Phenobarbital 前處置가 Halothane 麻醉時 肝病變에 미치는 影響에 關한 病理組織學的 硏究

姜俊求,姜大榮 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

Since halothane, as a new potent, nonexplosive, volatile agent, was introduced in 1956, many case reports of liver necrosis following halothane anesthesia have raised to possibility that the agent may damage the liver under certain circumstances. This study was carried out to investigate the histopathological effects of phenobarbital pretreated halothane anesthesia to the rat liver cells. Sprague-Dawley rats (male and female) were pretreated with phenobarbital; PBT(100 mg/kg/ day) for 3 days. All animals in each experimental group (saline-control, saline-anesthetized, PBT-control, and PBT-anesthetized) were fasted for 15 to 16 hours prior to each anesthesia period. PBT and Saline-pretreated animals were anesthetized together for 3 hours one to two times at 3 day intervals in a single chamber from a calibrated vaporizer. Stage III anesthesia was introduced with 1% halothane in oxygen and maintained with 0.8% to 1% halothane. Controls received the equivalent amount of saline solution. Each animal was sacrificed immediately, at 6, 12, 18, 24 and 48 hours after anesthesia respectively. The histopathological changes in the liver of the control and experimental groups were noted as follows; 1. Vacuolar degeneration of the hepatic cells of PBT pretreated rats showed more marked degree than the control. In repeated exposure of animals to the anesthetic at 3 day intervals aggravates the lesioned in control and PBT pretreated rats. 2. In first exposure to the anesthetic, fatty changes of the hepatic cells in PBT pretrea rats showed more marked in degree than the control. In repeated exposure of rats aggravates the lesions in control and PBT pretreated rats, and that of PBT pretreated rats was similar to the control. 3. The marked necrotic changes of hepatic cells were present in the PBT pretreated rats but those of the control were rarely observed. Repeated exposure of rats aggravate the lesion.

Halothane 및 Enflurane 麻醉가 肝病變에 미치는 影響에 關한 實驗的 硏究

姜俊求,姜大榮 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

In an attempt to elucidate the pathological and biochemical effects of phenobarbital and cimetidine on halothane and enflurane induced hepatic lesions, the present study in male SpragueDawley rats was undertaken to evaluate the relation betwen serum glutamic pyruvic transaminase (SGPT) and pathologic change of the liver at 0, 2, 6, 12, and 24 hours after halothane and enflurane anesthesia for 3 hours with pretreatment of phenobarbital and cimetidine. Groups of male rats received phenobarbitaal, 100mg/kg intraperitoneally, for 5 days and on the sixth day received either cimetidine, 180mg/kg intraperitoneally, or saline 60min before anesthesia. The rats received further closes of cimetidine (180mg/kg intraperitonally) or saline 1 hour and 5 hour, after anesthesia. The results were as follows 1. In the phenobarbital pretreated halothane anesthesia groups, the necrotic change of liver was mildly observed immediately after anesthesia, becoming gradually more severe, while that of enflurane anesthesia was moderately necrotic immediately after anesthesia, and after that becoming more severe. 2. In the phe:aobarbital and cimetidine pretreated halothane or enflurane anesthesia groups, the degree of the necrotic change of the liver was decreased, compared to that of phenobarbital pretreated halothane or enflurane anesthesia. 3. In the cimetidine pretreated halothane anesthesia group, the degree of the necrotic change of the liver cells was decreased, compared to that of non-cimetidine pretreated group. 4. In the phenobarbital pretreated groups, the fatty change of the liver after halothane anesthesia was similar to that of enflurane anesthesia, but in the non-phenobarbitall pretreated groups, the fatty change in ithe enflurane anesthesia group was more severe than that of halothane anesthesia. 5. In the phenobarbital pretreated group, the halothane anesthesia group followed a time course of SGPT elevation, but the SGPT value in the enflurane anesthesia group increased immediately after anesthesia and remained elevated approximately 24 hours after anesthesia. In the phenobarbital and cimetidine pretreated group, the SGPT values after halothane or enflurane anesthesia were decreased, compared to those of the non-cimetidine pretreated groups, but the decrease in SGPT concentration was significant. In summary, the results obtained by the present study indicate the pathological effects of pretreated cimetidine and phenobarbital upon acute hepatic lesions after halothane anesthesia were similar to that of enflurane anesthesia, but we supposed that the necrotic change due to enflurane anesthesia was increased by phenobarbital but relatively decreased by cimetidine.

