胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮 충남대학교 대학원 1976 論文集 Vol.6 No.-

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975 The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern with clinical considerations The results obtained were as follows 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis wth other diseases (13.%) 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically 3) Sec distr bution of stomach cancr was 20 malse (65%), and 14 females (35%) having 1 9 ratio Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases (57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%) Age distribution was the highest in both 4th decade 12 cases (30.8%) and 12 cases(30.8%) in 5th decade 5) The average diameter of malignant ulcers was 3.0-3.9 ㎝ in 14 cases (35.0%), and 6 cases were mort than 5.0㎝ in diameter In benign peptic ulcer mose frequent average size was 1.0-1.9 ㎝ in 16 cases (41.0%)and there was no case meauring over 5.0 ㎝ in diameter 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the greater curvature of the stomach The peptc ulcers also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 27.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperplasia.

독성 및 약인성 간손상 - 병리소견 -

강대영 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.1(S)

胃에 發生한 巨大한 平滑筋腫의 1例

姜大榮,金在權,朴成均 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Benign tumor of stomach is relatively rare, and leiomyoma is about 26% in all benign tumors of stomach. It's true etiology is unknown, and it is more prevalent in male. Abdominal pain, gastrointestinal bleeding and a palpable mass were the main symptoms and signs. Although incorrect still, radiologic finding was a clue of diagnosis. Recently we have experienced a case of very large smooth muscle tumor. A brief review of literatures and a discussion concerning leiomyoma of stomach are presented in this paper.

酸 및 알카리 溶液의 氣管內 注入에 依한 肺水鐘發生과 Sodium Thiosulfate의 效果에 關한 實驗的 硏究

姜大榮 부산의대 1971 부산의대잡지 - 부산대학교 의과대학 Vol.11 No.2

胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1976 충남의대잡지 Vol.3 No.1

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach, 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975. The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern, with clinical considerations. The results obtained were as follows: 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis with other diseases(13.1%). 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically. 3) Sex distribution of stomach cancer was 20 males(65%), and 14 females (35%) having 1.9:1 ratio. Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases(57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups. 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%). Age distribution was the highest in both 4th decade 12 cases (30.8%), and 12 cases (30.8%) in 5th decade. 5) The average diameter of malignant ulcers was 3.0∼3.9cm in 14 cases (35.0%), and 6 cases were more than 5.0cm in diameter. In benign peptic ulcer, most frequent average size was 1.0∼1.9cm in 16 cases (41.0%) and there was no case measuring over 5.0cm in diameter. 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the grater curvature of the stomach. The peptic ulcers, also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 25.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type. 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperlasial.

Dimethylhydrazine의 중독에 의한 만성 간 병변에 대한 연구

강대영 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

In an attempt to elucidate the chronic hepatic lesions induced by 1, 2-dimethylhydrazine (DMH), the present study in male Sprague-Dawley rats was undertaken to evaluate the death rate, the number of dyslastic cells, the average cell and nuclear size, hyperplastic lesion and bile duct changes. Hepatic lesions were induced in male Sprague-Dawley rats with 24 doses DMH 20mg/kg or 40mg/kg administered subcutaneously at the weekly intervals. All animals were sacrified at the 28th week. All organs were examined macroscopically and fixed in 10% buffered formalin. The results were as follows: 1. Dysplastic cells were only present in the DMH treated groups. The number of liver dysplastic cells of the DMH 40mg treated group was 4-7(average 5.2)/HPF, while that of the DMH 20mg treated group was 3-6 (average 4.3)/HPF. 2. The average cell size of the control group was 9.57±1.37mm, while those of the DMH 20mg, 40mg treated groups were 13.45±2.88mm and 17.10±3.18mm, respectively (P<0.001). 3. The average nuclear size of the control group was 4.50±0.52mm, while those of the DMH 20mg, 40mg treated groups were 7.30±0.92mm and 9.31±1.30mm respectively (P<0.001). 4. Bile duct proliferation with cystic dilatation in the DMH 40mg treated group was severe, but that of the DMH 20mg treated group was very mild. 5. Of the DMH induced bowel neoplasms, all (100%) developed colonic tumors. In summary, the result obtained by the present study indicates 1, 2-dimethylhydrazine induces liver cell dysplasia and bile duct proliferation accompanied by intestinal tumorigenesis.

忠南地方에 있어서 唾液腺 腫瘍의 病理組織學的 硏究

姜大榮,李載欣 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

For studies on salivary gland tumors in the Chungnam areas, the specimens were collected at the department of pathology, Chungnam National University School of Medicine from January 1972 to September 1983, and a statistical analysis on clinical or histological basis was made on 96 cases of salivary gland tumors. The results were as follows: 1. Out of 96 cases, 80 cases(83.3%) occurred at the salivary glands, in order of parotid gland in 54 cases (67.5%), submandibular gland in 25 cases (31.3%) and sublingual gland in 1 case (1.2%). Among minor salivary gland tumors, palate gland was the most favorite site with 10 cases (75%) out of 16. 2. Out of 96 cases, 82 cases (85.4%) were benign and 14 cases (14.6%) were malignant. Most common benign tumor was pleomorphic adenoma in 78 cases(85.1%), while mucoepidermoid carcinoma or adenoid cystic carcinoma in 4 cases (28.6%) was most common malignant tumor. 3. Overall sex distribution of salivary gland tumors was 40 cases for male and 56 case for female (male/female ratio was 1 : 1.4). 4. Mean age of patients with salivary gland tumor was 36.9 yeats and mean age for benign pleomorphic adenoma was 36.3 years. Mean age of carcinoma patients was 44.5 years. 5. Mean size of the salivary gland tumors was about 4.9㎝ in long diameter. Average size of benign tumor was 4.2㎝ and average size of carcinoma was 5.6㎝. 6. Mean value of time interval between onset of symptoms and diagnosis was 5.1 years. For benign tumor it was 5.2 years and carcinoma was about 4.8years.

