 권력 있는 흑인들이 더 약한 흑인과 대항한다. 이때 촐리, 피콜라의 또래 그룹과 흑· 백 혼혈인을 포함한 흑인 공동체는 권력 있는 흑인들이 된다. 흑인 공동체 구성원들은 백인 우월주의에 의해 생긴 자신들의 분노를 피콜라에게 쏟아 붓는다. 그들은 피콜라를 탓함으로써 자신들의 흑인성을 부정한다. 그들은 피콜라와의 인정투쟁에서 승리함으로써 그들의 주체성을 성취하며, 결과적으로 흑인 공동체는 그녀의 희생으로 정화된다. This novel has been approached from various in many points of view, including post colonialism and feminism. In this thesis, I focused on the relationship between gaze and power in The Bluest. This thesis draws on Hegel's recognition and Foucault's bio-power and micro-power concept. In this literary work, white people do violence against black people, fixing their gaze on the latter. For example, while Cholly Breedlove was having a sex ith his sweetheart in his youth, it was witnessed by two white men. In this case, their gaze is equal to the function of Pan-Opticon which Foucault pointed as a power of supervisor. Besides, Peacola and her mother, Pauline Breedlove experience the rejection of gaze by the whites. But among the Breedlove family members, Peacola’s suffering is the severest one. Because the family become the victims of the violence of gaze of the whites, they cannot establish their own subjectivity. That is, they lose in recognition competition. As a result, they internalize the gaze of whites and become “other - oriented – people”. But as time goes by, Cholly dose violence to his wife and daughter, Peacola, and he even rapes his daughter. This is a meaningful accident from the view point of Foucault, because sex is a kind of expression of power. At first, they were the “others” of whites. However, by and by, they internalize white-chauvinism and become the “other” by themselves. As the result, their lives alienate themselves. In the former part of the novel, whites confront blacks. But in the latter part of the novel, powerful blacks oppose weak blacks. Chooly, Peacola’s peer group and black community including the mixed between whites and blacks belong to the first group. The members of the black community pour their anger which was cuased by white-chauvinism into Peacola. They deny their blackness by blaming Peacola. They obtain their subjectivity through the victory in recognition competition with Peacola. Consequently, black community is purified with her sacrifice.

결합계수법을 이용한 interdigital filter 소형화 기술에 관한 연구

정주영(Juyoung Jung),김지원(Jiwon Kim),강태훈(Taehoon Kang),구서(Seo Koo),한상민(Sangmin Han),안달(Dal Ahn) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6

본 논문은 기존의 /4 전송선로를 이용한 Interdigital 구조에서 Pattern을 구현한 새로운 Band-Pass Filter를 설계하였다. 필터의 중심주파수는 3GHz이고, 대역폭은 400MHz이다. 공진선로에 Pattern을 추가하여 설계한 필터는 기존의 필터에 비해 7.4%만큼 공진기의 길이가 감소함을 확인하였다.

대학생의 직업기초능력 향상을 위한 액션러닝 프로그램 개발

정주영(Jung, Juyoung),홍광표(Hong, Kwangpyo) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.10

본 연구의 목적은 대학생의 직업기초능력 향상을 위한 액션러닝 프로그램을 개발하는 것이다. 연구 목적을 실현하기 위하여 문헌연구, 사례연구, 요구분석 등을 통해 프로그램의 초안을 구성하였다. 이후 전문가에 의한 1차 평가를 2017년 12월 1일부 터 5일간, 현장적용을 통한 2차 평가를 2018년 3월 1부터 4월 4주까지 총 13시간 실시하여 그 결과를 통해 프로그램의 최종안을 개발하였다. 개발된 프로그램은 사전활동, 본활동, 사후활동으로 구성되었다. 사전활동은 프로그램에 대한 안내와 자원을 확인한다. 본활동은 액션러닝의 활동 순서에 따라 직업기초능력 부재에 따른 문제상황을 인식하고 해결하는 과정을 통해 국가직무능력표준에서 제안하는 10가지 직업기초능력을 고루 갖출 수 있도록 하였다. 사후활동은 변화된 모습을 지속적으로 유지, 관리할 수 있도록 개발하였다. 본 연구를 통하여 직무 현장 및 이를 준비하는 교육 현장에서 직업기초능력 함양을 위한 대안적 방안을 마련하는데 실제적인 해결책을 제공해 줄 수 있으리라 기대한다. The purpose of this study is to develop an action learning program to improve basic skills of college students. In order to realize the purpose of the research, the draft of the program was made through literature research, case study and needs analysis. Then, the final draft of the program was developed through the first evaluation by experts and the second evaluation through field application. The developed program consisted of pre-activity, this activity, and post-activity. Preliminary activities identify the program and resources for the program. This activity was designed to equip 10 basic job skills proposed by national incompetence standard through the process of recognizing and solving the problem situation due to absence of job basic ability according to the order of activities of ACTION LEARNING. The post-hoc activities were designed to maintain and manage the changed aspects continuously. Through this study, it is expected that the practical and concrete alternatives for the development of job basic ability in the job field and the educational field preparing it can be provided.

고아 소녀의 가족 만들기: 『제인 에어』

정주영(Jung, JuYoung) 신영어영문학회 2018 신영어영문학 Vol.71 No.-

Charlotte Brontë’s Jane Eye has been examined from many perspectives, including feminism, psycho-analysis, and post-colonialism. However, this study focuses on the family narrative, which has been neglected by other researchers. Jane, an orphan girl, lives with several substitute families. The first of these, the Reed family, is an unpleasant experience. Her other substitute families include the Misses Temple and Helen in the LoWood Institution, Mrs. Fairfax and Adelé in Thorn Field, and Diana and Mary in Moor House. They severally take the role of Jane’s mother by nurturing her personality growth, in addition to taking care of her and assisting her academic advancement. Significantly, Jane becomes Adelé’s substitute mother, applying the love and care of the previous substitute mothers in the LoWood Institution. Jane therefore fills the gap of motherly love through her substitute families. This study also proposes that Jane’s marriage with Mr. Rochester is compensation for the absence of fatherly love.