卵巢 畸形腫의 病理組織學的 硏究

姜大榮,姜俊求 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

For study on cystic teratoma of ovary, the operation specimens were collected at the depatment of pathology, Chungnam National University College of Medicine from July 1975 to June 1984 and analyzed its histopathologic characteristics and clinical features. The results were as follows; 1. The total number of cystic teratorna were 220 cases, which were 105 cases (47. 7%) in the right ovary, 93 cases (42.3%) in the left ovary, and 22 cases (10%) in both ovaries. They occurred almost equally on either side. 2. The age distribution was highest in the third decade, 91 cases (41%). Ninety percent occurred during the reproductive years. 3. The average diameter was 8.7cm. 4. Microscopically ectodermal derivatives were most frequently present, followed by mesodermal structures and endodermal derivatives. 5. Most common complaint was palpable mass (37%), followed by pain. Most frequent complication was torsion, in which 23 cases (10%) were included. Malignant transformation was found in 2 cases (about 1%).

脛骨에서 發生한 Adamantinoma 1例

李鎬君,徐光善,姜俊求 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

Admanatinoma is a rare primary malignant tumor of long bone, most of which occur in tibia. This slow-growing tumor may occur at any age. There is considerable controversy regarding the pathogenesis. We experienced recently a case of adamantinoma of long bones in a 18 year-old female. Grossly, submitted specimen consists of multiple fragmented bony spicules admixed with some tumor mass, measuring 6 x 2.5 x 2 cm in dimension of the largest mass. These tumor masses were friable, gelatinous and gray to gray-white in color. Microscopically, sections reveal pseudoglandular pattern with intervening fibrous stroma. Also some strands and nests of undifferentiated appearing cells are noted. The intervening stroma is markedly abundant and fibrous. No squamous epithelial nests are noted.

성견에서 표면처리된 교정용 마이크로임플랜트의 골 접촉률 및 동요도

박승현,김성훈,류준하,강윤구,정규림,국윤아 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

The purpose of this study was to evaluate the mobility and ratio of the bone-implant contact (BIC) of a sandblasted, large grit and acid-etched (SLA) orthodontic micro-implant. Methods: Ninety-six micro-implants (48 SLA and 48 machined) were implanted in the upper and lower buccal alveolar bone, and palatal bone of four beagle dogs. Two weeks after surgery, orthodontic force (150 - 200 g) was applied. Two beagles were sacrificed at 4-weeks and the other two at 12-weeks. Histomorphometric comparisons were made between the SLA experimental group and the machined micro-implant as a control group to determine the ratio of contact between the bone and implant. Micro-implant mobility was also evaluated using Periotest. Results: Periotest values showed no statistically significant difference in the upper alveolar and palatal bone between groups except for the lower buccal area. BIC in the upper buccal area showed no significant difference between groups both at 4-weeks and 12-weeks. However, both the groups showed a significant difference in BIC ratio in the rest of the experimental areas between 4 weeks and 12 weeks. The experimental group showed active bone remodeling around the bone-implant interface compared to the control group. Conclusions: There were significant differences in the BIC and the Periotest values between the surface-treated and machined micro-implants according to bone quality in the early stage. 본 연구는 비글견에 식립된 sandblasted, large grit and acid-etched (SLA) 표면처리된 교정용 마이크로임플랜트와 평활면 마이크로임플랜트에 교정력을 가한 후 시간 경과에 따른 동요도와 골접촉률의 차이를 규명하기 위해 시행되었다. 비글 성견 네 마리를 이용하여 상, 하악 협측과 구개측 골에 대해 SLA 표면처리된 표면처리군 48개, 평활면의 비처리군 48개의 마이크로임플랜트 96개를 식립하고 2주의 치유기간 후 교정력(150 - 200 g)을 지속적으로 가했으며 식립 4주 후에 두 마리를 희생시키고, 12주 후에 나머지 2마리를 희생시켰다. 표면처리군과 비처리군 간의 마이크로 임플랜트의 동요도와 골과 임플랜트 간 접촉률을 조직학적인 측면에서 측정 비교하여 다음과 같은 결과를 얻었다. 상악 협측과 구개측에서는 표면처리군과 비처리군의 동요도에서 유의성 있는 차이가 없었으나 하악협측에서는 표면처리군이 유의하게 안정적인 동요도를 보였다. 마이크로임플랜트와 인접골 간 접촉률은 상악 협측에서는 4주와 12주 모두 표면처리군과 비처리군 간에 유의한 차이가 없었으나 하악 협측과 구개측의 경우 4주와 12주 모두 표면처리군이 비처리군에 비해 유의하게 높은 접촉률을 보였다. 표면처리군은 비처리군에 비해 임플랜트 주변에서 활발한 골개조가 관찰되었으며 모든 군에서 이물반응은 관찰되지 않았다. 본 연구를 통해 SLA 표면처리된 마이크로임플랜트는 평활면 마이크로임플랜트에 비하여 식립 초기에는 식립 부위에 따라 유의하게 높은 인접골 간 접촉률과 동요도의 안정성을 보임으로써 다양한 크기와 방향의 교정력의 적용이 가능할 것이라 생각한다.