卵巢의 原發性 惡性 絨毛上皮腫 : 症例 報告

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1975 충남의대잡지 Vol.2 No.2

A case of primary choriocarcinoma of the ovary in a 18-year-old virgin is reported. This tumor was very rare in the references. The diagnosis was not made preoperatively, and the evidence of precocious sexual signs was not stated. The prognosis is poor as illustrated in the cases reported (Table 1), death occurring in all cases in less than a years, and this case was expired 23 days after first excisional operation of the left ovarian tumor with possible metastasis to the brain.

Phenobarbital 前處置量이 Dimethylnitrosamine의 白鼠肝의 中毒性 病變에 미치는 影響에 關한 硏究

姜大榮 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

Dimethylnitrosamine, potent hepatotoxic and carcinogenic agent, is metabolized mainly in the liver, and its hepatotoxic action is influenced by the administration of phenobarbital which is thought as inducer of hepatic drug-metabolizing enzyme. In order to study the effects of phenobarbital pretreated dosage on the hepatotoxic changes of dimethylnitrosamine, phenobarbital were administered with 100mg every consecutive day to the male albino rats intraperitoneally, and then 60mg, 50mg, 40mg, and 30mg/kg of dimethylnitrosamine in physiologic saline solution were given by intraperitoneal injection. The mortality and histopathologic changes between control (dimethylnitrosamine only) and experimental groups were as follows: 1. Mortality in 60mg, 50mg, 40mg and 30mg injected rats indicated 80%, 50%, 40% and 15%, whereas phenobarbital 3 successive days' pretreated rats in corresponding group sustained 25%, 20%, 15%, and 5% of death rate, respectively, 6 successive days' pretreated rats 30%, 20%, 20% and 10%, 9 successive days' pretreated rats 75%, 70% and 17%. 2. The rats given 60mg, and 50mg of DMN, cause acute massive hemorrhage in the liver, and then the necrotic changes were more extensive and intensive in the early experimental days, and progressed with lessened thereafter. The phenobarbital 300mg pretreated groups were less intensive in their lesions and fastened their recovery than DMN-injected groups. The hemorrhagic necrotic changes in phenobarbital 600mg and 900mg phenobarbital groups, were less intensive on the first day of experiment, compared with 300mg pretreated groups, but after that more intensive and prolonged. 3. Necrotic changes in the 40mg and 30mg of DMN injected groups developed mild to moderate degree in the first experimental day, and became worse in successive 1-2 days, whereas in phenobarbital 300mg pretreated groups the lesions were more mild and shortened their course than those in DMN injected groups, but in phenobarbital 600mg and 900mg pretreated groups, necrotic changes were mild on the first day of experiment, but after that became more intensive and prolonged. 4. Hepatic fibrosis in both DMN-injected and phenobarbital pretreated groups developed around the date when necrotic changes were subsided, but in phenobarbital pretreated groups were less intensive and shorter course than each corresponding DMN-injected group. There are no specific relationships between necrotic or fibrotic change and phenobarbital pretreated dosage.

Butylated Hydroxytoluene 투여가 3´-Methyl-4-Dimethylaminoazobenzene으로 유발된 백서 간암 발생과정에 미치는 영향에 대한 연구 (I)

강대영,최정목 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

A morphologic study on the effect of butylated hydroxytoluene(BHT) on experimental hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene(3'-MeDAB) was investigated. A total of 184 Sprague-Dawley male rats weighing about 200g each were used in the experiment, and divided into 4 groups: the 3'-MeDAB treated group, the 3'-MeDAB+BHT treated group, the BHT treated group, and the contol group. The first and second groups received continuous pelletized feeding containing 0.09% 3'-MeDAB with and without 0.5% BHT, respectively. The third and fourth groups received feeding with and without 0.5% BHT, respectively. Four to eight rats in each group were sacrified on the 4th, 8th, 14th and 16th experimental week. The liver was examined with histochemical and immunohistochemical staining, and by light microscopy. The results were as follows; The following histopathological changes were noted in the 3'-MeDAB administered group: oval cell proliferation, bile ductular proliferation, nodular lesions(vacuolated, eosinophilic, basophilic and mixed), cholangiofibrosis and carcinoma. However, compared with the 3'-MeDAB treated group, the 3'-MeDAB+BHT treated group showed decreased presence of oval cells, bile ductular proliferation, cholangiofibrosis and carcinoma. The histopathologic changes in the BHT treated group were similar to those of the control group. Masson trichrome staining intensity increased over time from the 4th to the 16th week. Strong staining was especially detected at the portal areas and periphery of the proliferated bile ductules in portal areas of the 3'-MeDAB and the 3'-MeDAB+BHT treated groups. The staining intensity of the 3 MeDAB+BHT treated group decreased compared with that of 3'-MeDAB treated group. The expression of GST-P was examined with immunohistochemical staining. In the 3'MeDAB treated group, GST-P positive area was present in the cytoplasm and nuclei of the hepatocytes of the preneoplastic or neoplastic lesions and proliferated bile ductules. Staining intensity increased over time from the 4th to 16th week, Whereas negative staining was seen in the control and BHT groups. But the staining intensity of the 3'-MeDAB+BHT group decreased compared with that of the 3'-MeDAB group. These results suggest that dietary butylated hydroxytoluene has a protective/inhibitive effect on hepatocarcinogensis induced by 3'-methyl-4-dimethylamino-azobenzene.