Highly-ordered FePd Nanostructure and Magnetic Properties in Ultrahigh Density Magnetic Recording

Jun-Goo Kang,K. Takanashi,S. Mitani,Y. Sakuraba,Jae-Geun Ha 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Characteristics of CVD graphene nanoribbon formed by a ZnO nanowire hardmask

Kang, Chang Goo,Kang, Jang Won,Lee, Sang Kyung,Lee, Seung Yong,Cho, Chun Hum,Hwang, Hyeon Jun,Lee, Young Gon,Heo, Jinseong,Chung, Hyun-Jong,Yang, Heejun,Seo, Sunae,Park, Seong-Ju,Ko, Ki Young,Ahn, Jin IOP Pub 2011 Nanotechnology Vol.22 No.29

<P>A graphene nanoribbon (GNR) is an important basic structure to open a bandgap in graphene. The GNR processes reported in the literature are complex, time-consuming, and expensive; moreover, the device yield is relatively low. In this paper, a simple new process to fabricate a long and straight graphene nanoribbon with a high yield has been proposed. This process utilizes CVD graphene substrate and a ZnO nanowire as the hardmask for patterning. 8 µm long and 50–100 nm wide GNRs were successfully demonstrated in high density without any trimming, and ∼ 10% device yield was realized with a top-down patterning process. After passivating the surfaces of the GNRs using a low temperature atomic layer deposition (ALD) of Al<SUB>2</SUB>O<SUB>3</SUB>, high performance GNR MOSFETs with symmetric drain-current–gate-voltage (<I>I</I><SUB>d</SUB>–<I>V</I><SUB>g</SUB>) curves were demonstrated and a field effect mobility up to ∼ 1200 cm<SUP>2</SUP> V<SUP> − 1</SUP> s<SUP> − 1</SUP> was achieved at <I>V</I><SUB>d</SUB> = 10 mV. </P>

POSTER SESSION : NMR PEAK ASSIGNMENT FOR THE ELUCIDATION OF THE SOLUTION STRUCTURE OF T4 ENDONUCLEASE 5

Jun Goo Jee,Hoo Kang Im,Jun Suk Yu,Bong Jin Lee 한국생화학분자생물학회 (구 한국생화학회) 1996 추계학술대회집 Vol.- No.-

Structure and Magnetic Properties of Nonepitaxially-grown L10 FePdCu

Jun-Goo Kang,하재근 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

We investigated the effect of Cu addition on the FePd alloy. We sputter-deposited nonepitaxiallygrown L10 Cu-alloyed FePd thin films with (001) textures. The FePd films with different Cu contents were deposited directly on Si wafers without a seed layer or a buffer layer. All film thicknesses were 15 nm, which was achieved by adjusting the number of multilayers, n. After the deposition, the samples were annealed at 500℃ for 30 min. The results of X-ray diffraction indicate that a ternary FePdCu alloy was formed. The addition of Cu to FePd is more effective for enhancing the (001) orientation, with the (001) orientation increasing with the Cu content. Evidence shows that Cu alloys with FePd by substituting Fe or Pd in the L10 structure to form ternary FePdCu films.

Editorial : Gender and age differences in obesity among Korean adults

Jun Goo Kang,Cheol Young Park 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1